{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:18:41Z","timestamp":1790738321016,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1964,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.chom.2008.02.003","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T06:53:06Z","timestamp":1221029586000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":161,"title":["Selective Killing of Nonreplicating Mycobacteria"],"prefix":"10.1016","volume":"3","author":[{"given":"Ruslana","family":"Bryk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Venugopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Samy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Pupek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gurney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Hotha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Converse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Ehrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Vandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuju","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2008.02.003_bib1","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1021\/bi010575o","article-title":"Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes","volume":"40","author":"Argyrou","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.chom.2008.02.003_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nrmicro1065","article-title":"Tuberculosis - metabolism and respiration in the absence of growth","volume":"3","author":"Boshoff","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2008.02.003_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35025109","article-title":"Peroxynitrite reductase activity of bacterial peroxiredoxins","volume":"407","author":"Bryk","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.chom.2008.02.003_bib4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.1067798","article-title":"Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein","volume":"295","author":"Bryk","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.02.003_bib5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.bjp.0707432","article-title":"Novel approaches to developing new antibiotics for bacterial infection","volume":"152","author":"Coates","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chom.2008.02.003_bib6","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1016\/j.bmcl.2005.05.034","article-title":"Rhodanine derivatives as inhibitors of JSP-1","volume":"15","author":"Cutshall","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.chom.2008.02.003_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.mib.2004.08.011","article-title":"Prospects for new antitubercular drugs","volume":"7","author":"Duncan","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2008.02.003_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nchembio706","article-title":"Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis","volume":"1","author":"Ferreras","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chom.2008.02.003_bib9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/jac\/dkl314","article-title":"In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms","volume":"58","author":"Gualtieri","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.chom.2008.02.003_bib10","unstructured":"Henderson, J., Ricker, R., Bidlingmeyer, B., and Woodward, C. (2000). Rapid, accurate,\u00a0sensitive and reproducible HPLC analysis of amino acids. In Application bulletin 5980\u20131193E (Palo Alto, CA: Agilent Technologies)."},{"key":"10.1016\/j.chom.2008.02.003_bib11","first-page":"1031","article-title":"The in vitro action of antituberculous agents against multiplying and non-multiplying microbial cells","volume":"76","author":"Hobby","year":"1957","journal-title":"Am. Rev. Tuberc."},{"key":"10.1016\/j.chom.2008.02.003_bib12","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.68.5.2888-2898.2000","article-title":"Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis","volume":"68","author":"Hondalus","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.02.003_bib13","first-page":"317","article-title":"Sterilizing action of pyrazinamide in models of dormant and rifampicin-tolerant Mycobacterium tuberculosis","volume":"10","author":"Hu","year":"2006","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.chom.2008.02.003_bib14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/clinchem\/37.5.728","article-title":"Quantifying intermediary metabolites in whole blood after a simple deproteinization step with sulfosalicylic acid","volume":"37","author":"Khan","year":"1991","journal-title":"Clin. Chem."},{"key":"10.1016\/j.chom.2008.02.003_bib15","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1021\/jm061257w","article-title":"Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase","volume":"50","author":"Kumar","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chom.2008.02.003_bib16","first-page":"S98","article-title":"Nitroxidative stres: The dominant process of reactive nitrogen species chemistry under biological conditions","volume":"37","author":"Lancaster","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrmicro1445","article-title":"Non-inherited antibiotic resistance","volume":"4","author":"Levin","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2008.02.003_bib18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nature03193","article-title":"Navigating chemical space for biology and medicine","volume":"432","author":"Lipinski","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.chom.2008.02.003_bib19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1088063","article-title":"Immune control of tuberculosis by IFN-gamma-inducible LRG-47","volume":"302","author":"MacMicking","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.02.003_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1084\/jem.123.3.445","article-title":"Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues","volume":"123","author":"McCune","year":"1966","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1471-4914(00)01901-8","article-title":"Disease model: Pulmonary tuberculosis","volume":"7","author":"McMurray","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib22","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nm1252","article-title":"Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence","volume":"11","author":"Munoz-Elias","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/IAI.73.1.546-551.2005","article-title":"Replication dynamics of Mycobacterium tuberculosis in chronically infected mice","volume":"73","author":"Munoz-Elias","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.02.003_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/431899a","article-title":"Antibiotics at the crossroads","volume":"431","author":"Nathan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.chom.2008.02.003_bib25","series-title":"Tuberculosis","first-page":"215","article-title":"Nitric oxide in tuberculosis","author":"Nathan","year":"2004"},{"key":"10.1016\/j.chom.2008.02.003_bib26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/jm050859x","article-title":"SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase","volume":"49","author":"Powers","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chom.2008.02.003_bib27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1073\/pnas.0406133102","article-title":"S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense","volume":"102","author":"Rhee","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.02.003_bib28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2567.2006.02355.x","article-title":"Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice","volume":"118","author":"Rogerson","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.chom.2008.02.003_bib29","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nm765","article-title":"A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis","volume":"8","author":"Sambandamurthy","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","article-title":"Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment","volume":"198","author":"Schnappinger","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1073\/pnas.0136863100","article-title":"Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence","volume":"100","author":"Shi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.02.003_bib32","doi-asserted-by":"crossref","first-page":"15629","DOI":"10.1073\/pnas.0507850102","article-title":"Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration","volume":"102","author":"Shi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.02.003_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1128\/IAI.74.1.56-63.2006","article-title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis","volume":"74","author":"Shi","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.02.003_bib34","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1021\/ja048017v","article-title":"Identification of inhibitors for UDP-galactopyranose mutase","volume":"126","author":"Soltero-Higgin","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chom.2008.02.003_bib35","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/35016103","article-title":"A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis","volume":"405","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.chom.2008.02.003_bib36","doi-asserted-by":"crossref","first-page":"10670","DOI":"10.1073\/pnas.0501605102","article-title":"Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of alpha-ketoglutarate decarboxylase","volume":"102","author":"Tian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.02.003_bib37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1365-2958.2005.04741.x","article-title":"Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes","volume":"57","author":"Tian","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2008.02.003_bib38","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1073\/pnas.2436197100","article-title":"Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients","volume":"100","author":"Timm","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.02.003_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1084\/jem.20030205","article-title":"Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program","volume":"198","author":"Voskuil","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.02.003_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrmicro727","article-title":"Where will new antibiotics come from?","volume":"1","author":"Walsh","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2008.02.003_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1128\/CMR.00060-05","article-title":"Tuberculosis chemotherapy: The influence of bacillary stress and damage response pathways on drug efficacy","volume":"19","author":"Warner","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2008.02.003_bib42","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/iai.64.6.2062-2069.1996","article-title":"An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence","volume":"64","author":"Wayne","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.02.003_bib43","unstructured":"World Health Organization. (2006). Tuberculosis: Infection and Transmission (http:\/\/www.who.int\/mediacentre\/factsheets\/fs104\/en\/)."},{"key":"10.1016\/j.chom.2008.02.003_bib44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev.pharmtox.45.120403.100120","article-title":"The magic bullets and tuberculosis drug targets","volume":"45","author":"Zhang","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.chom.2008.02.003_bib45","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1073\/pnas.100114897","article-title":"Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol\/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence","volume":"97","author":"Zhong","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:07:12Z","timestamp":1761826032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312808000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1931312808000541"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2008.02.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1103637.559725","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1103637.561287","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective Killing of Nonreplicating Mycobacteria","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2008.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}