{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:09:48Z","timestamp":1792674588346,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Child Abuse & Neglect"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.chiabu.2020.104413","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T13:10:37Z","timestamp":1581685837000},"page":"104413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Social supports moderate the effects of child adversity on neural correlates of threat processing"],"prefix":"10.1016","volume":"102","author":[{"given":"Nicholas F.","family":"Wymbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Albaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Althoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"O\u2019Loughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Holbrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Garavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janitza L.","family":"Montalvo-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Mostofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hudziak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-2970","authenticated-orcid":false,"given":"Joan","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chiabu.2020.104413_bib0005","series-title":"Manual for ASEBA school-age forms & profiles","author":"Achenbach","year":"2001"},{"key":"10.1016\/j.chiabu.2020.104413_bib0010","first-page":"237","article-title":"Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents","volume":"5","author":"Angold","year":"1995","journal-title":"International Journal of Methods in Psychiatric Research"},{"key":"10.1016\/j.chiabu.2020.104413_bib0015","first-page":"8","article-title":"A method for the assessment of social support networks in community survey research","volume":"3","author":"Barrera","year":"1980","journal-title":"Connections"},{"issue":"3","key":"10.1016\/j.chiabu.2020.104413_bib0020","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1017\/S095457941400073X","article-title":"Intervening to enhance cortisol regulation among children at risk for neglect: Results of a randomized clinical trial","volume":"27","author":"Bernard","year":"2015","journal-title":"Developmental Psychopathology"},{"issue":"2","key":"10.1016\/j.chiabu.2020.104413_bib0025","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1467-8624.2011.01712.x","article-title":"Enhancing attachment organization among maltreated children: Results of a randomized clinical trial","volume":"83","author":"Bernard","year":"2012","journal-title":"Child Development"},{"issue":"1","key":"10.1016\/j.chiabu.2020.104413_bib0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/npp.2015.252","article-title":"Early adverse experiences and the developing brain","volume":"41","author":"Bick","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.chiabu.2020.104413_bib0035","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.biopsych.2018.09.020","article-title":"Early parenting intervention and adverse family environments affect neural function in middle childhood","volume":"85","author":"Bick","year":"2019","journal-title":"Biological Psychiatry"},{"issue":"19","key":"10.1016\/j.chiabu.2020.104413_bib0040","first-page":"31447","article-title":"Deficient amygdala habituation to threatening stimuli in borderline personality disorder relates to adverse childhood experiences","volume":"19","author":"Bilek","year":"2019","journal-title":"Biological Psychiatry"},{"issue":"4","key":"10.1016\/j.chiabu.2020.104413_bib0045","first-page":"545","article-title":"The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric characteristics","volume":"36","author":"Birmaher","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"10.1016\/j.chiabu.2020.104413_bib0050","first-page":"545","article-title":"The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric properties","volume":"36","author":"Birmaher","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"1","key":"10.1016\/j.chiabu.2020.104413_bib0055","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11682-015-9387-3","article-title":"Different neural modifications underpin PTSD after different traumatic events: An fMRI meta-analytic study","volume":"10","author":"Boccia","year":"2016","journal-title":"Brain Imaging and Behavior"},{"issue":"5","key":"10.1016\/j.chiabu.2020.104413_bib0060","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1037\/0022-006X.68.5.748","article-title":"Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults","volume":"68","author":"Brewin","year":"2000","journal-title":"Journal of Consulting and Clinical Psychology"},{"key":"10.1016\/j.chiabu.2020.104413_bib0065","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.psych.58.110405.085650","article-title":"Social bonds and posttraumatic stress disorder","volume":"59","author":"Charuvastra","year":"2008","journal-title":"Annual Review of Psychology"},{"issue":"14","key":"10.1016\/j.chiabu.2020.104413_bib0070","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1017\/S0033291716001847","article-title":"Changes in functional connectivity of the amygdala during cognitive reappraisal predict symptom reduction during trauma-focused cognitive-behavioral therapy among adolescent girls with post-traumatic stress disorder","volume":"46","author":"Cisler","year":"2016","journal-title":"Psychologie Medicale"},{"issue":"10","key":"10.1016\/j.chiabu.2020.104413_bib0075","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/scan\/nsx091","article-title":"Relationship status and perceived support in the social regulation of neural responses to threat","volume":"12","author":"Coan","year":"2017","journal-title":"Social Cognitive and Affective Neuroscience"},{"issue":"3","key":"10.1016\/j.chiabu.2020.104413_bib0080","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.chc.2015.02.005","article-title":"Trauma-focused cognitive behavior therapy for traumatized children and families","volume":"24","author":"Cohen","year":"2015","journal-title":"Child and Adolescent Psychiatric Clinics of North America"},{"issue":"4","key":"10.1016\/j.chiabu.2020.104413_bib0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.biopsych.2011.10.021","article-title":"Limbic scars: Long-term consequences of childhood maltreatment revealed by functional and structural MRI","volume":"71","author":"Dannlowski","year":"2012","journal-title":"Biological Psychiatry"},{"issue":"10","key":"10.1016\/j.chiabu.2020.104413_bib0090","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0006-3223(99)00045-1","article-title":"Developmental traumatology. Part II: Brain development","volume":"45","author":"De Bellis","year":"1999","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.chiabu.2020.104413_bib0095","article-title":"Predictors of PTSD treatment response trajectories in a sample of childhood sexual abuse survivors: The roles of social support, coping, and PTSD symptom clusters","author":"Fletcher","year":"2017","journal-title":"Journal of Interpersonal Violence"},{"issue":"5","key":"10.1016\/j.chiabu.2020.104413_bib0100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/da.21892","article-title":"Brain activation to facial expressions in youth with PTSD symptoms","volume":"29","author":"Garrett","year":"2012","journal-title":"Depression and Anxiety"},{"key":"10.1016\/j.chiabu.2020.104413_bib0105","first-page":"415","article-title":"Common neurocircuitry mediating drug and fear relapse in preclinical models","volume":"236","author":"Goode","year":"2019","journal-title":"Pharmacology"},{"key":"10.1016\/j.chiabu.2020.104413_bib0110","article-title":"Quantifying severity of maltreatment maltreatment, adversity, and trauma from child protective services case record files","author":"Grasso","year":"2019","journal-title":"Journal of Interpersonal Violence"},{"issue":"10","key":"10.1016\/j.chiabu.2020.104413_bib0115","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.biopsych.2008.03.015","article-title":"Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task","volume":"63","author":"Hare","year":"2008","journal-title":"Biological Psychiatry"},{"issue":"3","key":"10.1016\/j.chiabu.2020.104413_bib0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/jcpp.12651","article-title":"Research review: Neural response to threat in children, adolescents, and adults after child maltreatment - a quantitative meta-analysis","volume":"58","author":"Hein","year":"2017","journal-title":"Journal of Child Psychology and Psychiatry, and Allied Disciplines"},{"issue":"10","key":"10.1016\/j.chiabu.2020.104413_bib0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11920-017-0825-3","article-title":"Trauma, PTSD and the developing brain","volume":"19","author":"Herringa","year":"2017","journal-title":"Current Psychiatry Reports"},{"issue":"7","key":"10.1016\/j.chiabu.2020.104413_bib0130","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1017\/S0033291712002310","article-title":"Childhood and adult trauma both correlate with dorsal anterior cingulate activation to threat in combat veterans","volume":"43","author":"Herringa","year":"2017","journal-title":"Psycholical Medicinen"},{"issue":"3","key":"10.1016\/j.chiabu.2020.104413_bib0135","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-4079","article-title":"Global prevalence of past-year violence against children: A systematic review and minimum estimates","volume":"137","author":"Hillis","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.chiabu.2020.104413_bib0140","series-title":"Paper Presented at the American Academy of Child and Adolescent Psychiatry's 61st Annual Meeting","article-title":"The Yale-Vermont adversity in childhood scale: A quantitative approach to adversity assessment","author":"Holbrook","year":"2015"},{"key":"10.1016\/j.chiabu.2020.104413_bib0145","series-title":"Lewis\u2019 child and adolescent psychiatry: A comprehensive textbook","article-title":"Posttraumatic stress disorder","author":"Hoover","year":"2017"},{"issue":"7","key":"10.1016\/j.chiabu.2020.104413_bib0150","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neubiorev.2006.03.004","article-title":"A meta-analysis of structural brain abnormalities in PTSD","volume":"30","author":"Karl","year":"2006","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"2","key":"10.1016\/j.chiabu.2020.104413_bib0155","first-page":"257","article-title":"Depressive disorders in maltreated children","volume":"30","author":"Kaufman","year":"1991","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"10.1016\/j.chiabu.2020.104413_bib0160","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.biopsych.2005.10.026","article-title":"Brain-Derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children","volume":"59","author":"Kaufman","year":"2006","journal-title":"Biological Psychiatry"},{"issue":"49","key":"10.1016\/j.chiabu.2020.104413_bib0165","doi-asserted-by":"crossref","first-page":"17316","DOI":"10.1073\/pnas.0404376101","article-title":"Social supports and serotonin transporter gene moderate depression in maltreated children","volume":"101","author":"Kaufman","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.chiabu.2020.104413_bib0170","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpeds.2018.06.051","article-title":"Adverse childhood experiences, epigenetic measures, and obesity in youth","volume":"202","author":"Kaufman","year":"2018","journal-title":"Jornal de Pediatria"},{"issue":"11","key":"10.1016\/j.chiabu.2020.104413_bib0175","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1038\/s41386-018-0157-y","article-title":"Methylation in OTX2 and related genes, maltreatment, and depression in children","volume":"43","author":"Kaufman","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"20","key":"10.1016\/j.chiabu.2020.104413_bib0180","doi-asserted-by":"crossref","first-page":"R868","DOI":"10.1016\/j.cub.2007.08.005","article-title":"The amygdala","volume":"17","author":"LeDoux","year":"2007","journal-title":"Current Biology : CB"},{"issue":"1","key":"10.1016\/j.chiabu.2020.104413_bib0185","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1524838015591572","article-title":"The mental health consequences of mass shootings","volume":"18","author":"Lowe","year":"2017","journal-title":"Trauma, Violence & Abuse"},{"issue":"45","key":"10.1016\/j.chiabu.2020.104413_bib0190","doi-asserted-by":"crossref","first-page":"18274","DOI":"10.1073\/pnas.1310163110","article-title":"Early-life stress has persistent effects on amygdala function and development in mice and humans","volume":"110","author":"Malter Cohen","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/j.chiabu.2020.104413_bib0195","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/da.22368","article-title":"Cognition-childhood maltreatment interactions in the prediction of antidepressant outcomes in major depressive disorder patients: Results from the iSPOT-D trial","volume":"32","author":"Miller","year":"2015","journal-title":"Depression and Anxiety"},{"key":"10.1016\/j.chiabu.2020.104413_bib0200","series-title":"Paper Presented at the Annual Meeting of the Society of Biological Psychiatry","article-title":"Social supports moderate the effects of child maltreatment on neural correlates of threat processing","author":"Orr","year":"2016"},{"issue":"4","key":"10.1016\/j.chiabu.2020.104413_bib0205","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1077559519839491","article-title":"Adverse childhood experiences and amygdalar reduction: High-resolution segmentation reveals associations with subnuclei and psychiatric outcomes","volume":"24","author":"Oshri","year":"2019","journal-title":"Child Maltreatment"},{"issue":"2","key":"10.1016\/j.chiabu.2020.104413_bib0210","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pscychresns.2009.03.006","article-title":"Amygdala hyperactivation in untreated depressed individuals","volume":"173","author":"Peluso","year":"2009","journal-title":"Psychiatry Research"},{"issue":"11","key":"10.1016\/j.chiabu.2020.104413_bib0215","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0006-3223(99)00262-0","article-title":"A developmental psychopathology model of childhood traumatic stress and intersection with anxiety disorders","volume":"46","author":"Pynoos","year":"1999","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.chiabu.2020.104413_bib0220","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.biopsych.2019.04.033","article-title":"Neurological markers of resilience to depression following childhood maltreatment: The role of neural circuits supporting the cognitive control of emotion","volume":"86","author":"Rodman","year":"2019","journal-title":"Biological Psychiatry"},{"issue":"8","key":"10.1016\/j.chiabu.2020.104413_bib0225","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1002\/hbm.22829","article-title":"Neurobiological indicators of disinhibition in posttraumatic stress disorder","volume":"36","author":"Sadeh","year":"2015","journal-title":"Human Brain Mapping"},{"issue":"2","key":"10.1016\/j.chiabu.2020.104413_bib0230","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1017\/S0954579418000093","article-title":"Brain structural covariance network centrality in maltreated youth with PTSD and in maltreated youth resilient to PTSD","volume":"31","author":"Sun","year":"2018","journal-title":"Development and Psychopathology"},{"issue":"5","key":"10.1016\/j.chiabu.2020.104413_bib0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1248\/yakushi.15-00262-5","article-title":"Preliminary evidence for impaired brain activity of neural reward processing in children and adolescents with reactive attachment disorder","volume":"36","author":"Tomoda","year":"2016","journal-title":"Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan"},{"issue":"2","key":"10.1016\/j.chiabu.2020.104413_bib0240","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1467-7687.2010.00971.x","article-title":"Elevated amygdala response to faces following early deprivation","volume":"14","author":"Tottenham","year":"2011","journal-title":"Developmental Science"},{"issue":"3","key":"10.1016\/j.chiabu.2020.104413_bib0245","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jts.20525","article-title":"Parenting behaviors and posttraumatic symptoms in relation to children\u2019s symptomatology following a traumatic event","volume":"23","author":"Valentino","year":"2010","journal-title":"Journal of Traumatic Stress"},{"key":"10.1016\/j.chiabu.2020.104413_bib0250","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroimage.2013.12.058","article-title":"Cluster-extent based thresholding in fMRI analyses: Pitfalls and recommendations","volume":"91","author":"Woo","year":"2014","journal-title":"Neuroimage"},{"issue":"7","key":"10.1016\/j.chiabu.2020.104413_bib0255","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/da.22594","article-title":"Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression","volume":"34","author":"Zhu","year":"2017","journal-title":"Depression and Anxiety"}],"container-title":["Child Abuse & Neglect"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145213420300685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145213420300685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:13:35Z","timestamp":1758935615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145213420300685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":51,"alternative-id":["S0145213420300685"],"URL":"https:\/\/doi.org\/10.1016\/j.chiabu.2020.104413","relation":{},"ISSN":["0145-2134"],"issn-type":[{"value":"0145-2134","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Social supports moderate the effects of child adversity on neural correlates of threat processing","name":"articletitle","label":"Article Title"},{"value":"Child Abuse & Neglect","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chiabu.2020.104413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104413"}}