{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:09:19Z","timestamp":1790438959973,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"European Union's Horizon 2020 research and innovation program","doi-asserted-by":"publisher","award":["653316"],"award-info":[{"award-number":["653316"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007352","name":"Staatssekretariat f\u00fcr Bildung, Forschung und Innovation of Switzerland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007316","name":"Klaus Tschira Stiftung GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_149340"],"award-info":[{"award-number":["310030_149340"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PP00P3_152928"],"award-info":[{"award-number":["PP00P3_152928"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["326030_128782"],"award-info":[{"award-number":["326030_128782"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_149718"],"award-info":[{"award-number":["310030_149718"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013850","name":"Helmut Horten Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013850","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003357","name":"Gebert R\u00fcf Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.chom.2017.07.008","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T12:17:50Z","timestamp":1502972270000},"page":"354-365.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interferon-\u03b3-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever"],"prefix":"10.1016","volume":"22","author":[{"given":"Melissa M.","family":"Remy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Regen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Kreutzfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Fallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Doras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Bestmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe-Karsten","family":"Hanisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat A.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Merkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Pinschewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2017.07.008_bib1","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1084\/jem.20100124","article-title":"Pathogenic virus-specific T\u00a0cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation","volume":"207","author":"Araki","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib2","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.4049\/jimmunol.172.5.2861","article-title":"Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells","volume":"172","author":"Baize","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2017.07.008_bib3","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1128\/JVI.01948-08","article-title":"Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys","volume":"83","author":"Baize","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0166-0934(91)90018-U","article-title":"Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates","volume":"33","author":"Battegay","year":"1991","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.chom.2017.07.008_bib5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1099\/vir.0.82428-0","article-title":"Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity","volume":"88","author":"Bergthaler","year":"2007","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2017.07.008_bib7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1128\/JVI.02063-06","article-title":"HLA-A2-restricted protection against lethal lymphocytic choriomeningitis","volume":"81","author":"Botten","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI200112761","article-title":"Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery","volume":"108","author":"Cannon","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2017.07.008_bib9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/312548a0","article-title":"Therapy with monoclonal antibodies by elimination of T-cell subsets in\u00a0vivo","volume":"312","author":"Cobbold","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.chom.2017.07.008_bib10","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","article-title":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation","volume":"9","author":"Cosby","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1182\/blood-2004-03-0880","article-title":"Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease","volume":"104","author":"Crawford","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.chom.2017.07.008_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1586\/ers.09.39","article-title":"Bench-to-bedside review: the role of nitric oxide in sepsis","volume":"3","author":"De Cruz","year":"2009","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib13","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nm0695-546","article-title":"Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate","volume":"1","author":"Duncan","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0035-9203(72)90268-4","article-title":"The pathology of Lassa fever","volume":"66","author":"Edington","year":"1972","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2017.07.008_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ejphar.2007.09.033","article-title":"Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse","volume":"578","author":"Elekes","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.chom.2017.07.008_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2010.07.001","article-title":"Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression","volume":"33","author":"Farlik","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2017.07.008_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2017.07.008_bib18","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.1371\/journal.pntd.0000388","article-title":"Risk maps of lassa fever in West Africa","volume":"3","author":"Fichet-Calvet","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jmv.1890260204","article-title":"Hematologic dysfunction in Lassa fever","volume":"26","author":"Fisher-Hoch","year":"1988","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nm.2104","article-title":"Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T\u00a0cell immunity","volume":"16","author":"Flatz","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib21","doi-asserted-by":"crossref","first-page":"e1000836","DOI":"10.1371\/journal.ppat.1000836","article-title":"T cell-dependence of Lassa fever pathogenesis","volume":"6","author":"Flatz","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.008_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11010-009-0318-8","article-title":"New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications","volume":"334","author":"Garthwaite","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.chom.2017.07.008_bib23","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1038\/nm1142","article-title":"Exotic emerging viral diseases: progress and challenges","volume":"10","author":"Geisbert","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib24","doi-asserted-by":"crossref","first-page":"e5391","DOI":"10.1371\/journal.pone.0005391","article-title":"Peptide Bbeta(15-42) preserves endothelial barrier function in shock","volume":"4","author":"Groger","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2017.07.008_bib25","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.2174\/138161206778343000","article-title":"Therapeutic use of nitric oxide scavengers in shock and sepsis","volume":"12","author":"Harbrecht","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.chom.2017.07.008_bib26","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.4049\/jimmunol.158.9.4381","article-title":"In\u00a0vivo production and function of IL-12 p40 homodimers","volume":"158","author":"Heinzel","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2017.07.008_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1073\/pnas.0711200105","article-title":"Platelets prevent IFN-alpha\/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus","volume":"105","author":"Iannacone","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2017.07.008_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/380221a0","article-title":"S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control","volume":"380","author":"Jia","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.chom.2017.07.008_bib29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/infdis\/155.3.456","article-title":"Clinical virology of Lassa fever in hospitalized patients","volume":"155","author":"Johnson","year":"1987","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0005-2728(99)00020-1","article-title":"Nitric oxide metabolism and breakdown","volume":"1411","author":"Kelm","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chom.2017.07.008_bib31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.niox.2011.02.004","article-title":"Activation of MEK1\/ERK1\/2\/iNOS\/sGC\/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats","volume":"24","author":"Korkmaz","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.chom.2017.07.008_bib32","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1084\/jem.20122143","article-title":"Neuroprotective intervention by interferon-gamma blockade prevents CD8+ T\u00a0cell-mediated dendrite and synapse loss","volume":"210","author":"Kreutzfeldt","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib33","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1056\/NEJMc062800","article-title":"Effects of dietary nitrate on blood pressure in healthy volunteers","volume":"355","author":"Larsen","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib34","volume":"Vol. 10","author":"Lehmann-Grube","year":"1971"},{"key":"10.1016\/j.chom.2017.07.008_bib35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2-8","article-title":"Nitric oxide in the pathogenesis of vascular disease","volume":"190","author":"Li","year":"2000","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chom.2017.07.008_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.CCM.0000105581.01815.C6","article-title":"Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock","volume":"32","author":"Lopez","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.chom.2017.07.008_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jmv.2206","article-title":"Hemorrhagic fever occurs after intravenous, but not after intragastric, inoculation of rhesus macaques with lymphocytic choriomeningitis virus","volume":"67","author":"Lukashevich","year":"2002","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chom.2017.07.008_bib39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase","volume":"81","author":"MacMicking","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.chom.2017.07.008_bib40","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1086\/320722","article-title":"Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute Lassa fever","volume":"183","author":"Mahanty","year":"2001","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/infdis\/155.3.445","article-title":"A case-control study of the clinical diagnosis and course of Lassa fever","volume":"155","author":"McCormick","year":"1987","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM198601023140104","article-title":"Lassa fever. Effective therapy with ribavirin","volume":"314","author":"McCormick","year":"1986","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib43","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4269\/ajtmh.1986.35.401","article-title":"Lassa virus hepatitis: a study of fatal Lassa fever in humans","volume":"35","author":"McCormick","year":"1986","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2017.07.008_bib44","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm718","article-title":"Nitric oxide in the human respiratory cycle","volume":"8","author":"McMahon","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib45","doi-asserted-by":"crossref","first-page":"e1005656","DOI":"10.1371\/journal.ppat.1005656","article-title":"Chimeric mice with competent hematopoietic immunity reproduce key features of severe Lassa fever","volume":"12","author":"Oestereich","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.008_bib46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathol-020712-164041","article-title":"Pathogenesis of the viral hemorrhagic fevers","volume":"8","author":"Paessler","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.chom.2017.07.008_bib47","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1084\/jem.185.12.2043","article-title":"HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice","volume":"185","author":"Pascolo","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib48","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1172\/JCI200422374","article-title":"Kinetics of protective antibodies are determined by the viral surface antigen","volume":"114","author":"Pinschewer","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2017.07.008_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/19420862.2016.1269580","article-title":"Antibodies to watch in 2017","volume":"9","author":"Reichert","year":"2017","journal-title":"MAbs"},{"key":"10.1016\/j.chom.2017.07.008_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ibd.21038","article-title":"Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study","volume":"16","author":"Reinisch","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/1871528113666140828113158","article-title":"Dengue fever: theories of immunopathogenesis and challenges for vaccination","volume":"13","author":"Remy","year":"2014","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1016\/j.chom.2017.07.008_bib52","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/jvi.55.3.704-709.1985","article-title":"Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in Guinea pigs is associated with the L RNA segment","volume":"55","author":"Riviere","year":"1985","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib53","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/infdis\/jit004","article-title":"A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques","volume":"207","author":"Safronetz","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2017.07.008_bib54","doi-asserted-by":"crossref","first-page":"10370","DOI":"10.1128\/JVI.78.19.10370-10377.2004","article-title":"Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels","volume":"78","author":"Sanchez","year":"2004","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2017.07.008_bib55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1286-4579(01)01508-8","article-title":"Monitoring of clinical and laboratory data in two cases of imported Lassa fever","volume":"4","author":"Schmitz","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.chom.2017.07.008_bib56","doi-asserted-by":"crossref","first-page":"e1003073","DOI":"10.1371\/journal.ppat.1003073","article-title":"Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease","volume":"8","author":"Schnell","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.008_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1055\/s-0037-1613397","article-title":"Viral hemorrhagic fever\u2014a vascular disease?","volume":"89","author":"Schnittler","year":"2003","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.chom.2017.07.008_bib58","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.139.2.518","article-title":"Induction of nitrite\/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma","volume":"139","author":"Stuehr","year":"1987","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chom.2017.07.008_bib59","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1553-2712.2008.00109.x","article-title":"Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials","volume":"15","author":"Trzeciak","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.chom.2017.07.008_bib60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","article-title":"Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine\/nitric oxide area of research","volume":"851","author":"Tsikas","year":"2007","journal-title":"J.\u00a0Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chom.2017.07.008_bib61","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/CCM.0000000000000554","article-title":"Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX)","volume":"43","author":"Vincent","year":"2015","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.chom.2017.07.008_bib62","first-page":"349","article-title":"Pathologic and virologic study of fatal Lassa fever in man","volume":"107","author":"Walker","year":"1982","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chom.2017.07.008_bib63","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1164\/rccm.2110017","article-title":"Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis","volume":"165","author":"Wang le","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chom.2017.07.008_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI100840","article-title":"The nature of circulatory collapse induced by sodium nitrite","volume":"16","author":"Weiss","year":"1937","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2017.07.008_bib65","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0035-9203(72)90269-6","article-title":"Lassa fever. A study of 23 hospital cases","volume":"66","author":"White","year":"1972","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.chom.2017.07.008_bib66","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(14)62384-9","article-title":"Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care","volume":"385","author":"Wolf","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2017.07.008_bib67","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0042-6822(89)90610-7","article-title":"Neutralizing epitopes of lymphocytic choriomeningitis virus are conformational and require both glycosylation and disulfide bonds for expression","volume":"171","author":"Wright","year":"1989","journal-title":"Virology"},{"key":"10.1016\/j.chom.2017.07.008_bib68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2011.07.015","article-title":"Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever","volume":"92","author":"Zapata","year":"2011","journal-title":"Antiviral Res."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817302913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817302913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T23:41:53Z","timestamp":1692920513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312817302913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1931312817302913"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2017.07.008","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon-\u03b3-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2017.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}