{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:18:20Z","timestamp":1787793500044,"version":"build-2784847793"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.chest.2016.12.008","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T04:00:56Z","timestamp":1482379256000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Airway and Pulmonary \u03b22-Adrenergic Vasodilatory Function in Current Smokers and Never Smokers"],"prefix":"10.1016","volume":"151","author":[{"given":"Barry E.","family":"Hurwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana S.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meela","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Arana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chest.2016.12.008_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1152\/japplphysiol.90334.2008","article-title":"Endothelial dysfunction in healthy smokers","volume":"105","author":"Mendes","year":"2008","journal-title":"J\u00a0Appl Physiol"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1378\/chest.129.4.893","article-title":"Airway blood flow reactivity in healthy smokers and in ex-smokers with or without COPD","volume":"129","author":"Mendes","year":"2006","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.chest.2016.12.008_bib3","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1378\/chest.12-1033","article-title":"Airway and extrapulmonary vascular endothelial function in healthy smokers: effect of an inhaled glucocorticosteroid","volume":"143","author":"Mendes","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.chest.2016.12.008_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-7120-6-9","article-title":"Acute effects of caffeine and cigarette smoking on ventricular long-axis function in healthy subjects","volume":"6","author":"Giacomin","year":"2008","journal-title":"Cardiovasc Ultrasound"},{"issue":"11","key":"10.1016\/j.chest.2016.12.008_bib5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1164\/rccm.201001-0038PP","article-title":"Endothelial dysfunction in asthma and COPD","volume":"182","author":"Wanner","year":"2010","journal-title":"AmJ Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2016.12.008_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.chest.2016.12.008_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2016.12.008_bib8","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1152\/japplphysiol.01349.2005","article-title":"A\u00a0simplified noninvasive method to measure airway blood flow in humans","volume":"100","author":"Wanner","year":"2006","journal-title":"J\u00a0Appl Physiol"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib9","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1152\/jappl.1995.79.4.1386","article-title":"Measurement of airway blood flow with dimethylether: validation with microspheres","volume":"79","author":"Scuri","year":"1995","journal-title":"J\u00a0Appl Physiol"},{"issue":"1","key":"10.1016\/j.chest.2016.12.008_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"issue":"7","key":"10.1016\/j.chest.2016.12.008_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.CIR.70.4.657","article-title":"Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation","volume":"70","author":"Yock","year":"1984","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib13","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0735-1097(85)80477-0","article-title":"Continuous wave Doppler determination of right ventricular pressure: a simultaneous Doppler-catheterization study in 127 patients","volume":"6","author":"Currie","year":"1985","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.chest.2016.12.008_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.echo.2011.03.008","article-title":"Pulmonary artery acceleration time provides an accurate estimate of systolic pulmonary arterial pressure during transthoracic echocardiography","volume":"24","author":"Yared","year":"2011","journal-title":"J\u00a0Am Soc Echocardiogr"},{"issue":"2","key":"10.1016\/j.chest.2016.12.008_bib15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.CIR.68.2.302","article-title":"Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique","volume":"68","author":"Kitabatake","year":"1983","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.chest.2016.12.008_bib16","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0735-1097(97)00344-6","article-title":"Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures","volume":"30","author":"Nagueh","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.chest.2016.12.008_bib17","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1164\/ajrccm.154.5.8912781","article-title":"Effect of hyperventilation on airway mucosal blood flow in normal subjects","volume":"154","author":"Kim","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.chest.2016.12.008_bib18","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1592\/phco.31.8.748","article-title":"Effects of an inhaled \u03b22-agonist on cardiovascular function and sympathetic activity in healthy subjects","volume":"31","author":"Snyder","year":"2011","journal-title":"Pharmacotherapy"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s11906-012-0278-3","article-title":"Vasodilatory mechanisms of beta receptor blockade","volume":"14","author":"Rath","year":"2012","journal-title":"Curr Hypertens Rep"},{"issue":"2","key":"10.1016\/j.chest.2016.12.008_bib20","first-page":"47","article-title":"Physical exercise, \u03b2-adrenergic receptors, and vascular response","volume":"9","author":"Silva","year":"2010","journal-title":"J\u00a0Vasc Bras"},{"issue":"2","key":"10.1016\/j.chest.2016.12.008_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0031-6997(24)01495-9","article-title":"Vascular adrenoceptors: an update","volume":"53","author":"Guimar\u00e3es","year":"2001","journal-title":"Pharmacol Rev"},{"issue":"25","key":"10.1016\/j.chest.2016.12.008_bib22","doi-asserted-by":"crossref","first-page":"15583","DOI":"10.1074\/jbc.272.25.15583","article-title":"Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin","volume":"272","author":"Michel","year":"1997","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"10.1016\/j.chest.2016.12.008_bib23","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1161\/01.CIR.95.9.2293","article-title":"Effects of inhibition of the L-arginine\/nitric oxide pathway on vasodilation caused by beta-adrenergic agonists in human forearm","volume":"95","author":"Dawes","year":"1997","journal-title":"Circulation"},{"issue":"6736","key":"10.1016\/j.chest.2016.12.008_bib24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"issue":"Pt 2","key":"10.1016\/j.chest.2016.12.008_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1113\/jphysiol.2006.115998","article-title":"Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells","volume":"576","author":"Queen","year":"2006","journal-title":"J\u00a0Physiol"},{"issue":"12","key":"10.1016\/j.chest.2016.12.008_bib26","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1096\/fasebj.16.12.1584","article-title":"Early activation of the p42\/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism","volume":"16","author":"Wyatt","year":"2002","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000337486","article-title":"Increased vascular contractility and oxidative stress in \u03b2\u2082-adrenoceptor knockout mice: the role of NADPH oxidase","volume":"49","author":"Davel","year":"2012","journal-title":"J\u00a0Vasc Res"},{"issue":"6","key":"10.1016\/j.chest.2016.12.008_bib28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/01.ATV.0000127083.88549.58","article-title":"Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation","volume":"24","author":"Jaimes","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"18","key":"10.1016\/j.chest.2016.12.008_bib29","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1161\/01.CIR.0000066691.52789.BE","article-title":"Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in\u00a0vitro demonstration in human coronary artery endothelial cells","volume":"107","author":"Barua","year":"2003","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.chest.2016.12.008_bib30","first-page":"537","article-title":"Increased pulmonary vascular resistance in early stage systemic hypertension: a resting and exercise stress echocardiography study","volume":"31","author":"Vriz","year":"2015","journal-title":"Can J Cardiol"},{"issue":"5","key":"10.1016\/j.chest.2016.12.008_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.echo.2006.10.005","article-title":"Estimation of left ventricular filling pressure with exercise by Doppler echocardiography in patients with normal systolic function: a simultaneous echocardiographic-cardiac catheterization study","volume":"20","author":"Talreja","year":"2007","journal-title":"J\u00a0Am Soc Echocardiogr"},{"issue":"6 pt 1","key":"10.1016\/j.chest.2016.12.008_bib32","first-page":"908","article-title":"Endothelial dysfunction in pulmonary arteries of patients with mild COPD","volume":"274","author":"Peinado","year":"1998","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.chest.2016.12.008_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1476-5381.1993.tb13611.x","article-title":"Impairment of pulmonary-artery endothelium-dependent relaxation in COPD is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency","volume":"109","author":"Dinh-Xuan","year":"1993","journal-title":"Br J Pharmacol"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216626028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216626028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:32:16Z","timestamp":1757921536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216626028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0012369216626028"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2016.12.008","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Airway and Pulmonary \u03b22-Adrenergic Vasodilatory Function in Current Smokers and Never Smokers","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2016.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}