{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:14:55Z","timestamp":1791321295516,"version":"4.3.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":411,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.chom.2012.04.017","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T12:54:20Z","timestamp":1339592060000},"page":"617-630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Plasmacytoid Dendritic Cells Are Productively Infected and Activated through TLR-7 Early after Arenavirus Infection"],"prefix":"10.1016","volume":"11","author":[{"given":"M\u00f3nica","family":"Macal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin\u00a0M.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Flavell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0A.","family":"Harker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina\u00a0I.","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2012.04.017_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"Ahmed","year":"1984","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib2","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.4049\/jimmunol.172.5.2861","article-title":"Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells","volume":"172","author":"Baize","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.04.017_bib4","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1067\/mob.2002.126297","article-title":"Lymphocytic choriomeningitis virus: emerging fetal teratogen","volume":"187","author":"Barton","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.chom.2012.04.017_bib5","doi-asserted-by":"crossref","first-page":"21641","DOI":"10.1073\/pnas.1011998107","article-title":"Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression","volume":"107","author":"Bergthaler","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib6","first-page":"7","article-title":"Innate immune responses to LCMV infections: natural killer cells and cytokines","volume":"263","author":"Biron","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib7","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1128\/jvi.69.2.1059-1070.1995","article-title":"Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression","volume":"69","author":"Borrow","year":"1995","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib8","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1073\/pnas.1117359109","article-title":"Plasmacytoid dendritic cells control T-cell response to chronic viral infection","volume":"109","author":"Cervantes-Barragan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1073\/pnas.94.2.634","article-title":"Interferon-alpha\/beta inhibition of interleukin 12 and interferon-gamma production in\u00a0vitro and endogenously during viral infection","volume":"94","author":"Cousens","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.20011672","article-title":"Interferon alpha\/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in\u00a0vivo","volume":"195","author":"Dalod","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.20021522","article-title":"Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha\/beta","volume":"197","author":"Dalod","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib12","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.1073\/pnas.89.20.9939","article-title":"Selective disruption of growth hormone transcription machinery by viral infection","volume":"89","author":"de la Torre","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature01783","article-title":"Viral infection switches nonplasmacytoid dendritic cells into high interferon producers","volume":"424","author":"Diebold","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.04.017_bib14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4049\/jimmunol.121.4.1262","article-title":"Interactions between viruses and lymphocytes. I. In\u00a0vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections","volume":"121","author":"Doyle","year":"1978","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in\u00a0vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.04.017_bib16","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.0900088106","article-title":"Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest","volume":"106","author":"Emonet","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1189\/jlb.0909635","article-title":"Plasmacytoid dendritic cells in HIV infection: striking a delicate balance","volume":"87","author":"Fitzgerald-Bocarsly","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.chom.2012.04.017_bib18","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in detente","volume":"312","author":"Garcia-Sastre","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.04.017_bib19","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1038\/nm1142","article-title":"Exotic emerging viral diseases: progress and challenges","volume":"10","author":"Geisbert","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.1208421","article-title":"Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection","volume":"334","author":"Harker","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.04.017_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm1191","article-title":"Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7","volume":"11","author":"Hornung","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ni1207","article-title":"CD14 is required for MyD88-independent LPS signaling","volume":"6","author":"Jiang","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/JVI.01640-07","article-title":"Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88","volume":"82","author":"Jung","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2004.06.007","article-title":"TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function","volume":"21","author":"Krug","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2012.04.017_bib25","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.4049\/jimmunol.0804315","article-title":"Cutting Edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells","volume":"182","author":"Kumagai","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib26","doi-asserted-by":"crossref","first-page":"14282","DOI":"10.1128\/JVI.79.22.14282-14296.2005","article-title":"Post-translational modification of alpha-dystroglycan, the cellular receptor for arenaviruses by the glycosyltransferase LARGE is critical for virus binding","volume":"79","author":"Kunz","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib27","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.4049\/jimmunol.0802526","article-title":"Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice","volume":"182","author":"Lee","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib28","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.4049\/jimmunol.177.5.3266","article-title":"Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection","volume":"177","author":"Louten","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib29","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib30","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1128\/JVI.00555-06","article-title":"Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus","volume":"80","author":"Martinez-Sobrido","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib31","doi-asserted-by":"crossref","first-page":"12696","DOI":"10.1128\/JVI.00882-07","article-title":"Differential inhibition of type I interferon induction by arenavirus nucleoproteins","volume":"81","author":"Martinez-Sobrido","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib32","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1128\/jvi.67.12.7340-7349.1993","article-title":"Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus","volume":"67","author":"Matloubian","year":"1993","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib33","first-page":"75","article-title":"Lassa fever","volume":"262","author":"McCormick","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib34","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.4049\/jimmunol.160.9.4298","article-title":"Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development","volume":"160","author":"McRae","year":"1998","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib35","first-page":"139","article-title":"Arenaviruses: genomic RNAs, transcription, and replication","volume":"262","author":"Meyer","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib36","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1371\/journal.pone.0000458","article-title":"Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells","volume":"2","author":"Meyers","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.chom.2012.04.017_bib37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature00837","article-title":"Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies","volume":"418","author":"Michele","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2012.04.017_bib38","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510260337","article-title":"Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients","volume":"26","author":"Missale","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.chom.2012.04.017_bib39","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.174.4.1851","article-title":"Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN","volume":"174","author":"Montoya","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib40","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.1073\/pnas.0702579104","article-title":"Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection","volume":"104","author":"Mueller","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib41","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"Muller","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.chom.2012.04.017_bib42","first-page":"V","article-title":"Arenaviruses. I. The epidemiology molecular and cell biology of arenaviruses. Introduction","volume":"262","author":"Oldstone","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni0407-325","article-title":"A suspenseful game of \u2018hide and seek\u2019 between virus and host","volume":"8","author":"Oldstone","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib44","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1128\/JVI.02120-10","article-title":"Human dendritic cells infected with the nonpathogenic Mopeia virus induce stronger T-cell responses than those infected with Lassa virus","volume":"85","author":"Pannetier","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib45","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1056\/NEJMp068021","article-title":"Lymphocytic choriomeningitis virus\u2014an old enemy up to new tricks","volume":"354","author":"Peters","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2012.04.017_bib46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-031210-101345","article-title":"Plasmacytoid dendritic cells: recent progress and open questions","volume":"29","author":"Reizis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib47","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.4049\/jimmunol.0902522","article-title":"Dendritic cell inhibition is connected to exhaustion of CD8+ T\u00a0cell polyfunctionality during chronic hepatitis C virus infection","volume":"184","author":"Rodrigue-Gervais","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1462-5822.2007.01113.x","article-title":"Cell entry by human pathogenic arenaviruses","volume":"10","author":"Rojek","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2012.04.017_bib49","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1128\/JVI.00560-08","article-title":"Different mechanisms of cell entry by human-pathogenic Old World and New World arenaviruses","volume":"82","author":"Rojek","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib50","doi-asserted-by":"crossref","first-page":"20416","DOI":"10.1073\/pnas.0808537105","article-title":"Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in\u00a0vivo","volume":"105","author":"Scheu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib51","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.4049\/jimmunol.176.5.2888","article-title":"TLR7\/8 triggering exerts opposing effects in acute versus latent HIV infection","volume":"176","author":"Schlaepfer","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib52","first-page":"125","article-title":"Infection of dendritic cells by lymphocytic choriomeningitis virus","volume":"276","author":"Sevilla","year":"2003","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1440-1711.2000.00901.x","article-title":"Burnet oration: dendritic cells: multiple subtypes, multiple origins, multiple functions","volume":"78","author":"Shortman","year":"2000","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.chom.2012.04.017_bib54","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1073\/pnas.1019304108","article-title":"Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence","volume":"108","author":"Sullivan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib55","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.0105-2896.2009.00881.x","article-title":"Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance","volume":"234","author":"Swiecki","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chom.2012.04.017_bib56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.coviro.2011.10.026","article-title":"Type I interferons: diversity of sources, production pathways and effects on immune responses","volume":"1","author":"Swiecki","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib57","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2010.11.020","article-title":"Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T\u00a0cell accrual","volume":"33","author":"Swiecki","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2012.04.017_bib58","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1073\/pnas.1002301107","article-title":"Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection","volume":"107","author":"Takahashi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2012.04.017_bib59","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"Thompson","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.chom.2012.04.017_bib60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hep.21048","article-title":"Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection","volume":"43","author":"Untergasser","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.chom.2012.04.017_bib61","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1128\/jvi.69.8.4792-4796.1995","article-title":"Antiviral defense in mice lacking both alpha\/beta and gamma interferon receptors","volume":"69","author":"van den Broek","year":"1995","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib62","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.immuni.2008.09.002","article-title":"Antigen-presentation properties of plasmacytoid dendritic cells","volume":"29","author":"Villadangos","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2012.04.017_bib63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.chom.2012.04.016","article-title":"Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection","volume":"11","author":"Walsh","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2012.04.017_bib64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.chom.2012.05.003","article-title":"Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T\u00a0cell exhaustion and chronic viral infection","volume":"11","author":"Wang","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2012.04.017_bib65","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4049\/jimmunol.1003166","article-title":"Type I IFN substitutes for T\u00a0cell help during viral infections","volume":"186","author":"Wiesel","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib66","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/eji.200425730","article-title":"MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection","volume":"35","author":"Zhou","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib67","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1128\/JVI.00155-10","article-title":"Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus","volume":"84","author":"Zhou","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2012.04.017_bib68","first-page":"1","article-title":"Lymphocytic choriomeningitis virus and immunology","volume":"263","author":"Zinkernagel","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/intimm\/dxm119","article-title":"Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection","volume":"20","author":"Zucchini","year":"2008","journal-title":"Int. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib70","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/ni1136","article-title":"Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection","volume":"5","author":"Zuniga","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2012.04.017_bib71","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2008.08.016","article-title":"Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections","volume":"4","author":"Zuniga","year":"2008","journal-title":"Cell Host Microbe"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312812001643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312812001643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:12:07Z","timestamp":1761826327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312812001643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1931312812001643"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2012.04.017","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasmacytoid Dendritic Cells Are Productively Infected and Activated through TLR-7 Early after Arenavirus Infection","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2012.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2012.04.016","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2012.05.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}