{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:15:41Z","timestamp":1761826541792,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1482,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.chom.2009.07.003","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T04:29:38Z","timestamp":1250742578000},"page":"162-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection"],"prefix":"10.1016","volume":"6","author":[{"given":"Rekha G.","family":"Panchal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Bradfute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Peyser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly L.","family":"Warfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Ruthel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara A.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur O.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Raschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2009.07.003_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/smim.2000.0218","article-title":"The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function","volume":"12","author":"Alexander","year":"2000","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib2","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.exphem.2007.08.006","article-title":"Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model","volume":"35","author":"Alici","year":"2007","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.chom.2009.07.003_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2004.05.018","article-title":"Protein tyrosine phosphatases in the human genome","volume":"117","author":"Alonso","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.chom.2009.07.003_bib4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0035-9203(78)90058-5","article-title":"Ebola haemorrhagic fever: experimental infection of monkeys","volume":"72","author":"Bowen","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"Suppl 2","key":"10.1016\/j.chom.2009.07.003_bib5","doi-asserted-by":"crossref","first-page":"S296","DOI":"10.1086\/520602","article-title":"Lymphocyte death in a mouse model of Ebola virus infection","volume":"196","author":"Bradfute","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2009.07.003_bib6","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.4049\/jimmunol.180.6.4058","article-title":"Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection","volume":"180","author":"Bradfute","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/515386","article-title":"A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever","volume":"178","author":"Bray","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2009.07.003_bib8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.183.4.1707","article-title":"CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation","volume":"183","author":"Byth","year":"1996","journal-title":"J. Exp. Med."},{"issue":"Suppl 1","key":"10.1016\/j.chom.2009.07.003_bib9","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1086\/514305","article-title":"Pathogenesis of experimental Ebola virus infection in guinea pigs","volume":"179","author":"Connolly","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2009.07.003_bib10","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib11","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1002\/j.1460-2075.1994.tb06716.x","article-title":"The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation","volume":"13","author":"Desai","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2009.07.003_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bioinformatics\/btl567","article-title":"Using GOstats to test gene lists for GO term association","volume":"23","author":"Falcon","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2009.07.003_bib13","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2009.07.003_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/jcpa.2001.0502","article-title":"Pathogenesis of experimental Ebola Zaire virus infection in BALB\/c mice","volume":"125","author":"Gibb","year":"2001","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.chom.2009.07.003_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.immunol.21.120601.140946","article-title":"CD45: a critical regulator of signaling thresholds in immune cells","volume":"21","author":"Hermiston","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.molmed.2006.03.006","article-title":"Ebola virus: unravelling pathogenesis to combat a deadly disease","volume":"12","author":"Hoenen","year":"2006","journal-title":"Trends Mol. Med."},{"issue":"Suppl 2","key":"10.1016\/j.chom.2009.07.003_bib17","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.1086\/520611","article-title":"Cytokine and chemokine expression in humans infected with Sudan Ebola virus","volume":"196","author":"Hutchinson","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2009.07.003_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/35053086","article-title":"CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling","volume":"409","author":"Irie-Sasaki","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.chom.2009.07.003_bib19","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1002\/sim.1548","article-title":"On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles","volume":"22","author":"Kendziorski","year":"2003","journal-title":"Stat. Med."},{"key":"10.1016\/j.chom.2009.07.003_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/JVI.80.1.62-72.2006","article-title":"Anti-CD45RO Suppresses Human Immunodeficiency Virus Type 1 Replication in Microglia: Role of Hck Tyrosine Kinase and Implications for AIDS Dementia","volume":"80","author":"Kim","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.chom.2009.07.003_bib21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4049\/jimmunol.180.2.754","article-title":"Accumulation of effector CD4 T\u00a0cells during type 2 immune responses is negatively regulated by Stat6","volume":"180","author":"King","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2007.07.015","article-title":"The Differential Regulation of Lck Kinase Phosphorylation Sites by CD45 Is Critical for T Cell Receptor Signaling Responses","volume":"27","author":"McNeill","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2009.07.003_bib23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/jcm.13.4.791-793.1981","article-title":"Plaque assay for Ebola virus","volume":"13","author":"Moe","year":"1981","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.chom.2009.07.003_bib24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/156652409787581628","article-title":"Potential Factors Induced by Filoviruses that Lead to Immune Supression","volume":"9","author":"Mohamadzadeh","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.chom.2009.07.003_bib25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1089\/vim.2006.19.602","article-title":"Filoviruses and the balance of innate, adaptive, and inflammatory responses","volume":"19","author":"Mohamadzadeh","year":"2006","journal-title":"Viral Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2098","article-title":"How Ebola and Marburg viruses battle the immune system","volume":"7","author":"Mohamadzadeh","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib27","doi-asserted-by":"crossref","first-page":"12874","DOI":"10.1074\/jbc.M809633200","article-title":"Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis","volume":"284","author":"Panchal","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chom.2009.07.003_bib28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0960-9822(06)00188-6","article-title":"CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion","volume":"7","author":"Roach","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2009.07.003_bib29","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/BF01718165","article-title":"Ebola virus infection in guinea pigs: presumable role of granulomatous inflammation in pathogenesis","volume":"141","author":"Ryabchikova","year":"1996","journal-title":"Arch. Virol."},{"key":"10.1016\/j.chom.2009.07.003_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.iy.07.040189.002011","article-title":"The leukocyte common antigen family","volume":"7","author":"Thomas","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib31","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0167-5699(99)01506-6","article-title":"Positive and negative regulation of Src-family membrane kinases by CD45","volume":"20","author":"Thomas","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.chom.2009.07.003_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-2478(02)00236-5","article-title":"Regulation of T\u00a0cell migration during viral infection: role of adhesion molecules and chemokines","volume":"85","author":"Thomsen","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.chom.2009.07.003_bib33","doi-asserted-by":"crossref","first-page":"e1000212","DOI":"10.1371\/journal.ppat.1000212","article-title":"Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda","volume":"4","author":"Towner","year":"2008","journal-title":"PLoS Pathog."},{"issue":"Suppl 1","key":"10.1016\/j.chom.2009.07.003_bib34","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1086\/514283","article-title":"Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection","volume":"179","author":"Villinger","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.chom.2009.07.003_bib35","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1182\/blood-2002-07-1969","article-title":"A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency","volume":"101","author":"Virts","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.chom.2009.07.003_bib36","doi-asserted-by":"crossref","first-page":"19913","DOI":"10.1074\/jbc.M100448200","article-title":"The role of intron sequences in high level expression from CD45 cDNA constructs","volume":"276","author":"Virts","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chom.2009.07.003_bib37","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.4049\/jimmunol.158.7.3205","article-title":"Alterations in the level of CD45 surface expression affect the outcome of thymic selection","volume":"158","author":"Wallace","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib38","first-page":"9016","article-title":"In vivo antitumor activity of interleukin 21 mediated by natural killer cells","volume":"63","author":"Wang","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.chom.2009.07.003_bib39","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.234.9.1130","article-title":"Filovirus infections","volume":"234","author":"Warfield","year":"2009","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.chom.2009.07.003_bib40","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.4049\/jimmunol.175.2.1184","article-title":"Induction of humoral and CD8+ T\u00a0cell responses are required for protection against lethal Ebola virus infection","volume":"175","author":"Warfield","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2009.07.003_bib41","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.ppat.0020001","article-title":"Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers","volume":"2","author":"Warfield","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2009.07.003_bib42","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression Arrays","volume":"99","author":"Wu","year":"2004","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.chom.2009.07.003_bib43","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1161\/CIRCULATIONAHA.106.649244","article-title":"Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes","volume":"114","author":"Yang","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.chom.2009.07.003_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.immuni.2007.08.009","article-title":"Why is there so much CD45 on T\u00a0cells?","volume":"27","author":"Zamoyska","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2009.07.003_bib45","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4049\/jimmunol.167.3.1379","article-title":"Antibody-independent antiviral function of memory CD4+ T\u00a0cells in\u00a0vivo requires regulatory signals from CD8+ effector T\u00a0cells","volume":"167","author":"Zhong","year":"2001","journal-title":"J. Immunol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312809002480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312809002480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:09:42Z","timestamp":1761826182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312809002480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S1931312809002480"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2009.07.003","relation":{},"ISSN":["1931-3128"],"issn-type":[{"type":"print","value":"1931-3128"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2009.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}