{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:19:09Z","timestamp":1790054349699,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.chest.2017.01.021","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T19:20:47Z","timestamp":1485285647000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hematopoietic Processes in Eosinophilic Asthma"],"prefix":"10.1016","volume":"152","author":[{"given":"Brittany M.","family":"Salter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Sehmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chest.2017.01.021_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000236980","article-title":"Airways remodelling in asthma: no doubt, no more?","volume":"107","author":"Bousquet","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.163.2.9912091","article-title":"Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids","volume":"163","author":"Leuppi","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jaci.2009.06.029","article-title":"Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study","volume":"124","author":"van Veen","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2006.08.003","article-title":"Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and non-eosinophilic phenotypes","volume":"118","author":"Lemi\u00e8re","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib5","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(02)11679-5","article-title":"Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial","volume":"360","author":"Green","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.chest.2017.01.021_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.06.00137704","article-title":"Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations","volume":"27","author":"Jayaram","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2017.01.021_bib7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJMoa0805435","article-title":"Mepolizumab for prednisone-dependent asthma with sputum eosinophilia","volume":"360","author":"Nair","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.chest.2017.01.021_bib8","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1172\/JCI119789","article-title":"Allergen-induced increases in IL-5 receptor a-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects: a novel marker of progenitor cell commitment towards eosinophilic differentiation","volume":"100","author":"Sehmi","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.chest.2017.01.021_bib9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2567.2003.01686.x","article-title":"Allergen-induced fluctuations in CCR3 expression on bone marrow CD34+ cells from asthmatics subjects: significance for mobilization of hemopoietic progenitor cells in allergic inflammation","volume":"109","author":"Sehmi","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.chest.2017.01.021_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/1568010033484007","article-title":"Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseases","volume":"2","author":"Sehmi","year":"2003","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib11","series-title":"Allergy Frontiers: Classification and Pathomechanisms","first-page":"421","article-title":"Allergy and the bone marrow: transmigration pathways of hemopoietic progenitor cells from the bone marrow","author":"Sehmi","year":"2009"},{"key":"10.1016\/j.chest.2017.01.021_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1586\/1744666X.1.1.87","article-title":"Hemopoietic progenitors: the role of eosinophil\/basophil progenitors in allergic airway inflammation","volume":"1","author":"Gauvreau","year":"2005","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib13","series-title":"Allergy Frontiers: Classification and Pathomechanisms","first-page":"433","article-title":"Hematopoetic mechanisms in rhinitis and asthma","author":"Gauvreau","year":"2009"},{"key":"10.1016\/j.chest.2017.01.021_bib14","first-page":"3","article-title":"Enriched hematopoietic stem cells: basic\u00a0biology and clinical utility","volume":"1","author":"Szilvassy","year":"1995","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.chest.2017.01.021_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V87.1.1.1","article-title":"CD34: structure, biology and clinical utility","volume":"87","author":"Krause","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.01.021_bib16","series-title":"Human Eosinophils: Biological and Clinical Aspects","first-page":"29","article-title":"Differentiation of human eosinophils: role in allergic inflammation","author":"Sehmi","year":"2000"},{"key":"10.1016\/j.chest.2017.01.021_bib17","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V73.6.1504.1504","article-title":"Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparisons and interaction with IL-1, IL-3, IL-6 and GM-CSF","volume":"73","author":"Clutterbuck","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.01.021_bib18","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1182\/blood.V79.12.3101.bloodjournal79123101","article-title":"Interleukin-5, eosinophils, and disease","volume":"79","author":"Sanderson","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.01.021_bib19","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0092-8674(91)90040-6","article-title":"A\u00a0human high affinity interleukin-5 receptor (IL-5R) is composed of an IL-5 specific a-chain and a b-chain shared with a receptor for GM-CSF","volume":"66","author":"Tavernier","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.chest.2017.01.021_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1084\/jem.20081756","article-title":"Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor","volume":"206","author":"Mori","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.chest.2017.01.021_bib21","doi-asserted-by":"crossref","first-page":"f43","DOI":"10.1084\/jem.20020636","article-title":"Making eosinophils through subtle shifts in transcription factor expression","volume":"195","author":"McNagny","year":"2002","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.chest.2017.01.021_bib22","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ni.3225","article-title":"The transcription factor XBP1 is selectively required for eosinophil differentiation","volume":"16","author":"Bettigole","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib23","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood-2013-01-473405","article-title":"Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice","volume":"122","author":"Doyle","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.01.021_bib24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jaci.2008.10.022","article-title":"CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation","volume":"123","author":"Allakhverdi","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/iid3.20","article-title":"The effects of thymic stromal lymphopoietin and IL-3 on human eosinophil-basophil lineage commitment: Relevance to atopic sensitization","volume":"2","author":"Hui","year":"2014","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.chest.2017.01.021_bib26","doi-asserted-by":"crossref","first-page":"AB148","DOI":"10.1016\/j.jaci.2014.12.1420","article-title":"Human bronchial epithelial cell-derived factors from severe asthmatics can stimulate local eosinophilopoietic responses","volume":"135","author":"Smith","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib27","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.4049\/jimmunol.1600611","article-title":"IL-33 precedes IL-5 in regulating eosinophil commitment and is required for eosinophil homeostasis","volume":"197","author":"Johnston","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(01)00409-3","article-title":"The evolving concept of a stem cell: entity or function?","volume":"105","author":"Blau","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.chest.2017.01.021_bib29","first-page":"A880","article-title":"Increases in bone marrow derived CD34+ hemopoietic progenitor cells expressing the alpha-subunit of IL-3 receptors following allergen challenge in mild asthmatics","volume":"153","author":"Sehmi","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1164\/ajrccm.157.1.9704125","article-title":"Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects","volume":"157","author":"Wood","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib31","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0091-6749(85)90728-6","article-title":"Increased numbers of circulating basophil progenitors in atopic patients","volume":"76","author":"Denburg","year":"1985","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib32","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1034\/j.1398-9995.1999.00756.x","article-title":"Circulating eosinophil\/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis","volume":"54","author":"Linden","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1165\/ajrcmb.18.6.3006","article-title":"Allergen challenge increases cell traffic between bone marrow and lung","volume":"18","author":"Wood","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.chest.2017.01.021_bib34","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1164\/ajrccm.162.6.2001120","article-title":"Effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma","volume":"162","author":"Gauveau","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1165\/ajrcmb.15.5.8918371","article-title":"Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects","volume":"15","author":"Sehmi","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.chest.2017.01.021_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1165\/ajrcmb.20.3.3060","article-title":"Immunolocalization of CD34 in nasal polyposis. Effect of topical corticosteroids","volume":"20","author":"Kim","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.chest.2017.01.021_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.20.1.3449","article-title":"CD34+\/Interleukin-5Ra messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors","volume":"20","author":"Robinson","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.chest.2017.01.021_bib38","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1182\/blood-2003-05-1618","article-title":"Allergen exposure-induced differences in CD34+ cell phenotype: relationship to eosinophilopoietic responses in different compartments","volume":"103","author":"Sergejeva","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.01.021_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2222.2004.02038.x","article-title":"Increased numbers of CD34+ cells in nasal mucosa of allergic rhinitis patients: inhibition by a local steroid","volume":"35","author":"Sergejeva","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/rccm.200307-1024OC","article-title":"Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation","volume":"169","author":"Dorman","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib41","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.jaci.2014.12.1918","article-title":"Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma","volume":"135","author":"Smith","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib42","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2222.2007.02735.x","article-title":"Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers","volume":"37","author":"Menzies-Gow","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib43","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.4049\/jimmunol.164.3.1538","article-title":"Evidence of local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor","volume":"164","author":"Cameron","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib44","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/cea.12695","article-title":"Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma","volume":"46","author":"Sehmi","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/ACI.0000000000000090","article-title":"Type-2 innate lymphoid cells in human allergic disease","volume":"14","author":"Barlow","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1962","article-title":"The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling","volume":"12","author":"Spits","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib47","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ni.2617","article-title":"TH2, allergy and group 2 innate lymphoid cells","volume":"14","author":"Licona-Limon","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2014.06.024","article-title":"Enhanced innate type 2 immune response in peripheral blood from patients with asthma","volume":"134","author":"Bartemes","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2014.11.037","article-title":"Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33","volume":"136","author":"Christianson","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaci.2015.05.037","article-title":"Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia","volume":"137","author":"Smith","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2222.2011.03889.x","article-title":"Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to\u00a0stromal cell-derived factor-1alpha","volume":"42","author":"Punia","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ni.2208","article-title":"Transcription factor RORalpha is critical for nuocyte development","volume":"13","author":"Wong","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib53","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2012.08.015","article-title":"The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells","volume":"37","author":"Mjosberg","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.chest.2017.01.021_bib54","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/ni.3553","article-title":"Evidence of innate lymphoid cell redundancy in humans","volume":"17","author":"Vely","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib55","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1067\/mai.2003.1382","article-title":"Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics","volume":"111","author":"Menzies-Gow","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib56","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/cea.12244","article-title":"Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial","volume":"44","author":"Neighbour","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib57","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.chest.2017.01.021_bib58","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa1403291","article-title":"Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma","volume":"371","author":"Bel","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.chest.2017.01.021_bib59","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1164\/rccm.201103-0396OC","article-title":"Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study","volume":"184","author":"Castro","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.01.021_bib60","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaci.2013.05.020","article-title":"Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia","volume":"132","author":"Laviolette","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2017.01.021_bib61","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/19420862.2015.1119352","article-title":"CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors","volume":"8","author":"Panousis","year":"2016","journal-title":"MAbs"},{"key":"10.1016\/j.chest.2017.01.021_bib62","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1365-2222.2011.03816.x","article-title":"TPI ASM8 reduces eosinophil progenitors in the sputum after allergen challenge in mild asthmatics","volume":"14","author":"Imaoka","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.chest.2017.01.021_bib63","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1056\/NEJMoa1402895","article-title":"Effects of an anti-TSLP antibody on allergen-induced asthmatic responses","volume":"370","author":"Gauvreau","year":"2014","journal-title":"N\u00a0Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217300399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217300399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:34:18Z","timestamp":1757921658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369217300399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0012369217300399"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2017.01.021","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hematopoietic Processes in Eosinophilic Asthma","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2017.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}