{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:03:38Z","timestamp":1792119818962,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["HDTRA1-13-C-0018"],"award-info":[{"award-number":["HDTRA1-13-C-0018"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005561","name":"North Carolina Department of Health and Human Services","doi-asserted-by":"publisher","award":["AI132256"],"award-info":[{"award-number":["AI132256"]}],"id":[{"id":"10.13039\/100005561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005561","name":"North Carolina Department of Health and Human Services","doi-asserted-by":"publisher","award":["U19AI109711"],"award-info":[{"award-number":["U19AI109711"]}],"id":[{"id":"10.13039\/100005561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005561","name":"North Carolina Department of Health and Human Services","doi-asserted-by":"publisher","award":["U19AI109762"],"award-info":[{"award-number":["U19AI109762"]}],"id":[{"id":"10.13039\/100005561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","award":["HHSO100201700023C"],"award-info":[{"award-number":["HHSO100201700023C"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Host & Microbe"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.chom.2018.12.005","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T13:10:18Z","timestamp":1547039418000},"page":"49-58.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":125,"title":["A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates"],"prefix":"10.1016","volume":"25","author":[{"given":"Zachary A.","family":"Bornholdt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad E.","family":"Mire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Z.","family":"Wec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna M.","family":"Abelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah M.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Niaz","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya","family":"Borisevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Banadyga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn M.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle N.","family":"Agans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel S.","family":"Wirchnianski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Shestowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognian","family":"Bohorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Bohorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ailor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Whaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Zeitlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Geisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Dye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chom.2018.12.005_bib1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.aad5788","article-title":"Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak","volume":"351","author":"Bornholdt","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chom.2018.12.005_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/femsre\/fuw010","article-title":"Neglected filoviruses","volume":"40","author":"Burk","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.chom.2018.12.005_bib3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.aad5224","article-title":"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody","volume":"351","author":"Corti","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chom.2018.12.005_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/infdis\/jiw209","article-title":"The domestic ferret (Mustela putorius furo) as a lethal infection model for 3 species of ebolavirus","volume":"214","author":"Cross","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"issue":"suppl_5","key":"10.1016\/j.chom.2018.12.005_bib5","first-page":"S486","article-title":"Comparative transcriptomics in Ebola Makona-infected ferrets, nonhuman primates, and humans","volume":"218","author":"Cross","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2018.12.005_bib6","first-page":"584","article-title":"Ebola virus: a comparison, at ultrastructural level, of the behaviour of the Sudan and Zaire strains in monkeys","volume":"59","author":"Ellis","year":"1978","journal-title":"Br. J. Exp. Pathol."},{"issue":"Suppl 3","key":"10.1016\/j.chom.2018.12.005_bib7","doi-asserted-by":"crossref","first-page":"S1082","DOI":"10.1093\/infdis\/jir350","article-title":"Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with Bundibugyo ebolavirus","volume":"204","author":"Falzarano","year":"2011","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2018.12.005_bib8","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1128\/JVI.00561-09","article-title":"Single-injection vaccine protects nonhuman primates against infection with Marburg virus and three species of Ebola virus","volume":"83","author":"Geisbert","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.12.005_bib9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41564-018-0227-2","article-title":"The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses","volume":"3","author":"Goldstein","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2018.12.005_bib10","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1128\/JVI.01033-16","article-title":"Ferrets infected with Bundibugyo virus or Ebola virus recapitulate important aspects of human filovirus disease","volume":"90","author":"Kozak","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.12.005_bib11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nbt1094","article-title":"Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants","volume":"23","author":"Marillonnet","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chom.2018.12.005_bib12","article-title":"Single dose trivalent vesiculovax vaccine protects macaques from lethal ebolavirus and Marburgvirus challenge","author":"Matassov","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.12.005_bib13","doi-asserted-by":"crossref","first-page":"e2600","DOI":"10.1371\/journal.pntd.0002600","article-title":"Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus","volume":"7","author":"Mire","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.chom.2018.12.005_bib14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature14428","article-title":"Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus","volume":"520","author":"Mire","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.12.005_bib15","doi-asserted-by":"crossref","first-page":"18030","DOI":"10.1073\/pnas.1213709109","article-title":"Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques","volume":"109","author":"Olinger","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"suppl_5","key":"10.1016\/j.chom.2018.12.005_bib16","doi-asserted-by":"crossref","first-page":"S612","DOI":"10.1093\/infdis\/jiy285","article-title":"Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in non-human primates","volume":"218","author":"Pascal","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chom.2018.12.005_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chom.2018.12.005_bib18","doi-asserted-by":"crossref","first-page":"329ra33","DOI":"10.1126\/scitranslmed.aad9875","article-title":"Two-mAb cocktail protects macaques against the Makona variant of Ebola virus","volume":"8","author":"Qiu","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chom.2018.12.005_bib19","doi-asserted-by":"crossref","first-page":"16142","DOI":"10.1038\/nmicrobiol.2016.142","article-title":"Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA","volume":"1","author":"Thi","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chom.2018.12.005_bib20","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/jvi.70.2.1100-1108.1996","article-title":"Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1","volume":"70","author":"Trkola","year":"1996","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.12.005_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrmicro3475","article-title":"Broad-spectrum antivirals against viral fusion","volume":"13","author":"Vigant","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chom.2018.12.005_bib22","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.cell.2017.04.037","article-title":"Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses","volume":"169","author":"Wec","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chom.2018.12.005_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chom.2018.12.004","article-title":"Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection","volume":"25","author":"Wec","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chom.2018.12.005_bib24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1128\/JVI.02331-15","article-title":"Development and characterization of a guinea pig-adapted Sudan virus","volume":"90","author":"Wong","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chom.2018.12.005_bib25","doi-asserted-by":"crossref","first-page":"20690","DOI":"10.1073\/pnas.1108360108","article-title":"Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant","volume":"108","author":"Zeitlin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Host & Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312818306322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931312818306322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:17:19Z","timestamp":1761826639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931312818306322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1931312818306322"],"URL":"https:\/\/doi.org\/10.1016\/j.chom.2018.12.005","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/395533","asserted-by":"object"}]},"ISSN":["1931-3128"],"issn-type":[{"value":"1931-3128","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates","name":"articletitle","label":"Article Title"},{"value":"Cell Host & Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2018.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chom.2018.12.004","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}