{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:46:40Z","timestamp":1787312800450,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.chest.2017.05.017","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T19:47:32Z","timestamp":1496087252000},"page":"368-378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa"],"prefix":"10.1016","volume":"152","author":[{"given":"Pallavi","family":"Bedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.W.","family":"Govan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano G.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chest.2017.05.017_bib1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1164\/ajrccm.165.8.2107051","article-title":"Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice","volume":"165","author":"Chmiel","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.05.017_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1513\/pats.200408-039MS","article-title":"Local and systemic inflammation in chronic obstructive pulmonary disease","volume":"2","author":"Wouters","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.chest.2017.05.017_bib3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2010.02.043","article-title":"Anti-inflammatory agents: present and future","volume":"140","author":"Dinarello","year":"2010","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.chest.2017.05.017_bib4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/82219","article-title":"Statins as a newly recognized type of immunomodulator","volume":"6","author":"Kwak","year":"2000","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.chest.2017.05.017_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S2213-2600(14)70050-5","article-title":"Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial","volume":"2","author":"Mandal","year":"2014","journal-title":"Lancet Respir Med"},{"issue":"5","key":"10.1016\/j.chest.2017.05.017_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index. An international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.chest.2017.05.017_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.chest.2017.05.017_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-540-79842-2_16","article-title":"Clinical cough IV: what is the minimal important difference for the Leicester Cough Questionnaire?","volume":"187","author":"Raj","year":"2009","journal-title":"Handb Exp Pharmacol"},{"issue":"1","key":"10.1016\/j.chest.2017.05.017_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1183\/09031936.00160508","article-title":"Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis","volume":"34","author":"Murray","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2017.05.017_bib10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/thx.47.12.1019","article-title":"The development of a shuttle walking test of disability in patients with chronic airways obstruction","volume":"47","author":"Singh","year":"1992","journal-title":"Thorax"},{"key":"10.1016\/j.chest.2017.05.017_bib11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1164\/ajrccm.156.2.9607083","article-title":"Validation of the St George\u2019s Respiratory Questionnaire in bronchiectasis","volume":"156","author":"Wilson","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.05.017_bib12","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1365-2222.1997.tb01150.x","article-title":"Induced sputum to assess airway inflammation: a study of reproducibility","volume":"27","author":"Spanevello","year":"1997","journal-title":"Clin Exp Allergy"},{"issue":"7","key":"10.1016\/j.chest.2017.05.017_bib13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/thx.2010.142778","article-title":"British Thoracic Society Non-CF Bronchiectasis Guideline Group. British Thoracic Society guideline for non-CF bronchiectasis","volume":"65","author":"Pasteur","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.chest.2017.05.017_bib14","first-page":"101","article-title":"Modulation of multiple neutrophil functions by\u00a0preparative methods or trace concentrations of bacterial lipopolysaccharide","volume":"119","author":"Haslett","year":"1985","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.chest.2017.05.017_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1189\/jlb.0113040","article-title":"Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production","volume":"94","author":"Dorward","year":"2013","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.chest.2017.05.017_bib16","doi-asserted-by":"crossref","first-page":"14708","DOI":"10.1016\/S0021-9258(18)82391-2","article-title":"5-Hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism","volume":"268","author":"O'Flaherty","year":"1993","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.chest.2017.05.017_bib17","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0735-1097(97)00324-0","article-title":"HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia","volume":"30","author":"Weber","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.chest.2017.05.017_bib18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/heart.89.5.538","article-title":"Simvastatin attenuates leucocyte-endothelial interactions after coronary revascularisation with cardiopulmonary bypass","volume":"89","author":"Chello","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.chest.2017.05.017_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0022-3565(24)39169-4","article-title":"Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis","volume":"294","author":"Ando","year":"2000","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.chest.2017.05.017_bib20","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0006-2952(99)00260-9","article-title":"Selective inhibition of formyl-methionyl-leucyl-phenylalanine (fMLF)-dependent superoxide generation in neutrophils by pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase","volume":"58","author":"Kanno","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.chest.2017.05.017_bib21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/07853890008998823","article-title":"Non-lipid-related effects of statins","volume":"32","author":"Bellosta","year":"2000","journal-title":"Ann Med"},{"issue":"2","key":"10.1016\/j.chest.2017.05.017_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/bja\/aep361","article-title":"Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III","volume":"104","author":"McGown","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.chest.2017.05.017_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.bjp.0705634","article-title":"Lymphocyte function antigen-1 mediates leukocyte adhesion and subsequent liver damage in exotoxemic mice","volume":"141","author":"Li","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.chest.2017.05.017_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00011-012-0579-7","article-title":"Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity","volume":"62","author":"Aparecida","year":"2013","journal-title":"Inflamm Res"},{"key":"10.1016\/j.chest.2017.05.017_bib25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.immunol.19.1.497","article-title":"Calcium signaling mechanisms in T lymphocytes","volume":"19","author":"Lewis","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.chest.2017.05.017_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0091-679X(01)66011-4","article-title":"Calcium flux measurements in apoptosis","volume":"66","author":"McConkey","year":"2001","journal-title":"Methods Cell Biol"},{"issue":"2-3","key":"10.1016\/j.chest.2017.05.017_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1385\/IR:22:2-3:271","article-title":"Function and regulation of chemoattractant receptors","volume":"22","author":"Haribabu","year":"2000","journal-title":"Immunol Res"},{"key":"10.1016\/j.chest.2017.05.017_bib28","doi-asserted-by":"crossref","first-page":"243S","DOI":"10.1042\/bst025243s","article-title":"Effect of the protein phosphatase inhibitors, okadaic acid and calyculin A, on dexamethasone-mediated inhibition of neutrophil apoptosis","volume":"25","author":"Cousin","year":"1997","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"10.1016\/j.chest.2017.05.017_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/thx.2003.008037","article-title":"Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis","volume":"59","author":"Watt","year":"2004","journal-title":"Thorax"},{"issue":"9","key":"10.1016\/j.chest.2017.05.017_bib30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.95.08091479","article-title":"In\u00a0vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion","volume":"8","author":"Llewellyn-Jones","year":"1995","journal-title":"Eur Respir J"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217309662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217309662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:32:56Z","timestamp":1757921576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369217309662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0012369217309662"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2017.05.017","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2017.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}