{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:45:50Z","timestamp":1793853950323,"version":"4.6.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.chest.2023.04.029","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T23:48:49Z","timestamp":1682207329000},"page":"606-613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["The U-Shaped Relationship Between Eosinophil Count and Bronchiectasis Severity"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-1891","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Mart\u00ednez-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-9836","authenticated-orcid":false,"given":"Ra\u00fal","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casilda","family":"Olveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-0848","authenticated-orcid":false,"given":"Rosa","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda-Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-6238","authenticated-orcid":false,"given":"Luis","family":"M\u00e1iz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Sibila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-5322","authenticated-orcid":false,"given":"Rafael","family":"Golpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-2484","authenticated-orcid":false,"given":"Juan Luis","family":"Rodr\u00edguez-Hermosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Prados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodr\u00edguez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-7554","authenticated-orcid":false,"given":"Grace","family":"Oscullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-1771","authenticated-orcid":false,"given":"David","family":"de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chest.2023.04.029_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.arbres.2021.10.003","article-title":"Global Initiative for Asthma Strategy 2021. Executive summary and rationale for key changes","volume":"58","author":"Reddel","year":"2022","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S2213-2600(19)30190-0","article-title":"Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial","volume":"7","author":"Pascoe","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.chest.2023.04.029_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S2213-2600(18)30006-7","article-title":"Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomized trials","volume":"6","author":"Bafadhel","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.chest.2023.04.029_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa1916046","article-title":"Triple inhaled therapy at two glucocorticoid doses in moderate-to-very-severe COPD","volume":"383","author":"Rabe","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.chest.2023.04.029_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/rccm.202201-0209PP","article-title":"Blood eosinophils and chronic obstructive pulmonary disease: a Global Initiative for Chronic Obstructive Lung Disease Science Committee 2022 review","volume":"206","author":"Singh","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2023.04.029_bib6","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1164\/rccm.202108-1889OC","article-title":"Characterisation of eosinophilic bronchiectasis: a European multicohort study","volume":"205","author":"Shoemark","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2023.04.029_bib7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.arbres.2020.06.005","article-title":"Repeatability of circulating eosinophil measures and inhaled corticosteroids effect in bronchiectasis. A post hoc analysis of a randomized clinical trial","volume":"56","author":"Martinez-Garcia","year":"2020","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.arbres.2021.08.001","article-title":"Bronchiectasis and eosinophils","volume":"57","author":"Martinez-Garcia","year":"2021","journal-title":"Arch Bronconeumol"},{"issue":"4","key":"10.1016\/j.chest.2023.04.029_bib9","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jaip.2022.10.027","article-title":"Significance and potential role of eosinophils in non-cystic fibrosis bronchiectasis","volume":"11","author":"Guan","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.chest.2023.04.029_bib10","article-title":"Role of inhaled corticosteroids in reducing exacerbations in bronchiectasis patients with blood eosinophilia pooled post-hoc analysis of 2 randomized clinical trials","volume":"173","author":"Martinez-Garcia","year":"2020","journal-title":"Resp Med"},{"key":"10.1016\/j.chest.2023.04.029_bib11","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.3390\/ijerph18168431","article-title":"Phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity","volume":"18","author":"Wang","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.chest.2023.04.029_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.arbres.2022.01.010","article-title":"Biological biomarkers in respiratory diseases","volume":"58","author":"Garc\u00eda-R\u00edo","year":"2022","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib13","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01874-2019","article-title":"Blood eosinophil count in the general population: typical values and potential confounders","volume":"55","author":"Hartl","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2023.04.029_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.arbres.2019.12.021","article-title":"RIBRON: the Spanish Online Bronchiectasis Registry. Characterization of the first 1912 patients","volume":"57","author":"Martinez-Garc\u00eda","year":"2021","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib15","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1183\/09031936.00026313","article-title":"Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score","volume":"43","author":"Martinez-Garcia","year":"2014","journal-title":"Eur Resp J"},{"key":"10.1016\/j.chest.2023.04.029_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/COPD.S121943","article-title":"Predicting high risk of exacerbations in bronchiectasis: the E-FACED score","volume":"12","author":"Martinez-Garcia","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.chest.2023.04.029_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index. An international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2023.04.029_bib18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.arbres.2017.07.016","article-title":"Spanish guidelines on treatment of bronchiectasis in adults","volume":"54","author":"Mart\u00ednez-Garc\u00eda","year":"2018","journal-title":"Arch Bronconeumol"},{"issue":"3","key":"10.1016\/j.chest.2023.04.029_bib19","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2023.04.029_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.arbres.2019.12.017","article-title":"C-reactive protein concentration in steady-state bronchiectasis: prognostic value of future severe exacerbations. Data from the Spanish Registry of Bronchiectasis (RIBRON)","volume":"57","author":"Posadas","year":"2021","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201711-2202OC","article-title":"Characterization of the \u201cfrequent exacerbator phenotype\u201d in bronchiectasis","volume":"197","author":"Chalmers","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2023.04.029_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.arbres.2018.07.002","article-title":"Prognostic value of frequent exacerbations in bronchiectasis: the relationship with disease severity","volume":"55","author":"Martinez-Garcia","year":"2019","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.arbres.2017.07.015","article-title":"Spanish guidelines on the evaluation and diagnosis of bronchiectasis in adults","volume":"54","author":"Mart\u00ednez-Garc\u00eda","year":"2018","journal-title":"Arch Bronconeumol"},{"issue":"2","key":"10.1016\/j.chest.2023.04.029_bib24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12016-015-8525-4","article-title":"The eosinophil in infection","volume":"50","author":"Ravin","year":"2016","journal-title":"Clinic Rev Allerg Immunol"},{"issue":"10","key":"10.1016\/j.chest.2023.04.029_bib25","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.mayocp.2021.04.025","article-title":"Eosinophils in health and disease: a state-of-the-art review","volume":"96","author":"Wechsler","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.chest.2023.04.029_bib26","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.201912-2384PP","article-title":"Blood eosinophil counts in clinical trials for chronic obstructive pulmonary disease","volume":"202","author":"Singh","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2023.04.029_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arbres.2021.08.003","article-title":"The airway microbiome: present and future applications","volume":"58","author":"Aog\u00e1in","year":"2022","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.chest.2023.04.029_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.arbres.2021.11.003","article-title":"Treating neutrophilic inflammation in airways diseases","volume":"58","author":"Long","year":"2022","journal-title":"Arch Bronconeumol"},{"issue":"5","key":"10.1016\/j.chest.2023.04.029_bib29","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3390\/biomedicines10051044","article-title":"Blood neutrophil counts define specific clusters of bronchiectasis patients: a hint to differential clinical phenotypes","volume":"10","author":"Wang","year":"2022","journal-title":"Biomedicines"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223006049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223006049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T21:26:37Z","timestamp":1741296397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369223006049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0012369223006049"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2023.04.029","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The U-Shaped Relationship Between Eosinophil Count and Bronchiectasis Severity","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2023.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}