{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:30:53Z","timestamp":1787067053520,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001540","name":"CHEST Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["10,706,533"],"award-info":[{"award-number":["10,706,533"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007273","name":"Weill Cornell Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"Universit\u00e0 degli Studi di Parma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012308","name":"National Jewish Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017650","name":"Three Lakes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.chest.2021.06.035","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T04:15:35Z","timestamp":1624940135000},"page":"470-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Detection and Early Referral of Patients With Interstitial Lung Abnormalities"],"prefix":"10.1016","volume":"161","author":[{"given":"Gary M.","family":"Hunninghake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Goldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kadoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Kropski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan O.","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athol U.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereidoun G.","family":"Abtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamera J.","family":"Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao A.","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri A.","family":"Johannson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Oldham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Spagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Strek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Tomassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Washko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereidoun","family":"Abtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamera","family":"Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Crossno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Culver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Deveraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gudmundsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Hatabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Kanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Kazerooni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Noth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Oldham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Podolanczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venerino","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ravaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabetta","family":"Renzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Richeldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Ryerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasis","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Tomassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Spagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Strek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sverzellati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Washko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"150","key":"10.1016\/j.chest.2021.06.035_bib1","doi-asserted-by":"crossref","first-page":"180076","DOI":"10.1183\/16000617.0076-2018","article-title":"Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases","volume":"27","author":"Cottin","year":"2018","journal-title":"Eur Respir Rev"},{"issue":"1","key":"10.1016\/j.chest.2021.06.035_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-017-0560-x","article-title":"Barriers to timely diagnosis of interstitial lung disease in the real world: the INTENSITY survey","volume":"18","author":"Cosgrove","year":"2018","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.chest.2021.06.035_bib3","doi-asserted-by":"crossref","first-page":"h2072","DOI":"10.1136\/bmj.h2072","article-title":"The diagnosis and management of interstitial lung diseases","volume":"350","author":"Wallis","year":"2015","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.chest.2021.06.035_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/thoraxjnl-2018-212446","article-title":"Interstitial lung abnormalities: erecting fences in the path towards advanced pulmonary fibrosis","volume":"74","author":"Hunninghake","year":"2019","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.chest.2021.06.035_bib5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201108-1420PP","article-title":"Subclinical interstitial lung disease: why you should care","volume":"185","author":"Doyle","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2021.06.035_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1183\/09031936.00201809","article-title":"Interstitial lung diseases in a lung cancer screening trial","volume":"38","author":"Sverzellati","year":"2011","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.chest.2021.06.035_bib7","first-page":"1434","article-title":"High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study","volume":"196","author":"Podolanczuk","year":"2016","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.chest.2021.06.035_bib8","doi-asserted-by":"crossref","first-page":"1700559","DOI":"10.1183\/13993003.00559-2017","article-title":"Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study","volume":"50","author":"Sack","year":"2017","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.chest.2021.06.035_bib9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1164\/rccm.201312-2219PP","article-title":"Genetics and early detection in idiopathic pulmonary fibrosis","volume":"189","author":"Putman","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.chest.2021.06.035_bib10","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1164\/rccm.201512-2523OC","article-title":"Development and progression of interstitial lung abnormalities in the Framingham Heart Study","volume":"194","author":"Araki","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"23","key":"10.1016\/j.chest.2021.06.035_bib11","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1056\/NEJMoa1216076","article-title":"MUC5B promoter polymorphism and interstitial lung abnormalities","volume":"368","author":"Hunninghake","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.chest.2021.06.035_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.201406-1162OC","article-title":"Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease","volume":"191","author":"Kropski","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.chest.2021.06.035_bib13","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1164\/rccm.201903-0511OC","article-title":"Overlap of genetic risk between interstitial lung abnormalities and idiopathic pulmonary fibrosis","volume":"200","author":"Hobbs","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2021.06.035_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1164\/rccm.200812-1966OC","article-title":"Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study","volume":"180","author":"Lederer","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2021.06.035_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.201109-1618OC","article-title":"Interstitial lung abnormalities and reduced exercise capacity","volume":"185","author":"Doyle","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2021.06.035_bib16","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1164\/rccm.201708-1679LE","article-title":"Histopathology of interstitial lung abnormalities in the context of lung nodule resections","volume":"197","author":"Miller","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2021.06.035_bib17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jama.2016.0518","article-title":"Association between interstitial lung abnormalities and all-cause mortality","volume":"315","author":"Putman","year":"2016","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.chest.2021.06.035_bib18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJMoa1007285","article-title":"Lung volumes and emphysema in smokers with interstitial lung abnormalities","volume":"364","author":"Washko","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.chest.2021.06.035_bib19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.13120816","article-title":"Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate","volume":"268","author":"Jin","year":"2013","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.chest.2021.06.035_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.201809-1652OC","article-title":"Imaging patterns are associated with interstitial lung abnormality progression and mortality","volume":"200","author":"Putman","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.chest.2021.06.035_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1513\/AnnalsATS.201801-053RL","article-title":"Underreporting of interstitial lung abnormalities on lung cancer screening computed tomography","volume":"15","author":"Oldham","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"7","key":"10.1016\/j.chest.2021.06.035_bib22","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S2213-2600(20)30168-5","article-title":"Interstitial lung abnormalities detected incidentally on CT: a position paper from the Fleischner Society","volume":"8","author":"Hatabu","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.chest.2021.06.035_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12890-016-0168-6","article-title":"Treatment patterns, resource use and costs of idiopathic pulmonary fibrosis in Spain-results of a Delphi Panel","volume":"16","author":"Morell","year":"2016","journal-title":"BMC Pulm Med"},{"issue":"5","key":"10.1016\/j.chest.2021.06.035_bib24","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jpainsymman.2013.06.013","article-title":"Definition, categorization, and terminology of episodic breathlessness: consensus by an international Delphi survey","volume":"47","author":"Simon","year":"2014","journal-title":"J\u00a0Pain Symptom Manage"},{"issue":"10","key":"10.1016\/j.chest.2021.06.035_bib25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s12325-015-0249-6","article-title":"Development of a consensus statement for the definition, diagnosis, and treatment of acute exacerbations of idiopathic pulmonary fibrosis using the Delphi technique","volume":"32","author":"Maher","year":"2015","journal-title":"Adv Ther"},{"issue":"3","key":"10.1016\/j.chest.2021.06.035_bib27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2214\/AJR.17.18865","article-title":"Screening for lung cancer: lexicon for communicating with health care providers","volume":"210","author":"Carter","year":"2018","journal-title":"AJR Am J Roentgenol"},{"issue":"9","key":"10.1016\/j.chest.2021.06.035_bib28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1164\/rccm.201809-1699ED","article-title":"American Thoracic Society\/American Lung Association lung cancer screening implementation guide","volume":"198","author":"Thomson","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.chest.2021.06.035_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/rccm.201604-0818LE","article-title":"Interstitial lung abnormalities are associated with acute respiratory distress syndrome","volume":"195","author":"Putman","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.chest.2021.06.035_bib30","doi-asserted-by":"crossref","first-page":"1601814","DOI":"10.1183\/13993003.01814-2016","article-title":"Computed tomographic findings in subjects who died from respiratory disease in the National Lung Screening Trial","volume":"49","author":"Pompe","year":"2017","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.chest.2021.06.035_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/RTI.0000000000000097","article-title":"ACR-STR practice parameter for the performance and reporting of lung cancer screening thoracic computed tomography (CT): 2014 (Resolution 4)","volume":"29","author":"Kazerooni","year":"2014","journal-title":"J\u00a0Thorac Imaging"},{"key":"10.1016\/j.chest.2021.06.035_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2018.03.017","article-title":"Frequency and distribution of incidental findings deemed appropriate for S modifier designation on low-dose CT in a lung cancer screening program","volume":"120","author":"Reiter","year":"2018","journal-title":"Lung Cancer"},{"issue":"22","key":"10.1016\/j.chest.2021.06.035_bib33","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis","volume":"370","author":"Richeldi","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"22","key":"10.1016\/j.chest.2021.06.035_bib34","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A\u00a0phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"King","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"26","key":"10.1016\/j.chest.2021.06.035_bib35","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa1903076","article-title":"Nintedanib for systemic sclerosis-associated interstitial lung disease","volume":"380","author":"Distler","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.chest.2021.06.035_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S2213-2600(19)30341-8","article-title":"Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"8","author":"Maher","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"18","key":"10.1016\/j.chest.2021.06.035_bib37","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1056\/NEJMoa1908681","article-title":"Nintedanib in progressive fibrosing interstitial lung diseases","volume":"381","author":"Flaherty","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"22","key":"10.1016\/j.chest.2021.06.035_bib38","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMe1403448","article-title":"A\u00a0new hope for idiopathic pulmonary fibrosis","volume":"370","author":"Hunninghake","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.chest.2021.06.035_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.resinv.2015.06.002","article-title":"Efficacy of pirfenidone and disease severity of idiopathic pulmonary fibrosis: extended analysis of phase III trial in Japan","volume":"53","author":"Taguchi","year":"2015","journal-title":"Respir Investig"},{"issue":"4","key":"10.1016\/j.chest.2021.06.035_bib40","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/thoraxjnl-2016-208710","article-title":"Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume","volume":"72","author":"Kolb","year":"2017","journal-title":"Thorax"},{"issue":"9","key":"10.1016\/j.chest.2021.06.035_bib41","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S2213-2600(19)30255-3","article-title":"Biomarkers of extracellular matrix turnover in patients with idiopathic pulmonary fibrosis given nintedanib (INMARK study): a randomised, placebo-controlled study","volume":"7","author":"Maher","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"8","key":"10.1016\/j.chest.2021.06.035_bib42","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1164\/rccm.201612-2431OC","article-title":"Occupational exposures and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) Air-Lung Study","volume":"196","author":"Sack","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.chest.2021.06.035_bib43","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1164\/rccm.201904-0717ST","article-title":"The occupational burden of nonmalignant respiratory diseases. An official American Thoracic Society and European Respiratory Society statement","volume":"199","author":"Blanc","year":"2019","journal-title":"Am J Respir Crit Care Med"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221012630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221012630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:03:13Z","timestamp":1762124593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369221012630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0012369221012630"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2021.06.035","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection and Early Referral of Patients With Interstitial Lung Abnormalities","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2021.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}