{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:55:44Z","timestamp":1792083344466,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.chom.2015.02.007","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T15:53:56Z","timestamp":1426175636000},"page":"507-514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"title":["Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells"],"prefix":"10.1016","volume":"17","author":[{"given":"Nikolaus","family":"Rieber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Carevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bouzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Amich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Ballbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha\u00a0N.","family":"Klimosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u00a0N.R.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Krappmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Liese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Engeholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sch\u00fcle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut\u00a0Rainer","family":"Salih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Marodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Speckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Grimbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Ruland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon\u00a0D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beilhack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2015.02.007_bib1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores","volume":"460","author":"Aimanianda","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2015.02.007_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chom.2009.12.005","article-title":"How fungi have shaped our understanding of mammalian immunology","volume":"7","author":"Brown","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2015.02.007_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nm.2999","article-title":"Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth","volume":"19","author":"Bruchard","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2015.02.007_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1749-6632.2012.06754.x","article-title":"Inflammation in aspergillosis: the good, the bad, and the therapeutic","volume":"1273","author":"Carvalho","year":"2012","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.chom.2015.02.007_bib5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/IAI.06146-11","article-title":"Interplay between Candida albicans and the mammalian innate host defense","volume":"80","author":"Cheng","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2015.02.007_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib7","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.4049\/jimmunol.1400276","article-title":"Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1\u03b2 production in response to \u03b2-glucans and the fungal pathogen, Candida albicans","volume":"193","author":"Ganesan","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/QCO.0b013e32835fb920","article-title":"Pathogenesis of invasive fungal infections","volume":"26","author":"Garcia-Vidal","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.chom.2015.02.007_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01195","article-title":"Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response","volume":"420","author":"Garlanda","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chom.2015.02.007_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"Gow","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2015.02.007_bib11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2222","article-title":"Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1\u03b2 via a noncanonical caspase-8 inflammasome","volume":"13","author":"Gringhuis","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2015.02.007_bib13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans","volume":"5","author":"Hise","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2015.02.007_bib14","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.ppat.0010030","article-title":"Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display","volume":"1","author":"Hohl","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.02.007_bib15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ni1426","article-title":"The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens","volume":"8","author":"Hsu","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib16","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1221789","article-title":"Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis","volume":"336","author":"Iliev","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.chom.2015.02.007_bib17","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1172\/JCI42388","article-title":"Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T\u00a0cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis","volume":"120","author":"Kreindler","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2015.02.007_bib18","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.1000901","article-title":"Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells","volume":"185","author":"Lechner","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib19","doi-asserted-by":"crossref","first-page":"e1003079","DOI":"10.1371\/journal.ppat.1003079","article-title":"Candida and host determinants of susceptibility to invasive candidiasis","volume":"9","author":"Lionakis","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.02.007_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000321157","article-title":"Organ-specific innate immune responses in a mouse model of invasive candidiasis","volume":"3","author":"Lionakis","year":"2011","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.chom.2015.02.007_bib21","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1172\/JCI71307","article-title":"CX3CR1-dependent renal macrophage survival promotes Candida control and host survival","volume":"123","author":"Lionakis","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2015.02.007_bib22","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.169.6.3180","article-title":"CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis","volume":"169","author":"Mencacci","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chom.2010.08.002","article-title":"A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells","volume":"8","author":"Moyes","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2015.02.007_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2015.02.007_bib25","doi-asserted-by":"crossref","first-page":"e1000661","DOI":"10.1371\/journal.ppat.1000661","article-title":"IL-1beta processing in host defense: beyond the inflammasomes","volume":"6","author":"Netea","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.02.007_bib26","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1002\/eji.201343828","article-title":"Differential role of NK cells against Candida albicans\u00a0infection in immunocompetent or immunocompromised mice","volume":"44","author":"Quintin","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib27","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.4049\/jimmunol.1202144","article-title":"Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease","volume":"190","author":"Rieber","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib29","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.158.5.2356","article-title":"An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis","volume":"158","author":"Romani","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature06471","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease","volume":"451","author":"Romani","year":"2008","journal-title":"Nature"},{"issue":"Suppl 1","key":"10.1016\/j.chom.2015.02.007_bib31","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1080\/13693780802139867","article-title":"Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus","volume":"47","author":"Romani","year":"2009","journal-title":"Med. Mycol."},{"key":"10.1016\/j.chom.2015.02.007_bib32","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1128\/IAI.71.10.5756-5764.2003","article-title":"Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis","volume":"71","author":"Spellberg","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2015.02.007_bib33","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/430952","article-title":"Mice with disseminated candidiasis die of progressive sepsis","volume":"192","author":"Spellberg","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.02.007_bib34","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.ppat.0010042","article-title":"The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus","volume":"1","author":"Steele","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.02.007_bib35","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/eji.201242841","article-title":"\u03b2-glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells","volume":"43","author":"Tian","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib36","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood-2005-03-1239","article-title":"Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production","volume":"106","author":"Underhill","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.chom.2015.02.007_bib37","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1086\/597274","article-title":"Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans","volume":"199","author":"van de Veerdonk","year":"2009","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.02.007_bib38","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/503363","article-title":"Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis","volume":"193","author":"Vonk","year":"2006","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.02.007_bib39","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.4049\/jimmunol.0804250","article-title":"Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus","volume":"182","author":"Werner","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib40","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/eji.200737409","article-title":"IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance","volume":"37","author":"Zelante","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2015.02.007_bib41","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ncomms1685","article-title":"Sensing of mammalian IL-17A regulates fungal adaptation and virulence","volume":"3","author":"Zelante","year":"2012","journal-title":"Nat. Commun."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312815000645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312815000645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T18:59:36Z","timestamp":1691521176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312815000645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1931312815000645"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2015.02.007","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2015.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}