{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:17:07Z","timestamp":1789003027444,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL160588"],"award-info":[{"award-number":["R01HL160588"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001502","name":"Blue Cross Blue Shield of Michigan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CHEST"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chest.2026.03.002","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:57:59Z","timestamp":1773421079000},"page":"410-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Timely Antibiotics and Fluid Resuscitation With Increased Discharge to Home After Sepsis"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-6724","authenticated-orcid":false,"given":"Hallie C.","family":"Prescott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Seelye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Buxbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Hsaiky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Jayaprakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag N.","family":"Malani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Posa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Flanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.chest.2026.03.002_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"13","key":"10.1016\/j.chest.2026.03.002_bib2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.chest.2026.03.002_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/CCM.0000000000004225","article-title":"Sepsis among Medicare beneficiaries: 3. The methods, models, and forecasts of sepsis, 2012-2018","volume":"48","author":"Buchman","year":"2020","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.chest.2026.03.002_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis","volume":"319","author":"Prescott","year":"2018","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.chest.2026.03.002_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MLR.0000000000002000","article-title":"Identifying sources of inter-hospital variation in episode spending for sepsis care","volume":"62","author":"Sankaran","year":"2024","journal-title":"Med Care"},{"issue":"11","key":"10.1016\/j.chest.2026.03.002_bib8","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.chest.2026.03.002_bib9","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1164\/rccm.202310-1800OC","article-title":"Heterogeneity of benefit from earlier time-to-antibiotics for sepsis","volume":"207","author":"Hechtman","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2026.03.002_bib10","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.chest.2019.02.008","article-title":"ED door-to-antibiotic time and long-term mortality in sepsis","volume":"155","author":"Peltan","year":"2019","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.chest.2026.03.002_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.chest.2021.06.029","article-title":"Antibiotic timing and progression to septic shock among patients in the ED with suspected infection","volume":"161","author":"Bisarya","year":"2022","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.chest.2026.03.002_bib12","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/cid\/ciad450","article-title":"Risk of misleading conclusions in observational studies of time-to-antibiotics and mortality in suspected sepsis","volume":"77","author":"Pak","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.chest.2026.03.002_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1164\/rccm.201212-2199OC","article-title":"Multicenter implementation of a severe sepsis and septic shock treatment bundle","volume":"188","author":"Miller","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.chest.2026.03.002_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/CCM.0000000000002262","article-title":"Increased time to initial antimicrobial administration is associated with progression to septic shock in severe sepsis patients","volume":"45","author":"Whiles","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.chest.2026.03.002_bib16","doi-asserted-by":"crossref","DOI":"10.1164\/ajrccm.2025.211.Abstracts.A7078","article-title":"Understanding antibiotic delays in patients with sepsis-induced hypotension at Michigan hospitals [abstract]","volume":"211","author":"Munroe","year":"2025","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.chest.2026.03.002_bib17","article-title":"Variation in initial fluid resuscitation volume and type in patients with sepsis across Michigan hospitals [abstract]","volume":"209","author":"Munroe","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.chest.2026.03.002_bib18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.chest.2024.06.3769","article-title":"Development and validation of the Hospital Medicine Safety Sepsis Initiative Mortality Model","volume":"166","author":"Prescott","year":"2024","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.chest.2026.03.002_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/1475-6773.14337","article-title":"Requiem for odds ratios","volume":"59","author":"Norton","year":"2024","journal-title":"Health Serv Res"},{"key":"10.1016\/j.chest.2026.03.002_bib20","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.2014.2639","article-title":"Declining case fatality rates for severe sepsis: good data bring good news with ambiguous implications","volume":"311","author":"Iwashyna","year":"2014","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.chest.2026.03.002_bib21","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMra2403213","article-title":"Sepsis and septic shock","volume":"391","author":"Meyer","year":"2024","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.chest.2026.03.002_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1513\/AnnalsATS.202306-505OC","article-title":"Impact of reducing time-to-antibiotics on sepsis mortality, antibiotic use, and adverse events","volume":"21","author":"Donnelly","year":"2024","journal-title":"Ann Am Thorac Soc"},{"issue":"7","key":"10.1016\/j.chest.2026.03.002_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jamainternmed.2024.0581","article-title":"Mortality of patients with sepsis administered piperacillin-tazobactam vs cefepime","volume":"184","author":"Chanderraj","year":"2024","journal-title":"JAMA Intern Med"},{"issue":"2","key":"10.1016\/j.chest.2026.03.002_bib24","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00910-2022","article-title":"In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes","volume":"61","author":"Chanderraj","year":"2023","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.chest.2026.03.002_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S2213-2600(17)30469-1","article-title":"Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial","volume":"6","author":"Alam","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"12","key":"10.1016\/j.chest.2026.03.002_bib26","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1513\/AnnalsATS.201504-187OC","article-title":"Volume overload: prevalence, risk factors, and functional outcome in survivors of septic shock","volume":"12","author":"Mitchell","year":"2015","journal-title":"Ann Am Thorac Soc"},{"issue":"10","key":"10.1016\/j.chest.2026.03.002_bib27","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00134-025-08058-x","article-title":"European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: part 3. Fluid removal at de-escalation phase","volume":"51","author":"Ostermann","year":"2025","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.chest.2026.03.002_bib28","doi-asserted-by":"crossref","first-page":"A6379","DOI":"10.1016\/j.chest.2024.07.021","article-title":"Fluid overload and deresuscitation practices in Michigan ICUs","volume":"166","author":"Munroe","year":"2024","journal-title":"Chest"},{"key":"10.1016\/j.chest.2026.03.002_bib29","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3389\/fimmu.2018.02147","article-title":"Epidemiology and immune pathogenesis of viral sepsis","volume":"9","author":"Lin","year":"2018","journal-title":"Front Immunol"}],"container-title":["CHEST"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369226003004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369226003004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:20:53Z","timestamp":1786353653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369226003004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0012369226003004"],"URL":"https:\/\/doi.org\/10.1016\/j.chest.2026.03.002","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Timely Antibiotics and Fluid Resuscitation With Increased Discharge to Home After Sepsis","name":"articletitle","label":"Article Title"},{"value":"CHEST","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chest.2026.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. under license from the American College of Chest Physicians.","name":"copyright","label":"Copyright"}]}}