{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:34Z","timestamp":1791295354175,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":373,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.chom.2014.03.001","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T16:21:13Z","timestamp":1397060473000},"page":"435-445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["IcsA Is a Shigella flexneri Adhesin Regulated by the Type III Secretion System and Required for Pathogenesis"],"prefix":"10.1016","volume":"15","author":[{"given":"Anna","family":"Brotcke\u00a0Zumsteg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Goosmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Morona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Zychlinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2014.03.001_bib1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jmb.2007.12.034","article-title":"Single residue determines the specificity of neutrophil elastase for Shigella virulence factors","volume":"377","author":"Averhoff","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2014.03.001_bib2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1046\/j.1365-2958.1996.d01-1718.x","article-title":"Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression","volume":"22","author":"Bajaj","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib3","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.3201\/eid1611.090934","article-title":"Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia","volume":"16","author":"Bardhan","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2014.03.001_bib4","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/prot.23251","article-title":"Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure","volume":"80","author":"Barta","year":"2012","journal-title":"Proteins"},{"key":"10.1016\/j.chom.2014.03.001_bib5","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.86.10.3867","article-title":"Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin","volume":"86","author":"Bernardini","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.03.001_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.147.3.683","article-title":"The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes","volume":"147","author":"Blocker","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2014.03.001_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1586\/erv.12.135","article-title":"Recent progress towards development of a Shigella vaccine","volume":"12","author":"Camacho","year":"2013","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.chom.2014.03.001_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chom.2014.01.005","article-title":"A Fluorescent Reporter Reveals On\/Off Regulation of the Shigella Type III Secretion Apparatus during Entry and Cell-to-Cell Spread","volume":"15","author":"Campbell-Valois","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2014.03.001_bib9","doi-asserted-by":"crossref","first-page":"e1003245","DOI":"10.1371\/journal.ppat.1003245","article-title":"The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles","volume":"9","author":"Demers","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.03.001_bib10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/bi101365f","article-title":"Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion","volume":"50","author":"Dickenson","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.chom.2014.03.001_bib11","doi-asserted-by":"crossref","first-page":"e1003881","DOI":"10.1371\/journal.ppat.1003881","article-title":"A substrate-fusion protein is trapped inside the Type III Secretion System channel in Shigella flexneri","volume":"10","author":"Dohlich","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.03.001_bib12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","article-title":"Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2\/3 complex and bacterial actin-based motility","volume":"146","author":"Egile","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2014.03.001_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-59745-204-5_21","article-title":"Fungal and bacterial killing by neutrophils","volume":"470","author":"Ermert","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2014.03.001_bib14","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1128\/IAI.00440-06","article-title":"IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri","volume":"74","author":"Espina","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2958.2012.08092.x","article-title":"Shigella flexneri effectors OspE1 and OspE2 mediate induced adherence to the colonic epithelium following bile salts exposure","volume":"85","author":"Faherty","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib16","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1128\/jb.177.7.1719-1726.1995","article-title":"Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading","volume":"177","author":"Fukuda","year":"1995","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib17","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1073\/pnas.92.14.6572","article-title":"Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility","volume":"92","author":"Goldberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.03.001_bib18","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1128\/jb.175.8.2189-2196.1993","article-title":"Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement","volume":"175","author":"Goldberg","year":"1993","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib19","first-page":"210","article-title":"Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement","volume":"2","author":"Goldberg","year":"1993","journal-title":"Infect. Agents Dis."},{"key":"10.1016\/j.chom.2014.03.001_bib20","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/IAI.62.12.5664-5668.1994","article-title":"Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent","volume":"62","author":"Goldberg","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib21","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1128\/IAI.65.12.5165-5170.1997","article-title":"The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages","volume":"65","author":"Hilbi","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2958.1997.3731744.x","article-title":"Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance","volume":"24","author":"Hong","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sj.emboj.7601976","article-title":"Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella","volume":"27","author":"Jaumouill\u00e9","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2014.03.001_bib24","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1128\/JB.184.16.4409-4419.2002","article-title":"MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system","volume":"184","author":"Kane","year":"2002","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.chom.2009.05.011","article-title":"Bacterial adhesins in host-microbe interactions","volume":"5","author":"Kline","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2014.03.001_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2958.1995.mmi_18030413.x","article-title":"The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively","volume":"18","author":"Kocks","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib27","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"Kotloff","year":"1999","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.chom.2014.03.001_bib28","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1128\/IAI.70.4.2016-2021.2002","article-title":"Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults","volume":"70","author":"Kotloff","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib29","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1099\/mic.0.27639-0","article-title":"Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri","volume":"151","author":"Le Gall","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.chom.2014.03.001_bib30","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0092-8674(86)90880-9","article-title":"A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a","volume":"46","author":"Makino","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.chom.2014.03.001_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature08970","article-title":"Modulation of Shigella virulence in response to available oxygen in\u00a0vivo","volume":"465","author":"Marteyn","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chom.2014.03.001_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4161\/gmic.19325","article-title":"Shigella: a model of virulence regulation in\u00a0vivo","volume":"3","author":"Marteyn","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.chom.2014.03.001_bib33","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1046\/j.1365-2958.2002.02836.x","article-title":"Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus","volume":"43","author":"Mavris","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib34","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1128\/JB.00093-08","article-title":"Mutagenesis of the Shigella flexneri autotransporter IcsA reveals novel functional regions involved in IcsA biogenesis and recruitment of host neural Wiscott-Aldrich syndrome protein","volume":"190","author":"May","year":"2008","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib35","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","article-title":"Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells","volume":"175","author":"M\u00e9nard","year":"1993","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib36","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1002\/j.1460-2075.1994.tb06863.x","article-title":"The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD","volume":"13","author":"M\u00e9nard","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2014.03.001_bib37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1074\/jbc.M509644200","article-title":"Shigella Spa33 is an essential C-ring component of type III secretion machinery","volume":"281","author":"Morita-Ishihara","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2014.03.001_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-1097(03)00210-6","article-title":"Lipopolysaccharide O antigen chains mask IcsA (VirG) in Shigella flexneri","volume":"221","author":"Morona","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.chom.2014.03.001_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1462-5822.2000.00065.x","article-title":"The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri","volume":"2","author":"Moss","year":"2000","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1106036","article-title":"Escape of intracellular Shigella from autophagy","volume":"307","author":"Ogawa","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.03.001_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2958.1991.tb01839.x","article-title":"Virulence-associated chromosomal loci of Shigella flexneri identified by random Tn5 insertion mutagenesis","volume":"5","author":"Okada","year":"1991","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib42","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1128\/IAI.01599-06","article-title":"Bile salts stimulate recruitment of IpaB to the Shigella flexneri surface, where it colocalizes with IpaD at the tip of the type III secretion needle","volume":"75","author":"Olive","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.femsle.2005.08.046","article-title":"Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors","volume":"252","author":"Parsot","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.chom.2014.03.001_bib44","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/j.1365-2958.2005.04645.x","article-title":"A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri","volume":"56","author":"Parsot","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib45","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.180.4.1307","article-title":"Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis","volume":"180","author":"Perdomo","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2014.03.001_bib46","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1128\/IAI.63.9.3642-3648.1995","article-title":"Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts","volume":"63","author":"Pope","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib47","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.vaccine.2010.10.035","article-title":"Safety, dose, immunogenicity, and transmissibility of an oral live attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy adults and school children in Matlab, Bangladesh","volume":"29","author":"Rahman","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2014.03.001_bib48","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2958.1990.tb00635.x","article-title":"The cytotoxic protein YopE of Yersinia obstructs the primary host defence","volume":"4","author":"Rosqvist","year":"1990","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1128\/IAI.63.1.229-237.1995","article-title":"Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane","volume":"63","author":"Sandlin","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.001_bib50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbagen.2006.10.007","article-title":"IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus","volume":"1770","author":"Sani","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chom.2014.03.001_bib51","first-page":"351","article-title":"Plasmid-mediated invasiveness of \u201cShigella-like\u201d Escherichia coli","volume":"133","author":"Sansonetti","year":"1982","journal-title":"Ann. Microbiol. (Paris)"},{"key":"10.1016\/j.chom.2014.03.001_bib52","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0264-410X(91)90128-S","article-title":"OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis","volume":"9","author":"Sansonetti","year":"1991","journal-title":"Vaccine"},{"key":"10.1016\/j.chom.2014.03.001_bib53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0580-9517(02)31020-1","article-title":"Studying trafficking of intracellular pathogens in antigen-presenting cells","volume":"31","author":"Schaible","year":"2002","journal-title":"Method Microbiol"},{"key":"10.1016\/j.chom.2014.03.001_bib54","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1365-2958.1997.4681827.x","article-title":"Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility","volume":"25","author":"Shere","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2958.1999.01356.x","article-title":"The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surface","volume":"32","author":"Steinhauer","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib56","doi-asserted-by":"crossref","first-page":"18646","DOI":"10.1074\/jbc.M802799200","article-title":"Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip","volume":"283","author":"Stensrud","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2014.03.001_bib57","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1365-2958.1993.tb01644.x","article-title":"Regulation by Ca2+ in the Yersinia low-Ca2+ response","volume":"8","author":"Straley","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib58","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1074\/jbc.271.36.21878","article-title":"Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility","volume":"271","author":"Suzuki","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2014.03.001_bib59","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/emboj\/17.10.2767","article-title":"Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri","volume":"17","author":"Suzuki","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2014.03.001_bib60","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/JB.184.5.1244-1252.2002","article-title":"Shigella Spa32 is an essential secretory protein for functional type III secretion machinery and uniformity of its needle length","volume":"184","author":"Tamano","year":"2002","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2014.03.001_bib61","doi-asserted-by":"crossref","first-page":"e70508","DOI":"10.1371\/journal.pone.0070508","article-title":"LPS unmasking of Shigella flexneri reveals preferential localisation of tagged outer membrane protease IcsP to septa and new poles","volume":"8","author":"Tran","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.chom.2014.03.001_bib62","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1365-2958.1997.2541625.x","article-title":"Regulation of O-antigen chain length is required for Shigella flexneri virulence","volume":"23","author":"Van den Bosch","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.001_bib63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/417091a","article-title":"Neutrophil elastase targets virulence factors of enterobacteria","volume":"417","author":"Weinrauch","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2014.03.001_bib64","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1108472","article-title":"Optimization of virulence functions through glucosylation of Shigella LPS","volume":"307","author":"West","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.03.001_bib65","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2958.1994.tb00341.x","article-title":"IpaB mediates macrophage apoptosis induced by Shigella flexneri","volume":"11","author":"Zychlinsky","year":"1994","journal-title":"Mol. Microbiol."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814001000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814001000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T10:20:34Z","timestamp":1597659634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312814001000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1931312814001000"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2014.03.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718346712.793494305","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IcsA Is a Shigella flexneri Adhesin Regulated by the Type III Secretion System and Required for Pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2014.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}