{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:35:23Z","timestamp":1737610523469,"version":"3.33.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.chest.2023.09.006","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:47:15Z","timestamp":1694753235000},"page":"396-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Double-Tracer Gas Single-Breath Washout Test in a Pediatric Field Study"],"prefix":"10.1016","volume":"165","author":[{"given":"Anne-Christianne","family":"Kentgens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-4377","authenticated-orcid":false,"given":"Johanna M.","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-8668","authenticated-orcid":false,"given":"Rebeca","family":"Mozun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-2866","authenticated-orcid":false,"given":"Jakob","family":"Usemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-9954","authenticated-orcid":false,"given":"Eva S.L.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-2002","authenticated-orcid":false,"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5239-1571","authenticated-orcid":false,"given":"Philipp","family":"Latzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-4251","authenticated-orcid":false,"given":"Alexander","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-5664","authenticated-orcid":false,"given":"Florian","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Usemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Latzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Mozun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ardura-Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrofora","family":"Goutaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva S.L.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Christina","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kees","family":"de Hoogh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chest.2023.09.006_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1164\/rccm.201505-0870OC","article-title":"Outcomes of childhood asthma and wheezy bronchitis. a 50-year cohort study","volume":"193","author":"Tagiyeva","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2023.09.006_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1183\/09031936.00044312","article-title":"A\u00a0new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease","volume":"41","author":"Singer","year":"2013","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017588","article-title":"Tidal volume single breath washout of two tracer gases--a practical and promising lung function test","volume":"6","author":"Singer","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.chest.2023.09.006_bib4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jcf.2013.05.010","article-title":"Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis","volume":"12","author":"Abbas","year":"2013","journal-title":"J\u00a0Cyst Fibros"},{"issue":"5","key":"10.1016\/j.chest.2023.09.006_bib5","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1183\/09031936.00085713","article-title":"Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD","volume":"44","author":"Husemann","year":"2014","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1378\/chest.13-0784","article-title":"Abnormal small airways function in children with mild asthma","volume":"145","author":"Singer","year":"2014","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.chest.2023.09.006_bib7","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1183\/09031936.00005512","article-title":"Age and height dependence of lung clearance index and functional residual capacity","volume":"41","author":"Lum","year":"2013","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1164\/ajrccm\/142.3.555","article-title":"Predictors of asthma and persistent wheeze in a national sample of children in the United States. Association with social class, perinatal events, and race","volume":"142","author":"Schwartz","year":"1990","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"10.1016\/j.chest.2023.09.006_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1017\/S146342361000040X","article-title":"The frequency distribution of presenting symptoms in children aged six months to six years to primary care","volume":"12","author":"Whitburn","year":"2011","journal-title":"Prim Health Care Res Dev"},{"issue":"11","key":"10.1016\/j.chest.2023.09.006_bib10","first-page":"3762","article-title":"Effects of obesity and asthma on lung function and airway dysanapsis in adults and children","volume":"9","author":"Arismendi","year":"2020","journal-title":"J\u00a0Clin Med"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1475-097X.1987.tb00166.x","article-title":"Computerized single-breath nitrogen washout in children: variability and reproducibility","volume":"7","author":"Teculescu","year":"1987","journal-title":"Clin Physiol"},{"issue":"1","key":"10.1016\/j.chest.2023.09.006_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1475-097X.1993.tb00315.x","article-title":"Variability of the computerized single-breath nitrogen washout test in healthy adults. Results from a field survey in a French rural area","volume":"13","author":"Teculescu","year":"1993","journal-title":"Clin Physiol"},{"issue":"6","key":"10.1016\/j.chest.2023.09.006_bib13","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1183\/09031936.03.00049502","article-title":"Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis","volume":"22","author":"Gustafsson","year":"2003","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1164\/rccm.200407-895OC","article-title":"Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis","volume":"171","author":"Aurora","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2023.09.006_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ppul.21610","article-title":"Feasibility and variability of measuring the Lung Clearance Index in a multi-center setting","volume":"47","author":"Fuchs","year":"2012","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"10.1016\/j.chest.2023.09.006_bib16","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jaci.2020.12.643","article-title":"Burden of preschool wheeze and progression to asthma in the UK: population-based cohort 2007 to 2017","volume":"147","author":"Bloom","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.chest.2023.09.006_bib17","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2021.20544","article-title":"LuftiBus in the school (LUIS): a population-based study on respiratory health in schoolchildren","volume":"151","author":"Mozun","year":"2021","journal-title":"Swiss Med Wkly"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1183\/09031936.00069712","article-title":"Consensus statement for inert gas washout measurement using multiple- and single- breath tests","volume":"41","author":"Robinson","year":"2013","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1016\/j.chest.2023.09.006_bib19","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.chest.2023.09.006_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/all.12127","article-title":"Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma","volume":"68","author":"Singer","year":"2013","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.chest.2023.09.006_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.chest.2023.09.006_bib22","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.chest.2023.09.006_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/pr.2012.13","article-title":"Comparison of online single-breath vs. online multiple-breath exhaled nitric oxide in school-age children","volume":"71","author":"Fuchs","year":"2012","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.chest.2023.09.006_bib24","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1183\/09031936.00207514","article-title":"Dual gas techniques for peripheral airway function: diffusing the issues","volume":"45","author":"Verbanck","year":"2015","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.chest.2023.09.006_bib25","doi-asserted-by":"crossref","first-page":"00440","DOI":"10.1183\/23120541.00440-2021","article-title":"Novel volumetric capnography indices measure ventilation inhomogeneity in cystic fibrosis","volume":"8","author":"Fouzas","year":"2022","journal-title":"ERJ Open Res"},{"issue":"2","key":"10.1016\/j.chest.2023.09.006_bib26","doi-asserted-by":"crossref","first-page":"00618","DOI":"10.1183\/23120541.00618-2021","article-title":"Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren","volume":"8","author":"Mozun","year":"2022","journal-title":"ERJ Open Res"},{"issue":"5","key":"10.1016\/j.chest.2023.09.006_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ppul.24271","article-title":"Single-breath washout and association with structural lung disease in children with cystic fibrosis","volume":"54","author":"Yammine","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.chest.2023.09.006_bib28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/rccm.201605-1039OC","article-title":"Obesity and airway dysanapsis in children with and without asthma","volume":"195","author":"Forno","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"10118","key":"10.1016\/j.chest.2023.09.006_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(17)30879-6","article-title":"After asthma: redefining airways diseases","volume":"391","author":"Pavord","year":"2018","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.chest.2023.09.006_bib30","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/MIB.0000000000000779","article-title":"Function and ventilation of large and small airways in children and adolescents with inflammatory bowel disease","volume":"22","author":"Yammine","year":"2016","journal-title":"Inflamm Bowel Dis"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223054296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223054296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T02:04:47Z","timestamp":1737597887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369223054296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0012369223054296"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2023.09.006","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the Double-Tracer Gas Single-Breath Washout Test in a Pediatric Field Study","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2023.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}