{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:35:51Z","timestamp":1791200151329,"version":"4.2.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":685,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.chom.2011.08.004","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T10:51:53Z","timestamp":1316083913000},"page":"185-196","source":"Crossref","is-referenced-by-count":110,"title":["TRIM79\u03b1, an Interferon-Stimulated Gene Product, Restricts Tick-Borne Encephalitis Virus Replication by Degrading the Viral RNA Polymerase"],"prefix":"10.1016","volume":"10","author":[{"given":"R.\u00a0Travis","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk\u00a0J.","family":"Lubick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly\u00a0J.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0P.","family":"Broughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall\u00a0E.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade\u00a0A.","family":"Bresnahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja\u00a0M.","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2011.08.004_bib1","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1128\/JVI.02188-08","article-title":"NS5 of dengue virus mediates STAT2 binding and degradation","volume":"83","author":"Ashour","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.virusres.2008.12.001","article-title":"Vertical transmission of tick-borne encephalitis virus between generations of adapted reservoir small rodents","volume":"140","author":"Bakhvalova","year":"2009","journal-title":"Virus Res."},{"key":"10.1016\/j.chom.2011.08.004_bib3","doi-asserted-by":"crossref","first-page":"e1000007","DOI":"10.1371\/journal.ppat.1000007","article-title":"The interferon response inhibits HIV particle production by induction of TRIM22","volume":"4","author":"Barr","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2011.08.004_bib4","doi-asserted-by":"crossref","first-page":"12828","DOI":"10.1128\/JVI.79.20.12828-12839.2005","article-title":"Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist","volume":"79","author":"Best","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature09489","article-title":"2\u2032-O methylation of the viral mRNA cap evades host restriction by IFIT family members","volume":"468","author":"Daffis","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chom.2011.08.004_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-3527(09)74002-3","article-title":"Chapter 2. New insights into flavivirus nonstructural protein 5","volume":"74","author":"Davidson","year":"2009","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.chom.2011.08.004_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/jir.2009.0069","article-title":"Mechanisms of evasion of the type I interferon antiviral response by flaviviruses","volume":"29","author":"Diamond","year":"2009","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.chom.2011.08.004_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.virol.2005.12.040","article-title":"Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5","volume":"349","author":"Diaz-Griffero","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.chom.2011.08.004_bib9","doi-asserted-by":"crossref","first-page":"10362","DOI":"10.1128\/JVI.00703-07","article-title":"Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain","volume":"81","author":"Diaz-Griffero","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-ento-112408-085446","article-title":"Update on Powassan virus: emergence of a North American tick-borne flavivirus","volume":"55","author":"Ebel","year":"2010","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.chom.2011.08.004_bib11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1099\/vir.0.006288-0","article-title":"TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus","volume":"90","author":"Eldin","year":"2009","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.chom.2009.04.001","article-title":"Pathogenesis of flavivirus infections: using and abusing the host cell","volume":"5","author":"Fernandez-Garcia","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2011.08.004_bib13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2009.04.006","article-title":"Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I","volume":"5","author":"Gack","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2011.08.004_bib14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/hep.23011","article-title":"Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain","volume":"50","author":"Gao","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.chom.2011.08.004_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(08)60238-X","article-title":"Pathogenic flaviviruses","volume":"371","author":"Gould","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2011.08.004_bib16","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1099\/vir.0.83125-0","article-title":"West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein","volume":"88","author":"Hoenen","year":"2007","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00251-009-0358-y","article-title":"Molecular evolution of the antiretroviral TRIM5 gene","volume":"61","author":"Johnson","year":"2009","journal-title":"Immunogenetics"},{"key":"10.1016\/j.chom.2011.08.004_bib18","doi-asserted-by":"crossref","first-page":"19100","DOI":"10.1074\/jbc.270.32.19100","article-title":"Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5","volume":"270","author":"Kapoor","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2011.08.004_bib19","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses","volume":"203","author":"Kumar","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2011.08.004_bib20","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1128\/JVI.01161-09","article-title":"The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling","volume":"84","author":"Laurent-Rolle","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib21","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1523\/JNEUROSCI.4474-04.2005","article-title":"Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation","volume":"25","author":"Lim","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chom.2011.08.004_bib22","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1128\/JVI.02714-05","article-title":"Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism","volume":"80","author":"Lin","year":"2006","journal-title":"J.\u00a0Virol."},{"issue":"12, Suppl","key":"10.1016\/j.chom.2011.08.004_bib23","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","article-title":"Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses","volume":"10","author":"Mackenzie","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2011.08.004_bib24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.virol.2010.01.003","article-title":"Contribution of RING domain to retrovirus restriction by TRIM5alpha depends on combination of host and virus","volume":"399","author":"Maegawa","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.chom.2011.08.004_bib25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/605847","article-title":"Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation","volume":"200","author":"Mazzon","year":"2009","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2011.08.004_bib26","doi-asserted-by":"crossref","first-page":"11053","DOI":"10.1128\/JVI.79.17.11053-11061.2005","article-title":"Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion","volume":"79","author":"Medin","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib27","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nrmicro1248","article-title":"TRIM family proteins: retroviral restriction and antiviral defence","volume":"3","author":"Nisole","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2011.08.004_bib28","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1128\/JVI.00176-10","article-title":"Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles","volume":"84","author":"Overby","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2011.08.004_bib30","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1073\/pnas.142287799","article-title":"Positional cloning of the murine flavivirus resistance gene","volume":"99","author":"Perelygin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2011.08.004_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/eji.200737916","article-title":"Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells","volume":"38","author":"Rajsbaum","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2011.08.004_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12026-008-8065-6","article-title":"Tick-borne flaviviruses: dissecting host immune responses and virus countermeasures","volume":"43","author":"Robertson","year":"2009","journal-title":"Immunol. Res."},{"key":"10.1016\/j.chom.2011.08.004_bib33","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.0409853102","article-title":"Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain","volume":"102","author":"Sawyer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2011.08.004_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2011.08.004_bib35","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1002\/pmic.201000196","article-title":"The proteome of lysosomes","volume":"10","author":"Schr\u00f6der","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.chom.2011.08.004_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1577","article-title":"TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation","volume":"9","author":"Shi","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2011.08.004_bib37","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys","volume":"427","author":"Stremlau","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.chom.2011.08.004_bib38","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1073\/pnas.0509996103","article-title":"Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor","volume":"103","author":"Stremlau","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2011.08.004_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.virol.2010.09.018","article-title":"Human Trim5\u03b1 has additional activities that are uncoupled from retroviral capsid recognition","volume":"409","author":"Tareen","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.chom.2011.08.004_bib40","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1038\/emboj.2008.241","article-title":"Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1","volume":"27","author":"Terenzi","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2011.08.004_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-4690-4-40","article-title":"The control of viral infection by tripartite motif proteins and cyclophilin A","volume":"4","author":"Towers","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.chom.2011.08.004_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.ento.54.110807.090510","article-title":"Ecology and geographical expansion of Japanese encephalitis virus","volume":"54","author":"van den Hurk","year":"2009","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.chom.2011.08.004_bib43","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1128\/JVI.02546-10","article-title":"TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection","volume":"85","author":"Wang","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2011.08.004_bib44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1462-5822.2007.01076.x","article-title":"Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling","volume":"10","author":"Werme","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2011.08.004_bib45","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1073\/pnas.0510483103","article-title":"Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131281100254X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193131281100254X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T22:20:49Z","timestamp":1543530049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193131281100254X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S193131281100254X"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2011.08.004","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13441969.14816065","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}