{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:45:48Z","timestamp":1758055548335,"version":"3.44.0"},"reference-count":9,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.chest.2021.05.077","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T05:07:31Z","timestamp":1649135251000},"page":"e245-e248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Worsening Dyspnea in Patients With Idiopathic Portal Hypertension"],"prefix":"10.1016","volume":"161","author":[{"given":"Noriaki","family":"Iwahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuo","family":"Horii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chest.2021.05.077_bib1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.22275","article-title":"Clinical risk factors for portopulmonary hypertension","volume":"48","author":"Kawut","year":"2008","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"suppl25","key":"10.1016\/j.chest.2021.05.077_bib2","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.chest.2021.05.077_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.chest.2021.05.077_bib4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/jhep.2002.31432","article-title":"The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough","volume":"35","author":"Wiest","year":"2002","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"2","key":"10.1016\/j.chest.2021.05.077_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1517\/13543780802680186","article-title":"Endothelin receptor antagonism in portal hypertension","volume":"18","author":"Pitts","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"10.1016\/j.chest.2021.05.077_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1183\/09031936.06.00030206","article-title":"Sildenafil treatment for portopulmonary hypertension","volume":"28","author":"Reichenberger","year":"2006","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.chest.2021.05.077_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1183\/09031936.00117511","article-title":"Efficacy, safety and pharmacokinetics of bosentan in portopulmonary hypertension","volume":"41","author":"Savale","year":"2013","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.chest.2021.05.077_bib8","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S2213-2600(19)30091-8","article-title":"Macitentan for the treatment of portopulmonary hypertension (PORTICO): a multicentre, randomised, double-blind, placebo-controlled, phase 4 trial","volume":"7","author":"Sitbon","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.chest.2021.05.077_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.30197","article-title":"Treatment barriers in portopulmonary hypertension","volume":"69","author":"AbuHalimeh","year":"2019","journal-title":"Hepatology (Baltimore, Md.)"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221042537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221042537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:44:50Z","timestamp":1757925890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369221042537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0012369221042537"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2021.05.077","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Worsening Dyspnea in Patients With Idiopathic Portal Hypertension","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2021.05.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}