{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:57:05Z","timestamp":1758808625482,"version":"3.37.3"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012138","name":"Beijing Forestry University","doi-asserted-by":"publisher","award":["2015-66306-P"],"award-info":[{"award-number":["2015-66306-P"]}],"id":[{"id":"10.13039\/501100012138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["IT 849-13"],"award-info":[{"award-number":["IT 849-13"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry and Physics of Lipids"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.chemphyslip.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T21:36:21Z","timestamp":1484602581000},"page":"54-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin"],"prefix":"10.1016","volume":"203","author":[{"given":"Marco M.","family":"Manni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan G.","family":"Valero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"P\u00e9rez-Cormenzana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainara","family":"Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix M.","family":"Go\u00f1i","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/109374001301419737","article-title":"Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2'-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene","volume":"4","author":"Abu-Qare","year":"2000","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0010","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1038\/cddis.2011.139","article-title":"Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells","volume":"31","author":"Ajabnoor","year":"2012","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/CDLI.8.2.460-464.2001","article-title":"Use of Hoechst 33342 staining to detect apoptotic changes in bovine mononuclear phagocytes infected with Mycobacterium avium subsp. paratuberculosis","volume":"82","author":"Allen","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1096\/fj.03-0301fje","article-title":"Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells","volume":"18","author":"Artwohl","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0025","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2958.1995.tb02234.x","article-title":"Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene","volume":"152","author":"Awad","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbalip.2006.03.014","article-title":"Oxidative stress and arachidonic acid mobilization","volume":"1761","author":"Balboa","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0035","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1021\/pr201223p","article-title":"Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression","volume":"114","author":"Barr","year":"2012","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.chemphyslip.2017.01.002_bib0040","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.devcel.2012.10.009","article-title":"Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity","volume":"23","author":"Bigay","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0045","doi-asserted-by":"crossref","first-page":"26159","DOI":"10.1074\/jbc.272.42.26159","article-title":"Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase","volume":"27242","author":"Bratton","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI119566","article-title":"Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells","volume":"1003","author":"Bunting","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0055","doi-asserted-by":"crossref","first-page":"e9924","DOI":"10.1371\/journal.pone.0009924","article-title":"Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization","volume":"53","author":"Buron","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0060","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/sj.cdd.4401250","article-title":"Intravenously administered propidium iodide labels necrotic cells in the intact mouse brain after injury","volume":"108","author":"Cevik","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0070","doi-asserted-by":"crossref","first-page":"e59921","DOI":"10.1371\/journal.pone.0059921","article-title":"Free fatty acid induces endoplasmic reticulum stress and apoptosis of \u03b2-cells by Ca2+\/Calpain-2 pathways","volume":"83","author":"Cui","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0075","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molcel.2008.04.005","article-title":"To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: groove interactions","volume":"303","author":"Dewson","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0080","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0167-4889(92)90048-G","article-title":"Analysis and discrimination of necrosis and apoptosis programmed cell death by multiparameter flow cytometry","volume":"11333","author":"Dive","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0085","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1172\/JCI116876","article-title":"Release of ceramide after membrane sphingomyelin hydrolysis decreases the basolateral secretion of triacylglycerol and apolipoprotein B in cultured human intestinal cells","volume":"926","author":"Field","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0090","first-page":"1231","article-title":"Mechanisms of thymidine kinase\/ganciclovir and cytosine deaminase\/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells","volume":"247","author":"Fischer","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0095","doi-asserted-by":"crossref","first-page":"26680","DOI":"10.1074\/jbc.M500278200","article-title":"A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C","volume":"28029","author":"Flores-D\u00edaz","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0100","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.toxicon.2003.11.013","article-title":"Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene","volume":"428","author":"Flores-Diaz","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.anaerobe.2003.11.002","article-title":"Effects of Clostridium perfringens phospholipase C in mammalian cells","volume":"102","author":"Flores-Diaz","year":"2004","journal-title":"Anaerobe"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0110","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1476-5381.1986.tb10233.x","article-title":"Excitatory effect of Clostridium perfringens alpha toxin on the rat isolated aorta","volume":"883","author":"Fujii","year":"1986","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/excr.1993.1008","article-title":"Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetylcarnitine","volume":"2041","author":"Galli","year":"1993","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10495-009-0449-0","article-title":"Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane","volume":"155","author":"Ganesan","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0125","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1042\/BC20060038","article-title":"Bacterial protein toxins and lipids: role in toxin targeting and activity","volume":"98","author":"Genei","year":"2006","journal-title":"Biol. Cell"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/BC20050082","article-title":"Bacterial protein toxins and lipids:pore formation or toxin entry into cells","volume":"98","author":"Genei","year":"2006","journal-title":"Biol. Cell"},{"issue":"3","key":"10.1016\/j.chemphyslip.2017.01.002_bib0135","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.plipres.2012.03.002","article-title":"Phospholipases C and sphingomyelinases: lipids as substrates and modulators of enzyme activity","volume":"51","author":"Go\u00f1i","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/00365529009095500","article-title":"Phospholipase C from Clostridium perfringens stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells INT 407","volume":"254","author":"Gustafson","year":"1990","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0145","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1038\/sj.emboj.7600210","article-title":"Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes","volume":"2310","author":"Hill","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2275(20)32339-7","article-title":"Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis","volume":"421","author":"Igal","year":"2001","journal-title":"J. Lipid Res."},{"issue":"41","key":"10.1016\/j.chemphyslip.2017.01.002_bib0155","doi-asserted-by":"crossref","first-page":"14554","DOI":"10.1021\/ja507832e","article-title":"Lipid organization of the plasma membrane","volume":"136","author":"Ing\u00f3lfsson","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"10.1016\/j.chemphyslip.2017.01.002_bib0160","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.etp.2005.02.003","article-title":"Saturated free fatty acid, palmitic acid, induces apoptosis in fetal hepatocytes in culture","volume":"56","author":"Ji","year":"2005","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0165","doi-asserted-by":"crossref","first-page":"e10296","DOI":"10.1371\/journal.pone.0010296","article-title":"Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation","volume":"54","author":"Kang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0170","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0003-9861(84)90403-X","article-title":"Phospholipase C from Clostridium perfringens: preparation and characterization of homogeneous enzyme","volume":"2312","author":"Krug","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0175","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1115035","article-title":"Caspases 3 and 7: key mediators of mitochondrial events of apoptosis","volume":"3115762","author":"Lakhani","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0180","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.bbalip.2013.04.011","article-title":"Molecular lipidomes of exosomes released by PC-3 prostate cancer cells","volume":"1831","author":"Llorente","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0185","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/sj.cdd.4401828","article-title":"Small molecule inhibitors of Apaf-1-related caspase- 3\/-9 activation that control mitochondrial-dependent apoptosis","volume":"139","author":"Malet","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chemphyslip.2015.08.011","article-title":"Lipids that determine detergent resistance of MDCK cell membrane fractions","volume":"191","author":"Manni","year":"2015","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0195","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbamem.2014.11.028","article-title":"Interaction of Clostridium perfringens epsilon-toxin with biological and model membranes: a putative protein receptor in cells","volume":"1848","author":"Manni","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"journal-title":"Clostridium perfringens phospholipase C\/sphingomyelinase alpha-toxin effects on GM95 cells: A lipidomic study","year":"2017","author":"Manni","key":"10.1016\/j.chemphyslip.2017.01.002_bib0200"},{"issue":"Pt B","key":"10.1016\/j.chemphyslip.2017.01.002_bib0205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jprot.2015.01.019","article-title":"Enhancing metabolomics research through data mining","volume":"127","author":"Mart\u00ednez-Arranz","year":"2015","journal-title":"J. Proteomics"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0210","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/hep.26399","article-title":"Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis","volume":"584","author":"Mart\u00ednez-U\u00f1a","year":"2013","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.chemphyslip.2017.01.002_bib0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.bjc.6600675","article-title":"Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines","volume":"88","author":"McKeague","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0220","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1207\/s15327914nc5202_12","article-title":"Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation","volume":"522","author":"Merendino","year":"2005","journal-title":"Nutr. Cancer"},{"issue":"3","key":"10.1016\/j.chemphyslip.2017.01.002_bib0225","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1021\/jm701195j","article-title":"Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors?","volume":"51","author":"Mondragon","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0230","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1054\/plef.2001.0334","article-title":"Antineoplastic properties of arachidonic acid and its metabolites","volume":"66","author":"Monjazeb","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0235","doi-asserted-by":"crossref","first-page":"e86475","DOI":"10.1371\/journal.pone.0086475","article-title":"Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NF\u03baB activation","volume":"91","author":"Monturiol-Gross","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0240","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/cmi.12237","article-title":"Internalization of Clostridium perfringens \u03b1-toxin leads to ERK activation and is involved on its cytotoxic effect","volume":"64","author":"Monturiol-Gross","year":"2014","journal-title":"Cell. Microbiol."},{"issue":"5","key":"10.1016\/j.chemphyslip.2017.01.002_bib0245","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1128\/jb.177.5.1179-1185.1995","article-title":"Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin","volume":"177","author":"Nagahama","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0250","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/j.bbamem.2007.08.016","article-title":"Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes","volume":"1768","author":"Nagahama","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0255","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/1447","article-title":"Structure of the key toxin in gas gangrene","volume":"58","author":"Naylor","year":"1998","journal-title":"Nat. Struct. Biol."},{"issue":"12","key":"10.1016\/j.chemphyslip.2017.01.002_bib0260","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1128\/IAI.00947-15","article-title":"A global metabolomic analysis of a mammalian host infected with Bacillus anthracis","volume":"83","author":"Nguyen","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0265","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1074\/jbc.M307046200","article-title":"Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes","volume":"27913","author":"Ochi","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"39","key":"10.1016\/j.chemphyslip.2017.01.002_bib0270","doi-asserted-by":"crossref","first-page":"33070","DOI":"10.1074\/jbc.M112.393801","article-title":"Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex","volume":"287","author":"Oda","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0275","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0966-842X(98)01430-9","article-title":"Clostridium perfringens: toxinotype and genotype","volume":"73","author":"Petit","year":"1999","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0280","first-page":"6","article-title":"Antineoplastic and apoptotic effects of cannabinoids: n-acylethanolamines: protectors or killers","volume":"301","author":"Pushkarev","year":"2008","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0285","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.micro.52.1.333","article-title":"Virulence genes of Clostridium perfringens","volume":"52","author":"Rood","year":"1998","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0290","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-4781(97)00117-6","article-title":"Chinese hamster ovary cells lacking GM1 and GD1a synthesize gangliosides upon transfection with human GM2 synthase","volume":"1354","author":"Rosales-Fritz","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0295","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1042\/BST20140151","article-title":"Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors","volume":"425","author":"Ruban","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0300","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11306-013-0598-6","article-title":"Reflections on univariate and multivariate analysis of metabolomics data","volume":"103","author":"Saccenti","year":"2014","journal-title":"Metabolomics"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0305","doi-asserted-by":"crossref","first-page":"7183","DOI":"10.1158\/0008-5472.CAN-04-1918","article-title":"Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice","volume":"6420","author":"Schimmer","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0310","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1073\/pnas.022493799","article-title":"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater","volume":"992","author":"Shimizu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0315","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1438-4221(00)80074-0","article-title":"The pathogenesis of clostridial myonecrosis","volume":"2904-5","author":"Stevens","year":"2000","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0320","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0014-5793(98)00630-9","article-title":"Cytochrome c release and caspase activation in hydrogen peroxide-and tributyltin-induced apoptosis","volume":"429","author":"Stridh","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0325","doi-asserted-by":"crossref","first-page":"14861","DOI":"10.1073\/pnas.0804236105","article-title":"Mitochondrial potassium channel Kv1. 3 mediates Bax-induced apoptosis in lymphocytes","volume":"10539","author":"Szab\u00f3","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0330","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1074\/jbc.M111350200","article-title":"Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition","volume":"27712","author":"Tafani","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0335","doi-asserted-by":"crossref","first-page":"e0120497","DOI":"10.1371\/journal.pone.0120497","article-title":"Clostridium perfringens alpha-Toxin induces gm1a clustering and trka phosphorylation in the host cell membrane","volume":"10","author":"Takagishi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/anae.1999.0191","article-title":"The Clostridium perfringens alpha-toxin","volume":"52","author":"Titball","year":"1999","journal-title":"Anaerobe"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0345","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ijmm.2009.04.003","article-title":"The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation","volume":"2998","author":"Tumurkhuu","year":"2009","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0350","first-page":"1","article-title":"Phospholipase C and sphingomyelinase activities of the Clostridium perfringens alpha-toxin","volume":"1591","author":"Urbina","year":"2009","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0355","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbamem.2010.08.011","article-title":"Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens \u03b1-toxin","volume":"18081","author":"Urbina","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0360","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.bbamem.2011.06.008","article-title":"Unexpected wide substrate specificity of C. perfringens \u03b1-toxin phospholipase C","volume":"10","author":"Urbina","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0365","doi-asserted-by":"crossref","first-page":"e38620","DOI":"10.1371\/journal.pone.0038620","article-title":"\u03bc-Calpain conversion of antiapoptotic Bfl-1 BC1 BCEL2A1 into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-Mediated apoptosis","volume":"76","author":"Valero","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0370","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0375","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0264-410X(93)90051-X","article-title":"A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene","volume":"11","author":"Williamson","year":"1993","journal-title":"Vaccine"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0380","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1471-4159.2002.01145.x","article-title":"Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes","volume":"83","author":"Xu","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0385","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.prostaglandins.2013.05.004","article-title":"The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55","volume":"107","author":"Yamashita","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0390","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0167-4889(03)00047-8","article-title":"Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts","volume":"1641","author":"Yuan","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemphyslip.2017.01.002_bib0395","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/S0022-2275(20)37421-6","article-title":"Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes","volume":"387","author":"De Vries","year":"1997","journal-title":"J. Lipid Res."}],"container-title":["Chemistry and Physics of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009308416301177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009308416301177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T19:24:07Z","timestamp":1655925847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009308416301177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":79,"alternative-id":["S0009308416301177"],"URL":"https:\/\/doi.org\/10.1016\/j.chemphyslip.2017.01.002","relation":{},"ISSN":["0009-3084"],"issn-type":[{"type":"print","value":"0009-3084"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin","name":"articletitle","label":"Article Title"},{"value":"Chemistry and Physics of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemphyslip.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}