{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:31:59Z","timestamp":1793313119294,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["219199"],"award-info":[{"award-number":["219199"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chest.2026.02.043","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:00:28Z","timestamp":1774882828000},"page":"512-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of a Sea-Level Stay on Pulmonary Hemodynamics in Patients With Pulmonary Arterial Hypertension Living in Quito Near 2,850 m"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-5022","authenticated-orcid":false,"given":"Silvia","family":"Ulrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-5937","authenticated-orcid":false,"given":"Julian","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Saxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meret","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Schmucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Saragoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther I.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Cajamarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Hoyos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.chest.2026.02.043_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02474-2019","article-title":"Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m","volume":"56","author":"Lichtblau","year":"2020","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.chest.2026.02.043_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MCP.0000000000001092","article-title":"Pulmonary vascular diseases at high altitude\u2014is it safe to live in the mountains?","volume":"30","author":"Titz","year":"2024","journal-title":"Curr Opin Pulm Med"},{"issue":"2","key":"10.1016\/j.chest.2026.02.043_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/ham.2005.6.147","article-title":"Consensus statement on chronic and subacute high altitude diseases","volume":"6","author":"Le\u00f3n-Velarde","year":"2005","journal-title":"High Alt Med Biol"},{"issue":"38","key":"10.1016\/j.chest.2026.02.043_bib4","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.chest.2026.02.043_bib5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijcard.2021.03.057","article-title":"Extravascular lung water and cardiac function assessed by echocardiography in healthy lowlanders during repeated very high-altitude exposure","volume":"332","author":"Lichtblau","year":"2021","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.chest.2026.02.043_bib6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/japplphysiol.00394.2016","article-title":"Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis","volume":"121","author":"Soria","year":"2016","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12020","article-title":"Prevalence, incidence, and survival of pulmonary arterial hypertension: a systematic review for the global burden of disease 2020 study","volume":"12","author":"Emmons-Bell","year":"2022","journal-title":"Pulm Circ"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib8","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020977300","article-title":"Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review","volume":"11","author":"Leber","year":"2021","journal-title":"Pulm Circ"},{"issue":"6","key":"10.1016\/j.chest.2026.02.043_bib9","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1161\/CIRCULATIONAHA.114.006977","article-title":"Pathophysiology and treatment of high-altitude pulmonary vascular disease","volume":"131","author":"Wilkins","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.chest.2026.02.043_bib10","article-title":"The impact of breathing hypoxic gas and oxygen on pulmonary hemodynamics in patients with pulmonary hypertension","volume":"9","author":"Carta","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"10.1016\/j.chest.2026.02.043_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/eurheartj\/ehad789","article-title":"Overnight exposure to high altitude in pulmonary hypertension: adverse events and effect of oxygen therapy","volume":"45","author":"Schneider","year":"2024","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.chest.2026.02.043_bib12","article-title":"The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomized controlled cross-over trial","volume":"63","author":"M\u00fcller","year":"2024","journal-title":"Eur Respir J"},{"issue":"1S","key":"10.1016\/j.chest.2026.02.043_bib13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hfc.2022.11.001","article-title":"Oxygen therapy in pulmonary vascular disease: a systematic review, meta-analysis, and comment","volume":"19","author":"Schuster","year":"2023","journal-title":"Heart Fail Clin"},{"issue":"3","key":"10.1016\/j.chest.2026.02.043_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12404","article-title":"Characteristics and risk profiles of patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension living permanently at >2500 m of high altitude in Ecuador","volume":"14","author":"Hoyos","year":"2024","journal-title":"Pulm Circ"},{"issue":"7","key":"10.1016\/j.chest.2026.02.043_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"issue":"4","key":"10.1016\/j.chest.2026.02.043_bib16","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/ejechocard\/jen174","article-title":"European Association of Echocardiography recommendations for standardization of performance, digital storage and reporting of echocardiographic studies","volume":"9","author":"Evangelista","year":"2008","journal-title":"Eur J Echocard"},{"issue":"3","key":"10.1016\/j.chest.2026.02.043_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/01.CIR.67.3.593","article-title":"Noninvasive Doppler determination of cardiac output in man: clinical validation","volume":"67","author":"Huntsman","year":"1983","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2026.02.043_bib19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1467-842X.2001.tb00294.x","article-title":"How can I deal with missing data in my study?","volume":"25","author":"Bennett","year":"2001","journal-title":"Aust N Z J Public Health"},{"issue":"6","key":"10.1016\/j.chest.2026.02.043_bib20","doi-asserted-by":"crossref","first-page":"oeae097","DOI":"10.1093\/ehjopen\/oeae097","article-title":"The acute effect of high-dose supplemental oxygen on haemodynamics assessed by echocardiography in patients with pulmonary vascular disease living in Quito at 2850 m: a randomized, single-blind, placebo-controlled crossover trial","volume":"4","author":"M\u00fcller","year":"2024","journal-title":"Eur Heart J Open"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s12887-020-02334-z","article-title":"Pulse oximetry curves in healthy children living at moderate altitude: a cross-sectional study from the Ecuadorian Andes","volume":"20","author":"Andrade","year":"2020","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13054-018-1968-2","article-title":"Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis","volume":"22","author":"Smit","year":"2018","journal-title":"Crit Care"},{"issue":"13","key":"10.1016\/j.chest.2026.02.043_bib23","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jacc.2010.04.052","article-title":"Revisiting the role of oxygen therapy in cardiac patients","volume":"56","author":"Moradkhan","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"suppl 1","key":"10.1016\/j.chest.2026.02.043_bib24","article-title":"30 hours at high altitude (2500 m) in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension\u2014adverse events and effect of oxygen therapy [abstract]","volume":"209","author":"Ulrich","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.chest.2026.02.043_bib25","doi-asserted-by":"crossref","first-page":"00314","DOI":"10.1183\/23120541.00314-2021","article-title":"Effect of a day-trip to altitude (2500 m) on exercise performance in pulmonary hypertension: randomised crossover trial","volume":"7","author":"Schneider","year":"2021","journal-title":"ERJ Open Res"},{"issue":"9","key":"10.1016\/j.chest.2026.02.043_bib26","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/CIRCULATIONAHA.106.624544","article-title":"The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness","volume":"115","author":"Penaloza","year":"2007","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.chest.2026.02.043_bib27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/hrt.33.5.647","article-title":"Bradycardia, increased cardiac output, and reversal of pulmonary hypertension in altitude natives living at sea level","volume":"33","author":"Sime","year":"1971","journal-title":"Br Heart J"},{"issue":"4","key":"10.1016\/j.chest.2026.02.043_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01095-2024","article-title":"Pathology and pathobiology of pulmonary hypertension: current insights and future directions","volume":"64","author":"Guignabert","year":"2024","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1016\/j.chest.2026.02.043_bib29","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1164\/rccm.202208-1547OC","article-title":"Minimal clinically important difference in the six-minute walk distance for patients with pulmonary arterial hypertension","volume":"207","author":"Moutchia","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"issue":"15","key":"10.1016\/j.chest.2026.02.043_bib30","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/eurheartj\/ehx099","article-title":"Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial","volume":"38","author":"Ulrich","year":"2017","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.chest.2026.02.043_bib31","doi-asserted-by":"crossref","first-page":"00563","DOI":"10.1183\/23120541.00563-2022","article-title":"Hyperoxia improves exercise capacity in cardiopulmonary disease: a series of randomised controlled trials","volume":"9","author":"M\u00fcller","year":"2023","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.chest.2026.02.043_bib32","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/COPD.S173039","article-title":"Exercise performance and symptoms in lowlanders with COPD ascending to moderate altitude: randomized trial","volume":"13","author":"Furian","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"1","key":"10.1016\/j.chest.2026.02.043_bib33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1113\/EP092249","article-title":"Autonomic control of the pulmonary circulation: implications for pulmonary hypertension","volume":"110","author":"Plunkett","year":"2025","journal-title":"Exp Physiol"},{"issue":"2","key":"10.1016\/j.chest.2026.02.043_bib34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/01.CIR.33.2.249","article-title":"Pulmonary pressure, cardiac output, and arterial oxygen saturation during exercise at high altitude and at sea level","volume":"33","author":"Banchero","year":"1966","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.chest.2026.02.043_bib35","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/adc.2008.141838","article-title":"Child health and living at high altitude","volume":"94","author":"Niermeyer","year":"2009","journal-title":"Arch Dis Child"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236922600423X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236922600423X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:20:30Z","timestamp":1786353630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001236922600423X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S001236922600423X"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2026.02.043","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of a Sea-Level Stay on Pulmonary Hemodynamics in Patients With Pulmonary Arterial Hypertension Living in Quito Near 2,850 m","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2026.02.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}