{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T03:11:41Z","timestamp":1766545901669,"version":"3.48.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.chest.2025.05.048","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:53:11Z","timestamp":1751421191000},"page":"1517-1527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Discordant Pleural Fluid Exudates and Diagnostic Patterns"],"prefix":"10.1016","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7661-6165","authenticated-orcid":false,"given":"Dinesh N.","family":"Addala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Sundaralingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beenish","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alguili","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eihab O.","family":"Bedawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wrightson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Hallifax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najib M.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chest.2025.05.048_bib1","article-title":"The modern diagnosis and management of pleural effusions","volume":"351","author":"Bhatnagar","year":"2015","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.chest.2025.05.048_bib2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1086\/522996","article-title":"Diagnosis and management of parapneumonic effusions and empyema","volume":"45","author":"Sahn","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.chest.2025.05.048_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/17476348.2023.2174527","article-title":"Optimal diagnostic strategies for pleural diseases and identifying high-risk patients","volume":"17","author":"Addala","year":"2023","journal-title":"Expert Rev Respir Med"},{"issue":"suppl 2","key":"10.1016\/j.chest.2025.05.048_bib4","doi-asserted-by":"crossref","first-page":"ii41","DOI":"10.1136\/thx.2010.137000","article-title":"Management of pleural infection in adults: British Thoracic Society Pleural Disease Guideline 2010","volume":"65","author":"Davies","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.chest.2025.05.048_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7326\/0003-4819-77-4-507","article-title":"Pleural effusions: the diagnostic separation of transudates and exudates","volume":"77","author":"Light","year":"1972","journal-title":"Ann Intern Med"},{"issue":"suppl 2","key":"10.1016\/j.chest.2025.05.048_bib6","doi-asserted-by":"crossref","first-page":"ii4","DOI":"10.1136\/thx.2010.136978","article-title":"Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline 2010","volume":"65","author":"Hooper","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.chest.2025.05.048_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MCP.0b013e32836022dc","article-title":"Identifying transudates misclassified by Light\u2019s criteria","volume":"19","author":"Procel","year":"2013","journal-title":"Curr Opin Pulm Med"},{"issue":"6","key":"10.1016\/j.chest.2025.05.048_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.amjms.2016.08.016","article-title":"Concordant and discordant exudates and their effect on the accuracy of Light\u2019s criteria to diagnose exudative pleural effusions","volume":"352","author":"Ferreiro","year":"2016","journal-title":"Am J Med Sci"},{"issue":"5","key":"10.1016\/j.chest.2025.05.048_bib9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/jcp.2007.051318","article-title":"Categorisation of pleural fluids in routine clinical practice: analysis of pleural fluid protein and lactate dehydrogenase alone compared with modified Light\u2019s criteria","volume":"61","author":"Murphy","year":"2008","journal-title":"J Clin Pathol"},{"issue":"6","key":"10.1016\/j.chest.2025.05.048_bib10","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1378\/chest.07-2232","article-title":"Pleural fluid analysis in chylous pleural effusion","volume":"133","author":"Agrawal","year":"2008","journal-title":"Chest"},{"issue":"4S","key":"10.1016\/j.chest.2025.05.048_bib11","article-title":"Is it a transudate or an exudate? Dyssynchrony between pleural fluid protein and LDH in 211 initial thoracenteses","volume":"128","author":"Heidecker","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.chest.2025.05.048_bib16","series-title":"Textbook of Pleural Diseases. Second Edition","first-page":"209","article-title":"Pleural fluid analysis","author":"Sahn","year":"2008"},{"issue":"3","key":"10.1016\/j.chest.2025.05.048_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7861\/clinmedicine.19-3-213","article-title":"Interpreting pleural fluid results","volume":"19","author":"Mercer","year":"2019","journal-title":"Clin Med"},{"issue":"2","key":"10.1016\/j.chest.2025.05.048_bib14","first-page":"74","article-title":"Significance of lactate dehydrogenases in pleural effusions","volume":"42","author":"Saint-R\u00e9my","year":"1986","journal-title":"Rev Pneumol Clin"},{"issue":"7","key":"10.1016\/j.chest.2025.05.048_bib15","first-page":"1211","article-title":"Diagnostic approach to pleural effusion in adults","volume":"73","author":"Procel","year":"2006","journal-title":"Am Fam Physician"},{"issue":"2","key":"10.1016\/j.chest.2025.05.048_bib17","first-page":"114","article-title":"Vascular hyperpermeability and aging","volume":"5","author":"Oakley","year":"2014","journal-title":"Aging Dis"},{"issue":"5","key":"10.1016\/j.chest.2025.05.048_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0002-9343(01)00881-6","article-title":"The evaluation of pleural effusions in patients with heart failure","volume":"111","author":"Gotsman","year":"2001","journal-title":"Am J Med"},{"issue":"4","key":"10.1016\/j.chest.2025.05.048_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/17476348.2019.1578212","article-title":"Pleural infection: a closer look at the etiopathogenesis, microbiology and role of antibiotics","volume":"13","author":"Bedawi","year":"2019","journal-title":"Expert Rev Respir Med"},{"issue":"5","key":"10.1016\/j.chest.2025.05.048_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1378\/chest.64.5.591","article-title":"Diagnostic significance of pleural fluid pH and PCO2","volume":"64","author":"Light","year":"1973","journal-title":"Chest"},{"key":"10.1016\/j.chest.2025.05.048_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ccm.2021.08.001","article-title":"Parapneumonic effusion and empyema","volume":"42","author":"Addala","year":"2021","journal-title":"Clinics Chest Med"},{"issue":"5","key":"10.1016\/j.chest.2025.05.048_bib22","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.chest.2022.11.019","article-title":"Achieving molecular profiling in pleural biopsies: a multicenter, retrospective cohort study","volume":"163","author":"Sundaralingam","year":"2023","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.chest.2025.05.048_bib23","doi-asserted-by":"crossref","first-page":"00599","DOI":"10.1183\/23120541.00599-2022","article-title":"Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database","volume":"9","author":"Sundaralingam","year":"2023","journal-title":"ERJ Open Res"},{"issue":"4","key":"10.1016\/j.chest.2025.05.048_bib24","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.chest.2021.05.026","article-title":"Epidemiology of adult pleural disease in the United States","volume":"160","author":"Mummadi","year":"2021","journal-title":"Chest"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225008153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225008153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T01:11:34Z","timestamp":1766538694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369225008153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0012369225008153"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2025.05.048","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence of Discordant Pleural Fluid Exudates and Diagnostic Patterns","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2025.05.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}