{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:30:31Z","timestamp":1793532631824,"version":"4.5.0"},"reference-count":102,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AI122749"],"award-info":[{"award-number":["5R01AI122749"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI074951"],"award-info":[{"award-number":["R01AI074951"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.chom.2018.05.022","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T10:42:20Z","timestamp":1529404940000},"page":"57-68.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"title":["Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain"],"prefix":"10.1016","volume":"24","author":[{"given":"Yuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Gordesky-Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leney-Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan L.","family":"Weinbren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tudor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2018.05.022_bib1","doi-asserted-by":"crossref","first-page":"e1000120","DOI":"10.1371\/journal.ppat.1000120","article-title":"Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway","volume":"4","author":"Aggarwal","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2018.05.022_bib2","doi-asserted-by":"crossref","first-page":"e1000582","DOI":"10.1371\/journal.ppat.1000582","article-title":"A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response","volume":"5","author":"Avadhanula","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2018.05.022_bib3","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri3921","article-title":"STING: infection, inflammation and cancer","volume":"15","author":"Barber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nri3763","article-title":"Immunity in Drosophila melanogaster\u2014from microbial recognition to whole-organism physiology","volume":"14","author":"Buchon","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ni.2491","article-title":"STING and the innate immune response to nucleic acids in the cytosol","volume":"14","author":"Burdette","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.virol.2007.05.008","article-title":"Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA","volume":"367","author":"Burnham","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.chom.2018.05.022_bib8","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bbamcr.2009.03.003","article-title":"Autophagy in intracellular bacterial infection","volume":"1793","author":"Campoy","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chom.2018.05.022_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000365195","article-title":"Do the genes of the innate immune response contribute to neuroprotection in Drosophila?","volume":"7","author":"Cantera","year":"2015","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.chom.2018.05.022_bib10","doi-asserted-by":"crossref","first-page":"E1752","DOI":"10.1073\/pnas.1306220110","article-title":"Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain","volume":"110","author":"Cao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib11","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1084\/jem.20170957","article-title":"Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice","volume":"214","author":"Cao","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chom.2018.05.022_bib12","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1091\/mbc.e08-12-1250","article-title":"An Atg1\/Atg13 complex with multiple roles in TOR-mediated autophagy regulation","volume":"20","author":"Chang","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ni1019","article-title":"Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis","volume":"5","author":"Cherry","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib14","article-title":"Role of autophagy in Zika virus infection and pathogenesis","author":"Chiramel","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.chom.2018.05.022_bib15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2014.05.006","article-title":"The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy","volume":"40","author":"Choi","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2018.05.022_bib16","doi-asserted-by":"crossref","first-page":"e7436","DOI":"10.1371\/journal.pone.0007436","article-title":"The Imd pathway is involved in antiviral immune responses in Drosophila","volume":"4","author":"Costa","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2018.05.022_bib17","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of Zika virus","volume":"374","author":"D\u2019Ortenzio","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2018.05.022_bib18","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/jamaneurol.2017.1703","article-title":"Neurologic complications associated with the Zika virus in Brazilian adults","volume":"74","author":"da Silva","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.chom.2018.05.022_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3","volume":"19","author":"Dang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib20","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1073\/pnas.221458698","article-title":"Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays","volume":"98","author":"De Gregorio","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib21","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/ni.1664","article-title":"The DExD\/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila","volume":"9","author":"Deddouche","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib22","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.1304718110","article-title":"Human placental trophoblasts confer viral resistance to recipient cells","volume":"110","author":"Delorme-Axford","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","article-title":"Autophagy, immunity, and microbial adaptations","volume":"5","author":"Deretic","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib24","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1159\/000346388","article-title":"Autophagy and viruses: adversaries or allies?","volume":"5","author":"Dong","year":"2013","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.chom.2018.05.022_bib26","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ni1237","article-title":"The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila","volume":"6","author":"Dostert","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib27","volume":"Volume 2","author":"Fields","year":"2013"},{"key":"10.1016\/j.chom.2018.05.022_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1172\/JCI73944","article-title":"Autophagy and neurodegeneration","volume":"125","author":"Frake","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chom.2018.05.022_bib29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation","volume":"388","author":"Fran\u00e7a","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2018.05.022_bib30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ni1335","article-title":"Essential function in\u00a0vivo for Dicer-2 in host defense against RNA viruses in Drosophila","volume":"7","author":"Galiana-Arnoux","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cois.2015.01.006","article-title":"RNA interference-mediated antiviral defense in insects","volume":"8","author":"Gammon","year":"2015","journal-title":"Curr. Opin. Insect Sci."},{"key":"10.1016\/j.chom.2018.05.022_bib32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib33","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.1424098112","article-title":"RNASEK is required for internalization of diverse acid-dependent viruses","volume":"112","author":"Hackett","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib34","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.05.022_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.chom.2018.05.022_bib36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib38","doi-asserted-by":"crossref","first-page":"14564","DOI":"10.1073\/pnas.0813319106","article-title":"Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance","volume":"106","author":"Jia","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/jipa.1998.4830","article-title":"Molecular characterization of Drosophila C virus isolates","volume":"73","author":"Johnson","year":"1999","journal-title":"J.\u00a0Invertebr. Pathol."},{"key":"10.1016\/j.chom.2018.05.022_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12245","article-title":"Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay","volume":"5","author":"Kim","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.chom.2018.05.022_bib41","article-title":"Autophagy and human neurodegenerative diseases\u2014a fly\u2019s perspective","volume":"18","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chom.2018.05.022_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.dci.2013.05.014","article-title":"The Drosophila IMD pathway in the activation of the humoral immune response","volume":"42","author":"Kleino","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.celrep.2017.04.007","article-title":"NF-\u03baB immunity in the brain determines fly lifespan\u00a0in healthy aging and age-related neurodegeneration","volume":"19","author":"Kounatidis","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2018.05.022_bib44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.molcel.2015.07.022","article-title":"Ancient origin of cGAS-STING reveals mechanism of universal 2\u2032,3\u2032 cGAMP signaling","volume":"59","author":"Kranzusch","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mib.2014.05.006","article-title":"Induced antiviral innate immunity in Drosophila","volume":"20","author":"Lamiable","year":"2014","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.chom.2018.05.022_bib46","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1128\/JVI.00252-16","article-title":"Zika virus: new clinical syndromes and its emergence in the western hemisphere","volume":"90","author":"Lazear","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.05.022_bib47","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coi.2008.01.001","article-title":"Autophagy and antiviral immunity","volume":"20","author":"Lee","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib49","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib50","doi-asserted-by":"crossref","first-page":"e1004685","DOI":"10.1371\/journal.ppat.1004685","article-title":"Catch me if you can: the link between autophagy and viruses","volume":"11","author":"Lennemann","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2018.05.022_bib51","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/15548627.2016.1265192","article-title":"Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B","volume":"13","author":"Lennemann","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.chom.2018.05.022_bib52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib54","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika virus disrupts neural progenitor development and leads to microcephaly in mice","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2016.08.005","article-title":"Zika virus infects neural progenitors in the adult mouse brain and alters proliferation","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib56","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.neuron.2016.11.031","article-title":"The neurobiology of Zika virus","volume":"92","author":"Li","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.chom.2018.05.022_bib57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","article-title":"Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy","volume":"19","author":"Liang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib58","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cell.2011.12.024","article-title":"Regulation of circadian behavioral output via a MicroRNA-JAK\/STAT circuit","volume":"148","author":"Luo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib59","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.it.2017.03.004","article-title":"Evolutionary origins of cGAS-STING signaling","volume":"38","author":"Margolis","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib60","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/15548627.2015.1037062","article-title":"Reconciling West Nile virus with the autophagic pathway","volume":"11","author":"Mart\u00edn-Acebes","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.chom.2018.05.022_bib61","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.chom.2017.01.004","article-title":"Zika virus pathogenesis and tissue tropism","volume":"21","author":"Miner","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib62","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib63","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2018.05.022_bib64","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cell.2017.09.034","article-title":"STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum","volume":"171","author":"Moretti","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib65","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.chom.2016.08.003","article-title":"Signal integration by the I\u03baB protein Pickle shapes Drosophila innate host defense","volume":"20","author":"Morris","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.immuni.2013.10.020","article-title":"Antiviral autophagy restricts Rift Valley fever virus infection and is conserved from flies to mammals","volume":"40","author":"Moy","year":"2014","journal-title":"Immunity"},{"issue":"suppl_10","key":"10.1016\/j.chom.2018.05.022_bib67","doi-asserted-by":"crossref","first-page":"S897","DOI":"10.1093\/infdis\/jix511","article-title":"Neurological implications of Zika virus infection in adults","volume":"216","author":"Mu\u00f1oz","year":"2017","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2018.05.022_bib68","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.1103966","article-title":"Autophagy defends cells against invading group A Streptococcus","volume":"306","author":"Nakagawa","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chom.2018.05.022_bib69","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.immuni.2012.03.003","article-title":"Virus recognition by Toll-7 activates antiviral autophagy in Drosophila","volume":"36","author":"Nakamoto","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2018.05.022_bib70","doi-asserted-by":"crossref","first-page":"146767","DOI":"10.1155\/2012\/146767","article-title":"Selective autophagy in Drosophila","volume":"2012","author":"Nezis","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.chom.2018.05.022_bib71","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008839","article-title":"Autophagy and neuronal cell death in neurological disorders","volume":"4","author":"Nixon","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.chom.2018.05.022_bib72","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nn.4612","article-title":"Zika virus directly infects peripheral neurons and induces cell death","volume":"20","author":"Oh","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chom.2018.05.022_bib73","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1462-5822.2008.01175.x","article-title":"Autophagy and viral neurovirulence","volume":"10","author":"Orvedahl","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.chom.2018.05.022_bib74","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chom.2010.01.007","article-title":"Autophagy protects against Sindbis virus infection of the central nervous system","volume":"7","author":"Orvedahl","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib75","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1534\/genetics.113.150854","article-title":"The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia","volume":"194","author":"Petersen","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.chom.2018.05.022_bib76","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.celrep.2016.12.068","article-title":"Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus","volume":"18","author":"Rausch","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.chom.2018.05.022_bib77","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/S0140-6736(16)00742-X","article-title":"Microcephaly and Zika virus infection","volume":"387","author":"Rodrigues","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.chom.2018.05.022_bib78","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2011.06.009","article-title":"Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts","volume":"10","author":"Rose","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib79","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJMe1601862","article-title":"Zika virus and microcephaly","volume":"374","author":"Rubin","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chom.2018.05.022_bib80","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.1073\/pnas.1600544113","article-title":"Yellow fever virus capsid protein is a potent suppressor of RNA silencing that\u00a0binds double-stranded RNA","volume":"113","author":"Samuel","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib81","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.chom.2015.10.010","article-title":"Microbiota-dependent priming of antiviral intestinal immunity in Drosophila","volume":"18","author":"Sansone","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib82","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2004.07.009","article-title":"Role and regulation of starvation-induced autophagy in the Drosophila fat body","volume":"7","author":"Scott","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/dbio.2001.0411","article-title":"Peripheral glia direct axon guidance across the CNS\/PNS transition zone","volume":"238","author":"Sepp","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chom.2018.05.022_bib84","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.immuni.2009.02.009","article-title":"Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus","volume":"30","author":"Shelly","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.chom.2018.05.022_bib85","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11866","article-title":"Identification of a candidate therapeutic autophagy-inducing peptide","volume":"494","author":"Shoji-Kawata","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib86","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncb2979","article-title":"Cargo recognition and trafficking in selective autophagy","volume":"16","author":"Stolz","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chom.2018.05.022_bib87","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.semcdb.2010.04.003","article-title":"Autophagy and innate immunity: triggering, targeting and tuning","volume":"21","author":"Sumpter","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.chom.2018.05.022_bib88","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4161\/auto.7.3.14281","article-title":"Selective autophagy and viruses","volume":"7","author":"Sumpter","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.chom.2018.05.022_bib89","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib90","doi-asserted-by":"crossref","first-page":"e45800","DOI":"10.1371\/journal.pone.0045800","article-title":"West Nile virus (WNV) replication is independent of autophagy in mammalian cells","volume":"7","author":"Vandergaast","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chom.2018.05.022_bib91","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.chom.2015.05.004","article-title":"The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy","volume":"17","author":"Watson","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib92","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chom.2018.05.022_bib93","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.dci.2013.05.002","article-title":"Viruses and antiviral immunity in Drosophila","volume":"42","author":"Xu","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib94","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chom.2012.08.011","article-title":"Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila","volume":"12","author":"Xu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib95","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/ni.1634","article-title":"Autophagic control of listeria through intracellular innate immune recognition in Drosophila","volume":"9","author":"Yano","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chom.2018.05.022_bib96","doi-asserted-by":"crossref","first-page":"e1003914","DOI":"10.1371\/journal.ppat.1003914","article-title":"Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection","volume":"10","author":"Yasunaga","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chom.2018.05.022_bib97","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.05.022_bib98","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chom.2012.07.013","article-title":"A neuron-specific role for autophagy in antiviral defense against herpes simplex virus","volume":"12","author":"Yordy","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chom.2010.02.003","article-title":"How autophagy saves mice: a cell-autonomous defense system against Sindbis virus infection","volume":"7","author":"Yoshimori","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.05.022_bib100","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0409181102","article-title":"The Toll pathway is important for an antiviral response in Drosophila","volume":"102","author":"Zambon","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chom.2018.05.022_bib101","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature18625","article-title":"A CRISPR screen defines a signal peptide processing pathway required by flaviviruses","volume":"535","author":"Zhang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.05.022_bib102","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1084\/jem.20171093","article-title":"Zika virus has oncolytic activity against glioblastoma stem cells","volume":"214","author":"Zhu","year":"2017","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312818302762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312818302762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:14:59Z","timestamp":1761826499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312818302762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S1931312818302762"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2018.05.022","relation":{},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2018.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.05.029","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}