{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:29Z","timestamp":1792172609046,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":376,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["R01DE017732"],"award-info":[{"award-number":["R01DE017732"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["R01DE021921"],"award-info":[{"award-number":["R01DE021921"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.chom.2017.06.014","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T14:00:26Z","timestamp":1499868026000},"page":"120-128.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":360,"title":["Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity"],"prefix":"10.1016","volume":"22","author":[{"given":"E","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique Apolin\u00e1rio","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f4ice Dias","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Laino","family":"Albiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Bittinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana T.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2017.06.014_bib1","first-page":"12598","article-title":"IL-17: overview and role in oral immunity and microbiome","volume":"20","author":"Abusleme","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.chom.2017.06.014_bib2","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2017.06.014_bib3","first-page":"32","article-title":"A new method for non-parametric multivariate analysis of variance","volume":"26","author":"Anderson","year":"2001","journal-title":"Austral Ecology"},{"key":"10.1016\/j.chom.2017.06.014_bib4","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1177\/0022034512465292","article-title":"Gene expression dynamics during diabetic periodontitis","volume":"91","author":"Andriankaja","year":"2012","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2017.06.014_bib5","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/jcpe.12470","article-title":"Relationship between periodontitis-associated subgingival microbiota and clinical inflammation by 16S pyrosequencing","volume":"42","author":"Camelo-Castillo","year":"2015","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"issue":"4, Suppl","key":"10.1016\/j.chom.2017.06.014_bib7","first-page":"S106","article-title":"Diabetes and periodontal diseases: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"84","author":"Chapple","year":"2013","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib8","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1902\/jop.2012.110566","article-title":"Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray","volume":"83","author":"Colombo","year":"2012","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2567.2008.03017.x","article-title":"Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens","volume":"126","author":"Curtis","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.chom.2017.06.014_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2011.09.008","article-title":"The relationship of the oral microbiotia to periodontal health and disease","volume":"10","author":"Curtis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2017.06.014_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/jcpe.12664","article-title":"The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study","volume":"44","author":"Demmer","year":"2017","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib12","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chom.2017.06.014_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1902\/jop.1991.62.2.123","article-title":"Periodontal disease in non-insulin-dependent diabetes mellitus","volume":"62","author":"Emrich","year":"1991","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fmicb.2015.00143","article-title":"Ecological perspectives on synthetic biology: insights from microbial population biology","volume":"6","author":"Escalante","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chom.2017.06.014_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-051X.2007.01172.x","article-title":"The use of rodent models to investigate host-bacteria interactions related to periodontal diseases","volume":"35","author":"Graves","year":"2008","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.chom.2017.06.014_bib16","doi-asserted-by":"crossref","first-page":"14799","DOI":"10.1073\/pnas.1004204107","article-title":"Longitudinal shift\u00a0in diabetic wound microbiota correlates with prolonged skin defense response","volume":"107","author":"Grice","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2017.06.014_bib17","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/ismej.2011.191","article-title":"Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing","volume":"6","author":"Griffen","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.chom.2017.06.014_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2017.06.014_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4161\/21505594.2014.990806","article-title":"The enduring importance of animal models in understanding periodontal disease","volume":"6","author":"Hajishengallis","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.chom.2017.06.014_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0022034513487559","article-title":"Mobile microbiome: oral bacteria in extra-oral infections and inflammation","volume":"92","author":"Han","year":"2013","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2017.06.014_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2337\/dc14-0769","article-title":"Insights into the role of the microbiome in obesity and type 2 diabetes","volume":"38","author":"Hartstra","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.chom.2017.06.014_bib22","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/jbmr.2887","article-title":"Links between the microbiome and bone","volume":"31","author":"Hernandez","year":"2016","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.chom.2017.06.014_bib23","doi-asserted-by":"crossref","first-page":"e0127077","DOI":"10.1371\/journal.pone.0127077","article-title":"Microbiome profiles in periodontitis in relation to host and disease characteristics","volume":"10","author":"Hong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2017.06.014_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.chom.2013.04.005","article-title":"Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity","volume":"13","author":"Jiao","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2017.06.014_bib25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut microbiota promote hematopoiesis to control bacterial infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2017.06.014_bib26","doi-asserted-by":"crossref","first-page":"e71227","DOI":"10.1371\/journal.pone.0071227","article-title":"Bacterial community development in experimental gingivitis","volume":"8","author":"Kistler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2017.06.014_bib27","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1128\/JCM.00317-06","article-title":"Changes in periodontal health status are associated with bacterial community shifts as assessed by quantitative 16S cloning and sequencing","volume":"44","author":"Kumar","year":"2006","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.chom.2017.06.014_bib28","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.chom.2017.06.014_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molmed.2016.11.004","article-title":"Bacterial biofilms in colorectal cancer initiation and progression","volume":"23","author":"Li","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.chom.2017.06.014_bib30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/154405910608500606","article-title":"Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation","volume":"85","author":"Liu","year":"2006","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2017.06.014_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal disease. The sixth complication of diabetes mellitus","volume":"16","author":"L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.chom.2017.06.014_bib32","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.4049\/jimmunol.1400569","article-title":"Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis","volume":"192","author":"Maekawa","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2017.06.014_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.2041-1014.2012.00657.x","article-title":"Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment","volume":"27","author":"McIntosh","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.chom.2017.06.014_bib34","doi-asserted-by":"crossref","first-page":"e1004698","DOI":"10.1371\/journal.ppat.1004698","article-title":"Subgingival microbial communities in Leukocyte Adhesion Deficiency and their relationship with local immunopathology","volume":"11","author":"Moutsopoulos","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.06.014_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.0022-202X.2004.22711.x","article-title":"Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation","volume":"123","author":"Naguib","year":"2004","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.chom.2017.06.014_bib36","doi-asserted-by":"crossref","first-page":"e0134234","DOI":"10.1371\/journal.pone.0134234","article-title":"Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver","volume":"10","author":"Nakajima","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2017.06.014_bib37","first-page":"2","article-title":"Diabetes, periodontitis, and the subgingival microbiota","volume":"2","author":"Ohlrich","year":"2010","journal-title":"J.\u00a0Oral Microbiol."},{"key":"10.1016\/j.chom.2017.06.014_bib38","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1096\/fj.11-196279","article-title":"Diabetes aggravates periodontitis by limiting repair through enhanced inflammation","volume":"26","author":"Pacios","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.chom.2017.06.014_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0757.2006.00174.x","article-title":"The breadth of bacterial diversity in the human periodontal pocket and other oral sites","volume":"42","author":"Paster","year":"2006","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.chom.2017.06.014_bib40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1099\/mic.0.082610-0","article-title":"Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity","volume":"161","author":"Patterson","year":"2015","journal-title":"Microbiology"},{"key":"10.1016\/j.chom.2017.06.014_bib41","doi-asserted-by":"crossref","first-page":"e9490","DOI":"10.1371\/journal.pone.0009490","article-title":"FastTree 2--approximately maximum-likelihood trees for large alignments","volume":"5","author":"Price","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2017.06.014_bib42","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chom.2017.06.014_bib43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.archoralbio.2007.08.004","article-title":"Prevalence of Enterococcus faecalis in subgingival biofilm and saliva of subjects with chronic periodontal infection","volume":"53","author":"Souto","year":"2008","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.chom.2017.06.014_bib44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/jamasurg.2013.5","article-title":"The human gut microbiome: a review of the effect of obesity and surgically induced weight loss","volume":"148","author":"Sweeney","year":"2013","journal-title":"JAMA Surg."},{"key":"10.1016\/j.chom.2017.06.014_bib45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.molmet.2016.07.004","article-title":"Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome","volume":"5","author":"Ussar","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.chom.2017.06.014_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.micpath.2015.09.009","article-title":"Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance","volume":"94","author":"Vieira Colombo","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.chom.2017.06.014_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ijos.2015.2","article-title":"Diabetes mellitus related bone metabolism and periodontal disease","volume":"7","author":"Wu","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.chom.2017.06.014_bib48","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/0022034515625962","article-title":"Effect of aging on periodontal inflammation, microbial colonization, and disease susceptibility","volume":"95","author":"Wu","year":"2016","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.chom.2017.06.014_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000351896","article-title":"Bone remodeling under pathological conditions","volume":"18","author":"Xiao","year":"2016","journal-title":"Front. Oral Biol."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817302548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817302548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T17:48:58Z","timestamp":1541440138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312817302548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1931312817302548"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2017.06.014","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2017.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}