{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:37:53Z","timestamp":1785267473513,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":378,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Netherlands Organization for Scientific Research","award":["016.176.006"],"award-info":[{"award-number":["016.176.006"]}]},{"name":"ERC Consolidator Grant","award":["310372"],"award-info":[{"award-number":["310372"]}]},{"name":"ERC advanced grant","award":["FP\/2007-2013\/ERC grant 2012-322698"],"award-info":[{"award-number":["FP\/2007-2013\/ERC grant 2012-322698"]}]},{"name":"Spinoza Prize","award":["NWO SPI 92-266"],"award-info":[{"award-number":["NWO SPI 92-266"]}]},{"name":"Netherlands Organization for Scientific Research","award":["863.13.011"],"award-info":[{"award-number":["863.13.011"]}]},{"name":"STW","award":["13546"],"award-info":[{"award-number":["13546"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.chom.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T17:51:19Z","timestamp":1478195479000},"page":"822-833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Functional and Genomic Architecture of Borrelia burgdorferi -Induced Cytokine Responses in Humans"],"prefix":"10.1016","volume":"20","author":[{"given":"Marije","family":"Oosting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariska","family":"Kerstholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"ter Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Deelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Smeekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Lachmandas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedwig","family":"Vrijmoeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Lupse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Flonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart Jan","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramnik","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2016.10.006_bib1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-009-0448-1","article-title":"IL-22: a critical mediator in mucosal host defense","volume":"87","author":"Aujla","year":"2009","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.chom.2016.10.006_bib2","doi-asserted-by":"crossref","first-page":"e1001144","DOI":"10.1371\/journal.ppat.1001144","article-title":"Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1","volume":"6","author":"Bachmann","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2016.10.006_bib3","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1056\/NEJM199511163332004","article-title":"An epidemiologic study of Lyme disease in southern Sweden","volume":"333","author":"Berglund","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2016.10.006_bib4","doi-asserted-by":"crossref","first-page":"e00100","DOI":"10.1128\/mBio.00100-16","article-title":"Longitudinal transcriptome analysis reveals a sustained differential gene expression signature in patients treated for acute Lyme disease","volume":"7","author":"Bouquet","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.chom.2016.10.006_bib5","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1158\/0008-5472.CAN-07-2471","article-title":"Thyroid-stimulating hormone initiated proliferative signals converge in\u00a0vivo on the mTOR kinase without activating AKT","volume":"67","author":"Brewer","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.chom.2016.10.006_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1189\/jlb.4A0715-331R","article-title":"Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi","volume":"100","author":"Buffen","year":"2016","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.chom.2016.10.006_bib7","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.71.6.3437-3442.2003","article-title":"Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi","volume":"71","author":"Burchill","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2016.10.006_bib8","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.4049\/jimmunol.174.8.4670","article-title":"Glucose availability regulates IFN-\u03b3\u00a0production and p70S6 kinase activation in CD8+ effector T\u00a0cells","volume":"174","author":"Cham","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib9","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T\u00a0cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chom.2016.10.006_bib10","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1002\/art.23972","article-title":"Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis","volume":"58","author":"Codolo","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.chom.2016.10.006_bib11","doi-asserted-by":"crossref","first-page":"e1003486","DOI":"10.1371\/journal.ppat.1003486","article-title":"IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis","volume":"9","author":"De Luca","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2016.10.006_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1186\/1756-0500-7-901","article-title":"Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration","volume":"7","author":"Deelen","year":"2014","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.chom.2016.10.006_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nmeth.2307","article-title":"Improved whole-chromosome\u00a0phasing for disease and population genetic studies","volume":"10","author":"Delaneau","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chom.2016.10.006_bib14","first-page":"630","article-title":"Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis","volume":"259","author":"Djukic","year":"2012","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.chom.2016.10.006_bib15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nri2394","article-title":"The X-files in immunity: sex-based differences predispose immune responses","volume":"8","author":"Fish","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.chom.2016.10.006_bib16","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.chom.2016.10.006_bib17","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1007\/s00436-008-1060-y","article-title":"Epidemiological situation of Lyme borreliosis in germany: surveillance data from six Eastern German States, 2002 to 2006","volume":"103","author":"F\u00fcl\u00f6p","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chom.2016.10.006_bib18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng.3021","article-title":"Whole-genome sequence variation, population structure and demographic history of the Dutch population","volume":"46","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chom.2016.10.006_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.it.2012.01.010","article-title":"Metabolic pathways in T\u00a0cell fate and function","volume":"33","author":"Gerriets","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T\u00a0cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2016.10.006_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1534\/g3.111.001198","article-title":"Genotype imputation with thousands of genomes","volume":"1","author":"Howie","year":"2011","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.chom.2016.10.006_bib22","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.1501783","article-title":"Metabolic reprogramming supports IFN-\u03b3 production by CD56bright NK cells","volume":"196","author":"Keating","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/1040841X.2011.622716","article-title":"Translating the role of vitamin D3 in infectious diseases","volume":"38","author":"Khoo","year":"2012","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.chom.2016.10.006_bib24","article-title":"Peripheral facial palsy as an initial symptom of Lyme neuroborreliosis in an Austrian endemic area","author":"Kindler","year":"2015","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.chom.2016.10.006_bib25","doi-asserted-by":"crossref","first-page":"405310","DOI":"10.1155\/2011\/405310","article-title":"Innate immune recognition of Mycobacterium tuberculosis","volume":"2011","author":"Kleinnijenhuis","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib26","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.006_bib27","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1128\/CVI.00129-08","article-title":"Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species","volume":"15","author":"Kotloski","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/CVI.00052-11","article-title":"Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice","volume":"18","author":"Kuo","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib29","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.4139","article-title":"Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi","volume":"22","author":"Li","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2016.10.006_bib30","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.cell.2016.10.017","article-title":"A functional genomics approach to understand variation in cytokine production in humans","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2016.10.006_bib31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2815","article-title":"The X chromosome in immune functions: when a chromosome makes the difference","volume":"10","author":"Libert","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fped.2015.00054","article-title":"Glycans instructing immunity: the emerging role of altered glycosylation in clinical immunology","volume":"3","author":"Lyons","year":"2015","journal-title":"Front Pediatr."},{"key":"10.1016\/j.chom.2016.10.006_bib33","doi-asserted-by":"crossref","first-page":"41046","DOI":"10.1074\/jbc.M111.261545","article-title":"CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope","volume":"286","author":"Mak","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2016.10.006_bib34","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T\u00a0cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib35","first-page":"296","article-title":"Dermatological manifestations of Lyme borreliosis","volume":"14","author":"Mullegger","year":"2004","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.chom.2016.10.006_bib36","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3201\/eid2109.150417","article-title":"Incidence of clinician-diagnosed Lyme disease, United States, 2005\u20132010","volume":"21","author":"Nelson","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chom.2016.10.006_bib37","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2796.2012.02583.x","article-title":"Primary immunodeficiencies of pattern recognition receptors","volume":"272","author":"Netea","year":"2012","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.chom.2016.10.006_bib38","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1086\/652871","article-title":"Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction","volume":"201","author":"Oosting","year":"2010","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2016.10.006_bib39","doi-asserted-by":"crossref","first-page":"e25998","DOI":"10.1371\/journal.pone.0025998","article-title":"TLR1\/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes","volume":"6","author":"Oosting","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.chom.2016.10.006_bib40","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1128\/IAI.05242-11","article-title":"Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease","volume":"79","author":"Oosting","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2016.10.006_bib41","doi-asserted-by":"crossref","first-page":"E4478","DOI":"10.1073\/pnas.1410293111","article-title":"Human TLR10 is an anti-inflammatory pattern-recognition receptor","volume":"111","author":"Oosting","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2016.10.006_bib42","first-page":"233","article-title":"Innate immunity networks during infection with Borrelia burgdorferi","volume":"42","author":"Oosting","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.chom.2016.10.006_bib43","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.chom.2016.10.006_bib44","doi-asserted-by":"crossref","first-page":"23043","DOI":"10.1038\/srep23043","article-title":"Metabolic reprogramming by hexosamine biosynthetic and Golgi N-glycan branching pathways","volume":"6","author":"Ryczko","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2016.10.006_bib45","doi-asserted-by":"crossref","first-page":"29951","DOI":"10.1074\/jbc.M110.132704","article-title":"A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism","volume":"285","author":"Sakamoto","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2016.10.006_bib46","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2016.10.020","article-title":"Linking the human gut microbiome to inflammatory cytokine production capacity","volume":"167","author":"Schirmer","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2016.10.006_bib47","doi-asserted-by":"crossref","first-page":"e1002347","DOI":"10.1371\/journal.pbio.1002347","article-title":"FIH regulates cellular metabolism through hydroxylation of the Deubiquitinase OTUB1","volume":"14","author":"Scholz","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chom.2016.10.006_bib48","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/bioinformatics\/bts180","article-title":"optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants","volume":"28","author":"Shah","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2016.10.006_bib49","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/art.22441","article-title":"High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis","volume":"56","author":"Shin","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.chom.2016.10.006_bib50","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/ncomms2343","article-title":"Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans","volume":"4","author":"Smeekens","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chom.2016.10.006_bib51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2016.10.018","article-title":"Host and environmental factors influencing individual human cytokine responses","volume":"167","author":"ter Horst","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2016.10.006_bib52","doi-asserted-by":"crossref","first-page":"e006772","DOI":"10.1136\/bmjopen-2014-006772","article-title":"Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics","volume":"5","author":"Tigchelaar","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.chom.2016.10.006_bib53","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/clinids\/17.4.708","article-title":"Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis","volume":"17","author":"van Dam","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chom.2016.10.006_bib54","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","article-title":"Regulation of innate immune cell function by mTOR","volume":"15","author":"Weichhart","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2016.10.006_bib55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cmet.2010.03.001","article-title":"The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism","volume":"11","author":"Zhang","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.chom.2016.10.006_bib56","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/srep00020","article-title":"An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese","volume":"1","author":"Zhang","year":"2011","journal-title":"Sci. Rep."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312816304322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312816304322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:53:48Z","timestamp":1536281628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312816304322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1931312816304322"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2016.10.006","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.018","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.017","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.020","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}