{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:46:16Z","timestamp":1791942376865,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI112649"],"award-info":[{"award-number":["AI112649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI129992"],"award-info":[{"award-number":["AI129992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM083144"],"award-info":[{"award-number":["GM083144"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007588","name":"Washington State University funds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007588","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Paul G. Allen School for Global Animal Health"},{"DOI":"10.13039\/100005825","name":"USDA NIFA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"USDA NIFA postdoctoral fellowship","doi-asserted-by":"publisher","award":["2016-67012-25179"],"award-info":[{"award-number":["2016-67012-25179"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host &amp; Microbe"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.chom.2017.07.017","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T22:00:20Z","timestamp":1503612020000},"page":"317-329.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication"],"prefix":"10.1016","volume":"22","author":[{"given":"Cheryl N.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin P.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Cundiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh A.","family":"Knodler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bailey Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Lupashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Celli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2017.07.017_bib1","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1002\/eji.201040497","article-title":"Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection","volume":"40","author":"Archambaud","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.chom.2017.07.017_bib2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-micro-090110-102905","article-title":"Interactions of the human pathogenic Brucella species with their hosts","volume":"65","author":"Atluri","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fcell.2016.00023","article-title":"COG complex complexities: detailed characterization of a complete set of HEK293T cells lacking individual COG subunits","volume":"4","author":"Bailey Blackburn","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"Celli","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2017.07.017_bib5","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"Brucella coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"Celli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2017.07.017_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1462-5822.2001.00102.x","article-title":"Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole","volume":"3","author":"Comerci","year":"2001","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib7","doi-asserted-by":"crossref","first-page":"e1002575","DOI":"10.1371\/journal.ppat.1002575","article-title":"In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice","volume":"8","author":"Copin","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1462-5822.2011.01601.x","article-title":"Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2","volume":"13","author":"de Barsy","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib9","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1365-2958.2008.06487.x","article-title":"Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system","volume":"70","author":"de Jong","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib10","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/JB.00406-08","article-title":"VirB3 to\u00a0VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system","volume":"190","author":"den Hartigh","year":"2008","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2017.07.017_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/cmi.12224","article-title":"Identification of a type IV secretion substrate of Brucella abortus that participates in the early stages of intracellular survival","volume":"16","author":"D\u00f6hmer","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib12","doi-asserted-by":"crossref","first-page":"e1000487","DOI":"10.1371\/journal.ppat.1000487","article-title":"The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication","volume":"5","author":"Fugier","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1074\/mcp.M700569-MCP200","article-title":"Large scale screening for novel rab effectors reveals unexpected broad rab binding specificity","volume":"7","author":"Fukuda","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.chom.2017.07.017_bib14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1600-0854.2010.01087.x","article-title":"A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells","volume":"11","author":"Gordon","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2017.07.017_bib15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1462-5822.2011.01618.x","article-title":"In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system","volume":"13","author":"Ines Marchesini","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb883","article-title":"Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites","volume":"4","author":"Kagan","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib17","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1462-5822.2011.01635.x","article-title":"Coiled-coil domains enhance the membrane association of Salmonella type III effectors","volume":"13","author":"Knodler","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/tra.12020","article-title":"COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity","volume":"14","author":"Kudlyk","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2017.07.017_bib19","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/nsmb.1917","article-title":"Molecular organization of the COG vesicle tethering complex","volume":"17","author":"Lees","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.virusres.2014.08.015","article-title":"Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication","volume":"192","author":"Liu","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.chom.2017.07.017_bib21","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1074\/jbc.M112.426767","article-title":"Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF)","volume":"288","author":"Miller","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2017.07.017_bib22","doi-asserted-by":"crossref","first-page":"e1003556","DOI":"10.1371\/journal.ppat.1003556","article-title":"Brucella modulates secretory trafficking via multiple type IV secretion effector proteins","volume":"9","author":"Myeni","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib23","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1046\/j.1365-2958.1999.01569.x","article-title":"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis","volume":"33","author":"O'Callaghan","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib24","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1091\/mbc.e03-09-0699","article-title":"The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins","volume":"15","author":"Oka","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2017.07.017_bib25","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/IAI.00417-09","article-title":"Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system, and lipopolysaccharide O antigen","volume":"77","author":"Paix\u00e3o","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2017.07.017_bib26","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments","volume":"66","author":"Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chom.2017.07.017_bib27","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/glycob\/cwr028","article-title":"Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery","volume":"21","author":"Pokrovskaya","year":"2011","journal-title":"Glycobiology"},{"key":"10.1016\/j.chom.2017.07.017_bib28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1462-5822.2012.01747.x","article-title":"Chlamydia trachomatis hijacks intra-Golgi COG complex-dependent vesicle trafficking pathway","volume":"14","author":"Pokrovskaya","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2017.07.017_bib29","doi-asserted-by":"crossref","first-page":"e1000110","DOI":"10.1371\/journal.ppat.1000110","article-title":"RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1\u03b1 in supporting Brucella replication","volume":"4","author":"Qin","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib30","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1083\/jcb.200705145","article-title":"Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a\/Sed5 enhances intra-Golgi SNARE complex stability","volume":"179","author":"Shestakova","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib31","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1128\/JB.182.17.4849-4855.2000","article-title":"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication","volume":"182","author":"Sieira","year":"2000","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chom.2017.07.017_bib32","doi-asserted-by":"crossref","first-page":"e1003785","DOI":"10.1371\/journal.ppat.1003785","article-title":"Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages","volume":"9","author":"Smith","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib33","doi-asserted-by":"crossref","first-page":"e01730","DOI":"10.1128\/mBio.01730-16","article-title":"Postreplication roles of the Brucella VirB type IV secretion system uncovered via conditional expression of the VirB11 ATPase","volume":"7","author":"Smith","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.chom.2017.07.017_bib34","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1600-0854.2008.00718.x","article-title":"Brucella intracellular replication requires trafficking through the late endosomal\/lysosomal compartment","volume":"9","author":"Starr","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.chom.2017.07.017_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chom.2011.12.002","article-title":"Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle","volume":"11","author":"Starr","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2017.07.017_bib36","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1091\/mbc.e05-08-0822","article-title":"COG-7-deficient human fibroblasts exhibit altered recycling of Golgi proteins","volume":"17","author":"Steet","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2017.07.017_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.200111081","article-title":"The Sec34\/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins","volume":"157","author":"Suvorova","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib38","doi-asserted-by":"crossref","first-page":"e1004747","DOI":"10.1371\/journal.ppat.1004747","article-title":"Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection","volume":"11","author":"Taguchi","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2017.07.017_bib39","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1091\/mbc.10.6.1837","article-title":"A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates","volume":"10","author":"Tisdale","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2017.07.017_bib40","doi-asserted-by":"crossref","first-page":"29372","DOI":"10.1074\/jbc.271.46.29372","article-title":"Rab2 is essential for the maturation of pre-Golgi intermediates","volume":"271","author":"Tisdale","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2017.07.017_bib41","doi-asserted-by":"crossref","first-page":"17269","DOI":"10.1074\/jbc.273.27.17269","article-title":"Rab2 protein enhances coatomer recruitment to pre-Golgi intermediates","volume":"273","author":"Tisdale","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2017.07.017_bib42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.119.4.749","article-title":"GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex","volume":"119","author":"Tisdale","year":"1992","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib43","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.141.5.1107","article-title":"Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking","volume":"141","author":"VanRheenen","year":"1998","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib44","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.147.4.729","article-title":"Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p","volume":"147","author":"VanRheenen","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib45","doi-asserted-by":"crossref","first-page":"29565","DOI":"10.1074\/jbc.273.45.29565","article-title":"Purification and characterization of a novel 13\u00a0S hetero-oligomeric protein complex that stimulates in\u00a0VitroGolgi transport","volume":"273","author":"Walter","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chom.2017.07.017_bib46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1083\/jcb.200107045","article-title":"Maintenance of Golgi structure and function depends on the integrity of ER export","volume":"155","author":"Ward","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00418-013-1117-6","article-title":"The Golgi puppet master: COG complex at center stage of membrane trafficking interactions","volume":"140","author":"Willett","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.chom.2017.07.017_bib48","doi-asserted-by":"crossref","first-page":"29139","DOI":"10.1038\/srep29139","article-title":"COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex","volume":"6","author":"Willett","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chom.2017.07.017_bib49","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.200412003","article-title":"Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells","volume":"168","author":"Zolov","year":"2005","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Cell Host &amp; Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817303001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312817303001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:14:14Z","timestamp":1761826454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312817303001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1931312817303001"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2017.07.017","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2017.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}