{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:34:27Z","timestamp":1793558067127,"version":"4.5.0"},"reference-count":142,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry and Physics of Lipids"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.chemphyslip.2021.105055","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T15:49:33Z","timestamp":1612626573000},"page":"105055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":198,"special_numbering":"C","title":["Skin lipids in health and disease: A review"],"prefix":"10.1016","volume":"236","author":[{"given":"Sophie","family":"Knox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-4944","authenticated-orcid":false,"given":"Niamh M.","family":"O\u2019Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemphyslip.2021.105055_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.plefa.2018.05.001","article-title":"Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles","volume":"134","author":"Agrawal","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2017.06.002","article-title":"Corneocyte lipid envelope (Cle), the key structure for skin barrier function and ichthyosis pathogenesis","volume":"88","author":"Akiyama","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/ics.12042","article-title":"Stratum corneum fatty acids: their critical role in preserving barrier integrity during cleansing","volume":"35","author":"Ananthapadmanabhan","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-0625.2011.01259.x","article-title":"Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling","volume":"20","author":"Angelova-Fischer","year":"2011","journal-title":"Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0025","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1523-1747.2002.01846.x","article-title":"Decreased levels of Sphingosine, a natural antimicrobial agent, may Be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus","volume":"119","author":"Arikawa","year":"2002","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00216-019-02301-3","article-title":"Comprehensive characterization and simultaneous analysis of overall lipids in reconstructed human epidermis using Nplc\/Hr-Msn: 1-O-E (Eo) cer, a new ceramide subclass","volume":"412","author":"Assi","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-4362.1978.tb06082.x","article-title":"Acne vulgaris and lipid peroxidation: new concepts in pathogenesis and treatment","volume":"17","author":"Ayres","year":"1978","journal-title":"Int. J. Dermatol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0040","doi-asserted-by":"crossref","first-page":"17627","DOI":"10.1038\/s41598-017-18071-w","article-title":"Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria","volume":"7","author":"Becam","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0045","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.chemphyslip.2021.105055_bib0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/14789450.2019.1646128","article-title":"Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (Ad)","volume":"16","author":"Bhattacharya","year":"2019","journal-title":"Expert Rev. Proteomics"},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.molmed.2019.04.001","article-title":"Epidermal lipids: key mediators of atopic dermatitis pathogenesis","volume":"25","author":"Bhattacharya","year":"2019","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25051130","article-title":"Unbalanced sphingolipid metabolism and its implications for the pathogenesis of psoriasis","volume":"25","author":"Boche\u0144ska","year":"2020","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0065","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/ics.12162","article-title":"The physical chemistry of the stratum corneum lipids","volume":"36","author":"Boncheva","year":"2014","journal-title":"Int. J. Cosmet. Sci."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12944-016-0178-7","article-title":"The role of epidermal sphingolipids in dermatologic diseases","volume":"15","author":"Borodzicz","year":"2016","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0075","first-page":"23","article-title":"The lipid organisation in the skin barrier","volume":"208","author":"Bouwstra","year":"2000","journal-title":"J. Biol. Phys."},{"issue":"11","key":"10.1016\/j.chemphyslip.2021.105055_bib0080","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1194\/jlr.D008391","article-title":"Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry","volume":"51","author":"Camera","year":"2010","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0085","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1194\/jlr.M067942","article-title":"Use of lipidomics to investigate sebum dysfunction in juvenile acne","volume":"57","author":"Camera","year":"2016","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/ijmm.2016.2600","article-title":"Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)","volume":"38","author":"Cha","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"9","key":"10.1016\/j.chemphyslip.2021.105055_bib0095","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)38771-X","article-title":"Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation","volume":"27","author":"Chapkin","year":"1986","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0100","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1038\/srep12017","article-title":"Circulating levels of Sphingosine-1-Phosphate are elevated in severe, but not mild psoriasis and are unresponsive to Anti-Tnf-A treatment","volume":"5","author":"Checa","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2131\/jts.25.77","article-title":"Comedogenicity of squalene monohydroperoxide in the skin after topical application","volume":"25","author":"Chiba","year":"2000","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mad.2017.08.011","article-title":"Age related depth profiles of human stratum corneum barrier-related molecular parameters by confocal raman microscopy in vivo","volume":"172","author":"Choe","year":"2018","journal-title":"Mech. Ageing Dev."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0115","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/bjd.17981","article-title":"Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis","volume":"181","author":"Clayton","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00128071-200304020-00004","article-title":"Ceramides and skin function","volume":"4","author":"Coderch","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jdermsci.2017.05.005","article-title":"Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition","volume":"88","author":"Danso","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jaad.2017.03.016","article-title":"Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa","volume":"77","author":"Dany","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0135","volume":"Vol. 49","author":"Darlenski","year":"2016"},{"issue":"2072","key":"10.1016\/j.chemphyslip.2021.105055_bib0140","doi-asserted-by":"crossref","DOI":"10.1098\/rsta.2015.0126","article-title":"The physics of stratum corneum lipid membranes","volume":"374","author":"Das","year":"2016","journal-title":"Philos. Trans. R. Soc. A: Math. Phys. Eng. Sci."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/321494","article-title":"Surface lipids as multifunctional mediators of skin responses to environmental stimuli","volume":"2010","author":"De Luca","year":"2010","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1194\/jlr.R700016-JLR200","article-title":"Thematic review series: skin lipids. Antimicrobial lipids at the skin surface","volume":"49","author":"Drake","year":"2008","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.chemphyslip.2021.105055_bib0155","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1038\/jid.2013.153","article-title":"Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length","volume":"133","author":"Eckl","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbalip.2013.10.001","article-title":"Lipid abnormalities and lipid-based repair strategies in atopic dermatitis","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0165","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1172\/JCI111552","article-title":"Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-Linked ichthyosis","volume":"74","author":"Elias","year":"1984","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0170","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1194\/jlr.R800002-JLR200","article-title":"Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism","volume":"49","author":"Elias","year":"2008","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0175","first-page":"314","article-title":"Formation and functions of the corneocyte lipid envelope (Cle)","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Molec. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0180","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1364\/BOE.9.002436","article-title":"Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum corneum lipids and water in dermatology","volume":"9","author":"Ezerskaia","year":"2018","journal-title":"Biomed. Opt. Express"},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0185","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00216-005-0044-3","article-title":"Profiling of human stratum corneum ceramides by means of normal phase Lc\/Apci-Ms","volume":"383","author":"Farwanah","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"issue":"11","key":"10.1016\/j.chemphyslip.2021.105055_bib0190","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00403-005-0551-2","article-title":"Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin","volume":"296","author":"Farwanah","year":"2005","journal-title":"Arch. Dermatol. Res."},{"issue":"12","key":"10.1016\/j.chemphyslip.2021.105055_bib0195","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1194\/jlr.R700013-JLR200","article-title":"Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis","volume":"48","author":"Feingold","year":"2007","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.chemphyslip.2021.105055_bib0200","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/jid.2012.177","article-title":"Lamellar bodies: the key to cutaneous barrier function","volume":"132","author":"Feingold","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0205","doi-asserted-by":"crossref","first-page":"17508","DOI":"10.1038\/s41598-019-53938-0","article-title":"Mass spectrometry imaging of lipids in human skin disease model hidradenitis suppurativa by laser desorption ionization from silicon nanopost arrays","volume":"9","author":"Fincher","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/antibiotics9020075","article-title":"Antimicrobial activity of host-derived lipids","volume":"9","author":"Fischer","year":"2020","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2340\/00015555741214","article-title":"A domain mosaic model of the skin barrier","volume":"74","author":"Forslind","year":"1994","journal-title":"Acta Derm. Venereol."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0220","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1684\/ejd.2011.1494","article-title":"Confocal raman microspectroscopy of the skin","volume":"21","author":"F\u00f6rster","year":"2011","journal-title":"Eur. J. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/jid.1963.18","article-title":"The phospholipids of normal and psoriatic skin","volume":"40","author":"Gerstein","year":"1963","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0230","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1396-0296.2004.04S1001.x","article-title":"The stratum corneum: structure and function in health and disease","volume":"17","author":"Harding","year":"2004","journal-title":"Dermatol. Ther."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000322303","article-title":"Investigation of the molecular structure of the human stratum corneum ceramides [Np] and [Eos] by mass spectrometry","volume":"24","author":"Hinder","year":"2011","journal-title":"Skin Pharmacol. Physiol."},{"issue":"9","key":"10.1016\/j.chemphyslip.2021.105055_bib0240","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/intimm\/dxy087","article-title":"Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis","volume":"31","author":"Honda","year":"2019","journal-title":"Int. Immunol."},{"issue":"1, Supplement","key":"10.1016\/j.chemphyslip.2021.105055_bib0245","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1067\/mjd.2001.117020","article-title":"Lipid abnormalities in atopic dermatitis","volume":"45","author":"Imokawa","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0250","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","article-title":"Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?","volume":"96","author":"Imokawa","year":"1991","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.chemphyslip.2021.105055_bib0255","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.jid.2020.01.014","article-title":"Treatment with synthetic pseudoceramide improves atopic skin, switching the ceramide profile to a healthy skin phenotype","volume":"140","author":"Ishida","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.chemphyslip.2021.105055_bib0260","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1194\/jlr.P030338","article-title":"Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients","volume":"53","author":"Janssens","year":"2012","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0265","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/bjd.12908","article-title":"Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema","volume":"170","author":"Janssens","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0270","series-title":"Skin Barrier","article-title":"Chapter 32: the stratum corneum of the epidermis in atopic dermatitis","author":"Jensen","year":"2006"},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0275","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4161\/derm.3.2.14995","article-title":"The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes\/epidermis","volume":"3","author":"Jiang","year":"2011","journal-title":"DermatoEndocrinology"},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0280","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0536.2008.01320.x","article-title":"Lipids and skin barrier function-a clinical perspective","volume":"58","author":"Jungersted","year":"2008","journal-title":"Contact Derm."},{"issue":"7","key":"10.1016\/j.chemphyslip.2021.105055_bib0285","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1398-9995.2010.02326.x","article-title":"Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema","volume":"65","author":"Jungersted","year":"2010","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0290","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1194\/jlr.RA120000671","article-title":"Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by Lc\/Ms\/Ms","volume":"61","author":"Kawana","year":"2020","journal-title":"J. Lipid Res."},{"issue":"9, Part B","key":"10.1016\/j.chemphyslip.2021.105055_bib0295","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bbamem.2017.03.016","article-title":"Lipid functions in skin: differential effects of N-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model","volume":"1859","author":"Kendall","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Biomembr."},{"issue":"7","key":"10.1016\/j.chemphyslip.2021.105055_bib0300","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/exd.13558","article-title":"Lipidomics for translational skin research: a primer for the uninitiated","volume":"27","author":"Kendall","year":"2018","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0305","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jid.2016.10.034","article-title":"As in atopic dermatitis, nonlesional skin in allergic contact dermatitis displays abnormalities in barrier function and ceramide content","volume":"137","author":"Kim","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.chemphyslip.2021.105055_bib0310","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.jid.2019.03.1160","article-title":"Side-by-Side comparison of skin biopsies and skin tape stripping highlights abnormal stratum corneum in atopic dermatitis","volume":"139","author":"Kim","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.chemphyslip.2021.105055_bib0315","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/s00249-005-0488-6","article-title":"New insights into the structure and hydration of a stratum corneum lipid model membrane by neutron diffraction","volume":"34","author":"Kiselev","year":"2005","journal-title":"Eur. Biophys. J."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0320","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1038\/ncomms6338","article-title":"Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids","volume":"5","author":"Kondo","year":"2014","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0325","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000448400","article-title":"Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy","volume":"170","author":"Koppes","year":"2016","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0330","doi-asserted-by":"crossref","first-page":"714","DOI":"10.5114\/ada.2019.91422","article-title":"Serum sphingolipid level in psoriatic patients with obesity","volume":"36","author":"Koz\u0142owska","year":"2019","journal-title":"Postepy Dermatol. Alergol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0335","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejpb.2008.08.008","article-title":"The tape stripping procedure--Evaluation of some critical parameters","volume":"72","author":"Lademann","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0340","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-2275(20)38005-6","article-title":"Human stratum corneum lipids: characterization and regional variations","volume":"24","author":"Lampe","year":"1983","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0345","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/1523-1747.ep12323752","article-title":"Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis","volume":"105","author":"Lavrijsen","year":"1995","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0350","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/14789450.2016.1177462","article-title":"Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans","volume":"13","author":"Li","year":"2016","journal-title":"Expert Rev. Proteomics"},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0355","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/jocd.12345","article-title":"A review of the role of sebum in the mechanism of acne pathogenesis","volume":"16","author":"Li","year":"2017","journal-title":"J. Cosmet. Dermatol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0360","doi-asserted-by":"crossref","first-page":"13254","DOI":"10.1038\/s41598-019-49684-y","article-title":"Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols","volume":"9","author":"Lin","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0365","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF00509081","article-title":"Human stratum corneum polar lipids and desquamation","volume":"277","author":"Long","year":"1985","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0370","doi-asserted-by":"crossref","DOI":"10.1080\/19381980.2017.1375636","article-title":"Sebaceous-immunobiology is orchestrated by sebum lipids","volume":"9","author":"Lov\u00e1szi","year":"2017","journal-title":"DermatoEndocrinology"},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0375","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25030630","article-title":"Lipidomic analysis reveals specific differences between fibroblast and keratinocyte ceramide profile of patients with psoriasis vulgaris","volume":"25","author":"\u0141uczaj","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0380","doi-asserted-by":"crossref","first-page":"11500","DOI":"10.1038\/s41598-018-29742-7","article-title":"Influence of the sebaceous gland density on the stratum corneum lipidome","volume":"8","author":"Ludovici","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.chemphyslip.2021.105055_bib0385","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1194\/jlr.M800014-JLR200","article-title":"Characterization of overall ceramide species in human stratum corneum","volume":"49","author":"Masukawa","year":"2008","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0390","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/000155599750011183","article-title":"Difference in Ceramide Composition between \u201cdry\u201d and \u201cnormal\u201d skin in patients with atopic dermatitis","volume":"79","author":"Matsumoto","year":"1999","journal-title":"Acta Derm. Venereol."},{"issue":"11","key":"10.1016\/j.chemphyslip.2021.105055_bib0395","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/jdv.15786","article-title":"A randomized controlled trial of an emollient with ceramide and filaggrin-associated amino acids for the primary prevention of atopic dermatitis in high-risk infants","volume":"33","author":"McClanahan","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0400","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0846.1998.tb00089.x","article-title":"A (31) P nmr study of extracted phospholipid composition of human skin: full thickness skin, dermis, epidermis and granulation tissue","volume":"4","author":"Meneses","year":"1998","journal-title":"Skin Res. Technol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0405","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1208\/s12248-012-9400-3","article-title":"Variation of stratum corneum biophysical and molecular properties with anatomic site","volume":"14","author":"Mohammed","year":"2012","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0410","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5021\/ad.2013.25.3.321","article-title":"Altered levels of Sphingosine and Sphinganine in psoriatic epidermis","volume":"25","author":"Moon","year":"2013","journal-title":"Ann. Dermatol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0415","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/archderm.1994.01690040056007","article-title":"Abnormality of water barrier function in psoriasis: role of ceramide fractions","volume":"130","author":"Motta","year":"1994","journal-title":"Arch. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0420","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00403-016-1709-9","article-title":"Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients","volume":"309","author":"My\u015bliwiec","year":"2017","journal-title":"Arch. Dermatol. Res."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0425","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.5114\/aoms.2019.89451","article-title":"Abnormal serum fatty acid profile in psoriatic arthritis","volume":"15","author":"Mysliwiec","year":"2019","journal-title":"Arch. Med. Sci."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0430","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2133.2011.10662.x","article-title":"The fatty acid profile of the skin surface lipid layer in papulopustular rosacea","volume":"166","author":"N\u00ed Raghallaigh","year":"2012","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0435","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12523574","article-title":"Free fatty acids and fatty acids of triacylglycerols in normal and hyperkeratotic human stratum corneum","volume":"87","author":"Nicollier","year":"1986","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.chemphyslip.2021.105055_bib0440","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/10715762.2014.976213","article-title":"Lipid oxidation in the skin","volume":"49","author":"Niki","year":"2015","journal-title":"Free Radic. Res."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0445","first-page":"713","article-title":"Irritant and allergic contact dermatitis - skin lesion characteristics","volume":"57","author":"Novak-Bili\u0107","year":"2018","journal-title":"Acta Clin. Croat."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0450","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1194\/jlr.RA119000420","article-title":"Effects of Omega-O-acylceramide structures and concentrations in healthy and diseased skin barrier lipid membrane models","volume":"61","author":"Op\u00e1lka","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0455","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/858176","article-title":"Lipid mediators in acne","volume":"2010","author":"Ottaviani","year":"2010","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0460","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2133.1994.tb08452.x","article-title":"Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses","volume":"131","author":"Paige","year":"1994","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0465","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/derm.1.2.7811","article-title":"Epidermal surface lipids","volume":"1","author":"Pappas","year":"2009","journal-title":"DermatoEndocrinology"},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0470","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4161\/derm.1.3.8473","article-title":"Sebum analysis of individuals with and without acne","volume":"1","author":"Pappas","year":"2009","journal-title":"DermatoEndocrinology"},{"issue":"12","key":"10.1016\/j.chemphyslip.2021.105055_bib0475","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.jid.2020.04.011","article-title":"Lipidomics profiling of hidradenitis suppurativa skin lesions reveals lipoxygenase pathway dysregulation and accumulation of proinflammatory leukotriene B4","volume":"140","author":"Penno","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0480","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/ics.12208","article-title":"Oxidization of squalene, a human skin lipid: a new and reliable marker of environmental pollution studies","volume":"37","author":"Pham","year":"2015","journal-title":"Int. J. Cosmet. Sci."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0485","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/derm.1.2.8472","article-title":"Sebaceous gland lipids","volume":"1","author":"Picardo","year":"2009","journal-title":"DermatoEndocrinology"},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0490","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/535612","article-title":"Lipid disturbances in psoriasis: an update","volume":"2010","author":"Pietrzak","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0495","doi-asserted-by":"crossref","DOI":"10.1046\/j.0022-202x.2001.01455.x","article-title":"Abberant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthhyosis","author":"Pilgram","year":"2001","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0500","first-page":"409","article-title":"The important role of epidermal triacylglycerol metabolism for maintenance of the skin permeability barrier function","volume":"1841","author":"Radner","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Molec. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0505","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/1523-1747.ep12398620","article-title":"Stratum corneum moisturization at the molecular level","volume":"103","author":"Rawlings","year":"1994","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.chemphyslip.2021.105055_bib0510","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/BF02505294","article-title":"Stratum corneum lipids: the effect of ageing and the seasons","volume":"288","author":"Rogers","year":"1996","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0515","doi-asserted-by":"crossref","first-page":"43761","DOI":"10.1038\/srep43761","article-title":"Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry","volume":"7","author":"Sadowski","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0520","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000360009","article-title":"Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy","volume":"28","author":"Sahle","year":"2015","journal-title":"Skin Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0525","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1067\/mjd.2003.105","article-title":"Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis","volume":"48","author":"Sator","year":"2003","journal-title":"J. Am. Acad. Dermatol."},{"issue":"10","key":"10.1016\/j.chemphyslip.2021.105055_bib0530","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0022-2275(20)41642-6","article-title":"Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids","volume":"32","author":"Schmitz","year":"1991","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0535","series-title":"Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Drug Manipulation Strategies and Vehicle Effects","first-page":"19","article-title":"The importance of stratum corneum lipid organization for proper barrier function","author":"Schroeter","year":"2015"},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0540","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jid.2016.11.014","article-title":"The short-chain fatty acid sodium butyrate functions as a regulator of the skin immune system","volume":"137","author":"Schwarz","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0545","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/DER.0000000000000392","article-title":"Skin ceramide profile in children with atopic dermatitis","volume":"29","author":"Shen","year":"2018","journal-title":"Dermatitis"},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0550","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1038\/s41598-018-27455-5","article-title":"Oxidation of squalene by singlet oxygen and free radicals results in different compositions of squalene monohydroperoxide isomers","volume":"8","author":"Shimizu","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0555","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1038\/s41598-018-34286-x","article-title":"Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry","volume":"8","author":"Sj\u00f6vall","year":"2018","journal-title":"Sci. Rep."},{"issue":"50","key":"10.1016\/j.chemphyslip.2021.105055_bib0560","doi-asserted-by":"crossref","first-page":"15624","DOI":"10.1021\/la4037474","article-title":"Ceramides in the skin lipid membranes: length matters","volume":"29","author":"Skolov\u00e1","year":"2013","journal-title":"Langmuir"},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0565","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1194\/jlr.R700015-JLR200","article-title":"Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?","volume":"49","author":"Smith","year":"2008","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.chemphyslip.2021.105055_bib0570","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1021\/acs.analchem.5b04872","article-title":"Age-related changes to human stratum corneum lipids detected using time-of-flight secondary ion mass spectrometry following in vivo sampling","volume":"88","author":"Starr","year":"2016","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.chemphyslip.2021.105055_bib0575","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1194\/jlr.R300005-JLR200","article-title":"Cholesterol sulfate in human physiology: what\u2019s it all about?","volume":"44","author":"Strott","year":"2003","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0580","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/ac202646v","article-title":"Profiling and characterizing skin ceramides using reversed-phase liquid chromatography\u2013quadrupole time-of-flight mass spectrometry","volume":"84","author":"t\u2019Kindt","year":"2012","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0585","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI130675","article-title":"Sdr9c7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation","volume":"130","author":"Takeichi","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0590","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/exd.12423","article-title":"Comparison of structure and organization of cutaneous lipids in a reconstructed skin model and human skin: spectroscopic imaging and chromatographic profiling","volume":"23","author":"Tfayli","year":"2014","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0595","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21061958","article-title":"Altered levels of Sphingosine, Sphinganine and their ceramides in atopic dermatitis are related to skin barrier function, disease severity and local cytokine milieu","volume":"21","author":"Toncic","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0600","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/exd.13867","article-title":"Transcriptomic and lipidomic profiling of eicosanoid\/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients","volume":"28","author":"T\u00f6r\u00f6csik","year":"2019","journal-title":"Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0605","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00694626","article-title":"The phospholipid pattern in the involved and the uninvolved psoriatic epidermis","volume":"266","author":"Tsambaos","year":"1979","journal-title":"Arch. Dermatol. Res."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0610","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2133.1977.tb15058.x","article-title":"Thin-layer chromatography of phospholipid components of normal and psoriatic epidermis","volume":"97","author":"Tsambaos","year":"1977","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0615","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000485132","article-title":"Vitamin d and the pathophysiology of inflammatory skin diseases","volume":"31","author":"Umar","year":"2018","journal-title":"Skin Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0620","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/faat.1995.1036","article-title":"Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy","volume":"25","author":"van de Sandt","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0625","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000441540","article-title":"Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients","volume":"49","author":"van Smeden","year":"2016","journal-title":"Curr. Probl. Dermatol."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0630","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1194\/jlr.M014456","article-title":"Lc\/Ms analysis of stratum corneum lipids: ceramide profiling and discovery","volume":"52","author":"van Smeden","year":"2011","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0635","first-page":"70","article-title":"Combined Lc\/Ms-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes","volume":"1841","author":"van Smeden","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Molec. Cell Biol. Lipids"},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0640","first-page":"295","article-title":"The important role of stratum corneum lipids for the cutaneous barrier function","volume":"1841","author":"van Smeden","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Molec. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0645","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/jid.2013.517","article-title":"Intercellular skin barrier lipid composition and organization in Netherton syndrome patients","volume":"134","author":"van Smeden","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0650","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1194\/jlr.RA120000639","article-title":"Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities","volume":"61","author":"van Smeden","year":"2020","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.chemphyslip.2021.105055_bib0655","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1515\/afpuc-2017-0004","article-title":"Ceramides in the skin barrier","volume":"64","author":"V\u00e1vrov\u00e1","year":"2017","journal-title":"Eur. Pharm. J."},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0660","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.18632\/aging.102946","article-title":"Aging-associated alterations in epidermal function and their clinical significance","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0665","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s004030100212","article-title":"Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography","volume":"293","author":"Weerheim","year":"2001","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.chemphyslip.2021.105055_bib0670","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5954034","article-title":"Lipids and the permeability and antimicrobial barriers of the skin","author":"Wertz","year":"2018","journal-title":"J. Lipids"},{"issue":"6","key":"10.1016\/j.chemphyslip.2021.105055_bib0675","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000490800","article-title":"Age- and diabetes-related changes in the free fatty acid composition of the human stratum corneum","volume":"31","author":"Wohlrab","year":"2018","journal-title":"Skin Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.chemphyslip.2021.105055_bib0680","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01106105","article-title":"Stratum corneum lipid abnormalities in atopic dermatitis","volume":"283","author":"Yamamoto","year":"1991","journal-title":"Arch. Dermatol. Res."},{"issue":"11","key":"10.1016\/j.chemphyslip.2021.105055_bib0685","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1194\/jlr.M500168-JLR200","article-title":"A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters","volume":"46","author":"Yen","year":"2005","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.chemphyslip.2021.105055_bib0690","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12895-020-00102-1","article-title":"The ceramide [Np]\/[Ns] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation","volume":"20","author":"Yokose","year":"2020","journal-title":"BMC Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0695","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/bjd.16655","article-title":"Lipidomics reveals skin surface lipid abnormity in acne in young men","volume":"179","author":"Zhou","year":"2018","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.chemphyslip.2021.105055_bib0700","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/bjd.18474","article-title":"Lipidomic analysis of facial skin surface lipids reveals an altered lipid profile in infant acne","volume":"182","author":"Zhou","year":"2020","journal-title":"Br. J. Dermatol."},{"issue":"12","key":"10.1016\/j.chemphyslip.2021.105055_bib0705","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1111\/jocd.13374","article-title":"Skin surface lipidomics revealed the correlation between lipidomic profile and grade in adolescent acne","volume":"19","author":"Zhou","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"issue":"5","key":"10.1016\/j.chemphyslip.2021.105055_bib0710","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12298","article-title":"Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions","volume":"28","author":"Zouboulis","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."}],"container-title":["Chemistry and Physics of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009308421000086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009308421000086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:34:37Z","timestamp":1757860477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009308421000086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":142,"alternative-id":["S0009308421000086"],"URL":"https:\/\/doi.org\/10.1016\/j.chemphyslip.2021.105055","relation":{},"ISSN":["0009-3084"],"issn-type":[{"value":"0009-3084","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skin lipids in health and disease: A review","name":"articletitle","label":"Article Title"},{"value":"Chemistry and Physics of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemphyslip.2021.105055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105055"}}