{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:53:52Z","timestamp":1775642032919,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.chest.2025.08.004","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:13:57Z","timestamp":1767863637000},"page":"e17-e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 45-Year-Old Woman With Hereditary Hemorrhagic Telangiectasia and Persistent Exertional Dyspnea and Peripheral Edema"],"prefix":"10.1016","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-1214","authenticated-orcid":false,"given":"Helen","family":"Triantafyllidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysia","family":"Birmpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Fambri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Benas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"David","family":"Montani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chest.2025.08.004_bib1","doi-asserted-by":"crossref","first-page":"L209","DOI":"10.1152\/ajplung.00185.2005","article-title":"Vascular endothelial growth factor in the lung","volume":"290","author":"Voelkel","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.chest.2025.08.004_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mayocp.2017.11.013","article-title":"Intravenous bevacizumab for refractory hereditary hemorrhagic telangiectasia-related epistaxis and gastrointestinal bleeding","volume":"93","author":"Iyer","year":"2018","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"10.1016\/j.chest.2025.08.004_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13023-019-1239-6","article-title":"Systemic bevacizumab for high-output cardiac failure in hereditary hemorrhagic telangiectasia: an international survey of HHT centers","volume":"14","author":"Al-Samkari","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.chest.2025.08.004_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.rmed.2018.12.013","article-title":"Hospitalizations with hereditary hemorrhagic telangiectasia and pulmonary hypertension in the United States from 2000 to 2014","volume":"147","author":"Harder","year":"2019","journal-title":"Respir Med"},{"issue":"12","key":"10.1016\/j.chest.2025.08.004_bib5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7326\/M20-1443","article-title":"Second international guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia","volume":"173","author":"Faughnan","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.chest.2025.08.004_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2021.102033","article-title":"Treatment of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia: a case series and systematic review","volume":"68","author":"Abston","year":"2021","journal-title":"Pulm Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.chest.2025.08.004_bib7","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.3906\/sag-2101-76","article-title":"Effects of bevacizumab administration on the hypoxia - induced pulmonary hypertension rat model","volume":"51","author":"Demir","year":"2021","journal-title":"Turk J Med Sci"},{"issue":"12","key":"10.1016\/j.chest.2025.08.004_bib8","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1111\/bcp.15436","article-title":"Identifying new drugs associated with pulmonary arterial hypertension: a WHO pharmacovigilance database disproportionality analysis","volume":"88","author":"Hlavaty","year":"2022","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.chest.2025.08.004_bib9","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00879-2022","article-title":"ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.chest.2025.08.004_bib10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01324-2024","article-title":"Definition, classification and diagnosis of pulmonary hypertension","volume":"64","author":"Kovacs","year":"2024","journal-title":"Eur Respir J"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225051281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225051281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:05:28Z","timestamp":1775639128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369225051281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0012369225051281"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2025.08.004","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A 45-Year-Old Woman With Hereditary Hemorrhagic Telangiectasia and Persistent Exertional Dyspnea and Peripheral Edema","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2025.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Chest Physicians. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}