{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:11:15Z","timestamp":1784826675951,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30067"],"award-info":[{"award-number":["2022JJ30067"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.chest.2023.11.039","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T22:45:21Z","timestamp":1701297921000},"page":"1211-1223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Epicardial Adipose Tissue on Right Cardiac Function and Prognosis in Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"165","author":[{"given":"Yusi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandharajan","family":"Rathinasabapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-6635","authenticated-orcid":false,"given":"Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.chest.2023.11.039_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.chest.2023.11.039_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejphar.2017.11.006","article-title":"Osthole attenuates right ventricular remodeling via decreased myocardial apoptosis and inflammation in monocrotaline-induced rats","volume":"818","author":"Li","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"22","key":"10.1016\/j.chest.2023.11.039_bib3","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1042\/CS20190578","article-title":"Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis","volume":"133","author":"Anthony","year":"2019","journal-title":"Clin Sci (1979)"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2045894020952023","article-title":"Obesity, estrogens and adipose tissue dysfunction\u2014implications for pulmonary arterial hypertension","volume":"10","author":"Mair","year":"2020","journal-title":"Pulm Circ"},{"issue":"10","key":"10.1016\/j.chest.2023.11.039_bib5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ncpcardio0319","article-title":"Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart","volume":"2","author":"Iacobellis","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib6","doi-asserted-by":"crossref","first-page":"E253","DOI":"10.1002\/oby.20149","article-title":"Epicardial adipose tissue assessed by cardiac magnetic resonance imaging in patients with heart failure due to dilated cardiomyopathy","volume":"21","author":"Doesch","year":"2013","journal-title":"Obesity (Silver Spring, Md)"},{"issue":"6","key":"10.1016\/j.chest.2023.11.039_bib7","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/europace\/euaa412","article-title":"Epicardial adipose tissue modulates arrhythmogenesis in right ventricle outflow tract cardiomyocytes","volume":"23","author":"Lu","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.chest.2023.11.039_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2020.09.074","article-title":"Relationship between epicardial adipose tissue volume and coronary artery spasm","volume":"324","author":"Kataoka","year":"2021","journal-title":"Int J Cardiol"},{"issue":"10","key":"10.1016\/j.chest.2023.11.039_bib9","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1007\/s00330-021-07882-1","article-title":"Focal pericoronary adipose tissue attenuation is related to plaque presence, plaque type, and stenosis severity in coronary CTA","volume":"31","author":"Ma","year":"2021","journal-title":"Eur Radiol"},{"issue":"10151","key":"10.1016\/j.chest.2023.11.039_bib10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","article-title":"Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data","volume":"392","author":"Oikonomou","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.chest.2023.11.039_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1148\/radiol.212644","article-title":"The relationship between enhancing left atrial adipose tissue at CT and recurrent atrial fibrillation","volume":"305","author":"Huber","year":"2022","journal-title":"Radiology"},{"issue":"8","key":"10.1016\/j.chest.2023.11.039_bib12","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/ejhf.2513","article-title":"Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction","volume":"24","author":"Jin","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.009238","article-title":"Epicardial adipose tissue and outcome in heart failure with mid-range and preserved ejection fraction","volume":"15","author":"van Woerden","year":"2022","journal-title":"Circ Heart Fail"},{"issue":"38","key":"10.1016\/j.chest.2023.11.039_bib14","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.chest.2023.11.039_bib15","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/mrm.23143","article-title":"Assessment of right ventricle volumes and function by cardiac MRI: quantification of the regional and global interobserver variability","volume":"67","author":"Bonnemains","year":"2012","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.chest.2023.11.039_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1532-429X-11-15","article-title":"Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume","volume":"11","author":"Nelson","year":"2009","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1183\/09031936.00092311","article-title":"The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension","volume":"39","author":"Nickel","year":"2012","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.chest.2023.11.039_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.109.898122","article-title":"Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)","volume":"122","author":"Benza","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1183\/09031936.00057010","article-title":"Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension","volume":"36","author":"Humbert","year":"2010","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.chest.2023.11.039_bib20","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/ejhf.2337","article-title":"Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure","volume":"23","author":"Pugliese","year":"2021","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"10.1016\/j.chest.2023.11.039_bib21","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/ejhf.1283","article-title":"Epicardial fat in heart failure patients with mid-range and preserved ejection fraction","volume":"20","author":"van Woerden","year":"2018","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"10.1016\/j.chest.2023.11.039_bib22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jchf.2020.04.016","article-title":"Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction","volume":"8","author":"Koepp","year":"2020","journal-title":"JACC Heart Fail"},{"issue":"1","key":"10.1016\/j.chest.2023.11.039_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/biomedicines9010064","article-title":"Hypertrophy and insulin resistance of epicardial adipose tissue adipocytes: association with the coronary artery disease severity","volume":"9","author":"Naryzhnaya","year":"2021","journal-title":"Biomedicines"},{"issue":"20","key":"10.1016\/j.chest.2023.11.039_bib24","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.jacc.2018.03.509","article-title":"Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium","volume":"71","author":"Packer","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.chest.2023.11.039_bib25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5114\/aoms.2017.65479","article-title":"Epicardial fat thickness and oxidative stress parameters in patients with subclinical hypothyroidism","volume":"13","author":"Aydogdu","year":"2017","journal-title":"Arch Med Sci"},{"issue":"9","key":"10.1016\/j.chest.2023.11.039_bib26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41419-021-04111-x","article-title":"Secretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species accumulation","volume":"12","author":"Hao","year":"2021","journal-title":"Cell Death Dis"},{"issue":"6","key":"10.1016\/j.chest.2023.11.039_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrendo.2015.58","article-title":"Local and systemic effects of the multifaceted epicardial adipose tissue depot","volume":"11","author":"Iacobellis","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"18","key":"10.1016\/j.chest.2023.11.039_bib28","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jacc.2013.06.046","article-title":"Relationships between right ventricular function, body composition, and prognosis in advanced heart failure","volume":"62","author":"Melenovsky","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/2045-8932.87299","article-title":"Apelin and pulmonary hypertension","volume":"1","author":"Andersen","year":"2011","journal-title":"Pulm Circ"},{"issue":"9","key":"10.1016\/j.chest.2023.11.039_bib30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.7150\/ijms.19854","article-title":"Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure","volume":"14","author":"P\u00e9rez-Belmonte","year":"2017","journal-title":"Int J Med Sci"},{"issue":"7","key":"10.1016\/j.chest.2023.11.039_bib31","article-title":"Longitudinal associations of fitness and obesity in young adulthood with right ventricular function and pulmonary artery systolic pressure in middle age: the CARDIA study","volume":"10","author":"Patel","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.chest.2023.11.039_bib32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.23736\/S0026-4725.18.04592-9","article-title":"The obesity paradox: the protective effect of obesity on right ventricular function using echocardiographic strain imaging in patients with pulmonary hypertension","volume":"66","author":"Patel","year":"2018","journal-title":"Minerva Cardioangiol"},{"issue":"1","key":"10.1016\/j.chest.2023.11.039_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.rmed.2012.10.019","article-title":"The association between obesity, mortality and filling pressures in pulmonary hypertension patients; the \u201cobesity paradox.\u201d","volume":"107","author":"Zafrir","year":"2013","journal-title":"Respir Med"},{"issue":"3","key":"10.1016\/j.chest.2023.11.039_bib34","first-page":"355","article-title":"Role of epicardial adipose tissue in cardiovascular diseases: a review","volume":"11","author":"Konwerski","year":"2022","journal-title":"Biology (Basel)"},{"issue":"12","key":"10.1016\/j.chest.2023.11.039_bib35","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.acra.2017.07.003","article-title":"Increased epicardial fat volume is independently associated with the presence and severity of systemic sclerosis","volume":"24","author":"Long","year":"2017","journal-title":"Acad Radiol"},{"issue":"11","key":"10.1016\/j.chest.2023.11.039_bib36","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1513\/AnnalsATS.202003-247OC","article-title":"Thoracic visceral adipose tissue area and pulmonary hypertension in lung transplant candidates. The Lung Transplant Body Composition Study","volume":"17","author":"Al-Naamani","year":"2020","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"10.1016\/j.chest.2023.11.039_bib37","first-page":"176","article-title":"Short-term hemodynamic effects\u00a0of\u00a0apelin in patients with pulmonary arterial hypertension","volume":"3","author":"Brash","year":"2018","journal-title":"JACC\u00a0Basic Transl Sci"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223058312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369223058312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T12:57:30Z","timestamp":1717592250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369223058312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0012369223058312"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2023.11.039","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Epicardial Adipose Tissue on Right Cardiac Function and Prognosis in Pulmonary Arterial Hypertension","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2023.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}