{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:47:51Z","timestamp":1791866871950,"version":"4.3.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2025-25400201"],"award-info":[{"award-number":["RS-2025-25400201"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-23323645"],"award-info":[{"award-number":["RS-2025-23323645"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chemosphere.2026.144971","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:32:58Z","timestamp":1780975978000},"page":"144971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cyphenothrin disrupts the integrity of porcine trophectoderm and uterine luminal epithelial cell lines by inducing mitochondrial dysfunction and oxidative stress"],"prefix":"10.1016","volume":"407","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0598-5679","authenticated-orcid":false,"given":"Yuseok","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhun","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinhye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisoo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Min","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W.","family":"Bazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-5323","authenticated-orcid":false,"given":"Gwonhwa","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-0465","authenticated-orcid":false,"given":"Whasun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-2726","authenticated-orcid":false,"given":"Jiyeon","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2026.144971_bib1","article-title":"Pyrethroid pesticides: an overview on classification, toxicological assessment and monitoring","volume":"10","author":"Ahamad","year":"2023","journal-title":"J. Hazard. Mater. Adv."},{"key":"10.1016\/j.chemosphere.2026.144971_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103859","article-title":"Mitochondrial membrane potential and compartmentalized signaling: calcium, ROS, and beyond","volume":"86","author":"Ahmed Selim","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192114049","article-title":"Pesticides in the indoor environment of residential houses: a case study in strasbourg, France","volume":"19","author":"Al-Alam","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2026.144971_bib4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/tox.21802","article-title":"Reproductive toxicity and histopathological changes induced by lambda-cyhalothrin in Male mice","volume":"29","author":"Al-Sarar","year":"2014","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib5","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1530\/REP-21-0478","article-title":"Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling","volume":"164","author":"Alarcon","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.chemosphere.2026.144971_bib6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s11270-022-05860-x","article-title":"How does cyphenothrin affect the freshwater mussel as in vitro and in vivo models?","volume":"233","author":"Arslan","year":"2022","journal-title":"Water, Air, Soil Pollut."},{"key":"10.1016\/j.chemosphere.2026.144971_bib7","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1158\/1078-0432.CCR-17-3070","article-title":"Oxidative phosphorylation as an emerging target in cancer therapy","volume":"24","author":"Ashton","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/molehr\/gap095","article-title":"Novel pathways for implantation and establishment and maintenance of pregnancy in mammals","volume":"16","author":"Bazer","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.chemosphere.2026.144971_bib9","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib10","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders \u2014 a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.chemosphere.2026.144971_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death \u2013 apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.chemosphere.2026.144971_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2016.00089","article-title":"Safety evaluation of parastar\u00ae plus in dogs and assessment of transferable residue of fipronil and cyphenothrin from dogs to humans","volume":"3","author":"Case","year":"2016","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.chemosphere.2026.144971_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/MCB.00630-10","article-title":"Cyclin A promotes S-Phase entry via interaction with the replication licensing factor Mcm7","volume":"31","author":"Chibazakura","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib14","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/carcin\/21.7.1423","article-title":"Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium","volume":"21","author":"Chuang","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.chemosphere.2026.144971_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.envint.2012.05.007","article-title":"Pyrethroids in human breast milk: occurrence and nursing daily intake estimation","volume":"47","author":"Corcellas","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2026.144971_bib16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1681\/ASN.2008050514","article-title":"RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes","volume":"20","author":"Coughlan","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41419-021-04066-z","article-title":"Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-Induced apoptosis and cytokine induction","volume":"12","author":"Cui","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chemosphere.2026.144971_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139181","article-title":"Contamination of pyrethroids in agricultural soils from the Yangtze River Delta, China","volume":"731","author":"Deng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2026.144971_bib19","series-title":"Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology","first-page":"145","article-title":"Molecular mechanisms of superoxide production by the mitochondrial respiratory chain","author":"Dr\u00f6se","year":"2012"},{"key":"10.1016\/j.chemosphere.2026.144971_bib20","series-title":"Cyphenothrin Product-type 18: Assessment Report","first-page":"10","year":"2018"},{"key":"10.1016\/j.chemosphere.2026.144971_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.rbmo.2010.04.022","article-title":"High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation","volume":"21","author":"Farhi","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.chemosphere.2026.144971_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhydrol.2010.08.012","article-title":"Presence of pyrethroid pesticides in water and sediments of Ebro River Delta","volume":"393","author":"Feo","year":"2010","journal-title":"J. Hydrol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.14252\/foodsafetyfscj.D-23-00008","article-title":"Cyphenothrin (Veterinary medicinal products)","volume":"11","year":"2023","journal-title":"Food Safety"},{"key":"10.1016\/j.chemosphere.2026.144971_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/15548627.2016.1277309","article-title":"PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation","volume":"13","author":"Gelmetti","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.chemosphere.2026.144971_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aba3396","article-title":"Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice","volume":"13","author":"Gu","year":"2020","journal-title":"Sci. Signal."},{"key":"10.1016\/j.chemosphere.2026.144971_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12737","article-title":"ATP mediates the interaction between human blastocyst and endometrium","volume":"53","author":"Gu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.chemosphere.2026.144971_bib27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s12013-014-0081-7","article-title":"Calcium overload and in vitro apoptosis of the C6 glioma cells mediated by sonodynamic therapy (Hematoporphyrin monomethyl ether and ultrasound)","volume":"70","author":"Hao","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.chemosphere.2026.144971_bib28","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1039\/D1FO04086C","article-title":"Glucosamine enhances proliferation, barrier, and anti-oxidative functions in porcine trophectoderm cells","volume":"13","author":"He","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.chemosphere.2026.144971_bib29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/bies.201600057","article-title":"Bistability of mitotic entry and exit switches during open mitosis in mammalian cells","volume":"38","author":"H\u00e9garat","year":"2016","journal-title":"Bioessays"},{"key":"10.1016\/j.chemosphere.2026.144971_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114559","article-title":"Norflurazon causes cell death and inhibits implantation-related genes in porcine trophectoderm and uterine luminal epithelial cells","volume":"186","author":"Hong","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humrep\/dei286","article-title":"Adverse effects of retinoic acid on embryo development and the selective expression of retinoic acid receptors in mouse blastocysts","volume":"21","author":"Huang","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.chemosphere.2026.144971_bib32","series-title":"IRAC Mode of Action Classification Scheme","first-page":"8","year":"2025"},{"key":"10.1016\/j.chemosphere.2026.144971_bib33","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/en.2005-0090","article-title":"Functional effects of transforming growth factor \u03b2 on adhesive properties of porcine trophectoderm","volume":"146","author":"Jaeger","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2026.144971_bib34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.redox.2017.11.004","article-title":"DUSP1 alleviates cardiac ischemia\/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways","volume":"14","author":"Jin","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jgg.2021.01.001","article-title":"Cyclin A2\/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish","volume":"48","author":"Jin","year":"2021","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.chemosphere.2026.144971_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cyto.a.20357","article-title":"Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete \u201csub-G1\u201d peaks on DNA content histograms","volume":"71A","author":"Kajstura","year":"2007","journal-title":"Cytometry A"},{"key":"10.1016\/j.chemosphere.2026.144971_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jspr.2018.10.008","article-title":"Insecticidal efficacy of a binary combination of cyphenothrin and prallethrin, applied as surface treatment against four major stored-product insects","volume":"80","author":"Karanika","year":"2019","journal-title":"J. Stored Prod. Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib38","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1038\/s41598-024-58656-w","article-title":"Chronic replication stress invokes mitochondria dysfunction via impaired parkin activity","volume":"14","author":"Kawabata","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2026.144971_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12964-025-02191-2","article-title":"IGF-1 promotes trophectoderm cell proliferation of porcine embryos by activating the Wnt\/\u03b2-catenin pathway","volume":"23","author":"Kim","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.chemosphere.2026.144971_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.trim.2016.02.003","article-title":"Induction of IL-8(CXCL8) and MCP-1(CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell","volume":"35","author":"Kumar","year":"2016","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105615","article-title":"Pyrethroids toxicity in vertebrates and invertebrates and amelioration by bioactive compounds: a review","volume":"196","author":"Kumar","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib42","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/antiox11101995","article-title":"The complex interplay between Mitochondria, ROS and entire cellular metabolism","volume":"11","author":"Kuznetsov","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.chemosphere.2026.144971_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176441","article-title":"Resmethrin induces implantation failure by disrupting calcium homeostasis and forcing mitochondrial defects in porcine trophectoderm and uterine luminal epithelial cells","volume":"954","author":"Lee","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2026.144971_bib44","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1095\/biolreprod.103.015669","article-title":"Induction of p38 mitogen-activated protein kinase-mediated apoptosis is involved in outgrowth of trophoblast cells on endometrial epithelial cells in a model of human trophoblast-endometrial Interactions1","volume":"69","author":"Li","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.chemosphere.2026.144971_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104547","article-title":"Bcl-XL: a multifunctional anti-apoptotic protein","volume":"151","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib46","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12958-022-00973-8","article-title":"Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation","volume":"20","author":"Li","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib47","article-title":"CaM promotes cardiomyocyte mitophagy in myocardial ischemia-reperfusion injury involving in the regulation of the IP3R3-GRP75-VDAC1 complex","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2026.144971_bib48","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.envres.2018.12.045","article-title":"Deltamethrin toxicity: a review of oxidative stress and metabolism","volume":"170","author":"Lu","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.102971","article-title":"Protocol to assess bioenergetics and mitochondrial fuel usage in murine autoreactive immunocytes using the seahorse extracellular flux analyzer","volume":"5","author":"Mayberry","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.chemosphere.2026.144971_bib50","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/emboj\/18.3.632","article-title":"Bcl\u2010xL regulates apoptosis by heterodimerization\u2010dependent and \u2010independent mechanisms","volume":"18","author":"Minn","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.chemosphere.2026.144971_bib51","series-title":"Agricultural Pyrethroids Market Size & Share Analysis - Growth Trends and Forecast (2025 - 2030)","year":"2025"},{"key":"10.1016\/j.chemosphere.2026.144971_bib52","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.chemosphere.2026.144971_bib53","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/antiox10111824","article-title":"Mitochondrial management of reactive oxygen species","volume":"10","author":"Napolitano","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.chemosphere.2026.144971_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib55","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/j.bbamcr.2015.02.022","article-title":"Mitochondrial autophagy: origins, significance, and role of BNIP3 and NIX","volume":"1853","author":"Ney","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib56","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1021\/acs.jafc.3c01501","article-title":"Improved assessment of soil nonextractable residues of the pyrethroid insecticide cyphenothrin","volume":"71","author":"Okuda","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2026.144971_bib57","doi-asserted-by":"crossref","first-page":"31541","DOI":"10.1007\/s11356-021-17775-x","article-title":"Toxicokinetic of cyphenothrin in rabbits","volume":"29","author":"\u00d6zen","year":"2022","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.chemosphere.2026.144971_bib58","doi-asserted-by":"crossref","first-page":"89824","DOI":"10.18632\/oncotarget.21158","article-title":"Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia","volume":"8","author":"Pan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.chemosphere.2026.144971_bib59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/toxsci\/kfz212","article-title":"Evaluation of resmethrin toxicity to neonatal testes in organ culture","volume":"173","author":"Park","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2026.144971_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173097","article-title":"Beta-cyfluthrin impairs implantation process by inducing mitochondrial defects and changes in reactive oxygen species-mediated signaling pathways in porcine trophectoderm and uterine luminal epithelial cells","volume":"934","author":"Park","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2026.144971_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100065","article-title":"Mechanisms of female reproductive toxicity in pigs induced by exposure to environmental pollutants","volume":"47","author":"Park","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.chemosphere.2026.144971_bib62","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.129114","article-title":"Estradiol elicits proapoptotic and antiproliferative effects in human trophoblast Cells1","volume":"93","author":"Patel","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.chemosphere.2026.144971_bib63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.63.12.18","article-title":"AMPK\/MFF activation: role in mitochondrial fission and mitophagy in dry eye","volume":"63","author":"Peng","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.chemosphere.2026.144971_bib64","author":"Pharm"},{"key":"10.1016\/j.chemosphere.2026.144971_bib65","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1038\/onc.2008.308","article-title":"Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis","volume":"27","author":"Pinton","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.chemosphere.2026.144971_bib66","doi-asserted-by":"crossref","first-page":"13214","DOI":"10.1128\/JVI.77.24.13214-13224.2003","article-title":"Mechanisms governing maintenance of Cdk1\/Cyclin B1Kinase activity in cells infected with HumanCytomegalovirus","volume":"77","author":"Sanchez","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab060","article-title":"Uterine kisspeptin receptor critically regulates epithelial estrogen receptor \u03b1 transcriptional activity at the time of embryo implantation in a mouse model","volume":"27","author":"Schaefer","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.chemosphere.2026.144971_bib68","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2026.144971_bib69","series-title":"Advances in Neurotoxicology","first-page":"113","article-title":"Chapter three - neurotoxicology of pyrethroid insecticides","author":"Soderlund","year":"2020"},{"key":"10.1016\/j.chemosphere.2026.144971_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?","author":"Son","year":"2011","journal-title":"Journal of Signal Transduction"},{"key":"10.1016\/j.chemosphere.2026.144971_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.796358","article-title":"Revisiting the transcriptome landscape of pig embryo implantation site at single-cell resolution","volume":"10","author":"Tian","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib72","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3390\/ijerph15081614","article-title":"Effects of bisphenol A and 4-tert-Octylphenol on embryo implantation failure in mouse","volume":"15","author":"Tran","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2026.144971_bib73","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.3390\/cells10123327","article-title":"Regulation of cell cycle progression by growth factor-induced cell signaling","volume":"10","author":"Wang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.chemosphere.2026.144971_bib74","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1290\/1071-2690(2000)036<0650:IIAICO>2.0.CO;2","article-title":"Isolation, immortalization, and initial characterization of uterine cell lines: an in vitro model system for the procine uterus","volume":"36","author":"Wang","year":"2000","journal-title":"Cell. Dev. Biol.Anim."},{"key":"10.1016\/j.chemosphere.2026.144971_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.608447","article-title":"CYP11A1 upregulation leads to trophoblast oxidative stress and fetal neurodevelopmental toxicity that can be rescued by vitamin D","volume":"7","author":"Wang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.chemosphere.2026.144971_bib76","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.chemosphere.2026.144971_bib77","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.immuni.2025.07.012","article-title":"Mitochondria reactive oxygen species signaling in immune responses","volume":"58","author":"Weinberg","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.chemosphere.2026.144971_bib78","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tem.2018.04.001","article-title":"Progesterone receptor regulation of uterine adaptation for pregnancy","volume":"29","author":"Wu","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.chemosphere.2026.144971_bib79","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.chemosphere.2026.144971_bib80","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/mrd.21303","article-title":"Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle","volume":"78","author":"Yang","year":"2011","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.chemosphere.2026.144971_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104850","article-title":"Mechanisms of deleterious effects of some pesticide exposure on pigs","volume":"175","author":"Yang","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib82","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tem.2019.11.008","article-title":"Uterine luminal epithelium as the transient gateway for embryo implantation","volume":"31","author":"Ye","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib83","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150254","article-title":"Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization","volume":"6","author":"Yin","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.chemosphere.2026.144971_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102289","article-title":"IP3R1\/GRP75\/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling","volume":"52","author":"Yuan","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.chemosphere.2026.144971_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2026.144971_bib86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.chemosphere.2026.144971_bib87","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3892\/ol.2024.14339","article-title":"CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle","volume":"27","author":"Zhou","year":"2024","journal-title":"Oncol. Lett."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653526001487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653526001487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:23:48Z","timestamp":1791865428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653526001487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":87,"alternative-id":["S0045653526001487"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2026.144971","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyphenothrin disrupts the integrity of porcine trophectoderm and uterine luminal epithelial cell lines by inducing mitochondrial dysfunction and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2026.144971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"144971"}}