{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:29:56Z","timestamp":1791977396108,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":375,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.chom.2015.05.011","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T15:51:50Z","timestamp":1433951510000},"page":"775-787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Synergistic Action of Staphylococcus aureus \u03b1-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis"],"prefix":"10.1016","volume":"17","author":[{"given":"Michael\u00a0E.","family":"Powers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell\u00a0E.N.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold\u00a0R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Bubeck\u00a0Wardenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2015.05.011_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/MMBR.00055-13","article-title":"The bicomponent pore-forming leucocidins of Staphylococcus aureus","volume":"78","author":"Alonzo","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.chom.2015.05.011_bib2","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1001\/jama.2011.1853","article-title":"The search for effective therapy for sepsis: back to the drawing board?","volume":"306","author":"Angus","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.chom.2015.05.011_bib3","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2015.05.011_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/CCM.0000000000000555","article-title":"Variations in organism-specific severe sepsis mortality in the United States: 1999\u20132008","volume":"43","author":"Ani","year":"2015","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.chom.2015.05.011_bib5","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1128\/IAI.65.11.4652-4660.1997","article-title":"Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins","volume":"65","author":"Bayer","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2015.05.011_bib6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1159\/000360006","article-title":"Tissue-specific patterning of host innate immune responses by Staphylococcus aureus \u03b1-toxin","volume":"6","author":"Becker","year":"2014","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.chom.2015.05.011_bib7","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1182\/blood-2010-06-289108","article-title":"Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases","volume":"116","author":"Bender","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.chom.2015.05.011_bib8","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/toxins5061140","article-title":"Staphylococcus aureus \u03b1-toxin: nearly a century of intrigue","volume":"5","author":"Berube","year":"2013","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.chom.2015.05.011_bib9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.168.2.527","article-title":"Staphylococcal alpha toxin promotes blood coagulation via attack on human platelets","volume":"168","author":"Bhakdi","year":"1988","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2015.05.011_bib10","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/IAI.57.11.3512-3519.1989","article-title":"Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes","volume":"57","author":"Bhakdi","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2015.05.011_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1165\/ajrcmb.18.1.2314","article-title":"Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil beta2 (DC18) integrins","volume":"18","author":"Brown","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.chom.2015.05.011_bib12","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI61303","article-title":"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury","volume":"122","author":"Caudrillier","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2015.05.011_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2015.05.011_bib14","doi-asserted-by":"crossref","first-page":"e7446","DOI":"10.1371\/journal.pone.0007446","article-title":"Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells","volume":"4","author":"Craven","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.chom.2015.05.011_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13054-015-0796-x","article-title":"An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis","volume":"19","author":"Cui","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.chom.2015.05.011_bib16","doi-asserted-by":"crossref","first-page":"e1000964","DOI":"10.1371\/journal.ppat.1000964","article-title":"Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA","volume":"6","author":"Edwards","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.05.011_bib17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/infdis\/167.2.312","article-title":"Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen\/fibrin and platelet integrins","volume":"167","author":"Herrmann","year":"1993","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.05.011_bib18","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.4049\/jimmunol.168.10.5207","article-title":"Critical role of signaling through IL-1 receptor for development of arthritis and sepsis during Staphylococcus aureus infection","volume":"168","author":"Hultgren","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.05.011_bib19","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.2451","article-title":"A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice","volume":"17","author":"Inoshima","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2015.05.011_bib20","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/jid.2011.462","article-title":"Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection","volume":"132","author":"Inoshima","year":"2012","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.chom.2015.05.011_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/infdis\/jir846","article-title":"Staphylococcus aureus \u03b1-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome","volume":"205","author":"Kebaier","year":"2012","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.05.011_bib22","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme","volume":"267","author":"Kuida","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.chom.2015.05.011_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMcibr1007320","article-title":"Sepsis and endothelial permeability","volume":"363","author":"Lee","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2015.05.011_bib24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2015.05.011_bib25","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.chom.2015.05.011_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.intimp.2013.11.004","article-title":"Meprin-\u03b2 regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages","volume":"18","author":"Li","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.chom.2015.05.011_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature12510","article-title":"Key tissue targets responsible for anthrax-toxin-induced lethality","volume":"501","author":"Liu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2015.05.011_bib28","first-page":"3450","article-title":"Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury","volume":"119","author":"Looney","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2015.05.011_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2015.05.011_bib30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-pathol-011110-130158","article-title":"The acute respiratory distress syndrome: pathogenesis and treatment","volume":"6","author":"Matthay","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.chom.2015.05.011_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.chom.2015.03.001","article-title":"Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin","volume":"17","author":"Maurer","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2015.05.011_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000333447","article-title":"Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections","volume":"4","author":"McAdow","year":"2012","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.chom.2015.05.011_bib33","doi-asserted-by":"crossref","first-page":"G797","DOI":"10.1152\/ajpgi.00058.2013","article-title":"Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia","volume":"305","author":"McDonald","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.chom.2015.05.011_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.thromres.2004.06.046","article-title":"Platelet glycoprotein VI: its structure and function","volume":"114","author":"Moroi","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.chom.2015.05.011_bib35","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome","volume":"183","author":"Mu\u00f1oz-Planillo","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2015.05.011_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/cc11381","article-title":"Clinical review: The liver in sepsis","volume":"16","author":"Nesseler","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.chom.2015.05.011_bib37","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.95.10.2387","article-title":"Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets","volume":"95","author":"Neumann","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.chom.2015.05.011_bib38","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/emboj\/20.9.2120","article-title":"Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen","volume":"20","author":"Nieswandt","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.chom.2015.05.011_bib39","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1189\/jlb.0213080","article-title":"The impact of \u03b1-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300","volume":"94","author":"Nygaard","year":"2013","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.chom.2015.05.011_bib40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-micro-092412-155711","article-title":"Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens","volume":"68","author":"Okumura","year":"2014","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2015.05.011_bib41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/infdis\/jit235","article-title":"Staphylococcus aureus \u03b1-hemolysin promotes platelet-neutrophil aggregate formation","volume":"208","author":"Parimon","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.05.011_bib42","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1161\/ATVBAHA.110.211615","article-title":"P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease","volume":"30","author":"Polanowska-Grabowska","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.chom.2015.05.011_bib43","doi-asserted-by":"crossref","first-page":"e1003871","DOI":"10.1371\/journal.ppat.1003871","article-title":"Igniting the fire: Staphylococcus aureus virulence factors in the pathogenesis of sepsis","volume":"10","author":"Powers","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2015.05.011_bib44","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/infdis\/jis192","article-title":"ADAM10 mediates vascular injury induced by Staphylococcus aureus \u03b1-hemolysin","volume":"206","author":"Powers","year":"2012","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.05.011_bib45","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","article-title":"Role of neutrophils in the pathogenesis of acute inflammatory liver injury","volume":"35","author":"Ramaiah","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.chom.2015.05.011_bib46","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.semcdb.2008.11.002","article-title":"The \u201ca disintegrin and metalloprotease\u201d (ADAM) family of sheddases: physiological and cellular functions","volume":"20","author":"Reiss","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2015.05.011_bib47","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/infdis\/jiu223","article-title":"Targeting Staphylococcus aureus \u03b1-toxin as a novel approach to reduce severity of recurrent skin and soft-tissue infections","volume":"210","author":"Sampedro","year":"2014","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2015.05.011_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10739680500466343","article-title":"Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils","volume":"13","author":"Singer","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.chom.2015.05.011_bib49","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev-micro-092412-155746","article-title":"Neutrophils versus Staphylococcus aureus: a biological tug of war","volume":"67","author":"Spaan","year":"2013","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2015.05.011_bib50","doi-asserted-by":"crossref","first-page":"28283","DOI":"10.1074\/jbc.M113.493122","article-title":"Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma","volume":"288","author":"Thomer","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2015.05.011_bib51","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood.V96.4.1399","article-title":"Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment","volume":"96","author":"Tronik-Le Roux","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.chom.2015.05.011_bib52","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.94.21.11607","article-title":"Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells","volume":"94","author":"Valeva","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2015.05.011_bib53","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2015.05.011_bib54","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2015.05.011_bib55","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"Wong","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2015.05.011_bib56","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00018-009-0210-4","article-title":"Platelets in defense against bacterial pathogens","volume":"67","author":"Yeaman","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chom.2015.05.011_bib57","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI29499","article-title":"Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation","volume":"116","author":"Zarbock","year":"2006","journal-title":"J.\u00a0Clin. Invest."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312815002152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312815002152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T05:19:57Z","timestamp":1599110397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312815002152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S1931312815002152"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2015.05.011","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic Action of Staphylococcus aureus \u03b1-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2015.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}