{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:19:58Z","timestamp":1784546398595,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670031"],"award-info":[{"award-number":["81670031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370142"],"award-info":[{"award-number":["81370142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130001"],"award-info":[{"award-number":["81130001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.chest.2017.10.031","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T09:45:10Z","timestamp":1511948710000},"page":"863-875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["HDAC2 Suppresses IL17A-Mediated Airway Remodeling in Human and Experimental Modeling of COPD"],"prefix":"10.1016","volume":"153","author":[{"given":"Tianwen","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songmin","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9859","key":"10.1016\/j.chest.2017.10.031_bib1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.chest.2017.10.031_bib2","doi-asserted-by":"crossref","first-page":"15076","DOI":"10.1038\/nrdp.2015.76","article-title":"Chronic obstructive pulmonary disease","volume":"1","author":"Barnes","year":"2015","journal-title":"Nature Rev Primers"},{"issue":"4","key":"10.1016\/j.chest.2017.10.031_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1378\/chest.14-0460","article-title":"Anthracycline-dependent cardiotoxicity and extracellular matrix remodeling","volume":"146","author":"Nikitovic","year":"2014","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.chest.2017.10.031_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1165\/rcmb.2010-0426OC","article-title":"Matrix proteins from smoke-exposed fibroblasts are pro-proliferative","volume":"46","author":"Krimmer","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"26","key":"10.1016\/j.chest.2017.10.031_bib5","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","article-title":"The nature of small-airway obstruction in chronic obstructive pulmonary disease","volume":"350","author":"Hogg","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.chest.2017.10.031_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1183\/09031936.00017911","article-title":"Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells","volume":"39","author":"Zijlstra","year":"2012","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1378\/chest.13-0835","article-title":"Passive smoking impairs histone deacetylase-2 in children with severe asthma","volume":"145","author":"Kobayashi","year":"2014","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.chest.2017.10.031_bib9","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.bbadis.2017.05.003","article-title":"Formoterol and fluticasone propionate combination improves histone deacetylation and anti-inflammatory activities in bronchial epithelial cells exposed to cigarette smoke","volume":"1863","author":"Ferraro","year":"2017","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.chest.2017.10.031_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12192-013-0424-0","article-title":"Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells","volume":"18","author":"Pace","year":"2013","journal-title":"Cell Stress Chaperones"},{"issue":"8","key":"10.1016\/j.chest.2017.10.031_bib11","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2586","article-title":"Structure and signalling in the IL-17 receptor family","volume":"9","author":"Gaffen","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1378\/chest.12-0598","article-title":"T\u00a0helper 17 cells in airway diseases: from laboratory bench to bedside","volume":"143","author":"Halwani","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.chest.2017.10.031_bib13","doi-asserted-by":"crossref","first-page":"16355","DOI":"10.1038\/srep16355","article-title":"Reciprocal regulation of ROR\u03b3t acetylation and function by p300 and HDAC1","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.chest.2017.10.031_bib14","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1378\/chest.09-3058","article-title":"Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD","volume":"138","author":"Doe","year":"2010","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.chest.2017.10.031_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1378\/chest.10-0779","article-title":"Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD","volume":"139","author":"Eustace","year":"2011","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cyto.2015.07.013","article-title":"Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue: ex\u00a0vivo and in\u00a0vitro studies","volume":"76","author":"Montalbano","year":"2015","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.chest.2017.10.031_bib17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1164\/rccm.201409-1689OC","article-title":"IL-17A and the promotion of neutrophilia in acute exacerbation of chronic obstructive pulmonary disease","volume":"192","author":"Roos","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2017.10.031_bib18","unstructured":"GOLD Committee. Global strategy for the diagnosis, management, and prevention of COPD. http:\/\/www.goldcopd.org\/guidelines-pocket-guide-to-copd-diagnosis.html. Accessed May 3,\u00a02016."},{"issue":"4","key":"10.1016\/j.chest.2017.10.031_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/thx.53.4.248","article-title":"Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning","volume":"53","author":"Awadh","year":"1998","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.chest.2017.10.031_bib20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm1552","article-title":"Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity","volume":"13","author":"Trivedi","year":"2007","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.chest.2017.10.031_bib21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor ROR gammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"issue":"26","key":"10.1016\/j.chest.2017.10.031_bib22","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1056\/NEJMp048102","article-title":"Small airways in COPD","volume":"350","author":"Barnes","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.chest.2017.10.031_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1753465809348648","article-title":"Histone deacetylase-2 and airway disease","volume":"3","author":"Barnes","year":"2009","journal-title":"Ther Adv Respir Dis"},{"issue":"1","key":"10.1016\/j.chest.2017.10.031_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/ACI.0000000000000029","article-title":"Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions","volume":"14","author":"Royce","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T-cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.chest.2017.10.031_bib26","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","article-title":"Cutting edge: regulatory T-cells induce CD4+CD25-Foxp3-T-cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta","volume":"178","author":"Xu","year":"2007","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"10.1016\/j.chest.2017.10.031_bib27","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2008-01-133967","article-title":"Human CD25highFoxp3pos regulatory T\u00a0cells differentiate into IL-17-producing cells","volume":"112","author":"Koenen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.chest.2017.10.031_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1465-9921-11-165","article-title":"Variability in the precursor proteins of collagen I and III in different stages of COPD","volume":"30","author":"Harju","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.chest.2017.10.031_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12931-016-0338-3","article-title":"YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodeling","volume":"17","author":"Lai","year":"2016","journal-title":"Respir Res"},{"issue":"2","key":"10.1016\/j.chest.2017.10.031_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1378\/chest.11-2091","article-title":"Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis","volume":"142","author":"Kikuchi","year":"2012","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.chest.2017.10.031_bib31","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/cea.12744","article-title":"Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A","volume":"46","author":"Dessalle","year":"2016","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"10.1016\/j.chest.2017.10.031_bib32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1165\/rcmb.2014-0429OC","article-title":"Influence of an allergen-specific Th17 response on remodeling of the airways","volume":"54","author":"Peters","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.chest.2017.10.031_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1165\/rcmb.2008-0307OC","article-title":"Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthma","volume":"41","author":"Kohan","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"39-40","key":"10.1016\/j.chest.2017.10.031_bib34","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4414\/smw.2009.12528","article-title":"TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen","volume":"139","author":"Knigshoff","year":"2009","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.chest.2017.10.031_bib35","doi-asserted-by":"crossref","first-page":"L582","DOI":"10.1152\/ajplung.00152.2013","article-title":"Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD","volume":"305","author":"Brandsma","year":"2013","journal-title":"Am J Physio Lung Cell Mol Physiol"}],"updated-by":[{"DOI":"10.1016\/j.chest.2022.05.027","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000}}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217330441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369217330441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:48:34Z","timestamp":1778633314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369217330441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0012369217330441"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2017.10.031","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDAC2 Suppresses IL17A-Mediated Airway Remodeling in Human and Experimental Modeling of COPD","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2017.10.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}