{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:03:03Z","timestamp":1791295383945,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1811,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.chom.2008.07.002","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T07:23:39Z","timestamp":1218698619000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":161,"title":["The IL-8 Protease SpyCEP\/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing"],"prefix":"10.1016","volume":"4","author":[{"given":"Annelies S.","family":"Zinkernagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjuli M.","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan A.","family":"Pence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Locke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Mishalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiranee","family":"Sriskandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Hanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nizet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2008.07.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2007.03.002","article-title":"Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination","volume":"122","author":"Agnew","year":"2007","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.173.3.771","article-title":"Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1\/interleukin 8","volume":"173","author":"Bazzoni","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.07.002_bib3","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.07.002_bib4","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1128\/IAI.73.10.6935-6944.2005","article-title":"Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development","volume":"73","author":"Buchanan","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cub.2005.12.039","article-title":"DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps","volume":"16","author":"Buchanan","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2008.07.002_bib6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The\u00a0global burden of group A streptococcal diseases","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chom.2008.07.002_bib7","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/IAI.68.6.3523-3534.2000","article-title":"Genetic relatedness and superantigen expression in group A streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases","volume":"68","author":"Chatellier","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib8","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1126\/science.1132559","article-title":"ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.07.002_bib9","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1128\/iai.60.12.5219-5223.1992","article-title":"Streptococcal C5a peptidase is a highly specific endopeptidase","volume":"60","author":"Cleary","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib10","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1128\/IAI.66.11.5592-5597.1998","article-title":"A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion","volume":"66","author":"Cleary","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jama.1997.03540250046030","article-title":"An outbreak of invasive group A streptococcal disease associated with high carriage rates of the invasive clone among school-aged children","volume":"277","author":"Cockerill","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.chom.2008.07.002_bib12","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1086\/516376","article-title":"Molecular, serological, and clinical features of 16 consecutive cases of invasive streptococcal disease. Southeastern Minnesota Streptococcal Working Group","volume":"26","author":"Cockerill","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2008.07.002_bib13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1067\/mjd.2002.120536","article-title":"Fulminant group A streptococcal necrotizing fasciitis: clinical and pathologic findings in 7 patients","volume":"47","author":"Dahl","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.chom.2008.07.002_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.micpath.2006.01.005","article-title":"Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease","volume":"40","author":"Dalton","year":"2006","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.chom.2008.07.002_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1365-2958.2005.04583.x","article-title":"Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection","volume":"56","author":"Datta","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib16","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.167.7.4017","article-title":"Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1","volume":"167","author":"DiVietro","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.07.002_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1172\/JCI200317335","article-title":"Group B streptococcal \u03b2-hemolysin\/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis","volume":"112","author":"Doran","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chom.2008.07.002_bib18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1086\/432485","article-title":"Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes","volume":"192","author":"Edwards","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2008.07.002_bib19","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.071559398","article-title":"Complete genome sequence of an M1 strain of Streptococcus pyogenes","volume":"98","author":"Ferretti","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.07.002_bib20","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/IAI.69.4.1994-2000.2001","article-title":"Streptococcus iniae virulence is associated with a distinct genetic profile","volume":"69","author":"Fuller","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib21","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1128\/AEM.65.10.4346-4350.1999","article-title":"Cloning and analysis of the L-lactate utilization genes from Streptococcus iniae","volume":"65","author":"Gibello","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib22","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.humimm.2005.11.003","article-title":"Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia","volume":"66","author":"Gupta","year":"2005","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.chom.2008.07.002_bib23","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(04)15643-2","article-title":"Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections","volume":"363","author":"Hidalgo-Grass","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2008.07.002_bib24","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1038\/sj.emboj.7601327","article-title":"A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues","volume":"25","author":"Hidalgo-Grass","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2008.07.002_bib25","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1128\/JB.185.4.1208-1217.2003","article-title":"Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX","volume":"185","author":"Jeng","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chom.2008.07.002_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1128\/iai.64.2.503-510.1996","article-title":"C5a peptidase alters clearance and trafficking of group A streptococci by infected mice","volume":"64","author":"Ji","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/01902149109063278","article-title":"Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung","volume":"17","author":"Kunkel","year":"1991","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.chom.2008.07.002_bib28","first-page":"500","article-title":"Fournier's gangrene: ten-year experience in a medical center in northern Taiwan","volume":"40","author":"Kuo","year":"2007","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.chom.2008.07.002_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2217\/17460913.2.1.75","article-title":"How group A Streptococcus circumvents host phagocyte defenses","volume":"2","author":"Kwinn","year":"2007","journal-title":"Future Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib30","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1074\/jbc.M109173200","article-title":"Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass","volume":"277","author":"Lauth","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chom.2008.07.002_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3354\/dao076017","article-title":"Streptococcus iniae \u03b2-hemolysin streptolysin S is a virulence factor\u00a0in fish infection","volume":"76","author":"Locke","year":"2007","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.chom.2008.07.002_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)80422-5","article-title":"Transcytosis and surface presentation of IL-8 by venular endothelial cells","volume":"91","author":"Middleton","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.chom.2008.07.002_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jtbi.2006.11.009","article-title":"Control of Streptococcus pyogenes virulence: Modeling of the CovR\/S signal transduction system","volume":"246","author":"Mitrophanov","year":"2006","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.chom.2008.07.002_bib34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00006454-199903000-00009","article-title":"Emergence and spread of a new clone of M type 1 group A Streptococcus coincident with the increase in invasive diseases in Japan","volume":"18","author":"Murono","year":"1999","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.chom.2008.07.002_bib35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/35106587","article-title":"Innate antimicrobial peptide protects the skin from invasive bacterial infection","volume":"414","author":"Nizet","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.chom.2008.07.002_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1462-5822.2006.00768.x","article-title":"Adherence and internalization of Streptococcus gordonii by epithelial cells involves beta1 integrin recognition by SspA and SspB (antigen I\/II family) polypeptides","volume":"9","author":"Nobbs","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib37","first-page":"271","article-title":"Bacteriology of necrotizing fasciitis: a review of 58 cases","volume":"51","author":"Ou","year":"1993","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"issue":"Suppl.","key":"10.1016\/j.chom.2008.07.002_bib38","first-page":"44","article-title":"Promotion of fibronectin independent invasion by C5a peptidase into epithelial cells in group A\u00a0Streptococcus","volume":"119","author":"Purushothaman","year":"2004","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.chom.2008.07.002_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00024382-199702000-00002","article-title":"Studies on polymorphonuclear leukocyte bactericidal function: the role of exogenous cytokines","volume":"7","author":"Simms","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.chom.2008.07.002_bib40","first-page":"397","article-title":"Cytokine-induced neutrophil-derived interleukin-8","volume":"141","author":"Strieter","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2008.07.002_bib41","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1073\/pnas.0406641102","article-title":"Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response","volume":"102","author":"Sumby","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.07.002_bib42","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.ppat.0020005","article-title":"Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity","volume":"2","author":"Sumby","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2008.07.002_bib43","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1128\/IAI.01354-07","article-title":"A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response","volume":"76","author":"Sumby","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.07.002_bib44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1086\/520147","article-title":"Staging of the baboon response to group A streptococci administered intramuscularly: a descriptive study of the clinical symptoms and clinical chemical response patterns","volume":"29","author":"Taylor","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2008.07.002_bib45","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1096\/fasebj.2.11.2840318","article-title":"Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist","volume":"2","author":"Thelen","year":"1988","journal-title":"FASEB J."},{"key":"10.1016\/j.chom.2008.07.002_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2958.2006.05337.x","article-title":"Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence","volume":"62","author":"Timmer","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2008.07.002_bib47","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.4049\/jimmunol.173.2.1194","article-title":"Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense","volume":"173","author":"Voyich","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.07.002_bib48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0031-6997(24)01456-X","article-title":"Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature","volume":"52","author":"Wagner","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.chom.2008.07.002_bib49","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nm1612","article-title":"DNase Sda1 provides selection pressure for a switch to invasive group\u00a0A streptococcal infection","volume":"13","author":"Walker","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2008.07.002_bib50","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJM199708283370902","article-title":"Invasive infections due to a fish pathogen, Streptococcus iniae. S. iniae Study Group","volume":"337","author":"Weinstein","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chom.2008.07.002_bib51","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/iai.64.8.3407-3409.1996","article-title":"Interleukin-8 gene expression in\u00a0Staphylococcus aureus-infected endothelial cells","volume":"64","author":"Yao","year":"1996","journal-title":"Infect. Immun."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808002199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808002199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:08:06Z","timestamp":1761826086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312808002199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1931312808002199"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2008.07.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1121776.578849","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IL-8 Protease SpyCEP\/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2008.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}