{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:47:14Z","timestamp":1790797634731,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.chom.2014.07.005","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T12:04:53Z","timestamp":1407931493000},"page":"201-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells"],"prefix":"10.1016","volume":"16","author":[{"given":"Richard\u00a0J.","family":"Stanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Prod\u2019homme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco\u00a0A.","family":"Purbhoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca\u00a0J.","family":"Aicheler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Heinzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne\u00a0M.","family":"Bailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Antrobus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0P.","family":"Weekes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u00a0J.","family":"Lehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borivoj","family":"Vojtesek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly\u00a0L.","family":"Miners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin\u00a0S.","family":"Wilkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew\u00a0J.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie\u00a0C.Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tomasec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin\u00a0W.G.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2014.07.005_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-62703-601-6_20","article-title":"Functional NK cell cytotoxicity assays against virus infected cells","volume":"1064","author":"Aicheler","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ni1190","article-title":"Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus","volume":"6","author":"Arnon","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib3","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.4049\/jimmunol.162.12.6967","article-title":"Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus","volume":"162","author":"Benedict","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib4","doi-asserted-by":"crossref","first-page":"11539","DOI":"10.1128\/JVI.01016-06","article-title":"Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV","volume":"80","author":"Bentz","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2014.07.005_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2021","article-title":"Regulation of T-cell activation by the cytoskeleton","volume":"7","author":"Billadeau","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib6","doi-asserted-by":"crossref","first-page":"e1001152","DOI":"10.1371\/journal.pbio.1001152","article-title":"Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy","volume":"9","author":"Brown","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib7","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.cub.2009.10.029","article-title":"Distinct roles for the actin nucleators Arp2\/3 and hDia1 during NK-mediated cytotoxicity","volume":"19","author":"Butler","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib8","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.4049\/jimmunol.164.9.4775","article-title":"Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts","volume":"164","author":"Cerboni","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(00)80135-1","article-title":"The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18","volume":"11","author":"Chapman","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2014.07.005_bib10","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1099\/vir.0.018994-0","article-title":"Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture","volume":"91","author":"Dargan","year":"2010","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2014.07.005_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrm2399","article-title":"Membrane nanotubes: dynamic long-distance connections between animal cells","volume":"9","author":"Davis","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib12","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.4049\/jimmunol.167.9.5420","article-title":"Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6","volume":"167","author":"Evans","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib13","doi-asserted-by":"crossref","first-page":"e1004058","DOI":"10.1371\/journal.ppat.1004058","article-title":"Two\u00a0novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation","volume":"10","author":"Fielding","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.07.005_bib14","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.4049\/jimmunol.1000761","article-title":"Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization","volume":"185","author":"Gross","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-59745-413-1_14","article-title":"Cell adhesion assays","volume":"522","author":"Humphries","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-cellbio-100109-104104","article-title":"Regulation of integrin activation","volume":"27","author":"Kim","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib17","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.1128\/JVI.06005-11","article-title":"The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb\u2019-encoded modulation of TNF-\u03b1 signaling","volume":"85","author":"Le","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2014.07.005_bib18","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1182\/blood-2009-12-261487","article-title":"Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells","volume":"116","author":"Mace","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.chom.2014.07.005_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jim.2005.08.015","article-title":"A high-efficiency system of natural killer cell cloning","volume":"307","author":"Morris","year":"2005","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.chom.2014.07.005_bib20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nri2381","article-title":"Formation and function of the lytic NK-cell immunological synapse","volume":"8","author":"Orange","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib21","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1073\/pnas.96.17.9839","article-title":"Cytomegalovirus encodes a potent alpha chemokine","volume":"96","author":"Penfold","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.07.005_bib22","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.4049\/jimmunol.178.7.4473","article-title":"The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1- NK cells","volume":"178","author":"Prod\u2019homme","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib23","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1099\/vir.0.021931-0","article-title":"Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112","volume":"91","author":"Prod\u2019homme","year":"2010","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2014.07.005_bib24","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.4049\/jimmunol.1102068","article-title":"Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18","volume":"188","author":"Prod\u2019homme","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib25","doi-asserted-by":"crossref","first-page":"e1001151","DOI":"10.1371\/journal.pbio.1001151","article-title":"Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse","volume":"9","author":"Rak","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nmeth.1220","article-title":"Lifeact: a versatile marker to visualize F-actin","volume":"5","author":"Riedl","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2014.07.005_bib27","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/MCB.01483-08","article-title":"Regulation of cell-cell adhesion by Abi\/Diaphanous complexes","volume":"29","author":"Ryu","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1202007","article-title":"Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity","volume":"332","author":"Seo","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.07.005_bib29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2013.02.003","article-title":"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses","volume":"13","author":"Smith","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2014.07.005_bib30","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1128\/JVI.02247-06","article-title":"Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression","volume":"81","author":"Stanton","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2014.07.005_bib31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2144\/000112993","article-title":"Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function","volume":"45","author":"Stanton","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.chom.2014.07.005_bib32","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1172\/JCI42955","article-title":"Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication","volume":"120","author":"Stanton","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2014.07.005_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-62703-601-6_1","article-title":"A high-throughput yeast two-hybrid protocol to determine virus-host protein interactions","volume":"1064","author":"Striebinger","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: connecting the membrane to the cytoskeleton","volume":"8","author":"Takenawa","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chom.2014.07.005_bib35","doi-asserted-by":"crossref","first-page":"21685","DOI":"10.1074\/jbc.M301447200","article-title":"Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase","volume":"278","author":"Tani","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2014.07.005_bib36","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrmicro2574","article-title":"Subversion of the actin\u00a0cytoskeleton during viral infection","volume":"9","author":"Taylor","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2014.07.005_bib37","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.287.5455.1031","article-title":"Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40","volume":"287","author":"Tomasec","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.chom.2014.07.005_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ni1156","article-title":"Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141","volume":"6","author":"Tomasec","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2014.07.005_bib39","doi-asserted-by":"crossref","first-page":"e1002444","DOI":"10.1371\/journal.ppat.1002444","article-title":"A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection","volume":"7","author":"Umashankar","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2014.07.005_bib40","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1073\/pnas.112680099","article-title":"UL40-mediated NK evasion during productive infection with human cytomegalovirus","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2014.07.005_bib41","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1021\/pr201135e","article-title":"Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6","volume":"11","author":"Weekes","year":"2012","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.chom.2014.07.005_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcv.2007.10.027","article-title":"Modulation of natural killer cells by human cytomegalovirus","volume":"41","author":"Wilkinson","year":"2008","journal-title":"J.\u00a0Clin. Virol."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814002595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312814002595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T18:38:45Z","timestamp":1689446325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312814002595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1931312814002595"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2014.07.005","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2014.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}