{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:58:18Z","timestamp":1778176698564,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2022H001"],"award-info":[{"award-number":["LH2022H001"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Herbal Medicines"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.chmed.2025.01.005","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T19:31:26Z","timestamp":1738006286000},"page":"167-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7\/ADR cells by inhibiting PDGFR\u03b2\/PI3K\/Akt pathway"],"prefix":"10.1016","volume":"18","author":[{"given":"Xiang","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuerui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.chmed.2025.01.005_b0005","doi-asserted-by":"crossref","first-page":"28563","DOI":"10.1021\/acsomega.3c02953","article-title":"Hypophyllanthin and phyllanthin from Phyllanthus niruri synergize doxorubicin anticancer properties against resistant breast cancer cells","volume":"8","author":"Abdel-Sattar","year":"2023","journal-title":"ACS Omega"},{"issue":"17","key":"10.1016\/j.chmed.2025.01.005_b0010","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.3390\/ijms22179644","article-title":"New advances in the research of resistance to neoadjuvant chemotherapy in breast cancer","volume":"22","author":"An","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13058-021-01387-x","article-title":"PDGFR\u03b2 is an essential therapeutic target for BRCA1-deficient mammary tumors","volume":"23","author":"Bai","year":"2021","journal-title":"Breast Cancer Research"},{"key":"10.1016\/j.chmed.2025.01.005_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115825","article-title":"Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFR\u03b2 signaling in cancer-associated fibroblasts","volume":"301","author":"Chen","year":"2023","journal-title":"Journal of Ethnopharmacology"},{"issue":"4","key":"10.1016\/j.chmed.2025.01.005_b0025","doi-asserted-by":"crossref","first-page":"244","DOI":"10.6061\/clinics\/2017(04)09","article-title":"Breast cancer screening in developing countries","volume":"72","author":"da Costa Vieira","year":"2017","journal-title":"Clinics"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0030","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1186\/s12885-018-4500-9","article-title":"The PDGFR\u03b2\/ERK1\/2 pathway regulates CDCP1 expression in triple-negative breast cancer","volume":"18","author":"Forte","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.chmed.2025.01.005_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110516","article-title":"ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells","volume":"379","author":"Gao","year":"2023","journal-title":"Chemico-Biological Interactions"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Molecular Cancer"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12943-022-01587-9","article-title":"Hsa-miR-3178\/RhoB\/PI3K\/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer","volume":"21","author":"Gu","year":"2022","journal-title":"Molecular Cancer"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jdermsci.2011.01.006","article-title":"Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status","volume":"62","author":"Hammerov\u00e1","year":"2011","journal-title":"Journal of Dermatological Science"},{"issue":"3","key":"10.1016\/j.chmed.2025.01.005_b0055","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.phymed.2016.01.001","article-title":"Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells","volume":"23","author":"Havelek","year":"2016","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.chmed.2025.01.005_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126913","article-title":"Design, synthesis and apoptosis-related antiproliferative activities of chelidonine derivatives","volume":"30","author":"Huang","year":"2020","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"13","key":"10.1016\/j.chmed.2025.01.005_b0065","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1200\/JCO.20.03399","article-title":"Neoadjuvant chemotherapy, endocrine therapy, and targeted therapy for breast cancer: ASCO guideline","volume":"39","author":"Korde","year":"2021","journal-title":"Journal of Clinical Oncology"},{"issue":"9","key":"10.1016\/j.chmed.2025.01.005_b0070","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/iub.2772","article-title":"Combined doxorubicin and arctigenin treatment induce cell cycle arrest-associated cell death by promoting doxorubicin uptake in doxorubicin-resistant breast cancer cells","volume":"75","author":"Lee","year":"2023","journal-title":"IUBMB Life"},{"key":"10.1016\/j.chmed.2025.01.005_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6318179","article-title":"Chelidonine induces caspase-dependent and caspase-independent cell death through G2\/m arrest in the T98G human glioblastoma cell line","volume":"2019","author":"Lee","year":"2019","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"3","key":"10.1016\/j.chmed.2025.01.005_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033379","article-title":"Activation of PI3K\/AKT and MAPK pathway through a PDGFR\u03b2-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chmed.2025.01.005_b0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cbi.2019.05.012","article-title":"In vitro and in vivo studies of the metabolic activation of chelidonine","volume":"308","author":"Liu","year":"2019","journal-title":"Chemico-Biological Interactions"},{"issue":"4","key":"10.1016\/j.chmed.2025.01.005_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.currproblcancer.2023.100996","article-title":"Gynecologic and breast cancers: what\u2019s new in chemoresistance and chemosensitivity tests?","volume":"47","author":"Marcolin","year":"2023","journal-title":"Current Problems in Cancer"},{"issue":"11","key":"10.1016\/j.chmed.2025.01.005_b0095","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/cmdc.202000131","article-title":"Antitumour anthracyclines: Progress and perspectives","volume":"15","author":"Martins-Teixeira","year":"2020","journal-title":"ChemMedChem"},{"issue":"2","key":"10.1016\/j.chmed.2025.01.005_b0100","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.drudis.2021.09.020","article-title":"Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects","volume":"27","author":"Mirzaei","year":"2022","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.chmed.2025.01.005_b0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cbi.2014.09.013","article-title":"Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line","volume":"223","author":"Noureini","year":"2014","journal-title":"Chemico-Biological Interactions"},{"issue":"29","key":"10.1016\/j.chmed.2025.01.005_b0110","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.3748\/wjg.15.3603","article-title":"Transcriptional down regulation of hTERT and senescence induction in HepG2 cells by chelidonine","volume":"15","author":"Noureini","year":"2009","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.chmed.2025.01.005_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114491","article-title":"New insights about the PDGF\/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies","volume":"161","author":"Pandey","year":"2023","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"9","key":"10.1016\/j.chmed.2025.01.005_b0120","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3736\/jcim20120912","article-title":"Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K\/AKT signalling pathways","volume":"10","author":"Paul","year":"2012","journal-title":"Journal of Chinese Integrative Medicine"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxlet.2013.07.006","article-title":"Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo","volume":"222","author":"Paul","year":"2013","journal-title":"Toxicology Letters"},{"issue":"2","key":"10.1016\/j.chmed.2025.01.005_b0130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.tiv.2007.08.023","article-title":"Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects","volume":"22","author":"Philchenkov","year":"2008","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.chmed.2025.01.005_b0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phrs.2018.01.021","article-title":"The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders","volume":"129","author":"Roskoski","year":"2018","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.chmed.2025.01.005_b0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/bs.acr.2022.01.003","article-title":"Diverse roles of tumor-stromal PDGFB-to-PDGFR\u03b2 signaling in breast cancer growth and metastasis","volume":"154","author":"Shah","year":"2022","journal-title":"Advances in Cancer Research"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0145","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.1016\/j.chmed.2025.01.005_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.783317","article-title":"Cajanol sensitizes A2780\/taxol cells to paclitaxel by inhibiting the PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"12","author":"Sui","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1139\/bcb-2021-0305","article-title":"PDGFR\u03b2 modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K\/AKT\/mTOR\/c-Myc pathway","volume":"100","author":"Tang","year":"2022","journal-title":"Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire"},{"key":"10.1016\/j.chmed.2025.01.005_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104934","article-title":"Chelidonine selectively inhibits the growth of gefitinib-resistant non-small cell lung cancer cells through the EGFR-AMPK pathway","volume":"159","author":"Xie","year":"2020","journal-title":"Pharmacological Research"},{"issue":"1","key":"10.1016\/j.chmed.2025.01.005_b0165","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2189118","article-title":"Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity","volume":"30","author":"Zhang","year":"2023","journal-title":"Drug Delivery"},{"issue":"17","key":"10.1016\/j.chmed.2025.01.005_b0170","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1002\/cam4.3284","article-title":"Gene signature-based prediction of triple-negative breast cancer patient response to Neoadjuvant chemotherapy","volume":"9","author":"Zhao","year":"2020","journal-title":"Cancer Medicine"},{"key":"10.1016\/j.chmed.2025.01.005_b0175","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ijbiomac.2022.01.113","article-title":"Targeting the PDGF\/PDGFR signaling pathway for cancer therapy: A review","volume":"202","author":"Zou","year":"2022","journal-title":"International Journal of Biological Macromolecules"}],"container-title":["Chinese Herbal Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638425000097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1674638425000097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T01:24:01Z","timestamp":1769649841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1674638425000097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1674638425000097"],"URL":"https:\/\/doi.org\/10.1016\/j.chmed.2025.01.005","relation":{},"ISSN":["1674-6384"],"issn-type":[{"value":"1674-6384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7\/ADR cells by inhibiting PDGFR\u03b2\/PI3K\/Akt pathway","name":"articletitle","label":"Article Title"},{"value":"Chinese Herbal Medicines","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chmed.2025.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.","name":"copyright","label":"Copyright"}]}}