{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:06:54Z","timestamp":1793390814216,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.chest.2024.05.031","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T22:59:18Z","timestamp":1718751558000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparing Bispectral Index Monitoring vs\u00a0Clinical Assessment for Deep Sedation in the ICU"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-6981","authenticated-orcid":false,"given":"Ivan","family":"Huespe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-6033","authenticated-orcid":false,"given":"Diego","family":"Giunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9139-1749","authenticated-orcid":false,"given":"Debora","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devang","family":"Sanghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-4676","authenticated-orcid":false,"given":"Indalecio Carboni","family":"Bisso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-8787","authenticated-orcid":false,"given":"Sergio","family":"Giannasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-4067","authenticated-orcid":false,"given":"Federico C.","family":"Carini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.chest.2024.05.031_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1378\/chest.128.2.477","article-title":"Sedation and neuromuscular blockade in the ICU","volume":"128","author":"Weissman","year":"2005","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.chest.2024.05.031_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/ALN.0000000000002323","article-title":"Processed electroencephalogram monitoring and postoperative delirium: a systematic review and meta-analysis","volume":"129","author":"MacKenzie","year":"2018","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.chest.2024.05.031_bib3","article-title":"Bispectral index for improving anaesthetic delivery and postoperative recovery","volume":"2014","author":"Punjasawadwong","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.chest.2024.05.031_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1001\/jama.2018.22005","article-title":"Effect of electroencephalography-guided anesthetic administration on postoperative delirium among older adults undergoing major surgery: the ENGAGES randomized clinical trial","volume":"321","author":"Wildes","year":"2019","journal-title":"JAMA"},{"issue":"suppl 1","key":"10.1016\/j.chest.2024.05.031_bib5","doi-asserted-by":"crossref","first-page":"i98","DOI":"10.1093\/bja\/aet055","article-title":"Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction","volume":"110","author":"Radtke","year":"2013","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.chest.2024.05.031_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jclinane.2009.06.005","article-title":"General anesthesia occurs frequently in elderly patients during propofol-based sedation and spinal anesthesia","volume":"22","author":"Sieber","year":"2010","journal-title":"J\u00a0Clin Anesth"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/ANA.0b013e3182712fba","article-title":"BIS-guided anesthesia decreases postoperative delirium and cognitive decline","volume":"25","author":"Chan","year":"2013","journal-title":"J\u00a0Neurosurg Anesthesiol"},{"issue":"3","key":"10.1016\/j.chest.2024.05.031_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S2213-2600(20)30552-X","article-title":"Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study","volume":"9","author":"Pun","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"4","key":"10.1016\/j.chest.2024.05.031_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1164\/rccm.202002-0320OC","article-title":"Long-term outcomes in ICU patients with delirium: a population-based cohort study","volume":"204","author":"Fiest","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.chest.2024.05.031_bib10","doi-asserted-by":"crossref","first-page":"R210","DOI":"10.1186\/cc9333","article-title":"Delirium epidemiology in critical care (DECCA): an international study","volume":"14","author":"Salluh","year":"2010","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.chest.2024.05.031_bib11","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/CCM.0b013e3181e47be1","article-title":"Delirium as a predictor of long-term cognitive impairment in survivors of critical illness","volume":"38","author":"Girard","year":"2010","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.chest.2024.05.031_bib12","first-page":"CD011240","article-title":"BIS monitoring versus clinical assessment for sedation in mechanically ventilated adults in the intensive care unit and its impact on clinical outcomes and resource utilization","volume":"2","author":"Shetty","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.chest.2024.05.031_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.23736\/S0375-9393.16.10886-7","article-title":"Utilizing bi-spectral index (BIS) for the monitoring of sedated adult ICU patients: a systematic review","volume":"83","author":"Bilgili","year":"2017","journal-title":"Minerva Anestesiol"},{"issue":"6","key":"10.1016\/j.chest.2024.05.031_bib14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1007\/s00134-016-4282-y","article-title":"BIS monitoring in sedated, mechanically ventilated patients: right tool in the wrong patients? A meta-analysis","volume":"42","author":"Finger","year":"2016","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.chest.2024.05.031_bib15","first-page":"329","article-title":"Patient comfort in the intensive care unit: a multicentre, binational point prevalence study of analgesia, sedation and delirium management","volume":"15","author":"Green","year":"2013","journal-title":"Crit Care Resusc"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13054-015-0929-2","article-title":"Early deep sedation is associated with decreased in-hospital and two-year follow-up survival","volume":"19","author":"Balzer","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.chest.2024.05.031_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.839637","article-title":"Factors associated with deep sedation practice in mechanically ventilated patients: a analysis of a cross-sectional survey combined with a questionnaire for physicians on sedation practices","volume":"9","author":"Ma","year":"2022","journal-title":"Front Med"},{"issue":"10","key":"10.1016\/j.chest.2024.05.031_bib18","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.2107138","article-title":"The Richmond Agitation-Sedation Scale","volume":"166","author":"Sessler","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib19","first-page":"68","article-title":"Changes in the management and clinical outcomes of critically ill patients without COVID-19 during the pandemic","volume":"33","author":"Huespe","year":"2021","journal-title":"Rev Bras Ter Intensiva"},{"issue":"11","key":"10.1016\/j.chest.2024.05.031_bib20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7326\/0003-4819-152-11-201006010-00232","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials","volume":"152","author":"Schulz","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.chest.2024.05.031_bib21","series-title":"StatPearls [Internet]","article-title":"Bispectral index","author":"Mathur","year":"2024"},{"issue":"9","key":"10.1016\/j.chest.2024.05.031_bib22","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.chest.2024.05.031_bib23","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.35339","article-title":"Association of incident delirium with short-term mortality in adults with critical illness receiving mechanical ventilation","volume":"5","author":"Li","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"7","key":"10.1016\/j.chest.2024.05.031_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/00003246-200107000-00012","article-title":"Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)","volume":"29","author":"Ely","year":"2001","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2024.05.031_bib25","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S2213-2600(13)70166-8","article-title":"Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial","volume":"1","author":"Page","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.chest.2024.05.031_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/CCE.0000000000000085","article-title":"Effect of flumazenil on hypoactive delirium in the ICU: a double-blind, placebo-controlled pilot study","volume":"2","author":"Schomer","year":"2020","journal-title":"Crit Care Explor"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib27","first-page":"193","article-title":"Impact of vitamin C and thiamine administration on delirium-free days in patients with septic shock","volume":"9","author":"Park","year":"2020","journal-title":"J Clin Med Res"},{"issue":"9","key":"10.1016\/j.chest.2024.05.031_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S2213-2600(17)30234-5","article-title":"Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial","volume":"5","author":"Page","year":"2017","journal-title":"Lancet Respir Med"},{"issue":"10","key":"10.1016\/j.chest.2024.05.031_bib29","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1097\/CCM.0000000000003904","article-title":"A\u00a0core outcome set for critical care ventilation trials","volume":"47","author":"Blackwood","year":"2019","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.chest.2024.05.031_bib32","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jclinepi.2013.03.017","article-title":"Multiple imputation of missing values was not necessary before performing a longitudinal mixed-model analysis","volume":"66","author":"Twisk","year":"2013","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"4","key":"10.1016\/j.chest.2024.05.031_bib33","first-page":"220","article-title":"[A comparison of bispectral index and sedation agitation scale in guiding sedation therapy: a randomized controlled study in patients undergoing short term mechanical ventilation]","volume":"23","author":"Zhao","year":"2011","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"12","key":"10.1016\/j.chest.2024.05.031_bib34","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/BF01700659","article-title":"Pharmacokinetics and pharmacodynamics of propofol\/alfentanil infusions for sedation in ICU patients","volume":"21","author":"Frenkel","year":"1995","journal-title":"Intensive Care Med"},{"issue":"29","key":"10.1016\/j.chest.2024.05.031_bib35","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2174\/1381612043382846","article-title":"Propofol: therapeutic indications and side-effects","volume":"10","author":"Marik","year":"2004","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.chest.2024.05.031_bib36","series-title":"StatPearls [Internet]","article-title":"Midazolam","author":"Lingamchetty","year":"2024"},{"key":"10.1016\/j.chest.2024.05.031_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/2152-7806.141890","article-title":"Utility of bispectral index in the management of multiple trauma patients","volume":"5","author":"Mahmood","year":"2014","journal-title":"Surg Neurol Int"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12028-008-9184-6","article-title":"A\u00a0randomized evaluation of bispectral index-augmented sedation assessment in neurological patients","volume":"11","author":"Olson","year":"2009","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1016\/j.chest.2024.05.031_bib39","doi-asserted-by":"crossref","first-page":"100047","DOI":"10.1016\/j.chstcc.2024.100047","article-title":"Variation in sedative and analgesic use during the COVID-19 pandemic and associated outcomes","volume":"2","author":"Rucci","year":"2024","journal-title":"Chest Crit Care"},{"issue":"4","key":"10.1016\/j.chest.2024.05.031_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/cc11407","article-title":"The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies","volume":"16","author":"Gusmao-Flores","year":"2012","journal-title":"Crit Care"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224007748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224007748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:04:53Z","timestamp":1732248293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369224007748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0012369224007748"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2024.05.031","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing Bispectral Index Monitoring vs\u00a0Clinical Assessment for Deep Sedation in the ICU","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2024.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}