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Chem."},{"key":"10.1016\/j.chempr.2021.05.005_bib70","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1016\/j.tetlet.2004.07.095","article-title":"Facile one-step synthesis of N-\u03b1-Boc-1-alkyl-l-histidines","volume":"45","author":"Kaur","year":"2004","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.chempr.2021.05.005_bib71","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1016\/j.bmc.2009.02.030","article-title":"8-bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands","volume":"17","author":"Lambertucci","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chempr.2021.05.005_bib72","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1021\/ja900634m","article-title":"Highly diastereoselective formal nucleophilic substitution of bromocyclopropanes","volume":"131","author":"Alnasleh","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chempr.2021.05.005_bib73","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1021\/ol101228k","article-title":"Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained \u03b2-amino acid derivatives","volume":"12","author":"Prosser","year":"2010","journal-title":"Org. Lett."},{"key":"10.1016\/j.chempr.2021.05.005_bib74","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/ol300352z","article-title":"Formal nucleophilic substitution of Bromocyclopropanes with azoles","volume":"14","author":"Ryabchuk","year":"2012","journal-title":"Org. Lett."},{"key":"10.1016\/j.chempr.2021.05.005_bib75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/ja0676758","article-title":"Direct N-cyclopropylation of cyclic amides and azoles employing a cyclopropylbismuth reagent","volume":"129","author":"Gagnon","year":"2007","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chempr.2021.05.005_bib76","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1021\/jo801033y","article-title":"Copper-mediated N-cyclopropylation of azoles, amides, and sulfonamides by Cyclopropylboronic acid","volume":"73","author":"B\u00e9nard","year":"2008","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.chempr.2021.05.005_bib77","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1021\/ol800376f","article-title":"N-cyclopropylation of indoles and cyclic amides with copper(II) reagent","volume":"10","author":"Tsuritani","year":"2008","journal-title":"Org. Lett."},{"key":"10.1016\/j.chempr.2021.05.005_bib78","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1039\/b925499d","article-title":"Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid","volume":"46","author":"B\u00e9nard","year":"2010","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.chempr.2021.05.005_bib79","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1021\/acs.joc.7b03100","article-title":"Copper-catalyzed Chan-Lam cyclopropylation of phenols and azaheterocycles","volume":"83","author":"Derosa","year":"2018","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.chempr.2021.05.005_bib80","series-title":"Encyclopedia of Radicals in Chemistry, Biology and Materials","first-page":"107","article-title":"Radical kinetics and clocks","author":"Newcomb","year":"2012"},{"key":"10.1016\/j.chempr.2021.05.005_bib81","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1039\/C5CY00783F","article-title":"Copper-catalyzed carbon-carbon bond cleavage of primary propargyl alcohols: \u03b2-carbon elimination of hemiaminal intermediates","volume":"5","author":"Kang","year":"2015","journal-title":"Catal. Sci. Technol."},{"key":"10.1016\/j.chempr.2021.05.005_bib82","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1021\/acs.orglett.9b01747","article-title":"Photoredox-catalyzed multicomponent Petasis reaction with Alkyltrifluoroborates","volume":"21","author":"Yi","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.chempr.2021.05.005_bib83","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature19811","article-title":"Catalytic alkylation of remote C\u2013H bonds enabled by proton-coupled electron transfer","volume":"539","author":"Choi","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chempr.2021.05.005_bib84","doi-asserted-by":"crossref","first-page":"17433","DOI":"10.1021\/jacs.8b12025","article-title":"Metallaphotoredox-catalyzed cross-electrophile Csp3\u2013Csp3 coupling of aliphatic bromides","volume":"140","author":"Smith","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chempr.2021.05.005_bib85","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1021\/ja01019a018","article-title":"Mechanism of electron transfer oxidation of alkyl radicals by copper(II) complexes","volume":"90","author":"Kochi","year":"1968","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chempr.2021.05.005_bib86","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/ja00758a025","article-title":"Homolytic and ionic mechanisms in the ligand-transfer oxidation of alkyl radicals by copper(II) halides and pseudohalides","volume":"94","author":"Jenkins","year":"1972","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chempr.2021.05.005_bib87","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1039\/f19807601825","article-title":"Reactions of aliphatic free radicals with copper\u00a0cations in aqueous solution. \u2014Part 2. Reactions with cupric ions: a pulse radiolysis study","volume":"1","author":"Freiberg","year":"1980","journal-title":"J.\u00a0Chem. Soc. Faraday Trans."},{"key":"10.1016\/j.chempr.2021.05.005_bib88","unstructured":"Although the proposed mechanism is favored for coupling of nucleophilic radicals such as VII, we also recognize the possibility of an alternative pathway, wherein C\u2013N bond formation is achieved via outer-sphere group transfer (or copper-mediated radical-radical coupling) from Cu(II)-amido complex XI (formally a Cu-stabilized amido radical) to alkyl radical intermediate VII, ultimately furnishing product XIII and regenerating catalyst VIII in parallel with the radical capture\/reductive elimination pathway depicted in Scheme 2. For further discussion of both mechanistic possibilities and examples of outer-sphere bond formation involving Cu(II) complexes and radical intermediates, see Qi et\u00a0al.,89 Li and Lan,90 Zhang et\u00a0al.,91 and Zheng et\u00a0al.92."},{"key":"10.1016\/j.chempr.2021.05.005_bib89","doi-asserted-by":"crossref","first-page":"43579","DOI":"10.1038\/srep43579","article-title":"Stabilization of two radicals with one metal: a stepwise coupling model for copper-catalyzed radical-radical cross-coupling","volume":"7","author":"Qi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chempr.2021.05.005_bib90","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1039\/D0CC01946A","article-title":"Is Cu(III) a necessary intermediate in Cu-mediated coupling reactions? A mechanistic point of view","volume":"56","author":"Li","year":"2020","journal-title":"Chem. Commun. 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