{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:29:37Z","timestamp":1791300577676,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1513,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.chom.2009.05.008","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T04:16:52Z","timestamp":1244175412000},"page":"54-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":330,"title":["Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists"],"prefix":"10.1016","volume":"6","author":[{"given":"Fengwen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmina C.","family":"Landford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Virgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Munch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kirchhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Bieniasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Hatziioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2009.05.008_bib1","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1128\/JVI.79.6.3627-3638.2005","article-title":"Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production","volume":"79","author":"Abada","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib2","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1128\/JVI.73.7.5814-5825.1999","article-title":"Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1","volume":"73","author":"Alexander","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib3","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.ppat.0020107","article-title":"Quantitative membrane proteomics reveals new cellular targets of viral immune modulators","volume":"2","author":"Bartee","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2009.05.008_bib4","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1128\/jvi.70.12.8285-8300.1996","article-title":"The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses","volume":"70","author":"Bour","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/jvi.70.2.820-829.1996","article-title":"The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?","volume":"70","author":"Bour","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/34929","article-title":"HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T\u00a0lymphocytes","volume":"391","author":"Collins","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.chom.2009.05.008_bib7","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1128\/JVI.76.16.8298-8309.2002","article-title":"Characterization of a novel simian immunodeficiency virus with a vpu gene from greater spot-nosed monkeys (Cercopithecus nictitans) provides new insights into simian\/human immunodeficiency virus phylogeny","volume":"76","author":"Courgnaud","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/350508a0","article-title":"Serine phosphorylation-independent downregulation of cell-surface CD4 by nef","volume":"350","author":"Garcia","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.chom.2009.05.008_bib9","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1128\/JVI.02211-08","article-title":"Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin","volume":"83","author":"Jouvenet","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib10","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1073\/pnas.0811014106","article-title":"Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein","volume":"106","author":"Kaletsky","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2009.05.008_bib11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.2160735","article-title":"Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus","volume":"248","author":"Kestler","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.chom.2009.05.008_bib12","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1128\/JVI.73.10.8371-8383.1999","article-title":"The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in\u00a0vivo","volume":"73","author":"Kirchhoff","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib13","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s00018-008-8094-2","article-title":"Role of Nef in primate lentiviral immunopathogenesis","volume":"65","author":"Kirchhoff","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chom.2009.05.008_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0960-9822(99)80284-X","article-title":"Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner","volume":"9","author":"Lama","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2009.05.008_bib15","doi-asserted-by":"crossref","first-page":"e1000300","DOI":"10.1371\/journal.ppat.1000300","article-title":"Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants","volume":"5","author":"McNatt","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2009.05.008_bib16","doi-asserted-by":"crossref","first-page":"10547","DOI":"10.1128\/JVI.79.16.10547-10560.2005","article-title":"Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication","volume":"79","author":"Munch","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib17","doi-asserted-by":"crossref","first-page":"13852","DOI":"10.1128\/JVI.00904-07","article-title":"Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses","volume":"81","author":"Munch","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib18","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1371\/journal.ppat.0020039","article-title":"HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane","volume":"2","author":"Neil","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2009.05.008_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chom.2007.08.001","article-title":"An Interferon-alpha-Induced Tethering Mechanism Inhibits HIV-1 and Ebola Virus Particle Release but Is Counteracted by the HIV-1 Vpu Protein","volume":"2","author":"Neil","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2009.05.008_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature06553","article-title":"Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu","volume":"451","author":"Neil","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chom.2009.05.008_bib21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1128\/MMBR.00042-05","article-title":"Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways","volume":"70","author":"Roeth","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.chom.2009.05.008_bib22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0960-9822(99)80283-8","article-title":"Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein","volume":"9","author":"Ross","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2009.05.008_bib23","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/JVI.01607-08","article-title":"Inhibition of Lassa and Marburg virus production by tetherin","volume":"83","author":"Sakuma","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib24","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1128\/JVI.78.19.10588-10597.2004","article-title":"Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques","volume":"78","author":"Schindler","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.05.008_bib25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cell.2006.04.033","article-title":"Nef-mediated suppression of T\u00a0cell activation was lost in a lentiviral lineage that gave rise to HIV-1","volume":"125","author":"Schindler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.chom.2009.05.008_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nm0396-338","article-title":"Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein","volume":"2","author":"Schwartz","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2009.05.008_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/viro.2001.1244","article-title":"Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques","volume":"293","author":"Stephens","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.chom.2009.05.008_bib28","doi-asserted-by":"crossref","first-page":"12144","DOI":"10.1073\/pnas.221256498","article-title":"HIV-1 Nef impairs MHC class II antigen presentation and surface expression","volume":"98","author":"Stumptner-Cuvelette","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2009.05.008_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chom.2008.03.001","article-title":"The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein","volume":"3","author":"Van Damme","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2009.05.008_bib30","doi-asserted-by":"crossref","first-page":"15154","DOI":"10.1073\/pnas.2433165100","article-title":"Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production","volume":"100","author":"Varthakavi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2009.05.008_bib31","doi-asserted-by":"crossref","first-page":"20031","DOI":"10.1073\/pnas.0708002104","article-title":"Ubiquitin-dependent virus particle budding without viral protein ubiquitination","volume":"104","author":"Zhadina","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312809001759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312809001759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:09:19Z","timestamp":1761826159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312809001759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1931312809001759"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2009.05.008","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2009.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}