{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:25Z","timestamp":1791295525761,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":472,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.chom.2012.03.001","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T02:46:55Z","timestamp":1334803615000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Shigella Targets Epithelial Tricellular Junctions and Uses a Noncanonical Clathrin-Dependent Endocytic Pathway to Spread Between Cells"],"prefix":"10.1016","volume":"11","author":[{"given":"Makoto","family":"Fukumatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinaga","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeomi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Mimuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Sasakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2012.03.001_bib1","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1073\/pnas.0803711105","article-title":"Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.03.001_bib2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/29555","article-title":"Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis","volume":"394","author":"Chen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.03.001_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.cub.2011.05.048","article-title":"Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis","volume":"21","author":"Collins","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ceb.2010.05.009","article-title":"Converging views of endocytosis in yeast and mammals","volume":"22","author":"Conibear","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1046\/j.1398-9219.2003.0142.x","article-title":"AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin","volume":"4","author":"Conner","year":"2003","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2012.03.001_bib6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","article-title":"Bacterial invasion: the paradigms of enteroinvasive pathogens","volume":"304","author":"Cossart","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.03.001_bib7","doi-asserted-by":"crossref","first-page":"e1001127","DOI":"10.1371\/journal.ppat.1001127","article-title":"The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis","volume":"6","author":"Cureton","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2012.03.001_bib8","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1073\/pnas.0811253106","article-title":"Endocytosis is required for E-cadherin redistribution at mature adherens junctions","volume":"106","author":"de Beco","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.03.001_bib9","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1074\/jbc.275.9.6479","article-title":"Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites","volume":"275","author":"Drake","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2012.03.001_bib10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.coph.2009.06.022","article-title":"The tight junction in inflammatory disease: communication breakdown","volume":"9","author":"Edelblum","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.chom.2012.03.001_bib11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.devcel.2009.11.005","article-title":"Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits","volume":"17","author":"Ferguson","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature01020","article-title":"Curvature of clathrin-coated pits driven by epsin","volume":"419","author":"Ford","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.03.001_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1083\/jcb.200510043","article-title":"Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells","volume":"171","author":"Ikenouchi","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib14","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1091\/mbc.e08-05-0530","article-title":"Loss of occludin affects tricellular localization of tricellulin","volume":"19","author":"Ikenouchi","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib15","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.291.5506.1047","article-title":"Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis","volume":"291","author":"Itoh","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.03.001_bib16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bies.20203","article-title":"Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers","volume":"27","author":"Ivanov","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.chom.2012.03.001_bib17","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1091\/mbc.e06-05-0421","article-title":"A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors","volume":"17","author":"Keyel","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1749-6632.2009.04025.x","article-title":"Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions","volume":"1165","author":"Koch","year":"2009","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.chom.2012.03.001_bib19","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1091\/mbc.e09-01-0080","article-title":"Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability","volume":"20","author":"Krug","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib20","first-page":"219","article-title":"Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics","volume":"146","author":"Le","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/jcs.02855","article-title":"Regulation of membrane traffic by phosphoinositide 3-kinases","volume":"119","author":"Lindmo","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chom.2012.03.001_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF01868675","article-title":"Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions","volume":"116","author":"Madara","year":"1990","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2005.03.015","article-title":"Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells","volume":"121","author":"Merrifield","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1083\/jcb.200305145","article-title":"Clathrin-mediated endocytosis in AP-2-depleted cells","volume":"162","author":"Motley","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature08455","article-title":"Discovery of Atg5\/Atg7-independent alternative macroautophagy","volume":"461","author":"Nishida","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.03.001_bib27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1046\/j.1365-2958.2003.03489.x","article-title":"IcsB, secreted via the type III secretion system, is chaperoned by IpgA and required at the post-invasion stage of Shigella pathogenicity","volume":"48","author":"Ogawa","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2012.03.001_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrmicro1814","article-title":"The versatility of Shigella effectors","volume":"6","author":"Ogawa","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2012.03.001_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.200605012","article-title":"Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells","volume":"175","author":"Otani","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib30","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1371\/journal.ppat.0020003","article-title":"Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion","volume":"2","author":"Pentecost","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2012.03.001_bib31","doi-asserted-by":"crossref","first-page":"e1000900","DOI":"10.1371\/journal.ppat.1000900","article-title":"Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion","volume":"6","author":"Pentecost","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2012.03.001_bib32","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/bies.200900172","article-title":"Clathrin-mediated endocytosis: what works for small, also works for big","volume":"32","author":"Pizarro-Cerd\u00e1","year":"2010","journal-title":"Bioessays"},{"key":"10.1016\/j.chom.2012.03.001_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/416451a","article-title":"A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins","volume":"416","author":"Polo","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.03.001_bib34","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ncb1964","article-title":"The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria","volume":"11","author":"Rajabian","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib35","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1242\/jcs.113.19.3375","article-title":"Myosin light chain kinase plays an essential role in S. flexneri dissemination","volume":"113","author":"Rathman","year":"2000","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chom.2012.03.001_bib36","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1021\/jm000493i","article-title":"Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides","volume":"44","author":"Rong","year":"2001","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chom.2012.03.001_bib37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0092-8674(94)90358-1","article-title":"Cadherin expression is required for the spread of Shigella flexneri between epithelial cells","volume":"76","author":"Sansonetti","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.200711165","article-title":"The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state","volume":"181","author":"Shen","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11064-008-9780-z","article-title":"The expression of tumor necrosis factor-alpha (TNF-alpha) by the intrathecal injection of lipopolysaccharide in the rat spinal cord","volume":"34","author":"Shen","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.chom.2012.03.001_bib40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-physiol-012110-142150","article-title":"Tight junction pore and leak pathways: a dynamic duo","volume":"73","author":"Shen","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chom.2012.03.001_bib41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ncb790","article-title":"Epsins and Vps27p\/Hrs contain ubiquitin-binding domains that function in receptor endocytosis","volume":"4","author":"Shih","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tcb.2009.12.002","article-title":"Dynamics and functions of tight junctions","volume":"20","author":"Steed","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib43","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1083\/jcb.109.4.1597","article-title":"Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes","volume":"109","author":"Tilney","year":"1989","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib44","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/ncb1021","article-title":"Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells","volume":"5","author":"Tran Van Nhieu","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib45","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1091\/mbc.e06-03-0190","article-title":"Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly","volume":"17","author":"Troyanovsky","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2012.03.001_bib46","first-page":"484987","article-title":"Endocytosis and recycling of tight junction proteins in inflammation","volume":"2010","author":"Utech","year":"2010","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.chom.2012.03.001_bib47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2144\/000112265","article-title":"Selective blocking of clathrin-mediated endocytosis by RNA interference: epsin as target protein","volume":"41","author":"Vanden Broeck","year":"2006","journal-title":"Biotechniques"},{"key":"10.1016\/j.chom.2012.03.001_bib48","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/ncb1292","article-title":"Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells","volume":"7","author":"Veiga","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.200107069","article-title":"Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation","volume":"155","author":"Vieira","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2012.03.001_bib50","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00018-010-0313-y","article-title":"Tricellulin forms homomeric and heteromeric tight junctional complexes","volume":"67","author":"Westphal","year":"2010","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312812000935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312812000935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:11:40Z","timestamp":1761826300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312812000935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1931312812000935"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2012.03.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717985994.793472241","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shigella Targets Epithelial Tricellular Junctions and Uses a Noncanonical Clathrin-Dependent Endocytic Pathway to Spread Between Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2012.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}