{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:57:02Z","timestamp":1793307422124,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":373,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Government of Taiwan, Ministry of Science and Technology","award":["104-2917-I-564-017"],"award-info":[{"award-number":["104-2917-I-564-017"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI079022"],"award-info":[{"award-number":["AI079022"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.chom.2016.10.005","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T18:30:47Z","timestamp":1478716247000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Receptor-Mediated Sorting of Typhoid Toxin during Its Export from Salmonella Typhi-Infected Cells"],"prefix":"10.1016","volume":"20","author":[{"given":"Shu-Jung","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2016.10.005_bib1","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/S2214-109X(14)70009-9","article-title":"Are we adequately prepared for the emergence of Salmonella enterica serovar Paratyphi A?","volume":"2","author":"Baker","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.chom.2016.10.005_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tibs.2010.02.003","article-title":"Structure, biological functions, and applications of the AB5 toxins","volume":"35","author":"Beddoe","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chom.2016.10.005_bib3","first-page":"010401","article-title":"Typhoid fever and paratyphoid fever: systematic review to estimate global morbidity and mortality for 2010","volume":"2","author":"Buckle","year":"2012","journal-title":"J.\u00a0Glob. Health"},{"key":"10.1016\/j.chom.2016.10.005_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fcimb.2012.00051","article-title":"Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins","volume":"2","author":"Cho","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chom.2016.10.005_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid fever","volume":"50","author":"Crump","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2016.10.005_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1146\/annurev-biochem-061608-091319","article-title":"Protein sorting receptors in the early secretory pathway","volume":"79","author":"Dancourt","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.chom.2016.10.005_bib7","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.cell.2014.10.057","article-title":"Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi","volume":"159","author":"Deng","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chom.2016.10.005_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-micro-091313-103739","article-title":"Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever","volume":"68","author":"Dougan","year":"2014","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2016.10.005_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1708-8305.2008.00237.x","article-title":"Emergence of Salmonella paratyphi A as a major cause of enteric fever: need for early detection, preventive measures, and effective vaccines","volume":"15","author":"Fangtham","year":"2008","journal-title":"J.\u00a0Travel Med."},{"key":"10.1016\/j.chom.2016.10.005_bib10","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1099\/mic.0.058115-0","article-title":"Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors","volume":"158","author":"Figueira","year":"2012","journal-title":"Microbiology"},{"key":"10.1016\/j.chom.2016.10.005_bib11","first-page":"165","article-title":"Gangliosides as receptors for bacterial enterotoxins","volume":"25","author":"Fishman","year":"1993","journal-title":"Adv. Lipid Res."},{"key":"10.1016\/j.chom.2016.10.005_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.cellbio.17.1.53","article-title":"Salmonella interactions with host cells: type III secretion at work","volume":"17","author":"Gal\u00e1n","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2016.10.005_bib13","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1073\/pnas.86.16.6383","article-title":"Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells","volume":"86","author":"Gal\u00e1n","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.005_bib14","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1128\/IAI.59.9.2901-2908.1991","article-title":"Distribution of the invA, -B, -C, and -D genes of Salmonella typhimurium among other Salmonella serovars: invA mutants of Salmonella typhi are deficient for entry into mammalian cells","volume":"59","author":"Gal\u00e1n","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2016.10.005_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/MOG.0b013e3282f21388","article-title":"Pathogenesis of enteric Salmonella infections","volume":"24","author":"Grassl","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.chom.2016.10.005_bib16","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1073\/pnas.0400932101","article-title":"Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway","volume":"101","author":"Haghjoo","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.005_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/embor.2012.186","article-title":"A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion","volume":"14","author":"Hodak","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.chom.2016.10.005_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00001432-200110000-00011","article-title":"Typhoid fever: pathogenesis and disease","volume":"14","author":"House","year":"2001","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.chom.2016.10.005_bib19","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/j.1462-5822.2009.01368.x","article-title":"Salmonella\u2014the ultimate insider.\u00a0Salmonella virulence factors that modulate intracellular survival","volume":"11","author":"Ibarra","year":"2009","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2016.10.005_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0959-440X(95)80071-9","article-title":"AB5 toxins","volume":"5","author":"Merritt","year":"1995","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.chom.2016.10.005_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.med.52.1.259","article-title":"Salmonella: a model for bacterial pathogenesis","volume":"52","author":"Ohl","year":"2001","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.chom.2016.10.005_bib22","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid fever","volume":"347","author":"Parry","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2016.10.005_bib23","first-page":"260","article-title":"Clinical pathogenesis of typhoid fever","volume":"2","author":"Raffatellu","year":"2008","journal-title":"J.\u00a0Infect. Dev. Ctries."},{"key":"10.1016\/j.chom.2016.10.005_bib24","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chom.2016.10.005_bib25","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/tra.12100","article-title":"Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo","volume":"14","author":"Ravindran","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2016.10.005_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.semcdb.2010.02.010","article-title":"Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans","volume":"21","author":"Schachter","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2016.10.005_bib27","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/j.jmb.2016.05.020","article-title":"Gangliosides of the vertebrate nervous system","volume":"428","author":"Schnaar","year":"2016","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chom.2016.10.005_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.chom.2010.09.003","article-title":"A mouse model for the human pathogen Salmonella typhi","volume":"8","author":"Song","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2016.10.005_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature12377","article-title":"Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin","volume":"499","author":"Song","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2016.10.005_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chom.2007.11.001","article-title":"Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment","volume":"3","author":"Span\u00f2","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2016.10.005_bib31","doi-asserted-by":"crossref","first-page":"18418","DOI":"10.1073\/pnas.1111959108","article-title":"Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella","volume":"108","author":"Span\u00f2","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.005_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mib.2008.01.002","article-title":"The Salmonella-containing vacuole: moving with the times","volume":"11","author":"Steele-Mortimer","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2016.10.005_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0022-2275(20)40231-7","article-title":"The Gangliosides","volume":"5","author":"Svennerholm","year":"1964","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.chom.2016.10.005_bib34","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1073\/pnas.2131556100","article-title":"Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid","volume":"100","author":"Tangvoranuntakul","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.005_bib35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev-pathol-011110-130315","article-title":"Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology","volume":"6","author":"Varki","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.chom.2016.10.005_bib36","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0140-6736(13)62708-7","article-title":"Typhoid fever","volume":"385","author":"Wain","year":"2015","journal-title":"Lancet"}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312816304310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312816304310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T13:30:34Z","timestamp":1718890234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312816304310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1931312816304310"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2016.10.005","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Receptor-Mediated Sorting of Typhoid Toxin during Its Export from Salmonella Typhi-Infected Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2016.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}