{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:28:58Z","timestamp":1791206938776,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":373,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.chom.2014.03.005","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T16:21:35Z","timestamp":1397060495000},"page":"424-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["The Pla Protease of Yersinia pestis Degrades Fas Ligand to Manipulate Host Cell Death and Inflammation"],"prefix":"10.1016","volume":"15","author":[{"given":"Adam\u00a0J.","family":"Caulfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret\u00a0E.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay\u00a0M.","family":"Gielda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyndham\u00a0W.","family":"Lathem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2014.03.005_bib1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1086\/378675","article-title":"Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fc\u03b3 receptors correlates with intracellular bacterial load","volume":"188","author":"Ali","year":"2003","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2014.03.005_bib2","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1371\/journal.ppat.0030161","article-title":"Macrophage activation redirects Yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis","volume":"3","author":"Bergsbaken","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.03.005_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4614-3561-7_32","article-title":"Substrates of the plasminogen activator protease of Yersinia pestis","volume":"954","author":"Caulfield","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.chom.2014.03.005_bib4","doi-asserted-by":"crossref","first-page":"e1002814","DOI":"10.1371\/journal.ppat.1002814","article-title":"Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection","volume":"8","author":"Daigneault","year":"2012","journal-title":"PLoS Pathog."},{"issue":"Suppl 1","key":"10.1016\/j.chom.2014.03.005_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1538-7836.2007.02519.x","article-title":"Fibrin and fibrinolysis in infection and host defense","volume":"5","author":"Degen","year":"2007","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.chom.2014.03.005_bib6","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.4049\/jimmunol.171.10.5380","article-title":"Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection","volume":"171","author":"Dockrell","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.03.005_bib7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.cdd.4400594","article-title":"Caspase inhibitors","volume":"6","author":"Ekert","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chom.2014.03.005_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.290.5491.527","article-title":"CD95\/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa","volume":"290","author":"Grassm\u00e9","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.03.005_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1165\/ajrcmb.21.3.3397","article-title":"Induction of interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by Fas ligation","volume":"21","author":"Hagimoto","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.chom.2014.03.005_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1165\/ajrcmb.19.4.3100","article-title":"Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium","volume":"19","author":"Hamann","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.chom.2014.03.005_bib11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.191.7.1209","article-title":"Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival","volume":"191","author":"Hohlbaum","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2014.03.005_bib12","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/IAI.01417-12","article-title":"RfaL is required for Yersinia pestis type III secretion and virulence","volume":"81","author":"Houppert","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.005_bib13","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1128\/IAI.70.5.2591-2597.2002","article-title":"Enhanced disease severity in Helicobacter pylori-infected\u00a0mice deficient in Fas signaling","volume":"70","author":"Jones","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.005_bib14","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/ajrccm.163.3.2003065","article-title":"Fas\/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice","volume":"163","author":"Kitamura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chom.2014.03.005_bib15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1046\/j.1365-2958.2001.02451.x","article-title":"Protein regions important for plasminogen activation and inactivation of \u03b12-antiplasmin in the surface protease Pla of Yersinia pestis","volume":"40","author":"Kukkonen","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2014.03.005_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/cdd.2008.91","article-title":"Cell death in the host response to infection","volume":"15","author":"Labb\u00e9","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chom.2014.03.005_bib17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.chom.2012.10.020","article-title":"The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing","volume":"12","author":"LaRock","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2014.03.005_bib18","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1073\/pnas.0506840102","article-title":"Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity","volume":"102","author":"Lathem","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.03.005_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.1137195","article-title":"A plasminogen-activating protease specifically controls the development of primary pneumonic plague","volume":"315","author":"Lathem","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.03.005_bib20","doi-asserted-by":"crossref","first-page":"e01038-13","DOI":"10.1128\/mBio.01038-13","article-title":"Posttranscriptional regulation of the Yersinia pestis cAMP receptor protein Crp and impact on virulence","volume":"5","author":"Lathem","year":"2014","journal-title":"mBio."},{"key":"10.1016\/j.chom.2014.03.005_bib21","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/IAI.01517-07","article-title":"Interaction between Yersinia pestis and the host immune system","volume":"76","author":"Li","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2014.03.005_bib22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature12436","article-title":"Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains","volume":"501","author":"Li","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2014.03.005_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/14728222.9.1.119","article-title":"Considering Fas ligand as a target for therapy","volume":"9","author":"Linkermann","year":"2005","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.chom.2014.03.005_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mib.2008.12.005","article-title":"Translocated effectors of Yersinia","volume":"12","author":"Matsumoto","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2014.03.005_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9440(10)63953-3","article-title":"Fas (CD95) induces alveolar epithelial cell apoptosis in\u00a0vivo: implications for acute pulmonary inflammation","volume":"158","author":"Matute-Bello","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2014.03.005_bib26","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.175.6.4069","article-title":"Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung","volume":"175","author":"Matute-Bello","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.03.005_bib27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1086\/427261","article-title":"Blockade of the Fas\/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen","volume":"191","author":"Matute-Bello","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2014.03.005_bib28","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.pmed.0030076","article-title":"Lung infection\u2014a public health priority","volume":"3","author":"Mizgerd","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.chom.2014.03.005_bib29","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ni1386","article-title":"Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response","volume":"7","author":"Montminy","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2014.03.005_bib30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.chom.2014.03.005_bib31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9440(10)62290-0","article-title":"Relationship of acute lung inflammatory injury to Fas\/FasL system","volume":"166","author":"Neff","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2014.03.005_bib32","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.4049\/jimmunol.170.12.6209","article-title":"Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages","volume":"170","author":"Park","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.03.005_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature12524","article-title":"A type III effector antagonizes death receptor signalling during bacterial gut infection","volume":"501","author":"Pearson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2014.03.005_bib34","doi-asserted-by":"crossref","first-page":"e1003679","DOI":"10.1371\/journal.ppat.1003679","article-title":"Early host cell targets of Yersinia pestis during primary pneumonic plague","volume":"9","author":"Pechous","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.03.005_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis\u2014etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.chom.2014.03.005_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2007.04.031","article-title":"The CD95 receptor: apoptosis revisited","volume":"129","author":"Peter","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.chom.2014.03.005_bib37","doi-asserted-by":"crossref","first-page":"e1003324","DOI":"10.1371\/journal.ppat.1003324","article-title":"Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague","volume":"9","author":"Peters","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.03.005_bib38","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1073\/pnas.1112729109","article-title":"Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation","volume":"109","author":"Price","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.03.005_bib39","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1084\/jem.187.8.1205","article-title":"Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity","volume":"187","author":"Schneider","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2014.03.005_bib40","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.1439793","article-title":"A surface protease and the invasive character of plague","volume":"258","author":"Sodeinde","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.03.005_bib41","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.20120983","article-title":"TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice","volume":"209","author":"Steinwede","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2014.03.005_bib42","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(94)90375-1","article-title":"Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand","volume":"76","author":"Takahashi","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.chom.2014.03.005_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nm0198-031","article-title":"Downregulation of Fas ligand by shedding","volume":"4","author":"Tanaka","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2014.03.005_bib44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/mp.50.2.87","article-title":"Fas ligand is not only expressed in immune privileged human organs but is also coexpressed with Fas in various epithelial tissues","volume":"50","author":"Xerri","year":"1997","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.chom.2014.03.005_bib45","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cyto.2008.07.015","article-title":"Molecular regulation of inflammation and cell death","volume":"43","author":"Yeretssian","year":"2008","journal-title":"Cytokine"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814001048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814001048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T06:56:27Z","timestamp":1565333787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312814001048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1931312814001048"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2014.03.005","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Pla Protease of Yersinia pestis Degrades Fas Ligand to Manipulate Host Cell Death and Inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2014.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}