{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:59:32Z","timestamp":1774328372731,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173982"],"award-info":[{"award-number":["82173982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Herbal Medicines"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.chmed.2022.10.002","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T15:46:33Z","timestamp":1674056793000},"page":"251-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Preparation of tanshinone IIA self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts"],"prefix":"10.1016","volume":"15","author":[{"given":"Yanshan","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.chmed.2022.10.002_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.0040234","article-title":"Hypertrophic scar formation following burns and trauma: New approaches to treatment","volume":"4","author":"Aarabi","year":"2007","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.chmed.2022.10.002_b0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biomaterials.2017.02.040","article-title":"Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects","volume":"128","author":"Arya","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.chmed.2022.10.002_b0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.burns.2008.07.016","article-title":"Prevention and curative management of hypertrophic scar formation","volume":"35","author":"Bloemen","year":"2009","journal-title":"Burns"},{"issue":"5","key":"10.1016\/j.chmed.2022.10.002_b0020","first-page":"4438","article-title":"Mast cell chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating tgf\u03b21\/smads signaling pathway","volume":"14","author":"Chen","year":"2017","journal-title":"Experimental & Therapeutic Medicine"},{"issue":"10","key":"10.1016\/j.chmed.2022.10.002_b0025","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1875-5364(15)30075-3","article-title":"Drug-target networks for Tanshinone IIA identified by data mining","volume":"13","author":"Chen","year":"2015","journal-title":"Chinese Journal of Natural Medicines"},{"issue":"1\u20132","key":"10.1016\/j.chmed.2022.10.002_b0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Molecular Medicine"},{"issue":"s1","key":"10.1016\/j.chmed.2022.10.002_b0035","first-page":"S46","article-title":"Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar","volume":"15","author":"Ghahary","year":"2010","journal-title":"Wound Repair & Regeneration"},{"issue":"2","key":"10.1016\/j.chmed.2022.10.002_b0040","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1159\/000430385","article-title":"Loureirin B inhibits hypertrophic scar formation via inhibition of the TGF-\u03b21-ERK\/JNK pathway","volume":"37","author":"He","year":"2015","journal-title":"Cell Physiollogy Biochemistry"},{"issue":"2","key":"10.1016\/j.chmed.2022.10.002_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jccw.2013.06.001","article-title":"Role of hyaluronic acid treatment in the prevention of keloid scarring","volume":"4","author":"Hoffmann","year":"2012","journal-title":"The Journal of the American College of Clinical Wound Specialists"},{"key":"10.1016\/j.chmed.2022.10.002_b0050","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopha.2017.07.019","article-title":"Dissolving microneedles for transdermal drug delivery: Advances and challenges","volume":"93","author":"Ita","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.chmed.2022.10.002_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics9030029","article-title":"Efficient transdermal delivery of alendronate, a nitrogen-containing bisphosphonate, using tip-loaded self-dissolving microneedle arrays for the treatment of osteoporosis","volume":"9","author":"Katsumi","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.chmed.2022.10.002_b0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejps.2014.12.008","article-title":"Modelling of dissolving microneedles for transdermal drug delivery: Theoretical and experimental aspects","volume":"68","author":"Kim","year":"2015","journal-title":"European Journal of Pharmaceutical Sciences"},{"issue":"11","key":"10.1016\/j.chmed.2022.10.002_b0065","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.jid.2017.06.029","article-title":"Inhibition of fkbp10 attenuates hypertrophic scarring through suppressing fibroblast activity and extracellular matrix deposition","volume":"137","author":"Liang","year":"2017","journal-title":"Journal of Investigative Dermatology"},{"issue":"22","key":"10.1016\/j.chmed.2022.10.002_b0070","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2174\/0929867324666170526124053","article-title":"Microneedle patches as drug and vaccine delivery platform","volume":"24","author":"Li","year":"2017","journal-title":"Current Medicinal Chemistry"},{"issue":"2","key":"10.1016\/j.chmed.2022.10.002_b0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejpb.2013.10.001","article-title":"Transdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skin","volume":"86","author":"Liu","year":"2014","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"12","key":"10.1016\/j.chmed.2022.10.002_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0144489","article-title":"Effect of P144\u00ae (anti-TGF-\u03b2) in an \u201cin vivo\u201d human hypertrophic scar model in nude mice","volume":"10","author":"Qiu","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.chmed.2022.10.002_b0085","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00109-016-1430-3","article-title":"Sorafenib exerts an anti-keloid activity by antagonizing tgf-\u03b2\/Smad and mapk\/erk signaling pathways","volume":"94","author":"Wang","year":"2016","journal-title":"Journal of Molecular Medicine"},{"issue":"10","key":"10.1016\/j.chmed.2022.10.002_b0090","first-page":"1","article-title":"Ly2109761 reduces tgf-\u03b21-induced collagen production and contraction in hypertrophic scar fibroblasts","volume":"310","author":"Wei","year":"2018","journal-title":"Archives of Dermatological Research"},{"issue":"3","key":"10.1016\/j.chmed.2022.10.002_b0095","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1248\/bpb.b14-00502","article-title":"Improvement of transdermal delivery of sumatriptan succinate using a novel self-dissolving microneedle array fabricated from sodium hyaluronate in rats","volume":"38","author":"Wu","year":"2015","journal-title":"Biological and Pharmaceutical Bulletin"},{"issue":"10","key":"10.1016\/j.chmed.2022.10.002_b0100","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1002\/ptr.7253","article-title":"Combination therapy of tanshinone IIA and puerain for pulmonary fibrosis via targeting IL6-JAK2-STAT3\/STAT1 signaling pathways","volume":"35","author":"Xue","year":"2021","journal-title":"Phytotherapy Research"},{"issue":"1","key":"10.1016\/j.chmed.2022.10.002_b0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/bjd.14108","article-title":"Baicalein attenuates hypertrophic scar formation via inhibiting tgf-\u03b2\/smad2\/3 signaling pathway","volume":"174","author":"Zhang","year":"2016","journal-title":"British Journal of Dermatology"},{"issue":"2","key":"10.1016\/j.chmed.2022.10.002_b0110","first-page":"1803","article-title":"MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1","volume":"15","author":"Zhang","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"5","key":"10.1016\/j.chmed.2022.10.002_b0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.matbio.2013.02.004","article-title":"Transdermal siRNA-TGF-\u03b21-337 patch for hypertrophic scar treatment","volume":"32","author":"Zhao","year":"2013","journal-title":"Matrix Biology"},{"key":"10.1016\/j.chmed.2022.10.002_b0120","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.actbio.2016.06.005","article-title":"Rapidly separating microneedles for transdermal drug delivery","volume":"41","author":"Zhu","year":"2016","journal-title":"Acta Biomaterialia"},{"issue":"2","key":"10.1016\/j.chmed.2022.10.002_b0125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/03008207.2017.1311327","article-title":"FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression","volume":"59","author":"Zuo","year":"2018","journal-title":"Connective Tissue Research"}],"container-title":["Chinese Herbal Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638423000023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638423000023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:29:36Z","timestamp":1761654576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1674638423000023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1674638423000023"],"URL":"https:\/\/doi.org\/10.1016\/j.chmed.2022.10.002","relation":{},"ISSN":["1674-6384"],"issn-type":[{"value":"1674-6384","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation of tanshinone IIA self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Chinese Herbal Medicines","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chmed.2022.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.","name":"copyright","label":"Copyright"}]}}