{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:42:32Z","timestamp":1791322952077,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":777,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.chom.2011.05.005","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T19:37:52Z","timestamp":1308685072000},"page":"508-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["ATP-Mediated Erk1\/2 Activation Stimulates Bacterial Capture by Filopodia, which Precedes Shigella Invasion of Epithelial Cells"],"prefix":"10.1016","volume":"9","author":[{"given":"St\u00e9phane","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Grompone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Carayol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Mounier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Guadagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Prevost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe\u00a0J.","family":"Sansonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Tran\u00a0Van\u00a0Nhieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2011.05.005_bib1","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0021-9258(17)35894-5","article-title":"Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP","volume":"261","author":"Carlier","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2011.05.005_bib2","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.yexcr.2007.12.021","article-title":"Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells","volume":"314","author":"Clair","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chom.2011.05.005_bib3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","article-title":"Bacterial invasion: the paradigms of enteroinvasive pathogens","volume":"304","author":"Cossart","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2011.05.005_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ceb.2005.11.002","article-title":"The making of filopodia","volume":"18","author":"Faix","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nature05272","article-title":"Protein delivery into eukaryotic cells by type III secretion machines","volume":"444","author":"Gal\u00e1n","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.chom.2011.05.005_bib6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/art.20781","article-title":"Effects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: a randomized clinical trial","volume":"52","author":"Garg","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.chom.2011.05.005_bib7","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1126\/science.1056490","article-title":"Filopodial calcium transients promote substrate-dependent growth cone turning","volume":"291","author":"Gomez","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.chom.2011.05.005_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/glia.20738","article-title":"Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA","volume":"57","author":"Gorina","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.chom.2011.05.005_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.2008.170464","article-title":"Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease","volume":"59","author":"Guttman","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.chom.2011.05.005_bib10","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.1674624","article-title":"Discrimination between intracellular uptake and surface adhesion of bacterial pathogens","volume":"252","author":"Isberg","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.chom.2011.05.005_bib11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cub.2009.03.067","article-title":"A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level","volume":"19","author":"Kerber","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib13","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1093\/emboj\/cdf457","article-title":"Initial steps of Shigella infection depend on the cholesterol\/sphingolipid raft-mediated CD44-IpaB interaction","volume":"21","author":"Lafont","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2011.05.005_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroscience.2006.03.074","article-title":"Activation of Src\/kinase\/phospholipase C\/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor","volume":"141","author":"Lakshmi","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.chom.2011.05.005_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1083\/jcb.200503059","article-title":"Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells","volume":"170","author":"Lehmann","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib16","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1091\/mbc.e02-10-0656","article-title":"Localization of a class III myosin to filopodia tips in transfected HeLa cells requires an actin-binding site in its tail domain","volume":"14","author":"Les Erickson","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2011.05.005_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1242\/dev.011437","article-title":"Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos","volume":"135","author":"Liu","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.chom.2011.05.005_bib18","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1182\/blood.V95.7.2407","article-title":"Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase","volume":"95","author":"Mansfield","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.chom.2011.05.005_bib19","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1128\/MCB.24.12.5269-5280.2004","article-title":"Erk\/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP","volume":"24","author":"Martinez-Quiles","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/iai.49.1.164-171.1985","article-title":"Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri","volume":"49","author":"Maurelli","year":"1985","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2011.05.005_bib21","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","article-title":"Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells","volume":"175","author":"M\u00e9nard","year":"1993","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2011.05.005_bib22","doi-asserted-by":"crossref","first-page":"e1000138","DOI":"10.1371\/journal.pbio.1000138","article-title":"Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)","volume":"7","author":"Menna","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1128\/iai.65.2.774-782.1997","article-title":"Secretion of Shigella flexneri Ipa invasins on contact with epithelial cells and subsequent entry of the bacterium into cells are growth stage dependent","volume":"65","author":"Mounier","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2011.05.005_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/jb\/mvm034","article-title":"Effect of WAVE2 phosphorylation on activation of the Arp2\/3 complex","volume":"141","author":"Nakanishi","year":"2007","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.chom.2011.05.005_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrmicro1814","article-title":"The versatility of Shigella effectors","volume":"6","author":"Ogawa","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2011.05.005_bib26","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/glia.20489","article-title":"Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis","volume":"55","author":"Ohsawa","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.chom.2011.05.005_bib27","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.1059975","article-title":"Mechanism of actin-based motility","volume":"292","author":"Pantaloni","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.chom.2011.05.005_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2958.1995.tb02301.x","article-title":"Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures","volume":"16","author":"Parsot","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2011.05.005_bib29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.icb7100025","article-title":"Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?","volume":"85","author":"Phalipon","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(03)00156-9","article-title":"Communication by touch: role of cellular extensions in complex animals","volume":"112","author":"R\u00f8rth","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.chom.2011.05.005_bib31","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"Saez","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chom.2011.05.005_bib32","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1128\/MCB.26.9.3432-3445.2006","article-title":"Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins","volume":"26","author":"Scott","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ceb.2005.08.004","article-title":"The comings and goings of actin: coupling protrusion and retraction in cell motility","volume":"17","author":"Small","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0014-5793(03)00856-1","article-title":"Rapidly maturing red fluorescent protein variants with strongly enhanced brightness in bacteria","volume":"552","author":"S\u00f6rensen","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.chom.2011.05.005_bib35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncb1682","article-title":"Membrane nanotubes physically connect T\u00a0cells over long distances presenting a novel route for HIV-1 transmission","volume":"10","author":"Sowinski","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib36","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/glia.20429","article-title":"Functional connexin \u201chemichannels\u201d: a critical appraisal","volume":"54","author":"Spray","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.chom.2011.05.005_bib37","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1210\/jc.2003-032111","article-title":"Adenosine 5\u2032-triphosphate activates nuclear translocation of mitogen-activated protein kinases leading to the induction of early growth response 1 and raf expression in human granulosa-luteal cells","volume":"89","author":"Tai","year":"2004","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chom.2011.05.005_bib38","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/emboj\/16.10.2717","article-title":"Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin","volume":"16","author":"Tran Van Nhieu","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2011.05.005_bib39","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/ncb1021","article-title":"Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells","volume":"5","author":"Tran Van Nhieu","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2011.05.005_bib40","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/sj.onc.1210415","article-title":"MAP kinases and the control of nuclear events","volume":"26","author":"Turjanski","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.chom.2011.05.005_bib41","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/j.1365-2958.2007.05620.x","article-title":"The type III secretion system needle tip complex mediates host cell sensing and translocon insertion","volume":"63","author":"Veenendaal","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2011.05.005_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00249-006-0118-y","article-title":"Micromechanics of filopodia mediated capture of pathogens by macrophages","volume":"36","author":"Vonna","year":"2007","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.chom.2011.05.005_bib43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.185.2.281","article-title":"rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells","volume":"185","author":"Watarai","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2011.05.005_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1515\/BC.2002.076","article-title":"Structural and functional diversity of connexin genes in the mouse and human genome","volume":"383","author":"Willecke","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.chom.2011.05.005_bib45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1083\/jcb.116.1.197","article-title":"The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton","volume":"116","author":"Young","year":"1992","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312811001697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312811001697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:10:48Z","timestamp":1761826248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312811001697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1931312811001697"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2011.05.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11649956.12714054","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP-Mediated Erk1\/2 Activation Stimulates Bacterial Capture by Filopodia, which Precedes Shigella Invasion of Epithelial Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2011.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}