{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:04:25Z","timestamp":1784772265044,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.chest.2019.11.036","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:10:23Z","timestamp":1576840223000},"page":"1579-1590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Intratracheal Delivery of Nano- and Microparticles and Hyperpolarized Gases"],"prefix":"10.1016","volume":"157","author":[{"given":"Hongbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"23","key":"10.1016\/j.chest.2019.11.036_bib2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1056\/NEJMe0908771","article-title":"Volume CT for diagnosis of nodules found in lung-cancer screening","volume":"361","author":"Mulshine","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0034-5687(78)90104-4","article-title":"The normal human lung: ultrastructure and morphometric estimation of diffusion capacity","volume":"32","author":"Gehr","year":"1978","journal-title":"Respir Physiol"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3132\/pcrj.2007.00017","article-title":"Inhalation therapy: an historical review","volume":"16","author":"Sanders","year":"2007","journal-title":"Prim Care Respir J"},{"issue":"1-2","key":"10.1016\/j.chest.2019.11.036_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijpharm.2008.02.011","article-title":"Inhaled nanoparticles: a current review","volume":"356","author":"Yang","year":"2008","journal-title":"Int J Pharm"},{"issue":"10","key":"10.1016\/j.chest.2019.11.036_bib6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nbt1006-1211","article-title":"The emerging nanomedicine landscape","volume":"24","author":"Wagner","year":"2006","journal-title":"Nat Biotechnol"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrd2591","article-title":"Strategies in the design of nanoparticles for therapeutic applications","volume":"9","author":"Petros","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21691401.2016.1203794","article-title":"PLGA nanoparticles for ocular delivery of loteprednol etabonate: a corneal penetration study","volume":"45","author":"Sah","year":"2017","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib9","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/jmri.26177","article-title":"Folate receptor-targeted 19F MR molecular imaging and proliferation evaluation of lung cancer: 19F MR and proliferation evaluation","volume":"48","author":"Xu","year":"2018","journal-title":"J\u00a0Magn Reson Imaging"},{"issue":"34","key":"10.1016\/j.chest.2019.11.036_bib10","doi-asserted-by":"crossref","first-page":"15958","DOI":"10.1039\/C9NR03802G","article-title":"An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy","volume":"11","author":"Song","year":"2019","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.chest.2019.11.036_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10517-014-2382-7","article-title":"Reaction of dermal structures to subcutaneous injection of gold nanoparticles to CBA mice","volume":"156","author":"Reva","year":"2014","journal-title":"Bull Exp Biol Med"},{"issue":"216","key":"10.1016\/j.chest.2019.11.036_bib12","doi-asserted-by":"crossref","first-page":"216rv214","DOI":"10.1126\/scitranslmed.3005872","article-title":"Cancer nanomedicine: from drug delivery to imaging","volume":"5","author":"Chow","year":"2013","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.chest.2019.11.036_bib13","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/jcp.29126","article-title":"Nanoparticles and cancer therapy: perspectives for application of nanoparticles in the treatment of cancers","volume":"235","author":"Aghebati-Maleki","year":"2020","journal-title":"J\u00a0Cell Physiol"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib14","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ijrobp.2015.06.005","article-title":"Ventilation\/perfusion positron emission tomography-based assessment of radiation injury to lung","volume":"93","author":"Siva","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.7150\/thno.21466","article-title":"Local intratracheal delivery of perfluorocarbon nanoparticles to lung cancer demonstrated with magnetic resonance multimodal imaging","volume":"8","author":"Wu","year":"2018","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2008.11.018","article-title":"Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence","volume":"134","author":"Mizuno","year":"2009","journal-title":"J\u00a0Control Release"},{"issue":"1-2","key":"10.1016\/j.chest.2019.11.036_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2016.04.012","article-title":"The formulation of nanomedicines for treating tuberculosis","volume":"102","author":"Costa","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"10.1016\/j.chest.2019.11.036_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0021-8502(86)90035-2","article-title":"Deposition of particles in the human respiratory tract in the size range 0.005-15 \u03bcm","volume":"17","author":"Heyder","year":"1986","journal-title":"J\u00a0Aerosol Sci"},{"issue":"3","key":"10.1016\/j.chest.2019.11.036_bib19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11095-006-9174-3","article-title":"Particle engineering for pulmonary drug delivery","volume":"24","author":"Chow","year":"2007","journal-title":"Pharm Res"},{"key":"10.1016\/j.chest.2019.11.036_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2016.07.006","article-title":"On the contribution of the phagocytosis and the solubilization to the iron oxide nanoparticles retention in and elimination from lungs under long-term inhalation exposure","volume":"363-364","author":"Sutunkova","year":"2016","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s11095-012-0884-4","article-title":"Rapid lymph accumulation of polystyrene nanoparticles following pulmonary administration","volume":"30","author":"Mohammad","year":"2013","journal-title":"Pharm Res"},{"issue":"12","key":"10.1016\/j.chest.2019.11.036_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nbt.1696","article-title":"Rapid translocation of nanoparticles from the lung airspaces to the body","volume":"28","author":"Choi","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"suppl 1","key":"10.1016\/j.chest.2019.11.036_bib23","first-page":"51","article-title":"Endocytosis and exocytosis of nanoparticles in mammalian cells","volume":"9","author":"Oh","year":"2014","journal-title":"Int J Nanomedicine"},{"issue":"13","key":"10.1016\/j.chest.2019.11.036_bib24","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.biomaterials.2013.01.064","article-title":"Nanoparticle diffusion in respiratory mucus from humans without lung disease","volume":"34","author":"Schuster","year":"2013","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.chest.2019.11.036_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1601556","article-title":"Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation","volume":"3","author":"Schneider","year":"2017","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.chest.2019.11.036_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13550-015-0118-y","article-title":"Clinical value of measurement of pulmonary radioaerosol mucociliary clearance in the work up of primary ciliary dyskinesia","volume":"5","author":"Munkholm","year":"2015","journal-title":"EJNMMI Res"},{"issue":"1","key":"10.1016\/j.chest.2019.11.036_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13550-017-0332-x","article-title":"Automatic delineation of functional lung volumes with 68Ga-ventilation\/perfusion PET\/CT","volume":"7","author":"Le Roux","year":"2017","journal-title":"EJNMMI Res"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib28","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1007\/s00259-019-04338-z","article-title":"Independent and incremental value of ventilation\/perfusion PET\/CT and CT pulmonary angiography for pulmonary embolism diagnosis: results of the PECAN pilot study","volume":"46","author":"Le Roux","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1089\/jamp.2013.1120","article-title":"Analysis of three-dimensional aerosol deposition in pharmacologically relevant terms: beyond black or white ROIs","volume":"28","author":"Greenblatt","year":"2015","journal-title":"J\u00a0Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.chest.2019.11.036_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejpb.2018.05.037","article-title":"Preclinical evaluation of aerosol administration systems using positron emission tomography","volume":"130","author":"Coss\u00edo","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"issue":"1084","key":"10.1016\/j.chest.2019.11.036_bib31","doi-asserted-by":"crossref","first-page":"20170647","DOI":"10.1259\/bjr.20170647","article-title":"Hyperpolarized gas MRI in pulmonology","volume":"91","author":"Kern","year":"2018","journal-title":"Br J Radiol"},{"issue":"3","key":"10.1016\/j.chest.2019.11.036_bib32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1440-1843.2011.02117.x","article-title":"Quantitative pulmonary imaging using computed tomography and magnetic resonance imaging","volume":"17","author":"Washko","year":"2012","journal-title":"Respirology"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib33","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/mrm.26310","article-title":"Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy","volume":"77","author":"Stewart","year":"2017","journal-title":"Magn Reson Med"},{"issue":"12","key":"10.1016\/j.chest.2019.11.036_bib34","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00247-016-3672-1","article-title":"Feasibility, tolerability and safety of pediatric hyperpolarized 129Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis","volume":"46","author":"Walkup","year":"2016","journal-title":"Pediatr Radiol"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/mrm.25894","article-title":"Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance","volume":"76","author":"Li","year":"2016","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.chest.2019.11.036_bib36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2463\/mrms.tn.2015-0074","article-title":"Viability of oxygen-enhanced ventilation imaging of the lungs using ultra-short echo time MRI","volume":"16","author":"Sasaki","year":"2017","journal-title":"Magn Reson Med Sci"},{"issue":"11","key":"10.1016\/j.chest.2019.11.036_bib37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJM199609123351101","article-title":"Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome","volume":"335","author":"Leach","year":"1996","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.chest.2019.11.036_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00004424-199701000-00005","article-title":"Perfluorocarbon compound aerosols for delivery to the lung as potential 19F magnetic resonance reporters of regional pulmonary pO2","volume":"32","author":"Thomas","year":"1997","journal-title":"Invest Radiol"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1088\/0967-3334\/32\/2\/008","article-title":"High-resolution three-dimensional 19F-magnetic resonance imaging of rat lung in\u00a0situ: evaluation of airway strain in the perfluorocarbon-filled lung","volume":"32","author":"Weigel","year":"2011","journal-title":"Physiol Meas"},{"issue":"5557","key":"10.1016\/j.chest.2019.11.036_bib40","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.1068443","article-title":"Artificial blood","volume":"295","author":"Squires","year":"2002","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.chest.2019.11.036_bib41","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.2217\/nnm-2018-0051","article-title":"19F MRI in orthotopic cancer model via intratracheal administration of \u03b1v\u03b23-targeted perfluorocarbon nanoparticles","volume":"13","author":"Xu","year":"2018","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.chest.2019.11.036_bib42","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.2147\/IJN.S59394","article-title":"MR imaging and targeting of a specific alveolar macrophage subpopulation in LPS-induced COPD animal model using antibody-conjugated magnetic nanoparticles","volume":"9","author":"Al Faraj","year":"2014","journal-title":"Int J Nanomedicine"},{"issue":"13","key":"10.1016\/j.chest.2019.11.036_bib43","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.7150\/thno.26608","article-title":"In\u00a0vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring","volume":"8","author":"Tay","year":"2018","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib44","first-page":"5415","article-title":"Contrast-enhanced magnetic resonance imaging with a novel nano-size contrast agent for the clinical diagnosis of patients with lung cancer","volume":"15","author":"Gao","year":"2018","journal-title":"Exp Ther Med"},{"issue":"20","key":"10.1016\/j.chest.2019.11.036_bib45","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.biomaterials.2008.03.033","article-title":"Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer","volume":"29","author":"Tseng","year":"2008","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.chest.2019.11.036_bib46","doi-asserted-by":"crossref","first-page":"11642","DOI":"10.1021\/acsnano.5b04026","article-title":"Tracking of inhaled near-infrared fluorescent nanoparticles in lungs of SKH-1 mice with allergic airway inflammation","volume":"9","author":"Markus","year":"2015","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.chest.2019.11.036_bib47","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1248\/bpb.b13-00167","article-title":"Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique","volume":"36","author":"Okuda","year":"2013","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/jamp.2008.0693","article-title":"A\u00a0gamma scintigraphy study to investigate lung deposition and clearance of inhaled amikacin-loaded liposomes in healthy male volunteers","volume":"22","author":"Weers","year":"2009","journal-title":"J\u00a0Aerosol Med Pulm Drug Deliv"},{"issue":"9","key":"10.1016\/j.chest.2019.11.036_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108703","article-title":"Delivery of aerosolized liposomal amikacin as a novel approach for the treatment of nontuberculous mycobacteria in an experimental model of pulmonary infection","volume":"9","author":"Rose","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.chest.2019.11.036_bib50","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1164\/rccm.201807-1318OC","article-title":"Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): a prospective, open-label, randomized study","volume":"198","author":"Griffith","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2019.11.036_bib51","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s40265-019-01095-z","article-title":"Amikacin liposome inhalation suspension: a review in Mycobacterium avium complex lung disease","volume":"79","author":"Shirley","year":"2019","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib52","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bcp.12334","article-title":"Inhaled corticosteroids in chronic obstructive pulmonary disease: a pro-con perspective","volume":"78","author":"Babu","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.chest.2019.11.036_bib53","first-page":"236","article-title":"Lungs deposition and pharmacokinetic study of submicron budesonide particles in Wistar rats intended for immediate effect in asthma","volume":"16","author":"Rauf","year":"2017","journal-title":"EXCLI J"},{"key":"10.1016\/j.chest.2019.11.036_bib54","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.actbio.2019.06.056","article-title":"In\u00a0vitro-in\u00a0vivo correlation of inhalable budesonide-loaded large porous particles for sustained treatment regimen of asthma","volume":"96","author":"Li","year":"2019","journal-title":"Acta Biomater"},{"issue":"4","key":"10.1016\/j.chest.2019.11.036_bib55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.xphs.2016.12.025","article-title":"Low molecular weight heparin-coated and montelukast-filled inhalable particles: a dual-drug delivery system for combination therapy in asthma","volume":"106","author":"Patel","year":"2017","journal-title":"J\u00a0Pharm Sci"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib56","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.nano.2017.04.005","article-title":"Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)","volume":"13","author":"Garbuzenko","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.chest.2019.11.036_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2019.01.025","article-title":"Inhalation treatment of cystic fibrosis with lumacaftor and ivacaftor co-delivered by nanostructured lipid carriers","volume":"296","author":"Garbuzenko","year":"2019","journal-title":"J\u00a0Control Release"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-016-1921-5","article-title":"Synthesis and characterization of nanocomposite microparticles (nCmP) for the treatment of cystic fibrosis-related infections","volume":"33","author":"Wang","year":"2016","journal-title":"Pharm Res"},{"key":"10.1016\/j.chest.2019.11.036_bib59","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.colsurfb.2016.03.044","article-title":"Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs","volume":"143","author":"Melis","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib60","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3109\/10837450.2015.1081613","article-title":"Spray-dried particles as pulmonary delivery system of anti-tubercular drugs: design, optimization, in\u00a0vitro and in\u00a0vivo evaluation","volume":"21","author":"Garg","year":"2016","journal-title":"Pharm Dev Technol"},{"issue":"3","key":"10.1016\/j.chest.2019.11.036_bib61","first-page":"997","article-title":"Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis","volume":"44","author":"Garg","year":"2015","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"20","key":"10.1016\/j.chest.2019.11.036_bib62","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1158\/0008-5472.CAN-16-1131","article-title":"Bronchial artery angiogenesis drives lung tumor growth","volume":"76","author":"Eldridge","year":"2016","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.chest.2019.11.036_bib63","first-page":"463","article-title":"The bronchial circulation: small, but a vital attribute of the lung","volume":"135","author":"Deffebach","year":"1987","journal-title":"Am Rev Respir Dis"},{"issue":"6","key":"10.1016\/j.chest.2019.11.036_bib64","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/jps.20607","article-title":"Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles","volume":"95","author":"Hitzman","year":"2010","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.chest.2019.11.036_bib65","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jconrel.2014.11.008","article-title":"Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer","volume":"197","author":"Choi","year":"2015","journal-title":"J\u00a0Control Release"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib66","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/03639045.2017.1310223","article-title":"Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer","volume":"43","author":"Bakhtiary","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.chest.2019.11.036_bib67","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1038\/srep07085","article-title":"Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: pulmonary compatible and site-specific drug delivery in lung metastases","volume":"4","author":"Joshi","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.chest.2019.11.036_bib68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2018.06.027","article-title":"Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor\/herbal combined therapy of lung carcinoma","volume":"130","author":"Kabary","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"issue":"suppl 1","key":"10.1016\/j.chest.2019.11.036_bib69","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1038\/onc.2009.199","article-title":"Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer","volume":"28","author":"Hirsch","year":"2009","journal-title":"Oncogene"},{"issue":"21","key":"10.1016\/j.chest.2019.11.036_bib70","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1016\/j.biomaterials.2013.03.061","article-title":"Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy","volume":"34","author":"Sadhukha","year":"2013","journal-title":"Biomaterials"},{"issue":"31","key":"10.1016\/j.chest.2019.11.036_bib71","doi-asserted-by":"crossref","first-page":"7744","DOI":"10.1016\/j.biomaterials.2013.06.041","article-title":"In\u00a0vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models","volume":"34","author":"Conde","year":"2013","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.chest.2019.11.036_bib72","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2217\/fon.13.67","article-title":"Inhaled gene therapy in lung cancer: proof-of-concept for nano-oncology and nanobiotechnology in the management of lung cancer","volume":"9","author":"Zarogoulidis","year":"2013","journal-title":"Future Oncol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369219344484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369219344484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:18:27Z","timestamp":1757924307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369219344484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0012369219344484"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2019.11.036","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intratracheal Delivery of Nano- and Microparticles and Hyperpolarized Gases","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2019.11.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}