{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:11:21Z","timestamp":1776283881864,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011819","name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Herbal Medicines"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.chmed.2019.12.003","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T16:32:16Z","timestamp":1577205136000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Attenuation of inflammation in streptozotocin-induced diabetic rabbits by Matricaria chamomilla oil: A focus on targeting NF-\u03baB and NLRP3 signaling pathways"],"prefix":"10.1016","volume":"12","author":[{"given":"Saeid","family":"Saghahazrati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Abdulmajid","family":"Ayatollahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzad","family":"Kobarfard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bagher","family":"Minaii\u00a0Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13104-018-3960-y","article-title":"Antioxidant and anticancer activities of chamomile (Matricaria recutita L.)","volume":"12","author":"Al-Dabbagh","year":"2019","journal-title":"BMC Research Notes"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib0002","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s10875-007-9164-1","article-title":"Cytokine secretion in long-standing diabetes mellitus type 1 and 2: Associations with low-grade systemic inflammation","volume":"28","author":"Alexandraki","year":"2008","journal-title":"Journal of Clinical Immunology"},{"key":"10.1016\/j.chmed.2019.12.003_bib0004","doi-asserted-by":"crossref","DOI":"10.1002\/admi.201900572","article-title":"Controlling cell behavior through the design of biomaterial surfaces: A focus on surface modification techniques","author":"Amani","year":"2019","journal-title":"Advanced Materials Interfaces"},{"issue":"48","key":"10.1016\/j.chmed.2019.12.003_bib0005","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1039\/C7TB01689A","article-title":"Antioxidant nanomaterials in advanced diagnoses and treatments of ischemia reperfusion injuries","volume":"5","author":"Amani","year":"2017","journal-title":"Journal of Materials Chemistry B"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0006","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/s41598-019-42633-9","article-title":"Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling","volume":"9","author":"Amani","year":"2019","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0007","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1080\/21691401.2019.1639723","article-title":"Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: A review","volume":"47","author":"Amani","year":"2019","journal-title":"Artificial cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.chmed.2019.12.003_bib0008","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.2147\/IJN.S210035","article-title":"Would colloidal gold nanocarriers present an effective diagnosis or treatment for ischemic stroke?","volume":"14","author":"Amani","year":"2019","journal-title":"International Journal of Nanomedicine"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1021\/acsbiomaterials.8b00658","article-title":"Three-dimensional graphene foams: Synthesis, properties, biocompatibility, biodegradability, and applications in tissue engineering","volume":"5","author":"Amani","year":"2018","journal-title":"ACS Biomaterials Science & Engineering"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1590\/2359-3997000000003","article-title":"Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus","volume":"59","author":"Assmann","year":"2015","journal-title":"Archives of Endocrinology and Metabolism"},{"key":"10.1016\/j.chmed.2019.12.003_bib0011","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopha.2017.08.040","article-title":"Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats","volume":"95","author":"Chandirasegaran","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.chmed.2019.12.003_bib0012","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrendo.2009.275","article-title":"Immune therapy for type 1 diabetes mellitus\u2014What is unique about anti-CD3 antibodies?","volume":"6","author":"Chatenoud","year":"2010","journal-title":"Nature Reviews Endocrinology"},{"issue":"06","key":"10.1016\/j.chmed.2019.12.003_bib0013","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4236\/abb.2012.326092","article-title":"The influence of diabetes enhanced inflammation on cell apoptosis and periodontitis","volume":"3","author":"Chen","year":"2012","journal-title":"Advances in Bioscience and Biotechnology"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0014","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.chmed.2018.05.006","article-title":"Synergistic interactions of catalpol and stachyose in STZ-HFD induced diabetic mice: Synergism in regulation of blood glucose, lipids, and hepatic and renal function","volume":"11","author":"Chen","year":"2019","journal-title":"Chinese Herbal Medicines"},{"issue":"3","key":"10.1016\/j.chmed.2019.12.003_bib42","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-0031-1280454","article-title":"Diterpenoids including a novel dimeric conjugate from salvia leriaefolia","volume":"78","author":"Choudhary","year":"2012","journal-title":"Planta Medica"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2009.21","article-title":"The role of inflammation in insulitis and \u03b2-cell loss in type 1 diabetes","volume":"5","author":"Eizirik","year":"2009","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1016\/j.chmed.2019.12.003_bib0016","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4236\/jbise.2013.66079","article-title":"Diabetes, an inflammatory process: Oxidative stress and TNF-alpha involved in hepatic complication","volume":"6","author":"Frances","year":"2013","journal-title":"Journal of Biomedical Science and Engineering"},{"key":"10.1016\/j.chmed.2019.12.003_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2019.01.008","article-title":"Chamomile oil loaded solid lipid nanoparticles: a naturally formulated remedy to enhance the wound healing","author":"Gad","year":"2019","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.chmed.2019.12.003_bib0018","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.indcrop.2018.04.024","article-title":"Antimicrobial and toxicity profiles evaluation of the chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents","volume":"120","author":"G\u00f6ger","year":"2018","journal-title":"Industrial Crops and Products"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0019","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41598-017-18284-z","article-title":"The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls","volume":"8","author":"G\u00f6tze","year":"2018","journal-title":"Scientific Reports"},{"issue":"36","key":"10.1016\/j.chmed.2019.12.003_bib0020","doi-asserted-by":"crossref","first-page":"11318","DOI":"10.1073\/pnas.1513509112","article-title":"NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets","volume":"112","author":"Hu","year":"2015","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0021","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41598-018-38341-5","article-title":"eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of type 1 diabetes","volume":"9","author":"Imam","year":"2019","journal-title":"Scientific Reports"},{"key":"10.1016\/j.chmed.2019.12.003_bib0022","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.npep.2017.06.002","article-title":"Combine effect of chondroitinase ABC and low level laser (660nm) on spinal cord injury model in adult male rats","volume":"65","author":"Janzadeh","year":"2017","journal-title":"Neuropeptides"},{"issue":"2","key":"10.1016\/j.chmed.2019.12.003_bib0023","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.chmed.2019.03.003","article-title":"Tsc1\/Tsc2 complex: A molecular target of capsaicin for protection against testicular torsion induced injury in rats","volume":"11","author":"Javdan","year":"2019","journal-title":"Chinese Herbal Medicines"},{"issue":"12","key":"10.1016\/j.chmed.2019.12.003_bib0024","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/mnfr.201600112","article-title":"Conjugated linoleic acid rat pretreatment reduces renal damage in ischemia\/reperfusion injury: Unraveling antiapoptotic mechanisms and regulation of phosphorylated mammalian target of rapamycin","volume":"60","author":"Javedan","year":"2016","journal-title":"Molecular Nutrition & Food Research"},{"issue":"12","key":"10.1016\/j.chmed.2019.12.003_bib0025","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1021\/acsbiomaterials.8b00992","article-title":"Supercritical fluid-assisted decoration of nanoparticles on porous microcontainers for codelivery of therapeutics and inhalation therapy of diabetes","volume":"4","author":"Kankala","year":"2018","journal-title":"ACS Biomaterials Science & Engineering"},{"issue":"5","key":"10.1016\/j.chmed.2019.12.003_bib0026","first-page":"1770","article-title":"Microporous polymer scaffolds for the transplantation of embryonic stem cell derived pancreatic progenitors to a clinically translatable site for the treatment of type i diabetes","volume":"4","author":"Kasputis","year":"2018","journal-title":"ACS Biomaterials Science & Engineering"},{"issue":"17","key":"10.1016\/j.chmed.2019.12.003_bib0027","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1021\/jf8014365","article-title":"Protective effects of dietary chamomile tea on diabetic complications","volume":"56","author":"Kato","year":"2008","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.chmed.2019.12.003_bib0028","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopha.2017.07.102","article-title":"Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus","volume":"94","author":"Liu","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"2","key":"10.1016\/j.chmed.2019.12.003_bib0029","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chmed.2019.04.004","article-title":"Applications of Pueraria lobata in treating diabetics and reducing alcohol drinking","volume":"11","author":"Liu","year":"2019","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.chmed.2019.12.003_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2019.03.008","article-title":"Post-transcriptional markers associated with clinical complications in type 1 and type 2 diabetes mellitus","volume":"450","author":"Massaro","year":"2019","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib0031","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s12031-015-0636-0","article-title":"The protective effect of remote renal preconditioning against hippocampal ischemia reperfusion injury: Role of KATP channels","volume":"57","author":"Mehrjerdi","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0032","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jep.2012.04.014","article-title":"Antidiabetic and antioxidant potential ofEmblica officinalis Gaertn. Leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats","volume":"142","author":"Nain","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"10.1016\/j.chmed.2019.12.003_bib0033","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1590\/1678-775720150481","article-title":"TNF-alpha expression, evaluation of collagen, and tunel of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats","volume":"24","author":"Oliveira","year":"2016","journal-title":"Journal of Applied Oral Science"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0034","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/molecules24010053","article-title":"Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus\u2014A narrative review","volume":"24","author":"Rak","year":"2019","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.chmed.2019.12.003_bib0035","first-page":"e85247","article-title":"The protective effects of cultured mesenchymal stem cells onto the surface of electrospun poly-L-lactide acid scaffolds coated with Matricaria chamomilla L. oil in streptozotocin-induced diabetic rabbits","volume":"21","author":"Saghahazrati","year":"2019","journal-title":"Iranian Red Crescent Medical Journal"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib0036","first-page":"371","article-title":"The synergistic effect of glucagon-like peptide-1 and chamomile oil on differentiation of mesenchymal stem cells into insulin-producing cells","volume":"21","author":"Saghahazrati","year":"2020","journal-title":"Cell Journal (Yakhteh)"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib43","first-page":"759","article-title":"Triterpenes and steroids from Euphorbia denticulatalam. with anti-herpes symplex virus activity","volume":"12","author":"Shamsabadipour","year":"2013","journal-title":"Iranian Journal of Pharmaceutical Research"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0037","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1038\/s41598-018-22913-6","article-title":"Association of NF-E2 related factor 2 (Nrf2) and inflammatory cytokines in recent onset type 2 diabetes mellitus","volume":"8","author":"Sireesh","year":"2018","journal-title":"Scientific Reports"},{"issue":"6","key":"10.1016\/j.chmed.2019.12.003_bib0038","first-page":"895","article-title":"Chamomile: a herbal medicine of the past with a bright future","volume":"3","author":"Srivastava","year":"2010","journal-title":"Molecular Medicine Reports"},{"issue":"1","key":"10.1016\/j.chmed.2019.12.003_bib0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nut.2015.07.011","article-title":"Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus","volume":"32","author":"Zemestani","year":"2016","journal-title":"Nutrition"},{"issue":"4","key":"10.1016\/j.chmed.2019.12.003_bib0041","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1674-6384(15)60057-0","article-title":"Hypoglycemic and hypolipidemic effects of Lycium barbarum polysaccharide in diabetic rats","volume":"7","author":"Zhao","year":"2015","journal-title":"Chinese Herbal Medicines"}],"container-title":["Chinese Herbal Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638419301042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638419301042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:24:57Z","timestamp":1761654297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1674638419301042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1674638419301042"],"URL":"https:\/\/doi.org\/10.1016\/j.chmed.2019.12.003","relation":{},"ISSN":["1674-6384"],"issn-type":[{"value":"1674-6384","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuation of inflammation in streptozotocin-induced diabetic rabbits by Matricaria chamomilla oil: A focus on targeting NF-\u03baB and NLRP3 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Chinese Herbal Medicines","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chmed.2019.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Tianjin Press of Chinese Herbal Medicines. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}