{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:58:39Z","timestamp":1776751119957,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.chest.2024.11.021","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T09:07:01Z","timestamp":1732784821000},"page":"1068-1078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-9727","authenticated-orcid":false,"given":"Pierre-Gr\u00e9goire","family":"Guinot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5263-0962","authenticated-orcid":false,"given":"Corentin","family":"Evezard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-1487","authenticated-orcid":false,"given":"Maxime","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Pili-Floury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"Berthoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-4754","authenticated-orcid":false,"given":"Guillaume","family":"Besch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belaid","family":"Bouhemad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Kabbout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Radhouani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiberiu","family":"Constandache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastien","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Voizeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"GrosJean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenza","family":"Caruzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Alain","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Bonneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Perrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Chambade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Douguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenie","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13613-017-0253-x","article-title":"A\u00a0hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study","volume":"7","author":"Alegr\u00eda","year":"2017","journal-title":"Ann Intensive Care"},{"issue":"10","key":"10.1016\/j.chest.2024.11.021_bib2","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1007\/s00134-015-3955-2","article-title":"Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials","volume":"41","author":"Gu","year":"2015","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.chest.2024.11.021_bib3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.2010.158","article-title":"Lactate clearance vs\u00a0central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial","volume":"303","author":"Jones","year":"2010","journal-title":"JAMA"},{"issue":"suppl 11","key":"10.1016\/j.chest.2024.11.021_bib4","doi-asserted-by":"crossref","first-page":"S1551","DOI":"10.21037\/jtd.2019.01.109","article-title":"Venous-to-arterial pCO2 difference in high-risk surgical patients","volume":"11","author":"Huette","year":"2019","journal-title":"J\u00a0Thorac Dis"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13613-016-0110-3","article-title":"Ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content are better markers of global anaerobic metabolism than lactate in septic shock patients","volume":"6","author":"Mallat","year":"2016","journal-title":"Ann Intensive Care"},{"issue":"3","key":"10.1016\/j.chest.2024.11.021_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00134-002-1215-8","article-title":"Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients","volume":"28","author":"Mekontso-Dessap","year":"2002","journal-title":"Intensive Care Med"},{"issue":"suppl 11","key":"10.1016\/j.chest.2024.11.021_bib7","doi-asserted-by":"crossref","first-page":"S1544","DOI":"10.21037\/jtd.2019.03.52","article-title":"Combination of O2 and CO2-derived variables to detect tissue hypoxia in the critically ill patient","volume":"11","author":"Ospina-Tasc\u00f3n","year":"2019","journal-title":"J\u00a0Thorac Dis"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5492\/wjccm.v5.i1.47","article-title":"Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock","volume":"5","author":"Mallat","year":"2016","journal-title":"World J Crit Care Med"},{"issue":"15-16","key":"10.1016\/j.chest.2024.11.021_bib9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00508-012-0213-2","article-title":"Central venous to arterial pCO2 difference in cardiogenic shock","volume":"124","author":"Markota","year":"2012","journal-title":"Wien Klin Wochenschr"},{"issue":"6","key":"10.1016\/j.chest.2024.11.021_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/SHK.0000000000001554","article-title":"Prognosis value of early veno arterial PCO2 difference in patients under peripheral veno arterial extracorporeal membrane oxygenation","volume":"54","author":"Ellouze","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.chest.2024.11.021_bib11","article-title":"Using pCO2 gap in the differential diagnosis of hyperlactatemia outside the context of sepsis: a physiological review and case series","volume":"2019","author":"Waldauf","year":"2019","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.chest.2024.11.021_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.898406","article-title":"Treatment of hyperlactatemia in acute circulatory failure based on CO2-O2-derived indices: study protocol for a prospective, multicentric, single, blind, randomized, superiority study (the LACTEL study)","volume":"9","author":"Caruso","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.chest.2024.11.021_bib13","article-title":"Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021","volume":"41","author":"Joannes-Boyau","year":"2022","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"12","key":"10.1016\/j.chest.2024.11.021_bib14","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on circulatory shock and hemodynamic monitoring. Task Force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi","year":"2014","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.chest.2024.11.021_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205950","article-title":"The ratios of central venous to arterial carbon dioxide content and tension to arteriovenous oxygen content are not associated with overall anaerobic metabolism in postoperative cardiac surgery patients","volume":"13","author":"Abou-Arab","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89703-5","article-title":"Ratio of venous-to-arterial PCO2 to arteriovenous oxygen content difference during regional ischemic or hypoxic hypoxia","volume":"11","author":"Mallat","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13613-017-0288-z","article-title":"Venoarterial PCO2-to-arteriovenous oxygen content difference ratio is a poor surrogate for anaerobic metabolism in hemodilution: an experimental study","volume":"7","author":"Dubin","year":"2017","journal-title":"Ann Intensive Care"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5935\/0103-507X.20200017","article-title":"Central venous minus arterial carbon dioxide pressure to arterial minus central venous oxygen content ratio as an indicator of tissue oxygenation: a narrative review","volume":"32","author":"Dubin","year":"2020","journal-title":"Revista Brasileira de Terapia Intensiva"},{"key":"10.1016\/j.chest.2024.11.021_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jcrc.2018.09.009","article-title":"P(v-a)CO2\/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: a prospective multicenter randomized controlled clinical study","volume":"48","author":"Su","year":"2018","journal-title":"J\u00a0Crit Care"},{"issue":"5","key":"10.1016\/j.chest.2024.11.021_bib20","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1213\/ANE.0000000000005833","article-title":"Central venous-to-arterial CO2 difference-assisted goal-directed hemodynamic management during major surgery-a randomized controlled trial","volume":"134","author":"Lohith Kumar","year":"2022","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1016\/j.chest.2024.11.021_bib21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/jappl.2000.89.4.1317","article-title":"Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia","volume":"89","author":"Vallet","year":"2000","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.chest.2024.11.021_bib22","article-title":"Lack of correlation between central venous minus arterial PCO2 to arterial minus central venous O2 content ratio and respiratory quotient in patients with septic shock: a prospective observational study","author":"Gutierrez","year":"2024","journal-title":"Med Intensiva (Engl Ed)"},{"issue":"11","key":"10.1016\/j.chest.2024.11.021_bib23","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/EJA.0000000000001111","article-title":"Predicting postoperative complications with the respiratory exchange ratio after high-risk noncardiac surgery: a prospective cohort study","volume":"37","author":"Bar","year":"2020","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.chest.2024.11.021_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103586","article-title":"Increased ratio of P[v-a]CO2 to C[a-v]O2 without global hypoxia: the case of metformin-induced lactic acidosis","volume":"285","author":"Andreis","year":"2021","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"10.1016\/j.chest.2024.11.021_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00134-018-5213-x","article-title":"The\u00a0ten pitfalls of lactate clearance in sepsis","volume":"45","author":"Hernandez","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.chest.2024.11.021_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2021.110359","article-title":"Risk factors and determinants of intraoperative hyperlactatemia in major non-cardiac surgery","volume":"74","author":"Bar","year":"2021","journal-title":"J\u00a0Clin Anesth"},{"issue":"6","key":"10.1016\/j.chest.2024.11.021_bib27","doi-asserted-by":"crossref","first-page":"R294","DOI":"10.1186\/cc13160","article-title":"Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock","volume":"17","author":"Ospina-Tasc\u00f3n","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.chest.2024.11.021_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.759826","article-title":"\u0394PCO2 and \u0394PCO2\/C(a\u2212cv)O2 are not predictive of organ dysfunction after cardiopulmonary bypass","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.chest.2024.11.021_bib29","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000415","article-title":"Repeatability of blood gas parameters, PCO2 gap, and PCO2 gap to arterial-to-venous oxygen content difference in critically ill adult patients","volume":"94","author":"Mallat","year":"2015","journal-title":"Medicine (Baltimore)"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224055934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369224055934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:05:07Z","timestamp":1762124707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369224055934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0012369224055934"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2024.11.021","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2024.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}