{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:21:51Z","timestamp":1790378511790,"version":"4.1.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Herbal Medicines"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.chmed.2020.09.002","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T22:29:17Z","timestamp":1603837757000},"page":"49-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms"],"prefix":"10.1016","volume":"13","author":[{"given":"Jun-ying","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-huan","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-juan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-sheng","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chmed.2020.09.002_b0005","first-page":"1","article-title":"Flavonoids in cancer and apoptosis","volume":"28","author":"Abotaleb","year":"2019","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.chmed.2020.09.002_b0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yjmcc.2008.12.003","article-title":"Mechanisms of flavonoid protection against myocardial ischemia\u2013reperfusion injury","volume":"46","author":"Akhlaghi","year":"2009","journal-title":"Journal of Molecular & Cellular Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nutres.2009.11.002","article-title":"Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia\u2013reperfusion","volume":"30","author":"Akhlaghi","year":"2010","journal-title":"Nutrition Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0020","first-page":"1431","article-title":"Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia\u2013reperfusion through JAK2\/STAT3 activation","volume":"11","author":"An","year":"2010","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.chmed.2020.09.002_b0025","first-page":"1","article-title":"Quercetin reduces inflammatory responses in LPS-stimulated cardiomyoblasts","author":"Angeloni","year":"2012","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0030","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s11064-012-0786-1","article-title":"Catechin hydrate ameliorates redox imbalance and limits inflammatory response in focal cerebral ischemia","volume":"8","author":"Ashafaq","year":"2012","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jinorgbio.2011.11.014","article-title":"Quercetin as a shuttle for labile iron","volume":"1","author":"Baccan","year":"2012","journal-title":"Journal of Inorganic Biochemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.lfs.2016.09.013","article-title":"Reactive oxygen species-mediated cardiac-reperfusion injury: Mechanisms and therapies","volume":"165","author":"Bagheri","year":"2016","journal-title":"Life Sciences"},{"key":"10.1016\/j.chmed.2020.09.002_b0045","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3389\/fphar.2018.01445","article-title":"Danshensu for myocardial ischemic injury: Preclinical evidence and novel methodology of quality assessment tool","volume":"9","author":"Bao","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-005-3895-1","article-title":"Signal transduction mechanisms involved in cardiac precon- ditioning: Role of Ras-GTPase, Ca2\u00fe\/calmodulin-dependent protein kinase II and epidermal growth factor receptor","volume":"268","author":"Benter","year":"2005","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phytol.2019.01.006","article-title":"Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative","volume":"30","author":"Biedermann","year":"2019","journal-title":"Phytochemistry Letters"},{"key":"10.1016\/j.chmed.2020.09.002_b0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1124\/jpet.116.239459","article-title":"Luteolinidin protects the postischemic heart through CD38 Inhibition with preservation of NADPH","volume":"361","author":"Boslett","year":"2017","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.chmed.2020.09.002_b0065","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jsfa.2740350407","article-title":"Flavonol glycoside distribution in cultivars and hybrids of Leucaena leucocephala","volume":"35","author":"Brian","year":"1984","journal-title":"Journal of the Science of Food and Agriculture"},{"key":"10.1016\/j.chmed.2020.09.002_b0070","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0891-5849(02)00839-0","article-title":"Mitochondrial function in response to cardiac ischemia\u2013reperfusion after oral treatment with quercetin","volume":"32","author":"Brookes","year":"2002","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0075","first-page":"1","article-title":"Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia\u2013reperfusion in vitro","volume":"39","author":"Chahine","year":"2015","journal-title":"Drug and Chemical Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0080","first-page":"31","article-title":"Protective effects of myricitrin on ischemic\/reperfusion injury in isolated rat hearts","volume":"5","author":"Chen","year":"2016","journal-title":"Chinese Journal of Comparative Medicine"},{"issue":"2","key":"10.1016\/j.chmed.2020.09.002_b0085","first-page":"440","article-title":"The research progress of the effect of quercetin on cardiovascular diseases and its new formulations","volume":"30","author":"Chen","year":"2019","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0095","first-page":"48","article-title":"The protective effects of apigenin in myocardium of rats with ischemia reperfusion injury","volume":"2","author":"Cheng","year":"2011","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.chmed.2020.09.002_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0165575","article-title":"In vitro antioxidant versus metal ion chelating properties of flavonoids: A structure-activity Investigation","volume":"11","author":"Cherrak","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chmed.2020.09.002_b0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/bcpt.12319","article-title":"Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated H9c2 cardiomyocytes","volume":"2","author":"Daubney","year":"2015","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0110","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1038\/s41598-018-25143-y","article-title":"Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia\u2013reperfusion injury by suppression of the cardiac inflammatory response","volume":"1","author":"De Jong","year":"2018","journal-title":"Science. Report"},{"key":"10.1016\/j.chmed.2020.09.002_b0115","doi-asserted-by":"crossref","first-page":"607","DOI":"10.5897\/JMPR2014.5360","article-title":"A review on pathophysiology of ischemic-reperfusion injury of heart and ameliorating role of flavonoids and polyphenols","volume":"8","author":"Debnath","year":"2014","journal-title":"Journal of Medicinal Plants Research"},{"issue":"12","key":"10.1016\/j.chmed.2020.09.002_b0120","article-title":"Influence of breviscapine on myocardial apoptosis and NF-\u03baB pathway signaling molecules (\u03b17nAChR, p65 and IkB\u2013\u03b1) in rats with myocardial ischemia-reperfusion injury","volume":"10","author":"Ding","year":"2018","journal-title":"Chinese Journal of Evidence-Based Cardiovascular Medicine"},{"issue":"12","key":"10.1016\/j.chmed.2020.09.002_b0125","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.fct.2011.09.040","article-title":"Vitexin protects against myocardial ischemia\/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis","volume":"49","author":"Dong","year":"2011","journal-title":"Food & Chemical Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0130","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.fct.2008.03.033","article-title":"Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats","volume":"46","author":"El-Haggar","year":"2008","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0135","first-page":"5087","article-title":"Flavonoids and platelet aggregation: A brief review","volume":"12","author":"Faggio","year":"2017","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2017.10.017","article-title":"Effects of danhong injection on platelet aggregation in hyperlipidemia rats","volume":"212","author":"Fan","year":"2017","journal-title":"Journal of Ethnopharmacology"},{"issue":"12","key":"10.1016\/j.chmed.2020.09.002_b0145","first-page":"119","article-title":"Protection of total flavonoids of Puerariae Lobatae Flos on myocardial ischemia-reperfusion injury in rats","volume":"23","author":"Fan","year":"2017","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.chmed.2020.09.002_b0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2013.05.045","article-title":"How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo","volume":"66","author":"Forman","year":"2014","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0155","first-page":"3877","article-title":"Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1\/2Nrf2 signaling pathway","volume":"17","author":"Fu","year":"2018","journal-title":"Molecular Medicine Reports"},{"issue":"3","key":"10.1016\/j.chmed.2020.09.002_b0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/10286020500207347","article-title":"Anti-apoptotic effect and the mechanism of orientin on ischaemic\/reperfused myocardium","volume":"8","author":"Fu","year":"2006","journal-title":"Journal of Asian Natural Products Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0165","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.intimp.2011.03.012","article-title":"Anti-inflammatory activity of structurally related flavonoids, apigenin, luteolin and fisetin","volume":"11","author":"Funakoshi","year":"2011","journal-title":"International Immunopharmacology"},{"issue":"9","key":"10.1016\/j.chmed.2020.09.002_b0170","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/10715760903071656","article-title":"Protection against in vivo focal myocardial ischemia\/reperfusion injury induced arrhyth- mias and apoptosis by hesperidin","volume":"43","author":"Gandhi","year":"2009","journal-title":"Free Radical Research"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0175","first-page":"64","article-title":"Protective effect and the mechanisms of Harthorn leaves flavonoids on myocardial ischemia in rats","volume":"28","author":"Gao","year":"2012","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"issue":"3","key":"10.1016\/j.chmed.2020.09.002_b0180","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0254-6272(14)60102-3","article-title":"Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) effect the expression of CaL-\u03b11C and KATP-Kir6.1 mRNA of the myocardial cell membrane in myocardial ischemia-reperfusion arrhythmia rats","volume":"34","author":"Gao","year":"2014","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0185","first-page":"1","article-title":"The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: Revisited","author":"Gino","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cardiores.2005.06.007","article-title":"Cytochrome P450 and arachidonic acid metabolites: Role in myocardial ischemia\/reperfusion injury revisited","volume":"1","author":"Gross","year":"2005","journal-title":"Cardiovasc Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2125.2007.02881.x","article-title":"Flavonoids inhibit the platelet TxA[2] signalling pathway and antagonize TxA[2] receptors [TP] in platelets and smooth muscle cells","volume":"64","author":"Guerrero","year":"2007","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0210","first-page":"168","article-title":"Mechanism and protective effects of tilianin on myocardial ischemia-reperfusion injury in rats","volume":"19","author":"Guo","year":"2013","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"issue":"3","key":"10.1016\/j.chmed.2020.09.002_b0215","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.3892\/mmr.2014.2954","article-title":"Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury","volume":"11","author":"Guo","year":"2014","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.chmed.2020.09.002_b0220","doi-asserted-by":"crossref","first-page":"35319","DOI":"10.1038\/srep35319","article-title":"Hydroxysafflor yellow A alleviates myocardial ischemia\/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling","volume":"6","author":"Han","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.chmed.2020.09.002_b0225","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pharmthera.2017.03.005","article-title":"Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia\/reperfusion","volume":"177","author":"Han","year":"2017","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.chmed.2020.09.002_b0230","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/acs.jnatprod.6b01011","article-title":"Anti-inflammatory activity of natural geranylated flavonoids: Cyclooxygenase and lipoxygenase inhibitory properties and proteomic analysis","volume":"80","author":"Han\u00e1kov\u00e1","year":"2017","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.chmed.2020.09.002_b0235","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/aps.2016.14","article-title":"Methylophiopogonanone A suppresses ischemia\/reperfusion-induced myocardial apoptosis in mice via activating PI3K\/Akt\/eNOS signaling pathway","volume":"6","author":"He","year":"2016","journal-title":"Acta Pharmacologica. Sinica"},{"key":"10.1016\/j.chmed.2020.09.002_b0240","first-page":"2789","article-title":"Research progresson drug metabolism of flavanoids","volume":"21","author":"He","year":"2010","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.chmed.2020.09.002_b0245","doi-asserted-by":"crossref","first-page":"18175","DOI":"10.1039\/C8RA00443A","article-title":"Anti-inflammatory and antioxidant activities of flavonoids from the flowers of Hosta plantaginea","volume":"8","author":"He","year":"2018","journal-title":"RSC Advance"},{"key":"10.1016\/j.chmed.2020.09.002_b0250","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2010.09.004","article-title":"Tea flavonoids and cardiovascular health","volume":"31","author":"Hodgson","year":"2010","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3892\/ijmm.2016.2584","article-title":"Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt\/Nrf2\/HO-1 pathway","volume":"38","author":"Hu","year":"2016","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0260","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/jcmm.13477","article-title":"An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress","volume":"22","author":"Huang","year":"2018","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0265","first-page":"404","article-title":"Dietary polyphenol quercetin protects rat hearts during reperfusion: Enhanced antioxidant capacity with chronic treatment","volume":"7","author":"Ikizler","year":"2007","journal-title":"the Anatolian Journal of Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0270","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/0953710031000123681","article-title":"Dark chocolate inhibits platelet aggregation in healthy volunteers","volume":"14","author":"Innes","year":"2013","journal-title":"Platelet"},{"key":"10.1016\/j.chmed.2020.09.002_b0275","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1139\/cjpp-2016-0667","article-title":"Lingonberry anthocyanins protect cardiac cells from oxidative stress-induced apoptosis","volume":"8","author":"Isaak","year":"2017","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0280","first-page":"306","article-title":"Effects of phytoestrogen genistein on myocardial ischemia\/reperfusion injury and apoptosis in rabbits","volume":"3","author":"Ji","year":"2004","journal-title":"Acta Pharmacologica. Sinica"},{"issue":"6","key":"10.1016\/j.chmed.2020.09.002_b0285","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.thromres.2009.04.010","article-title":"The effects of twelve representative flavonoids on tissue factor expression in human monocytes: Structure-activity relationships","volume":"124","author":"Jiang","year":"2009","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0295","first-page":"1","article-title":"Fisetin confers cardioprotection against myocardial ischemia reperfusion injury by suppressing mitochondrial oxidative stress and mitochondrial dysfunction and inhibiting glycogen synthase kinase 3\\r, \u03b2\\r, Activity","author":"Karthi","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0300","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1021\/jf990153+","article-title":"Quantitation of flavonoid constituents in citrus fruits","volume":"9","author":"Kawaii","year":"1999","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0305","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/08923970701812530","article-title":"Kaempferol protects ischemia\/reperfusion-induced cardiac damage through the regulation of endoplasmic reticulum stress","volume":"30","author":"Kim","year":"2008","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2008.12.005","article-title":"Daidzein administration in vivo reduces myocardial injury in a rat ischemia\/reperfusion model by inhibiting NFkappaB activation","volume":"84","author":"Kim","year":"2009","journal-title":"Life Sciences"},{"key":"10.1016\/j.chmed.2020.09.002_b0315","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jnutbio.2011.10.004","article-title":"Curcumin reduces the cardiac ischemia-reperfusion injury: Involvement of the toll-like receptor 2 in cardiomyocytes","volume":"23","author":"Kim","year":"2012","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0320","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/biof.5520260303","article-title":"An integrated database of flavonoids","volume":"26","author":"Kinoshita","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.chmed.2020.09.002_b0325","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399409001112","article-title":"Molecular mechanisms of endothelial hyperpermeability: Implications in inflammation","volume":"11","author":"Kumar","year":"2009","journal-title":"Expert Reviews in Molecular Medicine"},{"issue":"1","key":"10.1016\/j.chmed.2020.09.002_b0330","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0960-894X(00)00589-8","article-title":"Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart","volume":"11","author":"Lebeau","year":"2001","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"2","key":"10.1016\/j.chmed.2020.09.002_b0335","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/FJC.0b013e31821a5078","article-title":"Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia\/reperfusion in rats","volume":"58","author":"Lee","year":"2011","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0340","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12012-013-9238-7","article-title":"Preventive effect of total flavones of Choerospondias axillarieson ischemia\/reperfusion-induced myocardial infarction-related MAPK signaling pathway","volume":"2","author":"Li","year":"2014","journal-title":"Cardiovascular Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0345","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphar.2018.00033","article-title":"Eriodictyol attenuates myocardial ischemia-reperfusion injury through the activation of JAK2","volume":"9","author":"Li","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0350","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.redox.2017.11.023","article-title":"Cardioprotection of CAPE-oNO2 against myocardial ischemia\/reperfusion induced ROS generation via regulating the SIRT1\/eNOS\/NF-\u03baB pathway in vivo and in vitro","volume":"15","author":"Li","year":"2018","journal-title":"Redox Biology"},{"key":"10.1016\/j.chmed.2020.09.002_b0370","first-page":"77","article-title":"Research progress of Nrf2 regulate oxidative stress in vascular endothelial cells","volume":"2","author":"Li","year":"2017","journal-title":"Journal of Kunming University of Science and Technology(Natural Science Edition)"},{"key":"10.1016\/j.chmed.2020.09.002_b0360","first-page":"829","article-title":"Protective effects of hyperin against ischemia\/reperfusion injury in rats","volume":"37","author":"Li","year":"2002","journal-title":"Chinese Pharmaceutical Journal"},{"key":"10.1016\/j.chmed.2020.09.002_b0355","first-page":"1","article-title":"Apigenin alleviates endotoxin-induced myocardial toxicity by modulating inflammation, oxidative stress, and autophagy","author":"Li","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"7","key":"10.1016\/j.chmed.2020.09.002_b0365","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.7314\/APJCP.2015.16.7.3035","article-title":"Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo","volume":"16","author":"Li","year":"2015","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0375","first-page":"23","article-title":"Separation and purification of quercetin-3-O-glucoside from Lophatherum gracile by high-speed counter-current chromatography coupled with UNIFAC mathematical model","volume":"17","author":"Lin","year":"2011","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.chmed.2020.09.002_b0380","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4137\/CMC.S33164","article-title":"Inflammation and inflammatory cells in myocardial infarction and reperfusion injury: A double-edged sword","volume":"10","author":"Liu","year":"2016","journal-title":"Clinical Medicine Insights. Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0385","first-page":"683","article-title":"Pretective effect of quercitrin-3'-glucoside on myocardial ischemic injury in mice","volume":"43","author":"Liu","year":"2008","journal-title":"Acta Universitatis Medicinalis Anhui"},{"key":"10.1016\/j.chmed.2020.09.002_b0390","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s10495-016-1306-6","article-title":"The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion induced apoptosis in vivo and in vitro via the PI3K\/Akt and HIF-1\u03b1 signaling pathways","volume":"12","author":"Liu","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.chmed.2020.09.002_b0395","first-page":"1379","article-title":"Protective effect of morin on myocardial ischemia reperfusion injury in rats","volume":"3","author":"Liu","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0400","first-page":"952","article-title":"Investigation of the microcosmic mechanism and the quantitative structure-activity relationship of natural flavones on the anti-apoptosis activity in rat cardiocyte","volume":"45","author":"Liu","year":"2010","journal-title":"Chinese Pharmaceutical Journal"},{"key":"10.1016\/j.chmed.2020.09.002_b0405","first-page":"1","article-title":"Flavonoids and platelet-derived thrombotic disorders","volume":"25","author":"Lopez","year":"2018","journal-title":"Current Medicinal Chemistry"},{"issue":"4","key":"10.1016\/j.chmed.2020.09.002_b0410","first-page":"487","article-title":"Antioxidation effect of dihydroquercetin pretreatment in isolated rat hearts during myocardial ischemia reperfusion injury","volume":"33","author":"Lu","year":"2017","journal-title":"Chinese Pharmacological Bulletin"},{"issue":"10","key":"10.1016\/j.chmed.2020.09.002_b0415","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1055\/s-0030-1250718","article-title":"Orientin-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition","volume":"77","author":"Lu","year":"2011","journal-title":"Planta Medica"},{"key":"10.1016\/j.chmed.2020.09.002_b0420","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.intimp.2015.07.018","article-title":"Kaempferol alleviates insulin resistance via hepatic IKK\/NF-\u03baB signal in type 2 diabetic rats","volume":"28","author":"Luo","year":"2015","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0425","first-page":"1","article-title":"The protective effect of total flavones from Rhododendron simsii Planch. on myocardial ischemia\/reperfusion injury and its underlying mechanism","author":"Luo","year":"2018","journal-title":"Evidence-based Complementary and Alternative Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0430","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.biopha.2017.01.060","article-title":"The cardioprotective effect of total flavonoids on myocardial ischemia\/reperfusion in rats","volume":"88","author":"Lv","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.chmed.2020.09.002_b0435","first-page":"1673","article-title":"Protective effect of PI3K\/Akt signaling pathway in puerarin pretreatment against myocardial ischemia-reperfusion injury in rat","volume":"34","author":"Ma","year":"2009","journal-title":"Journal of Chongqing Medical University"},{"key":"10.1016\/j.chmed.2020.09.002_b0440","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/nu9050523","article-title":"Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes","volume":"9","author":"Mattera","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.chmed.2020.09.002_b0445","first-page":"52","article-title":"Propolis ethanolic extracts reduce adenosine diphosphate induced platelet aggregation determined on whole blood","volume":"1","author":"Mirza","year":"2018","journal-title":"Nutrition Journal"},{"key":"10.1016\/j.chmed.2020.09.002_b0450","first-page":"690","article-title":"Comparison of protective effects of catechin applied in vitro or in vivo on ischemia-reperfusion injury in the isolated rat hearts","volume":"6","author":"Modun","year":"2003","journal-title":"Croatian Medical Journal"},{"key":"10.1016\/j.chmed.2020.09.002_b0455","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2014.08.015","article-title":"Molecular identity of the mitochondrial permeability transition pore and its role in ischemia\u2013reperfusion injury","volume":"78","author":"Morciano","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0460","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/CIRCRESAHA.117.309008","article-title":"Flavonoids, dairy foods, and cardiovascular and metabolic health. A review of emerging biologic pathways","volume":"122","author":"Mozaffarian","year":"2018","journal-title":"Circulation Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"Journal of Nutritional Science"},{"key":"10.1016\/j.chmed.2020.09.002_b0470","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12012-016-9382-y","article-title":"Systems pharmacology dissection of the protective effect of myricetin against acute ischemia\/reperfusion-induced myocardial injury in isolated rat heart","volume":"3","author":"Qiu","year":"2017","journal-title":"Cardiovascular Toxicology"},{"key":"10.1016\/j.chmed.2020.09.002_b0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082577","article-title":"Regulation of heat shock proteins 27 and 70, p-Akt\/p-eNOS and MAPKs by naringin dampens myocardial injury and dysfunction in vivo after ischemia\/reperfusion","volume":"8","author":"Rani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chmed.2020.09.002_b0480","first-page":"179","article-title":"Cardioprotective activity of silymarin in ischemia-reperfusion-induced myocardial infarction in albino rats","volume":"4","author":"Rao","year":"2007","journal-title":"Experimental and Clinical Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0485","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/iub.1352","article-title":"Ischemia and reperfusion related myocardial inflammation: A network of cells and mediators targeting the cardiomyocyte","volume":"67","author":"Rohrbach","year":"2015","journal-title":"Iubmb Life"},{"key":"10.1016\/j.chmed.2020.09.002_b0490","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.12.030","article-title":"Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases","volume":"124","author":"Roohbakhsh","year":"2015","journal-title":"Life Sciences"},{"key":"10.1016\/j.chmed.2020.09.002_b0495","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.trsl.2015.06.011","article-title":"Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation","volume":"167","author":"Ryter","year":"2016","journal-title":"Translational Research the Journal of Laboratory & Clinical Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0500","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.febslet.2008.12.037","article-title":"Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia\/reperfusion-induced injury","volume":"583","author":"Scarabelli","year":"2009","journal-title":"FEBS Letters"},{"issue":"8","key":"10.1016\/j.chmed.2020.09.002_b0505","first-page":"842","article-title":"Myocardial effects of flavonoids from Crataegus species","volume":"45","author":"Sclzuessler","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.chmed.2020.09.002_b0510","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3945\/jn.115.213025","article-title":"A new database facilitates characterization of flavonoid intake, sources, and positive associations with diet quality among US adults","volume":"145","author":"Sebastian","year":"2015","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.chmed.2020.09.002_b0515","first-page":"1","article-title":"Fisetin confers cardioprotection against myocardial ischemia reperfusion injury by suppressing mitochondrial oxidative stress and mitochondrial dysfunction and inhibiting glycogen synthase kinase 3\u03b2Activity","author":"Shanmugam","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0520","first-page":"1065","article-title":"Yinxing leaf total flavonoid mitigates myocardial ischemia and reperfusi on injury via regulating autophagy","volume":"6","author":"Shen","year":"2016","journal-title":"Anhui Medical & Pharmaceutical Journal"},{"key":"10.1016\/j.chmed.2020.09.002_b0525","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.12659\/MSM.907989","article-title":"Baicalin suppresses hypoxia-reoxygenation-induced arterial endothelial cell apoptosis via suppressing PKC\u03b4\/p53 signaling","volume":"23","author":"Shou","year":"2017","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0530","doi-asserted-by":"crossref","first-page":"A256","DOI":"10.1016\/S0735-1097(04)91090-X","article-title":"Epigallocatechin-3-gallate inhibits stat-1 activation and protects cardiac myocytes from ischemia\/reperfusion-induced apoptosis","volume":"43","author":"Stephanou","year":"2004","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0535","first-page":"1","article-title":"Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury","author":"Suchal","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0540","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jff.2016.08.031","article-title":"Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome","volume":"26","author":"Sun","year":"2016","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.chmed.2020.09.002_b0545","article-title":"Luteolin limits infarct size and improves cardiac function after myocardium ischemia\/reperfusion injury in diabetic rats","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chmed.2020.09.002_b0550","doi-asserted-by":"crossref","first-page":"64526","DOI":"10.1371\/journal.pone.0064526","article-title":"Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro","volume":"5","author":"Sun","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.chmed.2020.09.002_b0555","first-page":"232","article-title":"Effects of Bauhinia championii flavones on adjusting autophagy against myocardial ischemia\/reperfusion injury","volume":"31","author":"Sun","year":"2015","journal-title":"Chinese Pharmacological Bulletin"},{"key":"10.1016\/j.chmed.2020.09.002_b0560","first-page":"1","article-title":"Soy isoflavone protects myocardial ischemia\/reperfusion injury through increasing endothelial nitric oxide synthase and decreasing oxidative stress in ovariectomized rats","author":"Tang","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0565","first-page":"1","article-title":"Grape seed proanthocyanidin ameliorates cardiac toxicity induced by boldenone undecylenate through inhibition of NADPH oxidase and reduction in the expression of NOX2 and NOX4","author":"Tousson","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.chmed.2020.09.002_b0570","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.foodchem.2009.11.057","article-title":"Structure-dependent membrane interaction of flavonoids associated with their bioactivity","volume":"4","author":"Tsuchiya","year":"2010","journal-title":"Food Chemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0575","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.12659\/MSM.897618","article-title":"Plumbagin mediates cardioprotection against myocardial ischemia\/reperfusion injury through Nrf-2 signaling","volume":"22","author":"Wang","year":"2016","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0580","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajps.2017.08.004","article-title":"Bioactive flavonoids in medicinal plants: Structure, activity and biological fate","volume":"13","author":"Wang","year":"2018","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.chmed.2020.09.002_b0585","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1590\/1414-431X20133036","article-title":"Quercetin postconditioning attenuates myocardial ischemia\/reperfusion injury in rats through the PI3K\/Akt pathway","volume":"10","author":"Wang","year":"2013","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0590","first-page":"1238","article-title":"Action mechanism of total flavonoids of Hippophae rhamnoides in treatment of myocardial ischemia based on network pharmacology","volume":"7","author":"Wei","year":"2017","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.chmed.2020.09.002_b0595","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.1039\/c2ra01369j","article-title":"Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways","volume":"2","author":"Wen","year":"2012","journal-title":"RSC Advances"},{"key":"10.1016\/j.chmed.2020.09.002_b0600","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0891-5849(88)90008-1","article-title":"Leukocytes, oxygen radicals, and myocardial injury due to ischemia and reperfusion","volume":"4","author":"Werns","year":"1988","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0605","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/1541-4337.12351","article-title":"The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective","volume":"17","author":"Williamson","year":"2018","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"key":"10.1016\/j.chmed.2020.09.002_b0610","doi-asserted-by":"crossref","first-page":"13739","DOI":"10.1039\/C8RA00590G","article-title":"Chrysin attenuates myocardial ischemia\u2013reperfusion injury by inhibiting myocardial inflammation","volume":"25","author":"Wu","year":"2018","journal-title":"RSC Advances"},{"key":"10.1016\/j.chmed.2020.09.002_b0615","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fphar.2018.00497","article-title":"The natural flavone acacetin confers cardiomyocyte protection against hypoxia\/reoxygenation injury via AMPK-Mediated activation of Nrf2 signaling pathway","volume":"9","author":"Wu","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0620","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3892\/ijmm.2017.3014","article-title":"Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia\/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions","volume":"40","author":"Wu","year":"2017","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0625","first-page":"26","article-title":"Protective effects of flavonoids against ischemia\/reperfusion injury in rats and the research between structure and effect","volume":"4","author":"Wu","year":"2006","journal-title":"Journal of Hunan Normal University (Medical Sciences)"},{"key":"10.1016\/j.chmed.2020.09.002_b0630","first-page":"422","article-title":"Protective effect of erigeron breviscapine on ischemia-reperusion injury in isolated rabbit hearts","volume":"6","author":"Xu","year":"2005","journal-title":"Traditional Chinese Drug Research and Clinical Pharmacology"},{"issue":"6","key":"10.1016\/j.chmed.2020.09.002_b0635","first-page":"875","article-title":"Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury","volume":"49","author":"Xu","year":"2014","journal-title":"Acta Pharmacologica. Sinica"},{"issue":"8","key":"10.1016\/j.chmed.2020.09.002_b0640","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.phytochem.2007.02.013","article-title":"Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery","volume":"68","author":"Xu","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.chmed.2020.09.002_b0645","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1152\/ajpheart.00413.2008","article-title":"Short and long term effects of (-)-epicatechin on myocardial ischemia reperfusion injury","volume":"295","author":"Yamazaki","year":"2008","journal-title":"American Journal of Physiology Heart & Circulatory Physiology"},{"key":"10.1016\/j.chmed.2020.09.002_b0650","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/01.RES.72.6.1181","article-title":"Platelets protect against myocardial dysfunction and injury induced by ischemia and reperfusion in isolated rat hearts","volume":"72","author":"Yang","year":"1993","journal-title":"Circulation Research"},{"key":"10.1016\/j.chmed.2020.09.002_b0655","first-page":"1","article-title":"Proanthocyanidins against Oxidative Stress: From molecular mechanisms to clinical applications","author":"Yang","year":"2018","journal-title":"BioMed Research International"},{"issue":"1","key":"10.1016\/j.chmed.2020.09.002_b0660","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8546-9-1","article-title":"Protective effects of acacetin isolated from Ziziphora clinopodioides Lam. (Xintahua) on neonatal rat cardiomyocytes","volume":"9","author":"Yang","year":"2014","journal-title":"Chinese Medicine"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0665","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.3892\/mmr.2015.4293","article-title":"Apigenin attenuates myocardial ischemia\/reperfusion injury via the inactivation of p38 mitogenactivated protein kinase","volume":"12","author":"Yang","year":"2015","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.chmed.2020.09.002_b0670","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/j.1582-4934.2010.01127.x","article-title":"Endogenous toll-like receptor ligands and their biological significance","volume":"14","author":"Yu","year":"2010","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.chmed.2020.09.002_b0675","first-page":"1","article-title":"Pretreatment with total flavonoid extract from Dracocephalum moldavica L. Attenuates Ischemia Reperfusion-induced Apoptosis","volume":"1","author":"Zeng","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/j.chmed.2020.09.002_b0680","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.chmed.2020.09.002_b0685","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/poc.3025","article-title":"Mechanisms of interaction between luteolin and the catalytic zincion in matrix metalloproteinases: A computational study","volume":"12","author":"Zhang","year":"2012","journal-title":"Journal of Physical Organic Chemistry"},{"issue":"5","key":"10.1016\/j.chmed.2020.09.002_b0690","first-page":"78","article-title":"Effect of flavonoids from Cuscuta chinensis on apoptosis and expression of Bcl-2, Bax and Caspase-3 in rats with cerebral ischemia-reperfusion injury","volume":"30","author":"Zhang","year":"2014","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.chmed.2020.09.002_b0695","first-page":"1560","article-title":"Apigenin suppresses the apoptosis of H9c2 rat cardiomyocytes subjected to myocardial ischemia-reperfusion injury via upregulation of the PI3K\/Akt pathway","volume":"18","author":"Zhou","year":"2018","journal-title":"Molecular Medicine Reports"},{"issue":"3","key":"10.1016\/j.chmed.2020.09.002_b0700","first-page":"380","article-title":"Effects of luteolin and its analogues against myocardial ischemia\/reperfusion injury, lipid metabolism and apoptosis","volume":"36","author":"Zou","year":"2020","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"}],"container-title":["Chinese Herbal Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638420300976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638420300976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:25:59Z","timestamp":1761654359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1674638420300976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1674638420300976"],"URL":"https:\/\/doi.org\/10.1016\/j.chmed.2020.09.002","relation":{},"ISSN":["1674-6384"],"issn-type":[{"value":"1674-6384","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms","name":"articletitle","label":"Article Title"},{"value":"Chinese Herbal Medicines","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chmed.2020.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.","name":"copyright","label":"Copyright"}]}}