{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:02:50Z","timestamp":1789153370942,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024ZD0530000"],"award-info":[{"award-number":["2024ZD0530000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504405"],"award-info":[{"award-number":["2022YFC2504405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004610","name":"Science and Technology Support Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BF2024054"],"award-info":[{"award-number":["BF2024054"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470079"],"award-info":[{"award-number":["82470079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270083"],"award-info":[{"award-number":["82270083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","award":["210009"],"award-info":[{"award-number":["210009"]}],"id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.chest.2025.08.040","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:51:33Z","timestamp":1758379893000},"page":"665-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness"],"prefix":"10.1016","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-6352","authenticated-orcid":false,"given":"Zhengyong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianghong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenggan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1344-3084","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10030","key":"10.1016\/j.chest.2025.08.040_bib1","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/S0140-6736(16)30176-3","article-title":"Clinical challenges in mechanical ventilation","volume":"387","author":"Goligher","year":"2016","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.chest.2025.08.040_bib2","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1097\/CCM.0000000000004574","article-title":"Clinical practice guidelines for early mobilization in the ICU: a systematic review","volume":"48","author":"Lang","year":"2020","journal-title":"Crit Care Med"},{"issue":"19","key":"10.1016\/j.chest.2025.08.040_bib3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1056\/NEJMoa2209083","article-title":"Early active mobilization during mechanical ventilation in the ICU","volume":"387","author":"TEAM Study Investigators and the ANZICS Clinical Trials Group","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.chest.2025.08.040_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.834716","article-title":"Mucus clearance strategies in mechanically ventilated patients","volume":"13","author":"Goetz","year":"2022","journal-title":"Front Physiol"},{"issue":"8","key":"10.1016\/j.chest.2025.08.040_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/thoraxjnl-2019-214355","article-title":"Mucoactive agents for acute respiratory failure in the critically ill: a systematic review and meta-analysis","volume":"75","author":"Anand","year":"2020","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.chest.2025.08.040_bib6","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.chest.2021.04.039","article-title":"Global physiology and pathophysiology of cough: part 2. demographic and clinical considerations: CHEST Expert Panel Report","volume":"160","author":"McGarvey","year":"2021","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.chest.2025.08.040_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S2213-2600(23)00471-X","article-title":"Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial","volume":"12","author":"Dahyot-Fizelier","year":"2024","journal-title":"Lancet Respir Med"},{"issue":"5","key":"10.1016\/j.chest.2025.08.040_bib8","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.chest.2018.11.014","article-title":"Acute lobar atelectasis","volume":"155","author":"Marini","year":"2019","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.chest.2025.08.040_bib9","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00134-020-05980-0","article-title":"Ventilator-associated pneumonia in adults: a narrative review","volume":"46","author":"Papazian","year":"2020","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.chest.2025.08.040_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s13054-020-03198-6","article-title":"Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study","volume":"24","author":"Longhini","year":"2020","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.chest.2025.08.040_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2272720","article-title":"Effect of high-frequency oscillation on reduction of atelectasis in perioperative patients: a prospective randomized controlled study","volume":"55","author":"Qin","year":"2023","journal-title":"Ann Med"},{"issue":"8","key":"10.1016\/j.chest.2025.08.040_bib12","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.4187\/respcare.07904","article-title":"Airway clearance techniques for mechanically ventilated patients: insights for optimization","volume":"65","author":"Volpe","year":"2020","journal-title":"Respir Care"},{"issue":"5","key":"10.1016\/j.chest.2025.08.040_bib13","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jamcollsurg.2019.06.004","article-title":"Efficacy of oscillation and lung expansion in reducing postoperative pulmonary complication","volume":"229","author":"Huynh","year":"2019","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.chest.2025.08.040_bib14","doi-asserted-by":"crossref","DOI":"10.4081\/monaldi.2024.2734","article-title":"Feasibility of high-frequency percussions in people with severe acquired brain injury and tracheostomy: an observational study","author":"Sciurello","year":"2024","journal-title":"Monaldi Arch Chest Dis"},{"issue":"6","key":"10.1016\/j.chest.2025.08.040_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.21037\/atm-22-554","article-title":"Efficacy analysis of the lung recruitment maneuver in correcting pulmonary atelectasis in neurological intensive care unit\u2014a retrospective study","volume":"10","author":"Zhuang","year":"2022","journal-title":"Ann Transl Med"},{"issue":"7","key":"10.1016\/j.chest.2025.08.040_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-071273","article-title":"Effect of mechanical insufflation-exsufflation for ineffective cough on weaning duration in diseases of the peripheral or central nervous system (MEDINE): study protocol for a randomised controlled trial in a neurological weaning centre","volume":"13","author":"Seipp","year":"2023","journal-title":"BMJ Open"},{"issue":"2","key":"10.1016\/j.chest.2025.08.040_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/1751143720909704","article-title":"Feasibility and safety of intrapulmonary percussive ventilation in spontaneously breathing, non-ventilated patients in critical care: a retrospective pilot study","volume":"22","author":"Hassan","year":"2021","journal-title":"J Intensive Care Soc"},{"issue":"1","key":"10.1016\/j.chest.2025.08.040_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/XEB.0000000000000150","article-title":"Incidence and risk factors of pulmonary atelectasis in mechanically ventilated trauma patients in ICU: a prospective study","volume":"17","author":"Hongrattana","year":"2019","journal-title":"Int J Evid Based Healthc"},{"key":"10.1016\/j.chest.2025.08.040_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2024.154760","article-title":"Assessment of the comparative agreement between chest radiographs and CT scans in intensive care units","volume":"82","author":"Brooks","year":"2024","journal-title":"J Crit Care"},{"key":"10.1016\/j.chest.2025.08.040_bib20","first-page":"149","article-title":"Comparing ultrasound, chest X-ray, and CT scan for pneumonia detection","volume":"18","author":"Al Nufaiei","year":"2025","journal-title":"Med Devices (Auckl)"},{"issue":"3","key":"10.1016\/j.chest.2025.08.040_bib21","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10877-022-00970-7","article-title":"Benefits of secretion clearance with high frequency percussive ventilation in tracheostomized critically ill patients: a pilot study","volume":"37","author":"Garofalo","year":"2023","journal-title":"J Clin Monit Comput"},{"issue":"2","key":"10.1016\/j.chest.2025.08.040_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.chstcc.2024.100068","article-title":"Effects of intrapulmonary percussive ventilation in nonventilated patients who are critically ill on length of stay, oxygenation, and pulmonary complications: a randomized controlled trial","volume":"2","author":"Hassan","year":"2024","journal-title":"CHEST Crit Care"},{"issue":"21","key":"10.1016\/j.chest.2025.08.040_bib23","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.3390\/s24217066","article-title":"The neurological and hemodynamics safety of an airway clearance technique in patients with acute brain injury: an analysis of intracranial pressure pulse morphology using a non-invasive sensor","volume":"24","author":"de Almeida Souza","year":"2024","journal-title":"Sensors (Basel)"},{"issue":"1","key":"10.1016\/j.chest.2025.08.040_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13054-025-05286-x","article-title":"Physiology and pathophysiology of mucus and mucolytic use in critically ill patients","volume":"29","author":"Roe","year":"2025","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.chest.2025.08.040_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255005","article-title":"Effect of intrapulmonary percussive ventilation on intensive care unit length of stay, the incidence of pneumonia and gas exchange in critically ill patients: a systematic review","volume":"16","author":"Hassan","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.chest.2025.08.040_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ppul.27404","article-title":"Secretion movement during mechanical ventilation superimposed on intrapulmonary percussive ventilation (IPV) versus continuous high-frequency oscillation (CHFO): a bench study","volume":"60","author":"Liu","year":"2025","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.chest.2025.08.040_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2147\/COPD.S145440","article-title":"Safety and effectiveness of the high-frequency chest wall oscillation vs intrapulmonary percussive ventilation in patients with severe COPD","volume":"13","author":"Nicolini","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"6","key":"10.1016\/j.chest.2025.08.040_bib28","first-page":"1254","article-title":"Effect of intrathoracic oscillations on pulmonary functions in children with cerebral palsy","volume":"18","author":"El-Moatasem","year":"2023","journal-title":"J Taibah Univ Med Sci"},{"issue":"1","key":"10.1016\/j.chest.2025.08.040_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13054-019-2718-9","article-title":"Brainstem dysfunction in critically ill patients","volume":"24","author":"Benghanem","year":"2020","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.chest.2025.08.040_bib30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jcrc.2006.03.008","article-title":"Efficacy and safety of intrapulmonary percussive ventilation superimposed on conventional ventilation in obese patients with compression atelectasis","volume":"21","author":"Tsuruta","year":"2006","journal-title":"J Crit Care"},{"issue":"11","key":"10.1016\/j.chest.2025.08.040_bib31","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4187\/respcare.04368","article-title":"Continuous high-frequency oscillation therapy in invasively ventilated pediatric subjects in the critical care setting","volume":"61","author":"Morgan","year":"2016","journal-title":"Respir Care"},{"key":"10.1016\/j.chest.2025.08.040_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fped.2017.00099","article-title":"Intrapulmonary percussive ventilation as an airway clearance technique during venoarterial extracorporeal life support in an infant with pertussis","volume":"5","author":"Krawiec","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.chest.2025.08.040_bib33","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2147\/COPD.S29847","article-title":"Acute effects of intrapulmonary percussive ventilation in COPD patients assessed by using conventional outcome parameters and a novel computational fluid dynamics technique","volume":"7","author":"Ides","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"9","key":"10.1016\/j.chest.2025.08.040_bib34","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S1474-4422(24)00235-7","article-title":"Intracranial pressure monitoring in adult patients with traumatic brain injury: challenges and innovations","volume":"23","author":"Zoerle","year":"2024","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.chest.2025.08.040_bib35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4187\/respcare.10897","article-title":"Are short-term changes in physiological variables in ICU patients as a result of physiotherapy of any clinical relevance?","volume":"68","author":"Ntoumenopoulos","year":"2023","journal-title":"Respir Care"},{"issue":"4","key":"10.1016\/j.chest.2025.08.040_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/ptj\/pzy141","article-title":"Comparison of effects of manual and mechanical airway clearance techniques on intracranial pressure in patients with severe traumatic brain injury on a ventilator: randomized, crossover trial","volume":"99","author":"Tomar","year":"2019","journal-title":"Phys Ther"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225052638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369225052638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:32:48Z","timestamp":1773048768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369225052638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0012369225052638"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2025.08.040","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2025.08.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}