{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:45:13Z","timestamp":1792701913927,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.chest.2024.05.030","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T11:38:27Z","timestamp":1718797107000},"page":"998-1009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Associations Between Air Pollution and the Onset of Acute Exacerbations of COPD"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-8614","authenticated-orcid":false,"given":"Yue","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-1722","authenticated-orcid":false,"given":"Xia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-8999","authenticated-orcid":false,"given":"Haidong","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-0820","authenticated-orcid":false,"given":"Renjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.chest.2024.05.030_bib1","doi-asserted-by":"crossref","first-page":"ITC17","DOI":"10.7326\/AITC202008040","article-title":"Chronic obstructive pulmonary disease","volume":"173","author":"Labaki","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.chest.2024.05.030_bib2","article-title":"Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019","volume":"378","author":"Safiri","year":"2022","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.chest.2024.05.030_bib3","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01261-2018","article-title":"What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement","volume":"52","author":"Kim","year":"2018","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.chest.2024.05.030_bib4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/thx.2005.040527","article-title":"Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease","volume":"60","author":"Soler-Catalu\u00f1a","year":"2005","journal-title":"Thorax"},{"issue":"12","key":"10.1016\/j.chest.2024.05.030_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006720","article-title":"The impact of exacerbation frequency on mortality following acute exacerbations of COPD: a registry-based cohort study","volume":"4","author":"Schmidt","year":"2014","journal-title":"BMJ Open"},{"issue":"2","key":"10.1016\/j.chest.2024.05.030_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1378\/chest.15-0513","article-title":"Short-term exposure to ambient fine particulate matter increases hospitalizations and mortality in COPD: a systematic review and meta-analysis","volume":"149","author":"Li","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.chest.2024.05.030_bib7","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.2147\/COPD.S122282","article-title":"Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis","volume":"11","author":"Li","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"6","key":"10.1016\/j.chest.2024.05.030_bib8","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2542-5196(19)30085-3","article-title":"Associations between daily air quality and hospitalisations for acute exacerbation of chronic obstructive pulmonary disease in Beijing, 2013-17: an ecological analysis","volume":"3","author":"Liang","year":"2019","journal-title":"Lancet Planet Health"},{"issue":"6","key":"10.1016\/j.chest.2024.05.030_bib9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1183\/09031936.01.00005501","article-title":"Air pollution and hospital admissions for respiratory conditions in Rome, Italy","volume":"17","author":"Fusco","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2024.05.030_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111590","article-title":"Association of change in air quality with hospital admission for acute exacerbation of chronic obstructive pulmonary disease in Guangdong, China: a province-wide ecological study","volume":"208","author":"Wang","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"issue":"5","key":"10.1016\/j.chest.2024.05.030_bib11","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s10653-022-01363-0","article-title":"Association between short-term ambient air pollution and outpatient visits for acute exacerbation of chronic obstructive pulmonary disease in Lanzhou, 2013-19","volume":"45","author":"Dong","year":"2023","journal-title":"Environ Geochem Health"},{"issue":"7","key":"10.1016\/j.chest.2024.05.030_bib12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201806-1147OC","article-title":"Age-specific associations of ozone and fine particulate matter with respiratory emergency department visits in the United States","volume":"199","author":"Strosnider","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"pt 2","key":"10.1016\/j.chest.2024.05.030_bib13","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.scitotenv.2018.09.278","article-title":"Association of fine particulate matter on acute exacerbation of chronic obstructive pulmonary disease in Yancheng, China","volume":"650","author":"Sun","year":"2019","journal-title":"Sci Total Environ"},{"issue":"2","key":"10.1016\/j.chest.2024.05.030_bib14","doi-asserted-by":"crossref","DOI":"10.1029\/2021GH000529","article-title":"Association between air pollutants and acute exacerbation of chronic obstructive pulmonary disease: a time stratified case-crossover design with a distributed lag nonlinear model","volume":"6","author":"Liu","year":"2022","journal-title":"Geohealth"},{"issue":"pt 1","key":"10.1016\/j.chest.2024.05.030_bib15","article-title":"Environmental effects on acute exacerbations of respiratory diseases: a real-world big data study","volume":"806","author":"Fishe","year":"2022","journal-title":"Sci Total Environ"},{"issue":"11","key":"10.1016\/j.chest.2024.05.030_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.001081071","article-title":"Airborne particles are a risk factor for hospital admissions for heart and lung disease","volume":"108","author":"Zanobetti","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.chest.2024.05.030_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2147\/COPD.S281957","article-title":"Characteristics, management and in-hospital clinical outcomes among inpatients with acute exacerbation of chronic obstructive pulmonary disease in China: results from the phase I data of ACURE study","volume":"16","author":"Liang","year":"2021","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.chest.2024.05.030_bib18","series-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2024 Report)","year":"2024"},{"key":"10.1016\/j.chest.2024.05.030_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.rse.2020.112203","article-title":"Estimating PM(2.5) concentrations in Northeastern China with full spatiotemporal coverage, 2005-2016","volume":"253","author":"Meng","year":"2021","journal-title":"Remote Sens Environ"},{"issue":"24","key":"10.1016\/j.chest.2024.05.030_bib20","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCULATIONAHA.121.057179","article-title":"Hourly air pollutants and acute coronary syndrome onset in 1.29 million patients","volume":"145","author":"Chen","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.chest.2024.05.030_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.envres.2018.01.043","article-title":"Air pollution and emergency department visits for respiratory diseases: a multi-city case crossover study","volume":"163","author":"Szyszkowicz","year":"2018","journal-title":"Environ Res"},{"issue":"3","key":"10.1016\/j.chest.2024.05.030_bib22","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1007\/s11356-019-07236-x","article-title":"Effect of air pollution on hospitalization for acute exacerbation of chronic obstructive pulmonary disease, stroke, and myocardial infarction","volume":"27","author":"Chen","year":"2020","journal-title":"Environ Sci Pollut Res Int"},{"issue":"8","key":"10.1016\/j.chest.2024.05.030_bib23","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/atmos12080970","article-title":"A comparison analysis of causative impact of PM2.5 on acute exacerbation of chronic obstructive pulmonary disease (COPD) in two typical cities in China","volume":"12","author":"Xia","year":"2021","journal-title":"Atmosphere"},{"issue":"9","key":"10.1016\/j.chest.2024.05.030_bib24","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/thx.2006.076166","article-title":"Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong","volume":"62","author":"Ko","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.chest.2024.05.030_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-069X-8-25","article-title":"Air pollution and emergency department visits for cardiac and respiratory conditions: a multi-city time-series analysis","volume":"8","author":"Stieb","year":"2009","journal-title":"Environ Health"},{"issue":"6","key":"10.1016\/j.chest.2024.05.030_bib26","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1007\/s11356-020-12051-w","article-title":"Airway hyperresponsiveness development and the toxicity of PM2.5","volume":"28","author":"Lu","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"issue":"9","key":"10.1016\/j.chest.2024.05.030_bib27","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2023.38.e68","article-title":"Association between air pollution and viral infection in severe acute exacerbation of chronic obstructive pulmonary disease","volume":"38","author":"Choi","year":"2023","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.chest.2024.05.030_bib28","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.scitotenv.2019.04.358","article-title":"Chronic obstructive pulmonary disease patients have a higher risk of occurrence of pneumonia by air pollution","volume":"677","author":"Ho","year":"2019","journal-title":"Sci Total Environ"},{"issue":"1","key":"10.1016\/j.chest.2024.05.030_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12940-020-0568-1","article-title":"Lung function and systemic inflammation associated with short-term air pollution exposure in chronic obstructive pulmonary disease patients in Beijing, China","volume":"19","author":"Gao","year":"2020","journal-title":"Environ Health"},{"key":"10.1016\/j.chest.2024.05.030_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102587","article-title":"PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4\/Nrf2 redox imbalance-mediated mitophagy","volume":"59","author":"Fan","year":"2023","journal-title":"Redox Biol"},{"issue":"30","key":"10.1016\/j.chest.2024.05.030_bib31","doi-asserted-by":"crossref","first-page":"30866","DOI":"10.1007\/s11356-019-06244-1","article-title":"The hospitalization attributable burden of acute exacerbations of chronic obstructive pulmonary disease due to ambient air pollution in Shijiazhuang, China","volume":"26","author":"Qu","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.chest.2024.05.030_bib32","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/thorax-2022-219619","article-title":"Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort","author":"Ross","year":"2023","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.chest.2024.05.030_bib33","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3390\/ijerph19052823","article-title":"Short-term air pollution exposure and risk of acute exacerbation of chronic obstructive pulmonary disease in Korea: a national time-stratified case-crossover study","volume":"19","author":"Jung","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"10.1016\/j.chest.2024.05.030_bib34","article-title":"Association of meteorological factors and air NO(2) and O(3) concentrations with acute exacerbation of elderly chronic obstructive pulmonary disease","volume":"8","author":"Lin","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.chest.2024.05.030_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/ijerph14010047","article-title":"Impact of air pollutants on outpatient visits for acute respiratory outcomes","volume":"14","author":"Li","year":"2017","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"10.1016\/j.chest.2024.05.030_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1465-9921-13-95","article-title":"How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan","volume":"13","author":"Santus","year":"2012","journal-title":"Respir Res"},{"issue":"3","key":"10.1016\/j.chest.2024.05.030_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2147\/ciia.2006.1.3.253","article-title":"Effect of aging on respiratory system physiology and immunology","volume":"1","author":"Sharma","year":"2006","journal-title":"Clin Interv Aging"},{"issue":"9","key":"10.1016\/j.chest.2024.05.030_bib38","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.3390\/ijerph18094400","article-title":"Short-term effects of particulate matter and its constituents on emergency room visits for chronic obstructive pulmonary disease: a time-stratified case-crossover study in an urban area","volume":"18","author":"Huang","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"10.1016\/j.chest.2024.05.030_bib39","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01448-2018","article-title":"What is early COPD and why is it important?","volume":"52","author":"Soriano","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.chest.2024.05.030_bib40","article-title":"Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets","volume":"358","author":"Leung","year":"2017","journal-title":"BMJ"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224007451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224007451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T18:34:09Z","timestamp":1733337249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369224007451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0012369224007451"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2024.05.030","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations Between Air Pollution and the Onset of Acute Exacerbations of COPD","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2024.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}