{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:54:03Z","timestamp":1791388443143,"version":"4.3.3"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.chest.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T16:20:01Z","timestamp":1461342001000},"page":"661-672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic\u00a0Fibrosis"],"prefix":"10.1016","volume":"150","author":[{"suffix":"Jr.","given":"B\u00e9la","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libor","family":"Fila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka A.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"G\u00f6nczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Bede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"\u00dajhelyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anghelyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Bene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Fejes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Antal-Szalm\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjit Pal","family":"Bhattoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Balla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Kappelmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida D.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Milan","family":"Macek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.chest.2016.04.006_bib1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1136\/thoraxjnl-2013-203204","article-title":"Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications","volume":"68","author":"Cohen-Cymberknoh","year":"2013","journal-title":"Thorax"},{"issue":"19","key":"10.1016\/j.chest.2016.04.006_bib2","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1056\/NEJMra043184","article-title":"Cystic fibrosis","volume":"352","author":"Rowe","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(98)70344-0","article-title":"The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel","volume":"132","author":"Rosenstein","year":"1998","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12016-008-8078-x","article-title":"Diagnosis of cystic fibrosis","volume":"35","author":"Voter","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib5","first-page":"46","article-title":"Molecular analysis of cystic fibrosis patients in Hungary\u2014an update to the mutational spectrum","volume":"34","author":"Iv\u00e1dy","year":"2015","journal-title":"J\u00a0Med Biochem"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jcf.2010.12.009","article-title":"Distribution of CFTR mutations in Eastern Hungarians: relevance to genetic testing and to the introduction of newborn screening for cystic fibrosis","volume":"10","author":"Ivady","year":"2011","journal-title":"J\u00a0Cyst Fibros"},{"issue":"5","key":"10.1016\/j.chest.2016.04.006_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcf.2012.12.002","article-title":"Distribution of CFTR mutations in the Czech population: positive impact of integrated clinical and laboratory expertise, detection of novel\/de novo alleles and relevance for related\/derived populations","volume":"12","author":"Krenkova","year":"2013","journal-title":"J\u00a0Cyst Fibros"},{"key":"10.1016\/j.chest.2016.04.006_bib8","first-page":"4050","article-title":"Factors influencing quality of life and disease severity in Hungarian children and young adults with cystic fibrosis","author":"Bodnar","year":"2014","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.chest.2016.04.006_bib9","first-page":"1","article-title":"Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis","volume":"6","author":"Bergin","year":"2013","journal-title":"J\u00a0Inflamm Res"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.clim.2005.01.013","article-title":"Differential cytokine profile in children with cystic fibrosis","volume":"115","author":"Brazova","year":"2005","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.clim.2006.08.015","article-title":"Polymorphisms of TGF-beta1 in cystic fibrosis patients","volume":"121","author":"Brazova","year":"2006","journal-title":"Clin Immunol"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcf.2004.06.006","article-title":"Cytokines and inflammatory mediators in cystic fibrosis","volume":"3","author":"Courtney","year":"2004","journal-title":"J\u00a0Cyst Fibros"},{"issue":"suppl 1","key":"10.1016\/j.chest.2016.04.006_bib13","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.jcf.2014.03.010","article-title":"European Cystic Fibrosis Society standards of care: best practice guidelines","volume":"13","author":"Smyth","year":"2014","journal-title":"J\u00a0Cyst Fibros"},{"key":"10.1016\/j.chest.2016.04.006_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1465-9921-7-61","article-title":"WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung","volume":"7","author":"Bingle","year":"2006","journal-title":"Respir Res"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2014.06.002","article-title":"Influence of inflammatory response, infection, and pulmonary function in cystic fibrosis","volume":"109","author":"Pereira","year":"2014","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib16","doi-asserted-by":"crossref","first-page":"e89341","DOI":"10.1371\/journal.pone.0089341","article-title":"Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis","volume":"9","author":"Quon","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib17","doi-asserted-by":"crossref","first-page":"e88567","DOI":"10.1371\/journal.pone.0088567","article-title":"Candidate markers associated with the probability of future pulmonary exacerbations in cystic fibrosis patients","volume":"9","author":"Wojewodka","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.chest.2016.04.006_bib18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2466-14-28","article-title":"Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease","volume":"14","author":"Fantino","year":"2014","journal-title":"BMC Pulm Med"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ppul.20237","article-title":"Cytokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy","volume":"40","author":"Colombo","year":"2005","journal-title":"Pediatr Pulmonol"},{"issue":"11","key":"10.1016\/j.chest.2016.04.006_bib20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.1651-2227.2003.tb00495.x","article-title":"Association between serum oncofetal antigens CA 19-9 and CA 125 and clinical status in patients with cystic fibrosis","volume":"92","author":"Gronowitz","year":"2003","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10238-003-0014-z","article-title":"Serum CA 19-9 levels as a diagnostic marker in cystic fibrosis patients with borderline sweat tests","volume":"3","author":"Augarten","year":"2003","journal-title":"Clin Exp Med"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A\u00a0major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","author":"Kirchhoff","year":"1991","journal-title":"Biol Reprod"},{"issue":"13","key":"10.1016\/j.chest.2016.04.006_bib23","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstrom","year":"2003","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2008.08.031","article-title":"A\u00a0novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass","volume":"112","author":"Moore","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s13277-012-0356-9","article-title":"Serum HE4 as a diagnostic and prognostic marker for lung cancer","volume":"33","author":"Iwahori","year":"2012","journal-title":"Tumour Biol"},{"issue":"11","key":"10.1016\/j.chest.2016.04.006_bib26","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1515\/cclm-2014-0041","article-title":"Serum human epididymis protein 4 (HE4) as a tumor marker in men with lung cancer","volume":"52","author":"Nagy","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"9","key":"10.1016\/j.chest.2016.04.006_bib27","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/bjc.2011.109","article-title":"Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients","volume":"104","author":"Bignotti","year":"2011","journal-title":"Br J Cancer"},{"issue":"pt 1","key":"10.1016\/j.chest.2016.04.006_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj20020869","article-title":"A\u00a0locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein","volume":"368","author":"Clauss","year":"2002","journal-title":"Biochem J"},{"issue":"pt 3","key":"10.1016\/j.chest.2016.04.006_bib29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/bj3400569","article-title":"The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core","volume":"340","author":"Schalkwijk","year":"1999","journal-title":"Biochem J"},{"issue":"37","key":"10.1016\/j.chest.2016.04.006_bib30","doi-asserted-by":"crossref","first-page":"33648","DOI":"10.1074\/jbc.M203710200","article-title":"Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination","volume":"277","author":"Taggart","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.chest.2016.04.006_bib31","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1183\/09031936.99.13510299","article-title":"Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome","volume":"13","author":"Sallenave","year":"1999","journal-title":"Eur Respir J"},{"issue":"17","key":"10.1016\/j.chest.2016.04.006_bib32","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1038\/sj.onc.1205363","article-title":"The putative ovarian tumour marker gene HE4 (WFDC2) is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms","volume":"21","author":"Bingle","year":"2002","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.chest.2016.04.006_bib33","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.4049\/jimmunol.0901716","article-title":"Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation","volume":"183","author":"Weldon","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"10.1016\/j.chest.2016.04.006_bib34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","article-title":"Comprehensive analysis of HE4 expression in normal and malignant human tissues","volume":"19","author":"Galgano","year":"2006","journal-title":"Mod Pathol"},{"issue":"10","key":"10.1016\/j.chest.2016.04.006_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM199409083311003","article-title":"Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group","volume":"331","author":"Fuchs","year":"1994","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.chest.2016.04.006_bib36","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1164\/rccm.201003-0382OC","article-title":"Clinical phenotype and genotype of children with borderline sweat test and abnormal nasal epithelial chloride transport","volume":"182","author":"Sermet-Gaudelus","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2016.04.006_bib37","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1378\/chest.13-0693","article-title":"Systematic review of blood biomarkers in cystic fibrosis pulmonary exacerbations","volume":"144","author":"Shoki","year":"2013","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1471-2466-14-150","article-title":"Role of C-reactive protein as a biomarker for prediction of the severity of pulmonary exacerbations in patients with cystic fibrosis","volume":"14","author":"Giron-Moreno","year":"2014","journal-title":"BMC Pulm Med"},{"issue":"12","key":"10.1016\/j.chest.2016.04.006_bib39","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1515\/CCLM.2011.709","article-title":"The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses","volume":"49","author":"Lenhard","year":"2011","journal-title":"Clin Chem Lab Med"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ygyno.2007.10.017","article-title":"The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass","volume":"108","author":"Moore","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.chest.2016.04.006_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cca.2014.07.040","article-title":"Human epididymis protein 4 (HE4) in laboratory medicine and an algorithm in renal disorders","volume":"438","author":"Kappelmayer","year":"2015","journal-title":"Clin Chim Acta"},{"issue":"pt 4","key":"10.1016\/j.chest.2016.04.006_bib42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2011.011258","article-title":"Elevated human epididymis protein 4 concentrations in chronic kidney disease","volume":"49","author":"Nagy","year":"2012","journal-title":"Ann Clin Biochem"},{"issue":"10","key":"10.1016\/j.chest.2016.04.006_bib43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.5588\/ijtld.13.0058","article-title":"Evaluating the clinical significance of serum HE4 levels in lung cancer and pulmonary tuberculosis","volume":"17","author":"Liu","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"issue":"7-8","key":"10.1016\/j.chest.2016.04.006_bib44","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.clinbiochem.2009.01.006","article-title":"Borderline sweat test: utility and limits of genetic analysis for the diagnosis of cystic fibrosis","volume":"42","author":"Seia","year":"2009","journal-title":"Clin Biochem"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajog.2011.12.028","article-title":"Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age","volume":"206","author":"Moore","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.chest.2016.04.006_bib46","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jpeds.2008.04.067","article-title":"Diagnosis of cystic fibrosis by sweat testing: age-specific reference intervals","volume":"153","author":"Mishra","year":"2008","journal-title":"J\u00a0Pediatr"},{"issue":"18","key":"10.1016\/j.chest.2016.04.006_bib47","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMoa1105185","article-title":"A\u00a0CFTR potentiator in patients with cystic fibrosis and the G551D mutation","volume":"365","author":"Ramsey","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.chest.2016.04.006_bib48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1465-9921-14-38","article-title":"Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies","volume":"14","author":"Clarke","year":"2013","journal-title":"Respir Res"},{"issue":"5","key":"10.1016\/j.chest.2016.04.006_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ppul.20010","article-title":"Quantitative cytokine gene expression in CF airway","volume":"37","author":"Muhlebach","year":"2004","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1165\/rcmb.2005-0359OC","article-title":"Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease","volume":"35","author":"Wright","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib51","doi-asserted-by":"crossref","first-page":"L545","DOI":"10.1152\/ajplung.00065.2005","article-title":"CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia","volume":"289","author":"Zabner","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"10","key":"10.1016\/j.chest.2016.04.006_bib52","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1089\/jir.1998.18.851","article-title":"The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10","volume":"18","author":"Dosanjh","year":"1998","journal-title":"J\u00a0Interferon Cytokine Res"},{"issue":"6","key":"10.1016\/j.chest.2016.04.006_bib53","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1165\/ajrcmb.11.6.7946394","article-title":"Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils","volume":"11","author":"Inoue","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"38","key":"10.1016\/j.chest.2016.04.006_bib54","doi-asserted-by":"crossref","first-page":"35494","DOI":"10.1074\/jbc.M103543200","article-title":"Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88\/IRAK\/TRAF-6 in human bronchial epithelium","volume":"276","author":"Walsh","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.chest.2016.04.006_bib55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1465-9921-11-148","article-title":"MicroRNAs in inflammatory lung disease\u2014master regulators or target practice?","volume":"11","author":"Oglesby","year":"2010","journal-title":"Respir Res"},{"issue":"4","key":"10.1016\/j.chest.2016.04.006_bib56","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.4049\/jimmunol.0902669","article-title":"miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression","volume":"184","author":"Oglesby","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jir.2012.0074","article-title":"Differential regulation of inflammation by inflammatory mediators in cystic fibrosis lung epithelial cells","volume":"33","author":"Tsuchiya","year":"2013","journal-title":"J\u00a0Interferon Cytokine Res"},{"issue":"1","key":"10.1016\/j.chest.2016.04.006_bib58","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.bbrc.2014.06.075","article-title":"Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer","volume":"450","author":"Li","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.chest.2016.04.006_bib59","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pep.2014.08.004","article-title":"Expression and biochemical characterization of recombinant human epididymis protein 4","volume":"102","author":"Hua","year":"2014","journal-title":"Protein Expr Purif"},{"issue":"2","key":"10.1016\/j.chest.2016.04.006_bib60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.chest.2016.04.006_bib61","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/path.2118","article-title":"Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis","volume":"211","author":"Hajj","year":"2007","journal-title":"J\u00a0Pathol"},{"issue":"5","key":"10.1016\/j.chest.2016.04.006_bib62","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ygeno.2015.07.005","article-title":"Transcriptome meta-analysis reveals common differential\u00a0and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators","volume":"106","author":"Clarke","year":"2015","journal-title":"Genomics"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216485545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216485545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:30:25Z","timestamp":1757921425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216485545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0012369216485545"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2016.04.006","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic\u00a0Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}