{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:06:59Z","timestamp":1777486019107,"version":"3.51.4"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["UL1 TR002494"],"award-info":[{"award-number":["UL1 TR002494"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["IA-816386"],"award-info":[{"award-number":["IA-816386"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL144472"],"award-info":[{"award-number":["T32 HL144472"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016421","name":"Cardiovascular Medical Research and Education Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007150","name":"United Therapeutics Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.chest.2021.07.2159","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T20:31:04Z","timestamp":1627936264000},"page":"232-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Iron Deficiency Is Associated With More Severe Pulmonary Vascular Disease in Pulmonary Hypertension Caused by Chronic Lung Disease"],"prefix":"10.1016","volume":"161","author":[{"given":"Jasmine","family":"Tatah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Keen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha Z.","family":"Prisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pritzker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thenappan","family":"Thenappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt W.","family":"Prins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.chest.2021.07.2159_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.117.003973","article-title":"Increasing incidence and prevalence of World Health Organization groups 1 to 4 pulmonary hypertension: a population-based cohort study in Ontario, Canada","volume":"11","author":"Wijeratne","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"4","key":"10.1016\/j.chest.2021.07.2159_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1056\/NEJMoa2008470","article-title":"Inhaled treprostinil in pulmonary hypertension due to interstitial lung disease","volume":"384","author":"Waxman","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.chest.2021.07.2159_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203396","article-title":"The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension","volume":"13","author":"Sonnweber","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.chest.2021.07.2159_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.hlc.2013.08.007","article-title":"Iron deficiency in patients with idiopathic pulmonary arterial hypertension","volume":"23","author":"van Empel","year":"2014","journal-title":"Heart Lung Circ"},{"issue":"3","key":"10.1016\/j.chest.2021.07.2159_bib5","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1086\/682217","article-title":"Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency","volume":"5","author":"Ruiter","year":"2015","journal-title":"Pulm Circ"},{"issue":"6","key":"10.1016\/j.chest.2021.07.2159_bib6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1513\/AnnalsATS.202009-1131OC","article-title":"Supplementation with iron in pulmonary arterial hypertension. Two randomized crossover trials","volume":"18","author":"Howard","year":"2021","journal-title":"Ann Am Thorac Soc"},{"issue":"7","key":"10.1016\/j.chest.2021.07.2159_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-007911","article-title":"A\u00a0cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease","volume":"5","author":"Nickol","year":"2015","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.chest.2021.07.2159_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2020-000577","article-title":"Intravenous iron and chronic obstructive pulmonary disease: a randomised controlled trial","volume":"7","author":"Santer","year":"2020","journal-title":"BMJ Open Respir Res"},{"issue":"2","key":"10.1016\/j.chest.2021.07.2159_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.healun.2018.09.011","article-title":"Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide","volume":"38","author":"Rose","year":"2019","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"6","key":"10.1016\/j.chest.2021.07.2159_bib10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1183\/09031936.00037711","article-title":"Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target","volume":"38","author":"Rhodes","year":"2011","journal-title":"Eur Respir J"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221036102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369221036102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:27:08Z","timestamp":1777386428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369221036102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0012369221036102"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2021.07.2159","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron Deficiency Is Associated With More Severe Pulmonary Vascular Disease in Pulmonary Hypertension Caused by Chronic Lung Disease","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2021.07.2159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}