{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:32:29Z","timestamp":1791293549765,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1750,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.chom.2008.09.004","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T04:35:34Z","timestamp":1224131734000},"page":"350-361","source":"Crossref","is-referenced-by-count":143,"title":["Toll-Like Receptor 6 Drives Differentiation of Tolerogenic Dendritic Cells and Contributes to LcrV-Mediated Plague Pathogenesis"],"prefix":"10.1016","volume":"4","author":[{"given":"R. William","family":"DePaolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"InYoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Ciletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anning","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Schneewind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bana","family":"Jabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2008.09.004_bib1","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1128\/JB.98.3.1404-1406.1969","article-title":"Mutation rate to nonpigmentation in Pasteurella pestis","volume":"98","author":"Brubaker","year":"1969","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chom.2008.09.004_bib2","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.71.7.3673-3681.2003","article-title":"Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen)","volume":"71","author":"Brubaker","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib3","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1128\/IAI.64.6.1906-1912.1996","article-title":"Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway","volume":"64","author":"Cleveland","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.200205077","article-title":"Yersinia type III secretion: send in the effectors","volume":"158","author":"Cornelis","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chom.2008.09.004_bib5","first-page":"156","article-title":"Pathology of experimental pneumonic plague produced by fraction 1-positive and fraction 1-negative Yersinia pestis in African green monkeys (Cercopithecus aethiops)","volume":"120","author":"Davis","year":"1996","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.chom.2008.09.004_bib6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1172\/JCI27203","article-title":"Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance","volume":"116","author":"Dillon","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chom.2008.09.004_bib7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1053\/j.gastro.2007.06.018","article-title":"Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein","volume":"133","author":"Foligne","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.chom.2008.09.004_bib8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.1135299","article-title":"Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling","volume":"314","author":"Gavin","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.09.004_bib9","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1097\/01.TP.0000067944.90241.BD","article-title":"Type 1 T-regulatory cells: their role in the control of immune responses","volume":"75","author":"Groux","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.chom.2008.09.004_bib10","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.molimm.2008.02.010","article-title":"Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells","volume":"45","author":"Hirata","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib11","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.09.004_bib12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ni1207","article-title":"CD14 is required for MyD88-independent LPS signaling","volume":"6","author":"Jiang","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0167-5699(99)01547-9","article-title":"T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal","volume":"20","author":"Kalinski","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.chom.2008.09.004_bib14","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.178.5.2661","article-title":"Cutting edge: Regulatory T\u00a0cells prevent efficient clearance of Mycobacterium tuberculosis","volume":"178","author":"Kursar","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib15","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.178.8.5271","article-title":"Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release","volume":"178","author":"Li","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib16","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.1114580","article-title":"Plague bacteria target immune cells during infection","volume":"309","author":"Marketon","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.09.004_bib17","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ni1386","article-title":"Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response","volume":"7","author":"Montminy","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib19","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/IAI.63.8.3021-3029.1995","article-title":"Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization","volume":"63","author":"Nakajima","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1574-695X.2007.00353.x","article-title":"Role of TLR1 and TLR6 in the host defense against disseminated candidiasis","volume":"52","author":"Netea","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.chom.2008.09.004_bib21","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1128\/IAI.73.8.5152-5159.2005","article-title":"LcrV plague vaccine with altered immunomodulatory properties","volume":"73","author":"Overheim","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.MIB.0000195389.11645.ab","article-title":"Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases","volume":"12","author":"Pierik","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.chom.2008.09.004_bib24","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/IAI.01644-06","article-title":"Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis","volume":"75","author":"Pouliot","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1126\/science.1062060","article-title":"Sensing pathogens and tuning immune responses","volume":"293","author":"Pulendran","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.chom.2008.09.004_bib26","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1128\/IAI.00105-08","article-title":"Yersinia pestis caf1 variants and the limits of plague vaccine protection","volume":"76","author":"Quenee","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2008.09.004_bib27","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.4049\/jimmunol.173.12.7548","article-title":"IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells","volume":"173","author":"Re","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib28","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.micinf.2007.04.003","article-title":"The weak interaction of LcrV and TLR2 does not contribute to the virulence of Yersinia pestis","volume":"9","author":"Reithmeier-Rost","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1016\/j.chom.2008.09.004_bib29","doi-asserted-by":"crossref","first-page":"G829","DOI":"10.1152\/ajpgi.2000.278.6.G829","article-title":"Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(\u2212\/\u2212) mice and intestinal inflammation","volume":"278","author":"Rennick","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.chom.2008.09.004_bib30","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.174.2.1097","article-title":"Lipoprotein I, a TLR2\/4 ligand modulates Th2-driven allergic immune responses","volume":"174","author":"Revets","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1084\/jem.20020908","article-title":"Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression","volume":"196","author":"Sing","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chom.2008.09.004_bib32","doi-asserted-by":"crossref","first-page":"16049","DOI":"10.1073\/pnas.0504728102","article-title":"A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence","volume":"102","author":"Sing","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2008.09.004_bib33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1179\/096805102125001073","article-title":"Recognition of lipopeptides by Toll-like receptors","volume":"8","author":"Takeda","year":"2002","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.chom.2008.09.004_bib34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib35","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/intimm\/13.7.933","article-title":"Discrimination of bacterial lipoproteins by Toll-like receptor 6","volume":"13","author":"Takeuchi","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.chom.2008.09.004_bib36","doi-asserted-by":"crossref","first-page":"31002","DOI":"10.1074\/jbc.M602794200","article-title":"Membrane sorting of toll-like receptor (TLR)-2\/6 and TLR2\/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting","volume":"281","author":"Triantafilou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chom.2008.09.004_bib37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/JB.180.2.350-358.1998","article-title":"YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops","volume":"180","author":"Williams","year":"1998","journal-title":"J. Bacteriol."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808002989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312808002989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:00:19Z","timestamp":1589000419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312808002989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1931312808002989"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2008.09.004","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}